N-tert-Butyl--phenylnitrone

Empirical Formula (Hill Notation):	C11H15NO
Linear Formula:	C6H5CH=N(O)C(CH3)3
CAS Number:	3376-24-7
Molecular Weight:	177.24
Beilstein/REAXYS Number:	2044028
EC Number:	222-168-6
MDL number:	MFCD00008799
PubChem Substance ID:	329768721
NACRES:	NA.21

Кат. номер

80126-VAR

80126-1G

N-tert-Butyl-a-phenylnitrone was used as spin trapping agent during measurement of scavenging rate constant of carotenoid using EPR spin-trapping technique. This reagent helps in obtaining a six-line ESR spectrum and hyperfine coupling constants, confirming the presence of carbon-based radical in uric acid and peroxynitrite, using electron spin resonance spectroscopy and liquid chromatography mass spectrometry.
N-tert-butyl--phenylnitrone (PBN) is a commonly used free-radical spin trap. It has been shown to reduce the number of emboli-induced cerebral microinfarctions in the rabbit cortex and prevent neoplasia by its radical scavenging activity and its ability to inhibit cyclooxygenase-2 activity. Reported to inhibit the induction of nitric oxide synthase (iNOS), thereby preventing the overproduction of nitric oxide (NO). PBN in a dose of 100 mg/kg i.p. reduced necrosis of the substantia nigra, pars reticulate in flurothyl-induced status epilepticus in rats. It protects against some types of post-trauma epileptogenic events in an animal model of epilepsy. The lethal dose of PBN in rats was found to be approximately 100 mg/100 g body weight (0.564 mmol/100 g).

grade	for ESR-spectroscopy
Quality Level	100
assay	99.5% (HPLC)
mp	72-74 °C, 73-74 °C (lit.)
solubility	chloroform: 50 mg/mL, clear, colorless
storage temp.	20°C
SMILES string	CC(C)(C)[N+](\[O-])=C\c1ccccc1
InChI	1S/C11H15NO/c1-11(2,3)12(13)9-10-7-5-4-6-8-10/h4-9H,1-3H3/b12-9-
InChI key	IYSYLWYGCWTJSG-XFXZXTDPSA-N

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable