Nerve Growth Factor Human

MDL number:	MFCD00164982
NACRES:	NA.77

Кат. номер

H9666-10UG

H9666-10UG-PW

The nerve growth factor β (NGFB) gene is mapped to human chromosome 1p13.2.
HumanKine NGF- is expressed in human 293 cells as a non-glycosylated, non-disulfide bonded 13 kDa homodimer.
NGF- belongs to the nerve growth factor protein superfamily. It is a key growth factor in target-mediated regulation of peripheral innervation. During development, NGF- regulates nerve cell death, synaptic connectivity, fiber guidance, and dendritic morphology. The presence of NGF- in immune cells and endocrine cells as well as in the CNS limbic areas suggests that it may function as an intracellular messenger to regulate the bodys response to stress.
Nerve Growth Factor β Human has been used as a neurotrophic agent in luciferase reporter assay using mammalian cells.
Nerve Growth Factor β (NGFB) acts as a key mediator in neuronal and non-neuronal development, differentiation, and survival. Polymorphism of NGFB gene leads to hereditary sensory and autonomic neuropathies. Charcot arthropathy and thermal insensitivity are few of the related symptoms. NGFB is known to promote cancer cell proliferation and metastasis. It is associated with lung, breast, prostatic and pancreatic cancers. In animal models, NGFB is observed to prevent cholinergic neuron loss and enhances memory.
Lyophilized from a 0.2 μm filtered solution of 1X PBS
The specific activity was determined by the dose-dependent stimulation of the proliferation of the human TF-1 cells (human erythroleukemic indicator cell line).
3D Insert is a trademark of 3D Biotek, LLC
HumanKine is a registered trademark of Proteintech Group, Inc.

biological source	human
Quality Level	100,
recombinant	expressed in HEK 293 cells
assay	95% (SDS-PAGE)
form	lyophilized powder
potency	16 ng/mL ED50
quality	endotoxin tested
mol wt	13 kDa (non-glycosylated)
packaging	pkg of 10 µg
Торговая марка	HumanZyme
application(s)	cell culture | mammalian: suitable
impurities	1 EU/µg
storage temp.	20°C

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable