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APN-CHO 806021-50MG
Empirical Formula (Hill Notation): C10H5NO Molecular Weight: 155.15 PubChem Substance ID: 329768984 NACRES: NA.22 ApplicationAPN-Aldehyde is a bifunctional crosslinker for introduction of aldehyde into biomolecules. The coupling can be performed with high selectivity in biological medium using mild reaction conditions.
Packaging
50 mg in glass bottle
Preparation Note
Standard protein labeling procedure (cysteine labeling).- Dissolve the protein in the appropriate buffer with pH 6.5-9.0 (e.g. PBS) at 1-10 mg/mL concentration.
- Apply the appropriate amount of the stock solution of the reagent (1-5 molar eq. per free cysteine residue).
- Incubate at room temperature for 2 hours.
- If necessary, purify the protein-aldehyde conjugate using size exclusion chromatography or ultrafiltration.
- The conjugate can be readily coupled with hydrazides/hydrazones/hydroxylamines using standard protocols.
Параметрыform powder Quality Level 100, reaction suitability reagent type: cross-linking reagent storage temp. 2-8°C SMILES string N#CC#CC1=CC=C(C=O)C=C1 InChI 1S/C10H5NO/c11-7-1-2-9-3-5-10(8-12)6-4-9/h3-6,8H InChI key LYISHMGQKXLBHI-UHFFFAOYSA-N
Safety InformationRIDADR NONH for all modes of transport Узнать цену -
APN-COCI 807745-50MG
Empirical Formula (Hill Notation): C10H4ClNO Molecular Weight: 189.60 PubChem Substance ID: 329768747 ApplicationAPN-COCl is a bifunctional reagent appropriate for the introduction of APN function.
Packaging
50 mg in glass bottleOther NotesThe coupling between an amine and APN-COCl should be performed in dry organic solvents (e.g. THF) in the presence of a base (e.g. TEA). The resulting conjugate can be readily coupled with thiol-containing biomolecules using the following protocol:- Dissolve the protein in the appropriate buffer with pH 6.5-9.0 (e.g. PBS) at 1-10 mg/mL concentration.
- Apply the appropriate amount of the stock solution of the APN-labeled molecule (1-5 molar eq. per free cysteine residue).
- Incubate at room temperature for 2 hours.
Параметрыform powder Quality Level 100, reaction suitability reagent type: cross-linking reagent storage temp. 2-8°C SMILES string N#CC#CC1=CC=C(C(Cl)=O)C=C1 InChI 1S/C10H4ClNO/c11-10(13)9-5-3-8(4-6-9)2-1-7-12/h3-6H InChI key OWNJCJKKKZXTIX-UHFFFAOYSA-N
Safety Informationpictograms GHS05,GHS07 signalword Danger hcodes H302 - H314 pcodes P260 - P280 - P301 + P312 + P330 - P301 + P330 + P331 - P303 + P361 + P353 - P305 + P351 + P338 RIDADR UN 3261 8 / PGII WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Benzyl N-(3-hydroxypropyl)carbamate
Empirical Formula (Hill Notation): C11H15NO3 Linear Formula: HO(CH2)3NHCO2CH2C6H5 CAS Number: 34637-22-4 Molecular Weight: 209.24 MDL number: MFCD01321351 PubChem Substance ID: 24871568 NACRES: NA.22
Кат. номер 478709-25G 478709-5G Параметрыassay 97% reaction suitability reagent type: cross-linking reagent mp 50-53 °C (lit.) SMILES string OCCCNC(OCC1=CC=CC=C1)=O InChI 1S/C11H15NO3/c13-8-4-7-12-11(14)15-9-10-5-2-1-3-6-10/h1-3,5-6,13H,4,7-9H2,(H,12,14) InChI key WXQCFKYWSKKNKY-UHFFFAOYSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H315 - H319 - H335 pcodes P302 + P352 - P305 + P351 + P338 Target Organs Respiratory system Personal Protective Equipment dust mask type N95 (US),, Eyeshields,, Gloves, RIDADR NONH for all modes of transport Flash Point F 235.4 °F - closed cup Flash Point C 113 °C - closed cup Узнать цену -
Biotin-benzyl-tetrazine
Empirical Formula (Hill Notation): C19H23N7O2S Molecular Weight: 413.50 PubChem Substance ID: 329768072 NACRES: NA.22
Кат. номер 793329-5MG 793329-25MG ПараметрыQuality Level 100, assay 95% reaction suitability reagent type: cross-linking reagent storage temp. −20°C SMILES string O=C(CCCC[C@@H](SC1)[C@@]2([H])[C@]1([H])NC(N2)=O)NCC(C=C3)=CC=C3C4=NN=CN=N4 InChI 1S/C19H23N7O2S/c27-16(4-2-1-3-15-17-14(10-29-15)23-19(28)24-17)20-9-12-5-7-13(8-6-12)18-25-21-11-22-26-18/h5-8,11,14-15,17H,1-4,9-10H2,(H,20,27)(H2,23,24,28)/t14-,15?,17-/m1/s1 InChI key GBJXXSUDJUYIIH-XZDBBAETSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Biotin-dPEG®3-MAL QBD10201-50MG
Features and BenefitsEmpirical Formula (Hill Notation): C27H43N5O8S Molecular Weight: 597.72 PubChem Substance ID: 329823891 NACRES: NA.22
Biotin-dPEG®3-MAL takes advantage of the well-known, specific Michael reaction between a maleimide group and a free sulfhydryl to allow site-specific biotin labeling of molecules in aqueous media within the pH range of 6.5 – 7.5. The single molecular weight dPEG® spacer (24.9 ) provide precise spacing between the biotin moiety and the labeled molecule. The dPEG® spacer imparts water solubility to the labeled molecule while reducing immunogenicity, aggregation, and precipitation of labeled biomolecules or other labeled compounds.Legal InformationProducts Protected under U.S. Patents # 7,888,536 B2
dPEG is a registered trademark of Quanta BioDesignПараметрыassay >90% form solid or viscous liquid reaction suitability reaction type: Biotinylations
reactivity: thiol reactive, reagent type: cross-linking reagentpolymer architecture shape: linear
functionality: monofunctionalshipped in ambient storage temp. 20°C SMILES string O=C(NCCCOCCOCCOCCCNC(CCCCC1C2NC(NC2CS1)=O)=O)CCN3C(C=CC3=O)=O
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Bis(NHS)PEG5 803537-100MG
Empirical Formula (Hill Notation): C22H32N2O13 Molecular Weight: 532.50 NACRES: NA.22 General descriptionBy contrast to typical PEG reagents that contain heterogeneous mixtures of different PEG chain lengths, this PEG reagent is a homogeneous compound of defined molecular weight and spacer arm length, providing greater precision in optimization and characterization of crosslinking applications. Homobifunctional crosslinkers containing N-hydroxysuccinimide (NHS) esters are often used for low-resolution 3-D studies of protein structure and protein interaction analysis.
Features and Benefits- Reactive groups: NHS ester (both ends)
- Reactive towards: amino groups (primary amines)
- NHS esters react with—NH2 groups at pH 7-9, forming stable amide bonds
- Water-soluble; compare to non-pegylated BS3 (also soluble) and DSS (water-insoluble)
- Membrane-impermeable, allowing for cell surface labeling
- Irreversibly crosslink proteins or peptides by flexible PEG spacer arms
- Polyethylene glycol spacer arms help maintain conjugate solubility
- Pure compound with defined structure and molecular weight, ensuring reproducible protein-modification effects
- PEG spacer provides unique advantages, including increased stability, reduced tendency toward aggregation and reduced immunogenicity
- Ideal for small molecule or peptide conjugations
Caution
This product is sensitive to moisture. The vial is packaged in a resealable bag with a desiccant to reduce exposure to moisture. After cold storage, equilibrate the vial to room temperature before opening to reduce condensation inside the vial. Make fresh solutions. Storage of stock solutions is not recommended. After use, return the vial to the resealable bag. Close the bag and store the product at the recommended temperature.Параметрыform liquid Quality Level 100, mol wt 532.5 reaction suitability reagent type: cross-linking reagent storage condition desiccated solubility water: soluble shipped in ambient storage temp. −20°C
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
BM(PEG)2 (1,8-bismaleimido-diethyleneglycol) 803588-50MG
Empirical Formula (Hill Notation): C14H16N2O6 Molecular Weight: 308.29 MDL number: MFCD01096749 PubChem Substance ID: 329768819 NACRES: NA.22 General descriptionBM(PEG)2 and BM(PEG)3 are homobifunctional, maleimide crosslinkers for conjugation between sulfhydryl groups (-SH). Such bismaleimide crosslinkers are commonly used to explore and characterize protein structure (i.e. oligomerization) or protein interactions. Because BM(PEG)2 and BM(PEG)3 have the same reactivity but differ in length, the relative success of these and similar reagents in forming crosslinks between sites in a protein oligomer or interaction can assist in determining intra- and intermolecular distances.
Features and Benefits- Reactive groups: maleimide (both ends)
- Reactive towards: sulfhydryl groups
- Long, pegylated, sulfhydryl-to-sulfhydryl crosslinkers, composed of maleimide groups and 2-unit polyethylene glycol spacer arm
- PEG spacers provide unique advantages, including enhanced solubility, increased stability, reduced tendency toward aggregation and reduced immunogenicity
- Pure compounds with defined structure and molecular weight, ensuring reproducible protein-modification effects
- Ideal for small molecule or peptide conjugations
Caution
This product is sensitive to moisture. The vial is packaged in a resealable bag with a desiccant to reduce exposure to moisture. After cold storage, equilibrate the vial to room temperature before opening to reduce condensation inside the vial. Make fresh solutions. Storage of stock solutions is not recommended. After use, return the vial to the resealable bag. Close the bag and store the product at the recommended temperature.ПараметрыQuality Level 100, assay ≥90% form powder mol wt 308.29 reaction suitability reagent type: cross-linking reagent storage condition desiccated solubility water: soluble shipped in ambient storage temp. 2-8°C SMILES string O=C(C=CC1=O)N1CCOCCOCCN2C(C=CC2=O)=O InChI 1S/C14H16N2O6/c17-11-1-2-12(18)15(11)5-7-21-9-10-22-8-6-16-13(19)3-4-14(16)20/h1-4H,5-10H2 InChI key FERLGYOHRKHQJP-UHFFFAOYSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H315 - H319 - H335 pcodes P302 + P352 - P305 + P351 + P338 Target Organs Respiratory system RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
BM(PEG)3 (1,11-bismaleimido-triethyleneglycol) 803596-50MG
Empirical Formula (Hill Notation): C16H20N2O7 Molecular Weight: 352.34 MDL number: MFCD01863352 PubChem Substance ID: 329768820 NACRES: NA.22 General descriptionBM(PEG)2 and BM(PEG)3 are homobifunctional, maleimide crosslinkers for conjugation between sulfhydryl groups (-SH). Such bismaleimide crosslinkers are commonly used to explore and characterize protein structure (i.e. oligomerization) or protein interactions. Because BM(PEG)2 and BM(PEG)3 have the same reactivity but differ in length, the relative success of these and similar reagents in forming crosslinks between sites in a protein oligomer or interaction can assist in determining intra- and intermolecular distances.
Features and Benefits- Reactive groups: maleimide (both ends)
- Reactive towards: sulfhydryl groups
- Long, pegylated, sulfhydryl-to-sulfhydryl crosslinkers, composed of maleimide groups and 3-unit polyethylene glycol spacer arm
- PEG spacers provide unique advantages, including enhanced solubility, increased stability, reduced tendency toward aggregation and reduced immunogenicity
- Pure compounds with defined structure and molecular weight, ensuring reproducible protein-modification effects
- Ideal for small molecule or peptide conjugations
Caution
This product is sensitive to moisture. The vial is packaged in a resealable bag with a desiccant to reduce exposure to moisture. After cold storage, equilibrate the vial to room temperature before opening to reduce condensation inside the vial. Make fresh solutions. Storage of stock solutions is not recommended. After use, return the vial to the resealable bag. Close the bag and store the product at the recommended temperature.ПараметрыQuality Level 100, assay ≥90% form powder mol wt 352.34 reaction suitability reagent type: cross-linking reagent storage condition desiccated solubility water: soluble shipped in ambient storage temp. 2-8°C SMILES string O=C(C=CC1=O)N1CCOCCOCCOCCN2C(C=CC2=O)=O InChI 1S/C16H20N2O7/c19-13-1-2-14(20)17(13)5-7-23-9-11-25-12-10-24-8-6-18-15(21)3-4-16(18)22/h1-4H,5-12H2 InChI key OYRSKXCXEFLTEY-UHFFFAOYSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H315 - H319 - H335 pcodes P302 + P352 - P305 + P351 + P338 Target Organs Respiratory system RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
BMOE (bis-maleimidoethane) 803561-50MG
Empirical Formula (Hill Notation): C10H8N2O4 CAS Number: 5132-30-9 Molecular Weight: 220.18 MDL number: MFCD00458699 PubChem Substance ID: 329768818 NACRES: NA.22 General descriptionBMOE, BMB and BMH are homobifunctional, maleimide crosslinkers for conjugation between sulfhydryl groups (-SH). Such bismaleimide crosslinkers are commonly used to explore and characterize protein structure (i.e., oligomerization) or protein interactions. Because BMOE, BMB and BMH have the same reactivity but differ in length, the relative success of these three reagents in forming crosslinks between sites in a protein oligomer or interaction can assist in determining intra- and intermolecular distances.
Features and Benefits- Reactive groups: maleimide (both ends)
- Reactive towards: sulfhydryl groups
- Short (8.0), sulfhydryl-to-sulfhydryl crosslinker, composed of maleimide groups and 7-atom spacer arm
- Shortest bismaleimide crosslinker available for close proximity crosslinking
- Water-insoluble—dissolve first in DMF or DMSO, then add to aqueous reaction buffers
- Noncleavable
Caution
This product is sensitive to moisture. The vial is packaged in a resealable bag with a desiccant to reduce exposure to moisture. After cold storage, equilibrate the vial to room temperature before opening to reduce condensation inside the vial. Make fresh solutions. Storage of stock solutions is not recommended. After use, return the vial to the resealable bag. Close the bag and store the product at the recommended temperature.Параметрыform powder Quality Level 100, mol wt 220.18 reaction suitability reagent type: cross-linking reagent storage condition desiccated solubility DMSO or DMF: soluble shipped in ambient storage temp. 2-8°C SMILES string O=C(C=CC1=O)N1CCN2C(C=CC2=O)=O InChI 1S/C10H8N2O4/c13-7-1-2-8(14)11(7)5-6-12-9(15)3-4-10(12)16/h1-4H,5-6H2 InChI key PUKLCKVOVCZYKF-UHFFFAOYSA-N
Safety InformationRIDADR NONH for all modes of transport Узнать цену -
BMPH (N-(-maleimidopropionic acid) hydrazide, trifluoroacetic acid salt) 803529-50MG
Empirical Formula (Hill Notation): C7H9N3O3 · CF3CO2H Molecular Weight: 297.19 PubChem Substance ID: 329768815 NACRES: NA.22 General descriptionBMPH, EMCH and KMUH are heterobifunctional crosslinkers containing sulfhydryl-reactive maleimide and carbonyl-reactive hydrazide moieties. Maleimides react with free sulfhydryls (-SH) to form stable thioether bonds. Hydrazide groups react with carbonyls (aldehydes and ketones) to form stable hydrazone bonds. Aldehyde groups can be created by periodate-oxidation of sialic acid and other sugar components of glycoprotein polysaccharides. Thus, these crosslinkers are useful for conjugating glycoproteins and sulfhydryl-containing peptides or proteins. Alternatively, the amine of the hydrazide moiety can be reacted to carboxyl groups using the crosslinker EDC.
Features and Benefits- Reactive groups: maleimide and hydrazide
- Reactive towards: sulfhydryl groups and carbonyl (aldehyde) groups
- Short (8.1A), sulfhydryl-to-aldehyde crosslinker with simple spacer arm (noncleavable)
- Maleimide group reacts with sulfhydryl groups to form stable thioether linkages
- Hydrazide group conjugates to oxidized sugars of glycoproteins and carbohydrates
- Use sodium meta-periodate to oxidize glycosylation (e.g., sialic acid) to reactive aldehyde groups
- Use with EDC to conjugate primary amine of hydrazide group to carboxyl groups
Caution
This product is sensitive to moisture. The vial is packaged in a resealable bag with a desiccant to reduce exposure to moisture. After cold storage, equilibrate the vial to room temperature before opening to reduce condensation inside the vial. Make fresh solutions. Storage of stock solutions is not recommended. After use, return the vial to the resealable bag. Close the bag and store the product at the recommended temperature.ПараметрыQuality Level 100, assay ≥90% form powder mol wt 297.19 reaction suitability reagent type: cross-linking reagent storage condition desiccated solubility water: soluble shipped in ambient storage temp. 2-8°C SMILES string [NH3+]NC(CCN1C(C=CC1=O)=O)=O.[O-]C(C(F)(F)F)=O InChI 1S/C7H9N3O3.C2HF3O2/c8-9-5(11)3-4-10-6(12)1-2-7(10)13;3-2(4,5)1(6)7/h1-2H,3-4,8H2,(H,9,11);(H,6,7) InChI key BADCXPKRBUEEMA-UHFFFAOYSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
BocNH-PEG4-acid
Empirical Formula (Hill Notation): C15H29NO8 CAS Number: 876345-13-0 Molecular Weight: 351.39
Кат. номер 902551-250MG 902551-1G ApplicationThis heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and Boc-protected amino group at the other, which can be deprotected with mildly acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. BocNH-PEG4-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation,Other NotesA Hexylchloride-Based Catch-and-Release System for Chemical Proteomic Applications,
A Biocompatible Condensation Reaction for the Labeling of Terminal Cysteine Residues on Proteins,Legal InformationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under licenseПараметрыform liquid reaction suitability reaction type: Pegylations, reagent type: cross-linking reagent refractive index n/D 1.4641 density 1.1395 g/mL storage temp. 20°C SMILES string OC(COCCOCCOCCOCCNC(OC(C)(C)C)=O)=O, OC(COCCOCCOCCOCCNC(OC(C)(C)C)=O)=O
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
BocNH-PEG5-acid
Empirical Formula (Hill Notation): C17H33NO9 CAS Number: 890152-41-7 Molecular Weight: 395.45
Кат. номер 902683-250MG 902683-1G ApplicationThis heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and Boc-protected amino group at the other, which can be deprotected with mildly acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. BocNH-PEG5-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation,.Legal InformationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under licenseПараметрыform liquid reaction suitability reaction type: Pegylations, reagent type: cross-linking reagent storage temp. −20°C SMILES string OC(COCCOCCOCCOCCOCCNC(OC(C)(C)C)=O)=O, OC(COCCOCCOCCOCCOCCNC(OC(C)(C)C)=O)=O
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Bromoacetic acid N-hydroxysuccinimide ester
Empirical Formula (Hill Notation): C6H6BrNO4 CAS Number: 42014-51-7 Molecular Weight: 236.02 MDL number: MFCD00058571 PubChem Substance ID: 24892067 NACRES: NC.07
PackagingКат. номер B8271-1G B8271-250MG B8271-100MG
100, 250 mg in poly bottle
1 g in poly bottleApplicationA heterobifunctional cross-linking reagent which allows bromoacetylation of primary amine groups followed by coupling to sulfhydryl-containing compounds. Typically, initial reaction couples via ester to primary amine by amide bond formation in the pH range 6.5-8.5. The second reaction results in thioether bonding in pH range 7.0-8.0.
Caution
The bromoacetyl group is light sensitive.ПараметрыQuality Level 200, assay ≥95% form powder reaction suitability reagent type: cross-linking reagent solubility acetone: 25 mg/mL, DMF: soluble shipped in dry ice storage temp. −20°C SMILES string O=C(N1OC(CBr)=O)CCC1=O InChI 1S/C6H6BrNO4/c7-3-6(11)12-8-4(9)1-2-5(8)10/h1-3H2 InChI key NKUZQMZWTZAPSN-UHFFFAOYSA-N
Safety InformationPersonal Protective Equipment dust mask type N95 (US),, Eyeshields,, Gloves, RIDADR NONH for all modes of transport WGK Germany WGK 3 Узнать цену -
BS(PEG)9 (PEGylated bis(sulfosuccinimidyl)suberate) 803464-100MG
Empirical Formula (Hill Notation): C30H48N2O17 Molecular Weight: 708.71 NACRES: NA.22 General descriptionBy contrast to typical PEG reagents that contain heterogeneous mixtures of different PEG chain lengths, this PEG reagent is a homogeneous compound of defined molecular weight and spacer arm length, providing greater precision in optimization and characterization of crosslinking applications.ApplicationBS(PEG)9 (PEGylated bis(sulfosuccinimidyl)suberate) can be used as a cross-linker:- To study the domain structure of BfmR, a regulator of biofilm formation in Acinetobacter baumannii.
- In the study of the mechanism of visual excitation.
Features and Benefits- Reactive groups: sulfo-NHS ester (both ends)
- Reactive towards: amino groups (primary amines)
- NHS esters react with—NH2 groups at pH 7-9, forming stable amide bonds
- Water-soluble; compare to non-pegylated BS3 (also soluble) and DSS (water-insoluble)
- Membrane-impermeable, allowing for cell surface labeling
- Irreversibly crosslink proteins or peptides by flexible PEG spacer arms
- Polyethylene glycol spacer arms help maintain conjugate solubility
- Pure compound with defined structure and molecular weight, ensuring reproducible protein-modification effects
- PEG spacer provides unique advantages, including increased stability, reduced tendency toward aggregation and reduced immunogenicity
- Ideal for small molecule or peptide conjugations
Caution
This product is sensitive to moisture. The vial is packaged in a resealable bag with a desiccant to reduce exposure to moisture. After cold storage, equilibrate the vial to room temperature before opening to reduce condensation inside the vial. Make fresh solutions. Storage of stock solutions is not recommended. After use, return the vial to the resealable bag. Close the bag and store the product at the recommended temperature.ПараметрыQuality Level 100, form oil mol wt 708.71 reaction suitability reagent type: cross-linking reagent storage condition desiccated solubility water: soluble shipped in ambient storage temp. −20°C
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
CBTF 807664-50MG
Empirical Formula (Hill Notation): C16H4F4NNaO5S Molecular Weight: 421.26 PubChem Substance ID: 329768745 NACRES: NA.22 General descriptionCBTF (Sodium 4-((4-(cyanoethynyl)benzoyl)oxy)-2,3,5,6-tetrafluorobenzenesulfonate) is a heterobifunctional reagent. It bears a 3-arylpropionitrile (APN) group. CBTF can be prepared from 4-iodobenzoic acid. It participates in various amine-to-thiol coupling reactions. It participates in the synthesis of various antibody-dye conjugates. CBTF is widely used for antibody conjugation.ApplicationCBTF is a bifunctional crosslinker for amine-to-thiol coupling. The coupling can be performed with high selectivity in biological medium using mild reaction conditions. CBTF readily reacts with organic amines in basic conditions to produce APN-probes suitable for cysteine labeling.
Packaging
50 mg in glass bottleOther NotesStandard protein labeling procedure (lysine labeling):- Dissolve the protein in an appropriate buffer* with pH 7.5-9.0 (e.g. PBS) at 1-10mg/mL concentration.
- Apply the appropriate amount of the stock solution of the reagent (1-5 molar eq. per lysine residue).
- Incubate at room temperature for 2 hours.
- If necessary, purify the protein-APN conjugate using size exclusion chromatography or ultrafiltration.
- The conjugate can be readily coupled with thiol-containing substrates by incubating the components in aqueous buffer (pH 6.5-9.0) at ambient temperature for 2 hours.
Standard protein labeling procedure (cysteine labeling):
Dissolve the protein in the appropriate buffer* with pH 6.5-9.0 (e.g. PBS) at 1-10mg/mL concentration.
Apply the appropriate amount of the stock solution of the APN-labeled molecule (1-5 molar eq. per free cysteine residue).
Incubate at room temperature for 2 hours.
If necessary, purify the protein conjugate using size exclusion chromatography or ultrafiltration.
*Note: avoid amine- and thiol-containing buffers.Параметрыform powder Quality Level 100, reaction suitability reagent type: cross-linking reagent storage temp. −20°C SMILES string O=C(OC1=C(F)C(F)=C(S(=O)(O[Na])=O)C(F)=C1F)C2=CC=C(C#CC#N)C=C2 InChI 1S/C16H5F4NO5S.Na/c17-10-12(19)15(27(23,24)25)13(20)11(18)14(10)26-16(22)9-5-3-8(4-6-9)2-1-7-21;/h3-6H,(H,23,24,25);/q;+1/p-1 InChI key YFJYSJRZDOWXDH-UHFFFAOYSA-M
Safety Informationpictograms GHS06 signalword Danger hcodes H301 pcodes P301 + P310 + P330 RIDADR UN 2811 6.1 / PGIII WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
di-Boc-cystamine
Empirical Formula (Hill Notation): C14H28N2O4S2 CAS Number: 67385-10-8 Molecular Weight: 352.51 Beilstein/REAXYS Number: 4261397 MDL number: MFCD01861323 PubChem Substance ID: 57647640
PackagingКат. номер 17353-5G 17353-1G
5 g in poly bottleOther NotesBuilding block for the synthesis of thioethyl-modified peptidesПараметрыassay ≥98.0% (TLC) reaction suitability reagent type: cross-linking reagent mp 120-122 °C SMILES string CC(C)(C)OC(=O)NCCSSCCNC(=O)OC(C)(C)C InChI 1S/C14H28N2O4S2/c1-13(2,3)19-11(17)15-7-9-21-22-10-8-16-12(18)20-14(4,5)6/h7-10H2,1-6H3,(H,15,17)(H,16,18) InChI key HBTMWZADMHBLMY-UHFFFAOYSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H302 - H315 - H319 - H335 pcodes P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338 Target Organs Respiratory system Personal Protective Equipment dust mask type N95 (US),, Eyeshields,, Gloves, RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Dibenzocyclooctyne-PEG4-maleimide
Empirical Formula (Hill Notation): C36H42N4O9 Molecular Weight: 674.74 MDL number: MFCD22572659 PubChem Substance ID: 329766888 NACRES: NA.22
Кат. номер 760676-50MG 760676-5MG 760676-1MG ApplicationMaleimide functionalized cyclooctyne derivative for incorporation of the cyclooctyne moiety into thiol containing compounds or biomolecules. Cyclooctynes are useful in strain-promoted copper-free azide-alkyne cycloaddition reactions. This dibenzocyclooctyne will react with azide functionalized compounds or biomolecules without the need for a Cu(I) catalyst to result in a stable triazole linkage. The PEG lipophilic spacer helps to reduce aggregation and precipitation problems when labeling biomolecules.
Applications Include:- Protein-peptide conjugates
- Antibody-enzyme or antibody-drug conjugates
- Protein or peptide-oligonucleotide conjugates
- Surface modification
Packaging1, 5, 50 mg in amber glass bottleПараметрыreaction suitability reaction type: click chemistry, reagent type: cross-linking reagent storage temp. −20°C SMILES string O=C(CCOCCOCCOCCOCCNC(=O)CCN1C(=O)C=CC1=O)NCCC(=O)N2Cc3ccccc3C#Cc4ccccc24 InChI 1S/C36H42N4O9/c41-32(14-18-39-34(43)11-12-35(39)44)38-17-20-47-22-24-49-26-25-48-23-21-46-19-15-33(42)37-16-13-36(45)40-27-30-7-2-1-5-28(30)9-10-29-6-3-4-8-31(29)40/h1-8,11-12H,13-27H2,(H,37,42)(H,38,41) InChI key VVFZXPZWVJMYPX-UHFFFAOYSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Diethylene glycol monoallyl ether
Empirical Formula (Hill Notation): C7H14O3 Linear Formula: CH2=CHCH2OCH2CH2OCH2CH2OH CAS Number: 15075-50-0 Molecular Weight: 146.18 Beilstein/REAXYS Number: 1754585 EC Number: 239-131-5 MDL number: MFCD00078367 PubChem Substance ID: 57649667 NACRES: NA.22
Кат. номер 36816-1ML 36816-5ML Параметрыassay 95.0% (GC) reaction suitability reagent type: cross-linking reagent refractive index n20/D 1.446 density 1.010 g/mL at 20 °C (lit.) storage temp. 2-8°C SMILES string C=CCOCCOCCO InChI 1S/C7H14O3/c1-2-4-9-6-7-10-5-3-8/h2,8H,1,3-7H2 InChI key DIOZVWSHACHNRT-UHFFFAOYSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H319 pcodes P305 + P351 + P338 Personal Protective Equipment Eyeshields,, Gloves,, type ABEK (EN14387) respirator filter, RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F 215.6 °F - closed cup Flash Point C 102 °C - closed cup Узнать цену -
Dimethyl 3,3-dithiopropionimidate dihydrochloride
Empirical Formula (Hill Notation): C8H16N2O2S2 · 2HCl CAS Number: 38285-78-8 Molecular Weight: 309.28 MDL number: MFCD00043245 PubChem Substance ID: 57654084 NACRES: NA.22
Кат. номер D2388-100MG D2388-1G D2388-250MG ApplicationReactant for:- Synthesis of glutathione-sensitive cross-linked polyethylenimine gene vector
- Preparation of cyclodextrin-containing polymers designed for gene delivery
- Crosslinking of chick oviduct progesterone-receptor subunits
Packaging
100 mg in poly bottle
Caution
The reagant is readily hydrolyzed at neutral pH. Avoid use of reducing agents during coupling reactions.Other NotesNote that the amidine linkage preserves original primary amine positive charge. The disulfide linkage is cleavable by mild reduction. Incorporates an eight atom linker.Параметрыform powder Quality Level 100, reaction suitability reagent type: cross-linking reagent solubility H2O: 50 mg/mL storage temp. 2-8°C SMILES string Cl.Cl.COC(=N)CCSSCCC(=N)OC InChI 1S/C8H16N2O2S2.2ClH/c1-11-7(9)3-5-13-14-6-4-8(10)12-2;;/h9-10H,3-6H2,1-2H3;2*1H InChI key CQBCVFHLZAVNPF-UHFFFAOYSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H315 Personal Protective Equipment dust mask type N95 (US),, Eyeshields,, Gloves, RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
DST (disuccinimidyl tartrate) 803375-50MG
Empirical Formula (Hill Notation): C12H12O10N2 Molecular Weight: 344.23 MDL number: MFCD00049060 PubChem Substance ID: 329768802 General descriptionDST is a homobifunctional crosslinker that contains amine-reactive N-hydroxysuccinimide (NHS) ester groups and is periodate cleavable. DST is commonly used for conjugating radiolabeled ligands to cell surface receptors. DST must first be dissolved in an organic solvent, such as DMSO or DMF, then added to the aqueous reaction mixture. DST is lipophilic, membrane-permeable and does not possess a charged group, which makes it useful for intracellular and intramembrane protein conjugation.
Features and Benefits- Reactive groups: NHS ester (both ends)
- Reactive towards: amino groups (primary amines)
- Soluble in DMSO or DMF at a concentration of ~10 mM (3 mg/mL)
- Cleavable by sodium meta-periodate (Part No. 20504)
- Ideal for applications in which crosslink cleavability is desired without disturbing protein disulfide bonds
Caution
This product is sensitive to moisture. The vial is packaged in a resealable bag with a desiccant to reduce exposure to moisture. After cold storage, equilibrate the vial to room temperature before opening to reduce condensation inside the vial. Make fresh solutions. Storage of stock solutions is not recommended. After use, return the vial to the resealable bag. Close the bag and store the product at the recommended temperature.Параметрыassay ≥85% Quality Level 100, form powder mol wt 344.24 reaction suitability reagent type: cross-linking reagent storage condition desiccated solubility DMSO or DMF: soluble shipped in ambient storage temp. 2-8°C SMILES string O=C(C(O)C(O)C(ON1C(CCC1=O)=O)=O)ON2C(CCC2=O)=O InChI 1S/C12H12N2O10/c15-5-1-2-6(16)13(5)23-11(21)9(19)10(20)12(22)24-14-7(17)3-4-8(14)18/h9-10,19-20H,1-4H2 InChI key NXVYSVARUKNFNF-UHFFFAOYSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
DTME (dithio-bis-maleimidoethane) 803618-50MG
Empirical Formula (Hill Notation): C12H12N2S2O4 CAS Number: 71865-37-7 Molecular Weight: 312.36 MDL number: MFCD01863385 PubChem Substance ID: 329768821 NACRES: NA.22 General descriptionDTME is a homobifunctional, maleimide crosslinker for conjugation between sulfhydryl groups (-SH). Such bismaleimide crosslinkers are commonly used to explore and characterize protein structure (i.e., oligomerization) or protein interactions. DTME is similar in length to BMH but differs in containing a disulfide bond in its spacer arm, allowing crosslinks with DTME to be cleaved with reducing agent such as dithiothreitol (DTT).
Features and Benefits- Reactive groups: maleimide (both ends)
- Reactive towards: sulfhydryl groups
- Long (13.3A), cleavable, sulfhydryl-to-sulfhydryl crosslinker, composed of maleimide groups and 11-atom disulfide spacer arm
- Water-insoluble—dissolve first in DMF or DMSO, then add to aqueous reaction buffers
- Cleavable by reduction of disulfide spacer arm with DTT, TCEP or other reducing agent
Caution
This product is sensitive to moisture. The vial is packaged in a resealable bag with a desiccant to reduce exposure to moisture. After cold storage, equilibrate the vial to room temperature before opening to reduce condensation inside the vial. Make fresh solutions. Storage of stock solutions is not recommended. After use, return the vial to the resealable bag. Close the bag and store the product at the recommended temperature.ПараметрыQuality Level 100, assay ≥90% form powder mol wt 312.37 reaction suitability reagent type: cross-linking reagent storage condition desiccated solubility DMSO or DMF: soluble shipped in ambient storage temp. 2-8°C SMILES string O=C(C=CC1=O)N1CCSSCCN2C(C=CC2=O)=O InChI 1S/C12H12N2O4S2/c15-9-1-2-10(16)13(9)5-7-19-20-8-6-14-11(17)3-4-12(14)18/h1-4H,5-8H2 InChI key SGVWDRVQIYUSRA-UHFFFAOYSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H302 + H312 + H332 - H315 - H319 - H335 pcodes P280 - P301 + P312 + P330 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338 Target Organs Respiratory system RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
DTSSP (3,3-dithiobis(sulfosuccinimidyl propionate)) 803200-50MG
Empirical Formula (Hill Notation): C14H14N2O14S4Na2 Molecular Weight: 608.51 MDL number: MFCD00054980 PubChem Substance ID: 329768788 NACRES: NA.22 General descriptionDTSSP is 3,3′-Dithiobis(sulfosuccinimidylpropionate), which contains an amine-reactive N-hydroxysulfosuccinimide (sulfo-NHS) ester at each end of an 8-carbon spacer arm. Sulfo-NHS esters react with primary amines at pH 7-9 to form stable amide bonds, along with release of the N-hydroxysulfosuccinimide leaving group. Proteins, including antibodies, generally have several primary amines in the side chain of lysine (K) residues and the N-terminus of each polypeptide that are available as targets for sulfo-NHS-ester crosslinking reagents. DSS, the non-sulfonated analog of DTSSP is also available for applications that require a membrane-permeable crosslinker.Features and Benefits- Reactive groups: sulfo-NHS ester (both ends)
- Reactive towards: amino groups (primary amines)
- Sulfo-NHS ester reacts rapidly with any primary amine-containing molecule
- Disulfide bond in the spacer arm is readily cleaved by 10-50 mM DTT or TCEP at pH 8.5
- Spacer arm also easily cleaved with reducing SDS-PAGE sample loading
- Cleavable crosslinker allows separation of crosslinked products
- Water-soluble; compare with DSP
- Membrane-impermeable, allowing for cell surface labeling
CautionThis product is sensitive to moisture. The vial is packaged in a resealable bag with a desiccant to reduce exposure to moisture. After cold storage, equilibrate the vial to room temperature before opening to reduce condensation inside the vial. Make fresh solutions. Storage of stock solutions is not recommended. After use, return the vial to the resealable bag. Close the bag and store the product at the recommended temperature.ПараметрыQuality Level 100 assay ≥80% form powder mol wt 608.51 reaction suitability reagent type: cross-linking reagent storage condition desiccated solubility soluble (>6mg/ml in water) shipped in ambient storage temp. 2-8°C SMILES string O=C(CC1S(=O)([O-])=O)N(OC(CCSSCCC(ON2C(CC(S(=O)([O-])=O)C2=O)=O)=O)=O)C1=O.[Na+].[Na+] InChI 1S/C14H16N2O14S4.2Na/c17-9-5-7(33(23,24)25)13(21)15(9)29-11(19)1-3-31-32-4-2-12(20)30-16-10(18)6-8(14(16)22)34(26,27)28;;/h7-8H,1-6H2,(H,23,24,25)(H,26,27,28);;/q;2*+1/p-2 InChI key XRWWBWZHHSXBNC-UHFFFAOYSA-L
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
EMCH (N-(-maleimidocaproic acid) hydrazide, trifluoroacetic acid salt) 803677-50MG
Empirical Formula (Hill Notation): C10H15N3O3 · CF3CO2H Molecular Weight: 339.27 PubChem Substance ID: 329768826 NACRES: NA.22 General description3,3′-N-[ε-Maleimidocaproic acid] hydrazide, trifluoroacetic acid salt (EMCH) is a water-soluble, heterobifunctional, membrane permeable crosslinker. It contains a sulfhydryl reactive maleimide group and carbonyl reactive hydrazide group at each end of a 6-carbon spacer arm. Maleimides react with sulfhydryls at pH 6.5-7.5 to form stable thiol ether bonds, along with release of the maleimide leaving group. Proteins with cysteine residues not involved in disulfide bond formation are targets for maleimide reactive groups. Carbonyl groups, whilst not found naturally on proteins can be formed by ring sugar reduction to form aldehydes which react with hydrazides at pH5.5-7.5.
Features and Benefits- Reactive groups: maleimide and hydrazide
- Reactive towards: sulfhydryl groups and carbonyl (aldehyde) groups
- Mid-length (11.8), sulfhydryl-to-aldehyde crosslinker with simple spacer arm (noncleavable)
- Maleimide group reacts with sulfhydryl groups to form stable thioether linkages
- Hydrazide group conjugates to oxidized sugars of glycoproteins and carbohydrates
- Use sodium meta-periodate to oxidize glycosylation (e.g., sialic acid) to reactive aldehyde groups
- Use with EDC to conjugate primary amine of hydrazide group to carboxyl groups
Caution
This product is sensitive to moisture. The vial is packaged in a resealable bag with a desiccant to reduce exposure to moisture. After cold storage, equilibrate the vial to room temperature before opening to reduce condensation inside the vial. Make fresh solutions. Storage of stock solutions is not recommended. After use, return the vial to the resealable bag. Close the bag and store the product at the recommended temperature.ПараметрыQuality Level 100, assay ≥90% form powder mol wt 339.27 reaction suitability reagent type: cross-linking reagent storage condition desiccated solubility water: soluble shipped in ambient storage temp. 2-8°C SMILES string O=C(C=CC1=O)N1CCCCCC(N[NH3+])=O.[O-]C(C(F)(F)F)=O InChI 1S/C10H15N3O3.C2HF3O2/c11-12-8(14)4-2-1-3-7-13-9(15)5-6-10(13)16;3-2(4,5)1(6)7/h5-6H,1-4,7,11H2,(H,12,14);(H,6,7) InChI key DRURMGRBAVYWCL-UHFFFAOYSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H315 - H319 - H335 pcodes P302 + P352 - P305 + P351 + P338 Target Organs Respiratory system RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Hydroxy-PEG4-t-butyl ester
Empirical Formula (Hill Notation): C15H30O7 CAS Number: 518044-32-1 Molecular Weight: 322.39
Кат. номер 902586-250MG 902586-1G ApplicationThis heterobifunctional, PEGylated crosslinker features a hydroxyl group at one end and t-butyl-protected carboxylic acid at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Hydroxy-PEG4-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation,.Other NotesRecruiting cytotoxic T cells to folate-receptor-positive cancer cells,
Syntheses and characterizations of novel pyrrolocoumarin probes for SNAP-tag labeling technology,
High density orthogonal surface immobilization via photoactivated copper-free click chemistry,Legal InformationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under licenseПараметрыassay 95% form liquid reaction suitability reagent type: cross-linking reagent refractive index n/D 1.4492 density 1.04746 g/mL storage temp. 2-8°C SMILES string O=C(OC(C)(C)C)CCOCCOCCOCCOCCO, O=C(OC(C)(C)C)CCOCCOCCOCCOCCO
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Hydroxy-PEG5-t-butyl ester
Empirical Formula (Hill Notation): C17H34O8 CAS Number: 850090-09-4 Molecular Weight: 366.45 MDL number: MFCD20926402
Кат. номер 902691-250MG 902691-1G ApplicationThis heterobifunctional, PEGylated crosslinker features a hydroxyl group at one end and t-butyl-protected carboxylic acid at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Hydroxy-PEG5-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation,.Other NotesSynthesis and Application of Poly(phenylene Ethynylene)s for Bioconjugation: A Conjugated Polymer-Based Fluorogenic Probe for Proteases,Legal InformationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under licenseПараметрыassay 95% form liquid reaction suitability reagent type: cross-linking reagent refractive index n/D 1.448 density 1.071 storage temp. 20°C SMILES string O=C(OC(C)(C)C)CCOCCOCCOCCOCCOCCO, O=C(OC(C)(C)C)CCOCCOCCOCCOCCOCCO
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Hydroxy-PEG6-t-butyl ester
Empirical Formula (Hill Notation): C19H38O9 CAS Number: 361189-64-2 Molecular Weight: 410.50
Кат. номер 902578-250MG 902578-1G ApplicationThis heterobifunctional, PEGylated crosslinker features a hydroxyl group at one end and t-butyl-protected carboxylic acid at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Hydroxy-PEG6-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or roteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation,.Other NotesSynthesis and Molecular Recognition Studies of the HNK-1 Trisaccharide and Related Oligosaccharides. The Specificity of Monoclonal Anti-HNK-1 Antibodies as Assessed by Surface Plasmon Resonance and STD NMR,
Maleimide-oligo(ethylene glycol) Derivatives of Camptothecin as Albumin-Binding Prodrugs: Synthesis and Antitumor Efficacy,Legal InformationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under licenseПараметрыassay 95% form liquid reaction suitability reagent type: cross-linking reagent refractive index n/D 1.454 density 1.068 storage temp. 20°C SMILES string O=C(OC(C)(C)C)CCOCCOCCOCCOCCOCCOCCO, O=C(OC(C)(C)C)CCOCCOCCOCCOCCOCCOCCO
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Iodoacetic acid N-hydroxysuccinimide ester
Empirical Formula (Hill Notation): C6H6INO4 CAS Number: 39028-27-8 Molecular Weight: 283.02 MDL number: MFCD00058451 PubChem Substance ID: 57654310 NACRES: NA.22
PackagingКат. номер I9760-100MG I9760-50MG I9760-10MG
50, 100 mg in poly bottleApplicationA heterobifunctional cross-linking reagent with amine and sulfhydryl reactivity. Typically, coupled initially to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5) Second coupling specific for molecules containing free sulfydryl by thioether linkage buffered at pH 7.5 (7.0-8.0). Useful for preparation of enzyme immunoconjugates and hapten carrier molecule conjugates. Provides a 2-atom linker.
Caution
The iodoacetyl group is light sensitive.Параметрыform powder Quality Level 200, reaction suitability reagent type: cross-linking reagent application(s) peptide synthesis: suitable solubility DMF: 50 mg/mL storage temp. 20°C SMILES string O=C(N1OC(CI)=O)CCC1=O InChI 1S/C6H6INO4/c7-3-6(11)12-8-4(9)1-2-5(8)10/h1-3H2 InChI key VRDGQQTWSGDXCU-UHFFFAOYSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H315 - H319 - H335 pcodes P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338 Target Organs Respiratory system Personal Protective Equipment dust mask type N95 (US),, Eyeshields,, Gloves, RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
LC-SDA (NHS-LC-Diazirine) (succinimidyl 6-(4,4-azipentanamido)hexanoate) 803421-50MG
Empirical Formula (Hill Notation): C15H22N4O5 Molecular Weight: 338.36 PubChem Substance ID: 329768806 NACRES: NA.22 General descriptionSuccinimidyl-diazirine (SDA) reagents are a new class of crosslinkers that combine proven amine-reactive chemistry with an innovative and efficient diazirine-based photochemistry for conjugating amine-containing molecules to nearly any other functional group. The SDA crosslinkers include six compounds differing in spacer arm lengths, ability to cleave the crosslinked proteins, and presence or absence of a charged group for membrane permeability. Protein crosslinking is an important technique used to understand protein structure and to stabilize protein-protein interactions, and these SDA reagents extend the efficiency and range of interactions that can be explored by this approach.
Features and Benefits- Membrane-permeable—suitable for in vivo intracellular protein crosslinking
- Heterobifunctional—NHS ester group reacts with primary amines at pH 7 to 9 to form covalent amide bonds; diazirine (azipentanoate) group reacts efficiently with any amino acid side chain or peptide backbone upon activation with long-wave UV light (330-370 nm)
- Controllable—two-step chemical crosslinking is activated using common laboratory UV lamps
- Easy to use—these crosslinkers are photo-stable under typical laboratory lighting conditions so there is no need to perform experiments in the dark
- Better than aryl azides—the diazirine photoreactive group has better photostability in normal light than phenyl azide groups of traditional photoreactive crosslinkers, yet the diazirine group is more efficiently activated by long-wave UV light
Caution
This product is sensitive to moisture. The vial is packaged in a resealable bag with a desiccant to reduce exposure to moisture. After cold storage, equilibrate the vial to room temperature before opening to reduce condensation inside the vial. Make fresh solutions. Storage of stock solutions is not recommended. After use, return the vial to the resealable bag. Close the bag and store the product at the recommended temperature.ПараметрыQuality Level 100, assay ≥90% form powder mol wt 338.36 reaction suitability reagent type: cross-linking reagent storage condition desiccated solubility DMSO or DMF: soluble shipped in ambient storage temp. 2-8°C SMILES string CC1(N=N1)CCC(NCCCCCC(ON2C(CCC2=O)=O)=O)=O InChI 1S/C15H22N4O5/c1-15(17-18-15)9-8-11(20)16-10-4-2-3-5-14(23)24-19-12(21)6-7-13(19)22/h2-10H2,1H3,(H,16,20) InChI key DYNYVLFTFJHMCW-UHFFFAOYSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
LC-SMCC (succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxy-(6-amidocaproate)) 803383-50MG
Empirical Formula (Hill Notation): C22H29N3O7 Molecular Weight: 447.48 MDL number: MFCD01863459 PubChem Substance ID: 329768803 NACRES: NA.22 General descriptionLC-SMCC is a heterobifunctional crosslinker with N-hydroxysuccinimide (NHS) ester and maleimide groups that allow covalent conjugation of amine- and sulfhydryl-containing molecules. NHS esters react with primary amines at pH 7-9 to form amide bonds, while the maleimides react with sulfhydryl groups at pH 6.5-7.5 to form stable thioether bonds. In aqueous solutions, hydrolytic degradation of the NHS ester is a competing reaction whose rate increases with pH. The maleimide group is more stable than the NHS-ester group but will slowly hydrolyze and also lose its reaction specificity for sulfhydryls at pH values greater than 7.5. For these reasons, conjugation experiments involving this type of heterobifunctional crosslinker are usually performed at pH 7.2-7.5, with the NHS-ester (amine-targeted) reaction being accomplished before or simultaneous with the maleimide (sulfhydryl-targeted) reaction
Features and Benefits- Reactive groups: NHS ester and maleimide
- Reactive toward: amino and sulfhydryl groups
- Long-chain variety of SMCC
- High purity, crystalline reagent can be used to create high-purity maleimide-activated derivatives
- Non-cleavable
- Water-insoluble (dissolve first in DMF or DMSO)
- Cyclohexane bridge confers added stability to the maleimide group making LC-SMCC an ideal crosslinking agent for maleimide activation of proteins. Maleimide groups are stable for 64 hours in 0.1 M sodium phosphate buffer, pH 7 at 4°C.
Caution
This product is sensitive to moisture. The vial is packaged in a resealable bag with a desiccant to reduce exposure to moisture. After cold storage, equilibrate the vial to room temperature before opening to reduce condensation inside the vial. Make fresh solutions. Storage of stock solutions is not recommended. After use, return the vial to the resealable bag. Close the bag and store the product at the recommended temperature.ПараметрыQuality Level 100, assay ≥90% form powder mol wt 447.48 reaction suitability reagent type: cross-linking reagent storage condition desiccated solubility DMSO or DMF: soluble shipped in ambient storage temp. 2-8°C SMILES string O=C(CCC1=O)N1OC(CCCCCNC(C2CCC(CN3C(C=CC3=O)=O)CC2)=O)=O InChI 1S/C22H29N3O7/c26-17-9-10-18(27)24(17)14-15-5-7-16(8-6-15)22(31)23-13-3-1-2-4-21(30)32-25-19(28)11-12-20(25)29/h9-10,15-16H,1-8,11-14H2,(H,23,31) InChI key IHVODYOQUSEYJJ-UHFFFAOYSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
LC-SPDP (succinimidyl 6-[3(2-pyridyldithio)propionamido]hexanoate) 803642-50MG
Empirical Formula (Hill Notation): C18 H23 O5 N3 S2 CAS Number: 158913-22-5 Molecular Weight: 425.52 MDL number: MFCD00083163 PubChem Substance ID: 329768823 NACRES: NA.22 General descriptionThe amine-reactive portion of SPDP reagents is the N-hydroxysuccinimide (NHS) ester. Reactions are most commonly performed in phosphate, carbonate/bicarbonate, or borate buffers at pH 7-8. Other buffers can be used provided they do not contain primary amines (or thiols or disulfide reducing reagents – see discussion of the sulfhydryl reactivity). The rate of reaction and degradation by hydrolysis increases with increasing pH; for example, the half-life of the NHS ester is several hours at pH 7 and less than 10 minutes at pH 9. NHS-ester reagents like SPDP and LC-SPDP have limited aqueous solubility and must be dissolved in organic solvent before adding them to a reaction mixture. Sulfo-NHS-ester reagents like Sulfo-LC-SPDP are water-soluble and can be added directly to aqueous reaction mixtures.
Features and Benefits- Reactive groups: NHS ester and pyridyldithiol
- Reactive towards: amino and sulfhydryl groups
- Releases a detectable by-product when reacted with a free sulfhydryl group; by measuring the release of pyridine-2-thione at 343 nm, the reaction can be easily followed
- Disulfide bond in the spacer arm is readily cleaved by 10-50 mM DTT or TCEP at pH 8.5
- Spacer arm is also easily cleaved using reducing SDS-PAGE sample loading buffer
- Cleavable crosslinker allows separation of crosslinked products
- Water-insoluble (dissolve first in DMF or DMSO)
- SPDP crosslinker is membrane permeable, so crosslinking can be done inside the cells
- Compare to other varieties of SPDP-type reagents, including pegylated forms
Caution
This product is sensitive to moisture. The vial is packaged in a resealable bag with a desiccant to reduce exposure to moisture. After cold storage, equilibrate the vial to room temperature before opening to reduce condensation inside the vial. Make fresh solutions. Storage of stock solutions is not recommended. After use, return the vial to the resealable bag. Close the bag and store the product at the recommended temperature.ПараметрыQuality Level 100, assay ≥95% form powder mol wt 425.52 reaction suitability reagent type: cross-linking reagent storage condition desiccated solubility DMSO or DMF: soluble shipped in ambient storage temp. 2-8°C SMILES string O=C1CCC(N1OC(CCCCCNC(CCSSC2=CC=CC=N2)=O)=O)=O InChI 1S/C18H23N3O5S2/c22-14(10-13-27-28-15-6-3-5-12-20-15)19-11-4-1-2-7-18(25)26-21-16(23)8-9-17(21)24/h3,5-6,12H,1-2,4,7-11,13H2,(H,19,22) InChI key QYEAAMBIUQLHFQ-UHFFFAOYSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Maleimide-PEG12-succinimidyl ester
Empirical Formula (Hill Notation): C38H63N3O19 CAS Number: 1426151-00-9 Molecular Weight: 865.92 MDL number: MFCD11041148 PubChem Substance ID: 329765749 NACRES: NA.22
Кат. номер 746215-50MG 746215-250MG ApplicationHeterobifunctional crosslinker with an ethylene oxide spacer for linking amine- to sulfhydryl-containing compounds or biomolecules. Maleimide functional group will react with sulfhydryls and the succinimidyl ester group will react with amines. Spacer length is 53.3 angstroms.
Packaging
50, 250 mg in amber glass bottleПараметрыreaction suitability reaction type: Pegylations, reagent type: cross-linking reagent Quality Level 100, storage temp. 20°C SMILES string O=C(N1CCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(ON(C(CC2)=O)C2=O)=O)=O)C=CC1=O InChI 1S/C38H63N3O19/c42-33(5-8-40-34(43)1-2-35(40)44)39-7-10-49-12-14-51-16-18-53-20-22-55-24-26-57-28-30-59-32-31-58-29-27-56-25-23-54-21-19-52-17-15-50-13-11-48-9-6-38(47)60-41-36(45)3-4-37(41)46/h1-2H,3-32H2,(H,39,42) InChI key LWNZLSLPQXOOAO-UHFFFAOYSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Maleimide-PEG2-succinimidyl ester
Empirical Formula (Hill Notation): C18H23N3O9 CAS Number: 955094-26-5 Molecular Weight: 425.39 MDL number: MFCD11041137 PubChem Substance ID: 329765750 NACRES: NA.22
Кат. номер 746223-50MG 746223-250MG ApplicationHeterobifunctional crosslinker with short ethylene oxide spacer for linking amine- to sulfhydryl-containing compounds or biomolecules. Maleimide functional group will react with sulfhydryls and the succinimidyl ester group will react with amines. Spacer length is 17.6 angstroms.Packaging50, 250 mg in amber glass bottleПараметрыQuality Level 100 assay 95% reaction suitability reaction type: Pegylations, reagent type: cross-linking reagent mp 92-94 °C storage temp. 20°C SMILES string O=C(N1CCC(NCCOCCOCCC(ON(C(CC2)=O)C2=O)=O)=O)C=CC1=O InChI 1S/C18H23N3O9/c22-13(5-8-20-14(23)1-2-15(20)24)19-7-10-29-12-11-28-9-6-18(27)30-21-16(25)3-4-17(21)26/h1-2H,3-12H2,(H,19,22) InChI key TZPDZOJURBVWHS-UHFFFAOYSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Maleimide-PEG6-succinimidyl ester
Empirical Formula (Hill Notation): C26H39N3O13 CAS Number: 1137109-21-7 Molecular Weight: 601.60 MDL number: MFCD11041093 PubChem Substance ID: 329765747 NACRES: NA.22
Кат. номер 746193-50MG 746193-250MG ApplicationHeterobifunctional crosslinker with an ethylene oxide spacer for linking amine- to sulfhydryl-containing compounds or biomolecules. Maleimide functional group will react with sulfhydryls and the succinimidyl ester group will react with amines. Spacer length is 31.7 angstroms.
Packaging
50, 250 mg in amber glass bottleПараметрыreaction suitability reaction type: Pegylations, reagent type: cross-linking reagent Quality Level 100, storage temp. 20°C SMILES string O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCOCCOCCNC(CCN2C(C=CC2=O)=O)=O InChI 1S/C26H39N3O13/c30-21(5-8-28-22(31)1-2-23(28)32)27-7-10-37-12-14-39-16-18-41-20-19-40-17-15-38-13-11-36-9-6-26(35)42-29-24(33)3-4-25(29)34/h1-2H,3-20H2,(H,27,30) InChI key AVCPTIUOZBWCKE-UHFFFAOYSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Maleimide-PEG8-succinimidyl ester
Empirical Formula (Hill Notation): C30H47N3O15 CAS Number: 756525-93-6 Molecular Weight: 689.71 MDL number: MFCD11041144 PubChem Substance ID: 329765748
Кат. номер 746207-50MG 746207-250MG ApplicationHeterobifunctional crosslinker with an ethylene oxide spacer for linking amine- to sulfhydryl-containing compounds or biomolecules. Maleimide functional group will react with sulfhydryls and the succinimidyl ester group will react with amines. Spacer length is 39.2 angstroms.
Packaging
50 mg in clear glass bottle
250 mg in amber glass bottleПараметрыreaction suitability reaction type: Pegylations, reagent type: cross-linking reagent Quality Level 100, storage temp. 20°C SMILES string O=C(N1CCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCC(ON2C(CCC2=O)=O)=O)=O)C=CC1=O InChI 1S/C30H47N3O15/c34-25(5-8-32-26(35)1-2-27(32)36)31-7-10-41-12-14-43-16-18-45-20-22-47-24-23-46-21-19-44-17-15-42-13-11-40-9-6-30(39)48-33-28(37)3-4-29(33)38/h1-2H,3-24H2,(H,31,34) InChI key MTPWCXBUZLEBDD-UHFFFAOYSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
N-(2-Aminoethyl)maleimide trifluoroacetate salt
Empirical Formula (Hill Notation): C6H8N2O2 · C2HF3O2 CAS Number: 146474-00-2 Molecular Weight: 254.16 MDL number: MFCD01073617 PubChem Substance ID: 57651612 NACRES: NA.22
Кат. номер 56951-1G-F 56951-250MG-F 56951-500MG-F ApplicationN-(2-Aminoethyl)maleimide trifluoroacetate salt may can be to synthesize:- N-(2-{3-iodobenzoyl}aminoethyl)maleimide
- N-(2-{3-(tri-n-butylstannyl)benzoyl}aminoethyl)maleimide
- maleimide-functionalized cymantrenyl derivatives
- maleimide-incorporated anisotropic biohybrid microparticles (maleimide-MPs)
Packaging250 mg in poly bottle
1 g in poly tubeOther NotesHeterobifunctional linker for introducing a maleimide function into the widely used NOSu-modified fluorescent labels.ПараметрыQuality Level 100 assay 95% (HPLC), 98% (T) reaction suitability reagent type: cross-linking reagent SMILES string OC(=O)C(F)(F)F.NCCN1C(=O)C=CC1=O InChI 1S/C6H8N2O2.C2HF3O2/c7-3-4-8-5(9)1-2-6(8)10;3-2(4,5)1(6)7/h1-2H,3-4,7H2;(H,6,7) InChI key YNHKVOGCDPODMT-UHFFFAOYSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H315 - H319 - H335 pcodes P302 + P352 - P305 + P351 + P338 Target Organs Respiratory system Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
N-(2-Bromoethyl)phthalimide
Empirical Formula (Hill Notation): C10H8BrNO2 CAS Number: 574-98-1 Molecular Weight: 254.08 Beilstein/REAXYS Number: 148736 EC Number: 209-379-9 MDL number: MFCD00005902 PubChem Substance ID: 24891924 NACRES: NA.22
Кат. номер B66302-25G B66302-100G B66302-10KG ПараметрыQuality Level 200, assay 95% reaction suitability reagent type: cross-linking reagent mp 80-83 °C (lit.) SMILES string BrCCN1C(C2=CC=CC=C2C1=O)=O InChI 1S/C10H8BrNO2/c11-5-6-12-9(13)7-3-1-2-4-8(7)10(12)14/h1-4H,5-6H2 InChI key CHZXTOCAICMPQR-UHFFFAOYSA-N
Safety InformationPersonal Protective Equipment Eyeshields,, Gloves,, type N95 (US), RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
N-(2-Hydroxyethyl)maleimide
Empirical Formula (Hill Notation): C6H7NO3 CAS Number: 1585-90-6 Molecular Weight: 141.12 MDL number: MFCD00465266 PubChem Substance ID: 329767614 NACRES: NA.22
Кат. номер 773263-250MG 773263-1G ApplicationN-(2-Hydroxyethyl)maleimide can be used:- In the synthesis of (EFA)-based multifunctional oligoester resins with maleimides as end groups by reacting with 9,10-epoxy-18-hydroxyoctadecanoic acid (EFA) and dimethyl adipate catalyzed by Candida antarctica lipase B (CalB).
- As an initiator in ring-opening polymerization of -valerolactone catalyzed by trifluoromethanesulfonimide.
- In one-pot synthesis of bio-based polyurethane-imides by reacting with castor oil, eleostearic acid diethanol amide and isophorone diisocyanate.
N-(2-Hydroxyethyl)maleimide may be used to synthesize [2,2-bis(maleimidoethoxy)-
propane (BMEP)], a protein cross-linking reagent with potential application in constructing immunotoxins. It may also be used in preparing thermoresponsive self-healing polyurethanes with the shape-memory property.
Packaging
1 g in glass bottle
250 mg in glass bottleПараметрыassay 97% reaction suitability reagent type: cross-linking reagent mp 66-67 °C (lit.), 67-74 °C storage temp. 2-8°C SMILES string O=C(N1CCO)C=CC1=O InChI 1S/C6H7NO3/c8-4-3-7-5(9)1-2-6(7)10/h1-2,8H,3-4H2 InChI key AXTADRUCVAUCRS-UHFFFAOYSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H319 pcodes P305 + P351 + P338 RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
N-(2-Hydroxyethyl)trifluoroacetamide
Empirical Formula (Hill Notation): C4H6F3NO2 Linear Formula: CF3CONHCH2CH2OH CAS Number: 6974-29-4 Molecular Weight: 157.09 Beilstein/REAXYS Number: 1934914 MDL number: MFCD00216653 PubChem Substance ID: 24867603 NACRES: NA.22
PackagingКат. номер 440507-25ML 440507-5ML
25 mL in glass bottleApplicationUsed in the development of a microwave-mediated method for O-allylation of amido alcohols on chromatographic alumina.Параметрыassay 97% reaction suitability reagent type: cross-linking reagent mp 32-35 °C (lit.) density 1.413 g/mL at 25 °C (lit.) SMILES string O=C(NCCO)C(F)(F)F InChI 1S/C4H6F3NO2/c5-4(6,7)3(10)8-1-2-9/h9H,1-2H2,(H,8,10) InChI key NPSVCXHBJVBBAD-UHFFFAOYSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H302 + H312 + H332 - H315 - H319 - H335 pcodes P261 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338 Target Organs Respiratory system Personal Protective Equipment dust mask type N95 (US),, Eyeshields,, Gloves, RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F 134.6 °F - closed cup Flash Point C 57 °C - closed cup Узнать цену -
N-(3-Bromopropyl)phthalimide
Empirical Formula (Hill Notation): C11H10BrNO2 CAS Number: 5460-29-7 Molecular Weight: 268.11 Beilstein/REAXYS Number: 157547 EC Number: 226-738-5 MDL number: MFCD00005904 PubChem Substance ID: 24892035
Кат. номер B80003-25G B80003-100G B80003-10G ПараметрыQuality Level 200, assay 98% reaction suitability reagent type: cross-linking reagent mp 72-74 °C (lit.) SMILES string BrCCCN1C(C2=CC=CC=C2C1=O)=O InChI 1S/C11H10BrNO2/c12-6-3-7-13-10(14)8-4-1-2-5-9(8)11(13)15/h1-2,4-5H,3,6-7H2 InChI key VKJCJJYNVIYVQR-UHFFFAOYSA-N
Safety InformationPersonal Protective Equipment Eyeshields,, Gloves,, type N95 (US), RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
N-(4-Bromobutyl)phthalimide
Empirical Formula (Hill Notation): C12H12BrNO2 CAS Number: 5394-18-3 Molecular Weight: 282.13 Beilstein/REAXYS Number: 164119 EC Number: 226-401-2 MDL number: MFCD00005905 PubChem Substance ID: 24846427 NACRES: NA.22
Кат. номер 100919-10G 100919-1G ApplicationN-(4-Bromobutyl)phthalimide can be used to synthesize:- Biologically important N4,N9-disubstituted 4,9-diaminoacridine derivatives.
- Imidazo[4,5-b]pyridine derivatives applicable in the preparation of ketolide antibiotics.
- Calix[4]arene and thiacalix[4]arene-based oxamate ligands.
Packaging
10 g in glass bottleПараметрыQuality Level 100, assay 98% reaction suitability reagent type: cross-linking reagent mp 76-80 °C (lit.) SMILES string O=C1N(CCCCBr)C(C2=CC=CC=C21)=O InChI 1S/C12H12BrNO2/c13-7-3-4-8-14-11(15)9-5-1-2-6-10(9)12(14)16/h1-2,5-6H,3-4,7-8H2 InChI key UXFWTIGUWHJKDD-UHFFFAOYSA-N
Safety InformationPersonal Protective Equipment dust mask type N95 (US),, Eyeshields,, Gloves, RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
N-(4-Hydroxybutyl)trifluoroacetamide
Empirical Formula (Hill Notation): C6H10F3NO2 CAS Number: 128238-43-7 Molecular Weight: 185.14 Beilstein/REAXYS Number: 6644043 MDL number: MFCD00632418 PubChem Substance ID: 57653443 NACRES: NA.22
PackagingКат. номер 91678-1ML 91678-5ML
1 mL in glass bottleOther NotesBuilding block to introduce a 4-aminobutyl residue in a daunomycinone giving optimal intercalation with DNA; Protecting group in phosphodiesters; cleavage occurs by cyclo-de-esterificationПараметрыQuality Level 100, assay 98.0% (GC) reaction suitability reagent type: cross-linking reagent refractive index n20/D 1.413 density 1.262 g/mL at 20 °C (lit.) SMILES string O=C(NCCCCO)C(F)(F)F InChI 1S/C6H10F3NO2/c7-6(8,9)5(12)10-3-1-2-4-11/h11H,1-4H2,(H,10,12) InChI key LZUDPIMZEXACCH-UHFFFAOYSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H315 - H319 - H335 pcodes P261 - P305 + P351 + P338 Personal Protective Equipment Eyeshields,, Gloves,, type ABEK (EN14387) respirator filter, RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
N-(5-Hydroxypentyl)trifluoroacetamide
Empirical Formula (Hill Notation): C7H12F3NO2 CAS Number: 128238-44-8 Molecular Weight: 199.17 Beilstein/REAXYS Number: 6644762 MDL number: MFCD01863126 PubChem Substance ID: 57653445 NACRES: NA.22
PackagingКат. номер 91681-5ML 91681-1ML
5 mL in glass bottleOther NotesSelective mono-O-alkylation is accomplished by N,O-dianion formation prior to alkylation; otherwise, preferential N-alkylation takes placeПараметрыQuality Level 100, assay 98.0% (GC) reaction suitability reagent type: cross-linking reagent refractive index n20/D 1.420 density 1.248 g/mL at 20 °C (lit.) SMILES string OCCCCCNC(=O)C(F)(F)F InChI 1S/C7H12F3NO2/c8-7(9,10)6(13)11-4-2-1-3-5-12/h12H,1-5H2,(H,11,13) InChI key SCHGQSPQAJAJRI-UHFFFAOYSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H315 - H319 - H335 pcodes P261 - P305 + P351 + P338 Personal Protective Equipment Eyeshields,, Gloves,, type ABEK (EN14387) respirator filter, RIDADR NONH for all modes of transport WGK Germany WGK 3 Узнать цену -
N-(6-Hydroxyhexyl)trifluoroacetamide
Empirical Formula (Hill Notation): C8H14F3NO2 CAS Number: 40248-34-8 Molecular Weight: 213.20 Beilstein/REAXYS Number: 1949232 MDL number: MFCD00465535 PubChem Substance ID: 57653444 NACRES: NA.22
PackagingКат. номер 91679-1G 91679-5G
1 g in glass bottleOther NotesEmployed for preparing libraries of oligosaccharides with an amino tetherПараметрыQuality Level 100, assay ≥98.0% (GC) reaction suitability reagent type: cross-linking reagent mp 46-49 °C SMILES string OCCCCCCNC(=O)C(F)(F)F InChI 1S/C8H14F3NO2/c9-8(10,11)7(14)12-5-3-1-2-4-6-13/h13H,1-6H2,(H,12,14) InChI key BGCYSPBEPMOQII-UHFFFAOYSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H315 - H319 - H335 pcodes P261 - P305 + P351 + P338 Personal Protective Equipment dust mask type N95 (US),, Eyeshields,, Gloves, RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
N-Boc- 2,2-(ethylenedioxy)diethylamine
Empirical Formula (Hill Notation): C11H24N2O4 CAS Number: 153086-78-3 Molecular Weight: 248.32 MDL number: MFCD03788155 PubChem Substance ID: 57653355 NACRES: NA.22
PackagingКат. номер 89761-5G-F 89761-1G-F
1, 5 g in poly bottleApplicationLinker reagent for the prep. of a broad variety of linked tags, monomers for polymerisation, ionophores etc., e.g. biotinylation reagents.ПараметрыQuality Level 100, assay 95.0% (NT) reaction suitability reagent type: cross-linking reagent, reagent type: spacer density 1.046 g/mL at 20 °C SMILES string NCCOCCOCCNC(OC(C)(C)C)=O InChI 1S/C11H24N2O4/c1-11(2,3)17-10(14)13-5-7-16-9-8-15-6-4-12/h4-9,12H2,1-3H3,(H,13,14) InChI key OCUICOFGFQENAS-UHFFFAOYSA-N
Safety InformationPersonal Protective Equipment Eyeshields,, Gloves, RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
N-Boc-1,3-propanediamine
Empirical Formula (Hill Notation): C8H18N2O2 Linear Formula: (CH3)3COCONH(CH2)3NH2 CAS Number: 75178-96-0 Molecular Weight: 174.24 Beilstein/REAXYS Number: 3588328 MDL number: MFCD00210021 PubChem Substance ID: 57647415 NACRES: NA.22
PackagingКат. номер 15408-1ML 15408-INTR 15408-5ML
1, 5 mL in glass bottleOther NotesSynthesis of spermidine analogues; Preparation of pharmacologically active compounds.ПараметрыQuality Level 100, assay 97.0% (GC/NT) reaction suitability reagent type: cross-linking reagent, reagent type: spacer refractive index n20/D 1.454 (lit.), n20/D 1.459 bp 203 °C (lit.) mp 22 °C (lit.) density 0.998 g/mL at 20 °C (lit.) SMILES string NCCCNC(OC(C)(C)C)=O InChI 1S/C8H18N2O2/c1-8(2,3)12-7(11)10-6-4-5-9/h4-6,9H2,1-3H3,(H,10,11) InChI key POHWAQLZBIMPRN-UHFFFAOYSA-N
Safety Informationpictograms GHS05,GHS07 signalword Danger hcodes H302 - H314 pcodes P280 - P305 + P351 + P338 - P310 Personal Protective Equipment Faceshields,, Gloves,, Goggles,, type ABEK (EN14387) respirator filter, RIDADR UN 3259PSN1 8 / PGIII WGK Germany WGK 3 Flash Point F 228.2 °F - closed cup Flash Point C 109 °C - closed cup Узнать цену -
N-Boc-1,3-propanediamine 436992-1G
Empirical Formula (Hill Notation): C8H18N2O2 Linear Formula: (CH3)3COCONH(CH2)3NH2 CAS Number: 75178-96-0 Molecular Weight: 174.24 Beilstein/REAXYS Number: 3588328 MDL number: MFCD00210021 PubChem Substance ID: 24867318 Параметрыassay 95% reaction suitability reagent type: cross-linking reagent, reagent type: spacer refractive index n20/D 1.454 (lit.) bp 203 °C (lit.) mp 22 °C (lit.) density 0.998 g/mL at 20 °C (lit.) SMILES string NCCCNC(OC(C)(C)C)=O InChI 1S/C8H18N2O2/c1-8(2,3)12-7(11)10-6-4-5-9/h4-6,9H2,1-3H3,(H,10,11) InChI key POHWAQLZBIMPRN-UHFFFAOYSA-N
Safety Informationpictograms GHS05, GHS07 signalword Danger hcodes H302-H314 pcodes P280-P305 + P351 + P338-P310 Personal Protective Equipment Faceshields,, Gloves,, Goggles,, type ABEK (EN14387) respirator filter, RIDADR UN 3259PSN1 8 / PGIII WGK Germany 3 Flash Point F 228.2 °F Flash Point C 109 °C Узнать цену -
N-Boc-1,4-butanediamine
Empirical Formula (Hill Notation): C9H20N2O2 Linear Formula: (CH3)3COCONH(CH2)4NH2 CAS Number: 68076-36-8 Molecular Weight: 188.27 Beilstein/REAXYS Number: 1937878 MDL number: MFCD00210019 PubChem Substance ID: 57647412
PackagingКат. номер 15404-1ML 15404-INTR 15404-5ML
1, 5 mL in glass bottleOther NotesPreparation of pharmacologically active compounds. Preparation of spermidine analogues. Introduction of a C4-spacer.ПараметрыQuality Level 100, assay 97.0% (GC/NT) reaction suitability reagent type: cross-linking reagent, reagent type: spacer refractive index n20/D 1.460 density 0.984 g/mL at 20 °C (lit.) SMILES string NCCCCNC(OC(C)(C)C)=O InChI 1S/C9H20N2O2/c1-9(2,3)13-8(12)11-7-5-4-6-10/h4-7,10H2,1-3H3,(H,11,12) InChI key ZFQWJXFJJZUVPI-UHFFFAOYSA-N
Safety Informationpictograms GHS05 signalword Danger hcodes H314 pcodes P280 - P305 + P351 + P338 - P310 Personal Protective Equipment Faceshields,, Gloves,, Goggles,, type ABEK (EN14387) respirator filter, RIDADR UN 2735PSN2 8 / PGIII WGK Germany WGK 3 Flash Point F 228.2 °F - closed cup Flash Point C 109.0 °C - closed cup Узнать цену -
N-Boc-1,6-hexanediamine
Empirical Formula (Hill Notation): C11H24N2O2 CAS Number: 51857-17-1 Molecular Weight: 216.32 Beilstein/REAXYS Number: 2219107 MDL number: MFCD00671489 PubChem Substance ID: 57652779 NACRES: NA.22
Кат. номер 79229-5G 79229-1G ApplicationN-Boc-1,6-hexanediamine can be used as a linear hexyl spacer (C6-spacer) to synthesize:- Biodegradable poly(disulfide amine)s for gene delivery.
- A multifunctional dendrimer for theranostics.
- Polyamide platinum anti-cancer complexes designed to target cancer specific DNA sequences.
- Self-assembled monolayers (SAMs) that resist adsorption of proteins.
- [N-(6-(4-Hydroxy-6-isopropylamino-1,3,5-triazin-2-ylamino)hexyl)-5-hydroxy-1,4-naphthoquinone-3-propionamide] (JUG-HATZ), which can be used in designing electrochemical immunosensors.
Reagent for the introduction of a C6-spacer.
Packaging
1, 5 g in glass bottleПараметрыQuality Level 200, assay 98.0% (NT) reaction suitability reagent type: cross-linking reagent, reagent type: spacer refractive index n20/D 1.462 density 0.965 g/mL at 20 °C (lit.) SMILES string NCCCCCCNC(OC(C)(C)C)=O InChI 1S/C11H24N2O2/c1-11(2,3)15-10(14)13-9-7-5-4-6-8-12/h4-9,12H2,1-3H3,(H,13,14) InChI key RVZPDKXEHIRFPM-UHFFFAOYSA-N
Safety Informationpictograms GHS05 signalword Danger hcodes H314 pcodes P280 - P301 + P330 + P331 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363 Personal Protective Equipment Faceshields,, Gloves,, Goggles,, type ABEK (EN14387) respirator filter, RIDADR UN 2735PSN1 8 / PGII WGK Germany WGK 3 Flash Point F 257.0 °F - closed cup Flash Point C 125 °C - closed cup Узнать цену
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Анна Гловацкая
Менеджер по работе с клиентами
С 2010 года мы поставляем оборудование с заводов Европы. Берем на себя все — от подбора оборудования до внедрения на предприятии
Все сотрудники имеют высшее образование, закончили ведущие химические вузы страны, такие как РХТУ им Менделеева.
У большинства компаний срок ожидания составляет 10-12 недель.
Оборудование хранится на сухом отапливаемом складе, где поддерживается ровная температура.
Работаем с PonyExpress и Деловыми линиями. Вы также можете выбрать свою транспортную компанию или забрать товар со склада в Москве.
В случае любых неполадок за свой счет выполним ремонт в сервисном центре или на заводе-изготовителе. Или бесплатно заменим прибор на новый.
Производим пуско-наладку оборудования, валидацию, обучение сотрудников. Если нужно, привлекаем инженеров с заводов- изготовителей.
