Streptomycin solution

Empirical Formula (Hill Notation):	C21H39N7O12 · 1.5H2SO4
CAS Number:	3810-74-0
Molecular Weight:	728.69
MDL number:	MFCD00037023
PubChem Substance ID:	329769423
NACRES:	NA.24

Кат. номер

85886-10ML

85886-VAR

Chemical structure: aminoglycoside
Streptomycin is used to study mechanisms of streptomycin resistance and is often used together with penicillin and other agents to inhibit bacterial contamination in cell culture applications. It is recommended for use in molecular biology applications at 25-50μg/mL, in cell culture applications at 100 mg/L and in embryo culture at 50 mg/L.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Streptomycin solution has been used as a standard in the determination of streptomycin, present in honey using high performance liquid chromatography(HPLC).
Mode of Action: Streptomycin acts by inhibiting prokaryote protein synthesis by binding to the S12 protein of the 30S ribosomal subunit, thus preventing the transition from imitation complex to chain-elongating ribosome. This causes miscoding or inhibits initiation.
Mode of Resistance: A mutation in rpsL, a gene for S12 ribosomal protein, prevents binding of streptomycin to the ribosome. An aminoglycoside phosphotransferase also inactivates streptomycin.
Antimicrobial Spectrum: Streptomycin acts against gram-negative and gram-positive bacteria.
10ml
This product contains 1 mg/mL Streptomycin in 1 mM EDTA and should be stored at 2-8°C.
Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Quality Level	100
grade	analytical standard
form	liquid
concentration	~1 mg/mL in 1 mM EDTA
application(s)	HPLC: suitable, gas chromatography (GC): suitable
color	colorless
Featured Industry	Pharmaceutical (small molecule)
Mode of action	protein synthesis | interferes
antibiotic activity spectrum	Gram-negative bacteria, Gram-positive bacteria, mycobacteria
format	single component solution
storage temp.	2-8°C
SMILES string	OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@H]2[C@@H](O[C@@H](C)[C@]2(O)C=O)O[C@@H]3[C@@H](O)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]3NC(N)=N.CN[C@H]4[C@H](O)[C@@H](O)[C@H](CO)O[C@H]4O[C@H]5[C@@H](O[C@@H](C)[C@]5(O)C=O)O[C@@H]6[C@@H](O)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]6NC(N)=N
InChI	1S/2C21H39N7O12.3H2O4S/c2*1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35;3*1-5(2,3)4/h2*4-18,26,29,31-36H,3H2,1-2H3,(H4,22,23,27)(H4,24,25,28);3*(H2,1,2,3,4)/t2*5-,6-,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,21+;;;/m00.../s1
InChI key	QTENRWWVYAAPBI-YZTFXSNBSA-N

Personal Protective Equipment	Eyeshields, Gloves
RIDADR	NONH for all modes of transport
WGK Germany	WGK 1
Flash Point F	Not applicable
Flash Point C	Not applicable