Amphotericin B – Low Endotoxin

Кат. номер

E3789-1G

E3789-500MG

E3789-100MG

Amphotericin B is a polyene antifungal antibiotic from Streptomyces sp. It has a high affinity for sterols,primarily ergosterols, of fungal and bacterial cell membranes.After binding to sterols, it forms channels in the membranes, causing small molecules to leak out.Amphotericin B is effective against fungi and yeast.The name of the drug is derived from the amphoteric behavior of the drug, due to the carboxyl group on the main ring and a primary amino group on the mycosamine ring.
Amphotericin B induces K+ leakage, which is separate from its lethal action, as was demonstrated in human erythrocytes and is due to the inhibitory effect on the Na+/K+ pump.At sub-lethal concentrations, this drug stimulates either the activity of some membrane enzymes or cellular metabolism,in particular stimulation of some cells of the immune system.
If reconstituted at 25 mg/10 mL of sterile water, there is no need to filter sterilize. This will yield a slightly hazy yellow solution.
Amphotericin B remains active for 3 days in culture at 37°C. For long term, storage at 2−8°C, protected from air and light, is recommended. Under these conditions the products remain active for 5 years.

biological source	Streptomyces sp. (Microbial)
form	powder
mol wt	924.08
application(s)	cell culture | mammalian: suitable
storage temp.	2-8°C

pictograms	GHS08
signalword	Danger
hcodes	H372
pcodes	P260 - P264 - P270 - P314 - P501
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable