-Estradiol

Empirical Formula (Hill Notation):	C18H24O2
CAS Number:	50-28-2
Molecular Weight:	272.38
Beilstein/REAXYS Number:	1914275
EC Number:	200-023-8
MDL number:	MFCD00003693
PubChem Substance ID:	24894483
NACRES:	NA.77

Кат. номер

E2758-1G

E2758-5G

E2758-250MG

E2758-25G

-Estradiol or estradiol-17 (E2) is secreted majorly by the large preovulatory follicles in the ovary. In addition, estradiol can be synthesized de novo from cholesterol have androgens synthesized from cholesterol. The aromatization of androgen by enzyme aromatase (P450arom) results in the -estradiol production.
β-Estradiol is used to study cell differentiation and transformations (tumorigenicity).
-Estradiol has been used:

• as a component of Dulbeccos modified Eagle medium (DMEM) for culturing mammary tumor cells
• as a oestrogenic compound for testing neuroprotective effects
• as a component of medium199 for culturing oocytes

250 mg in glass bottle
1, 5 g in glass bottle
The major estrogen secreted by the premenopausal ovary. Estrogens direct the development of the female phenotype in embryogenesis and during puberty by regulating gene transcription and, thus, protein synthesis. It also induces the production of gonadotropins which, in turn, induce ovulation. Exposure to estradiol increases breast cancer incidence and proliferation.
β-Estradiol (E2) is a major premenopausal hormone in women and is essential for spermiogenesis, sperm maturation and motility in men. Cultured bone marrow stem cells (BMSCs) have ability to synthesize E2 and could be exploited for treating estrogen deficiency. It mediates physiological functions through estrogen receptor (ER) α and ERβ.
powder-RT; stock-frozen in working aliquots, avoid repeated freeze/thaw
To prepare a 20 μg/ml stock solution, add 1 ml absolute ethanol to 1 mg β-estradiol; gently swirl to dissolve; add 49 ml sterile medium while mixing.

Quality Level	200
biological source	synthetic (organic)
product line	BioReagent
assay	98% (HPLC)
form	powder
application(s)	cell culture | mammalian: suitable
mp	176-180 °C (lit.)
solubility	ethanol: 50 mg/mL, clear, colorless
shipped in	ambient
storage temp.	room temp
SMILES string	O[C@H]1CC[C@@]2([H])[C@]3([H])CCC4=CC(O)=CC=C4[C@@]3([H])CC[C@@]21C
InChI	1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1
InChI key	VOXZDWNPVJITMN-ZBRFXRBCSA-N
Gene Information	human ... ESR1(2099), ESR2(2100), ESRRA(2101), ESRRB(2103), GPER(2852), SERPINA6(866) mouse ... Esr1(13982), Esr2(13983), Esrra(26379) rat ... Afp(24177), Ar(24208), Esr1(24890), Esr2(25149), Shbg(24775)

Pictograms	GHS08,GHS09
Signal Word	Danger
Hazard Statements	H351 - H360FD - H362 - H410
Precautionary Statements	P202 - P260 - P263 - P264 - P273 - P308 + P313
Personal Protective Equipment	Eyeshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable