Anti-Arc (C-terminal) antibody produced in rabbit SAB4200460-200UL

NACRES:

NA.41

Activity-regulated cytoskeleton-associated protein (ARC) encodes a growth factor and is an immediate early gene (IEG) that is enriched in brain. It is also known as Arg3.1.
synthetic peptide corresponding to a sequence at the C-terminus of human Arc, conjugated to KLH. The corresponding sequence is highly conserved (89% sequence identity) in rat and mouse Arc.
Anti-Arc (C-terminal) antibody produced in rabbit has been used in immunoblotting.
Biochem/physiol Actions
Activity-regulated cytoskeleton-associated protein (ARC) is associated with synaptic plasticity and normal development in the central nervous system (CNS) induced by neuronal activity. Arc expression is tightly controlled by neuronal activity and its mRNA is rapidly localized to neuronal dendrites and spines where it undergoes local translation. Arc induction is required for late long-term potentiation (LTP) and memory consolidation, as well as LTP-induced cofilin phosphorylation and F-actin stabilization. Arc is known to regulate endocytosis of AMPA receptors mediated interaction with endophilin 3 and dynamin 2, notch signalling and spine morphology.
Physical form
Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

biological source	rabbit
Quality Level	200
antibody form	IgG fraction of antiserum
antibody product type	primary antibodies
clone	polyclonal
form	buffered aqueous solution
mol wt	antigen ~55 kDa
species reactivity	human, mouse
enhanced validation	recombinant expression
application(s)	western blot: 1:2000-1:3000 using mouse brain extracts (P2 fraction)","western blot: 1:3000-1:5000 using lysates of HEK-293T cells overexpressing human Arc
conjugate	unconjugated
UniProt accession no.	Q7LC44,
shipped in	dry ice
storage temp.	20°C
Gene Information	human ... ARC(23237) mouse ... Arc(11838)

RIDADR	NONH for all modes of transport
Flash Point F	Not applicable
Flash Point C	Not applicable