Fibroblast Growth Factor from bovine pituitary

CAS Number:	62031-54-3
MDL number:	MFCD00166724
NACRES:	NA.77

Кат. номер

F3133-10UG

F3133-PH

F3133-10UG-PW

F3133-5X10UG

Fibroblast growth factors (FGF) are glycoproteins concealed in the extracellular matrix and cell surface. There are around 22 different types of FGFs known. These factors weigh in the range of 17 to 34kDa and they possess a conserved sequence of 120 amino acids.
Fibroblast Growth Factor from bovine pituitary has been used in in vitro testicular cell culture. It has also been used as a component of myogenic culture medium.
A natural mitogenic growth factor used in cell culture applications to study cell signaling and to promote fibroblast and endothelial cell growth and survival.
Fibroblast growth factors (FGF) actively participate in cellular responses including embryogenesis and organogenesis. It specifically controls cell proliferation, differentiation and migration. FGF is known to regulate nervous system functions, tissue repair mechanism and wound healing. It also controls angiogenesis of tumor cells. Abnormal FGF mediated signaling induces tumor angiogenesis, by stimulating cancer cell proliferation and survival. FGFs carries out its function by mediating through four receptor tyrosine kinases : FGF-receptors FGFR1, FGFR2, FGFR3 and FGFR4.
Although the major mitogenic component of this product is FGF2, the activity per unit weight of protein is less than that of purified FGF2.
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 0.1 mg/ml BSA.
Purified glands by a modification of the method of Gospodarowicz.
The biological activity is measured using a 3-day MTT assay.

biological source	bovine pituitary glands
Quality Level	200,
form	lyophilized powder
potency	1-100 ng/mL
mol wt	16.4 kDa
packaging	pkg of 10 and 5X10 μg
storage condition	avoid repeated freeze/thaw cycles
application(s)	cell culture | mammalian: suitable
impurities	endotoxin, tested
color	white to off-white
storage temp.	−20°C

Personal Protective Equipment	Eyeshields,, Gloves,, type N95 (US),
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable