- Производитель:
- Sigma-Aldrich
MDL number: | MFCD09265355 |
NACRES: | NA.41 |
Anti-Calsequestrin-1 antibody produced in rabbit is suitable for western blotting at a concentration of 0.5-1μg/mL using extracts of rat skeletal muscle S1 fraction.
Biochem/physiol Actions
Calsequestrin-1 is a putative auto-antigen associated with eye muscle inflammation in Graves disease. Calsequestrin-2 (55 kDa) is found in the SRs terminal cisternae luminal space of cardiac, slow skeletal muscle cells and may be in platelets. The major Ca2+ binding protein in cardiac and skeletal muscle is a high-capacity, low-affinity Ca2+ binding glycoprotein, which functions as an internal Ca2+ store in the lumen of the SR. It helps in controlling the smooth-muscle contraction. Calsequestrin is expected to modulate ryanodine receptor (RyR) signaling and Ca2+ release with the help of triadin and junction proteins.†
Target description
Calsequestrin (CS also known as CSQ), the major Ca2+ binding protein in cardiac and skeletal muscle, is a high-capacity, low-affinity Ca2+ binding glycoprotein, which function as an internal Ca2+ store in the lumen of the SR.1-3 In mammals, two forms of the protein exist, calsequestrin-1 (CASQ-1) and calsequestrin-2 (CASQ-2), which encode the fast-twitch skeletal muscle and cardiac calsequestrin, respectively. Calsequestrin-1 is found in the SRs terminal cisternae luminal space of fast skeletal muscle cells. Calsequestrin-1 is a putative autoantigen associated with eye muscle inflammation in Graves disease.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
biological source | rabbit |
Quality Level | 200 |
antibody form | affinity isolated antibody |
antibody product type | primary antibodies |
clone | polyclonal |
form | buffered aqueous solution |
mol wt | antigen ~60 kDa |
species reactivity | human, rat, mouse, canine |
enhanced validation | recombinant expression |
concentration | ~1.6 mg/mL |
application(s) | western blot: 0.5-1 µg/mL using extracts of rat skeletal muscle S1 fraction |
conjugate | unconjugated |
UniProt accession no. | P31415, |
shipped in | dry ice |
storage temp. | 20°C |
Gene Information | human ... CASQ1(844) mouse ... Casq1(12372) |
Personal Protective Equipment | Eyeshields,, Gloves,, multi-purpose combination respirator cartridge (US), |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point F | Not applicable |
Flash Point C | Not applicable |
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