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(1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-ylmethyl N-succinimidyl carbonate
Empirical Formula (Hill Notation): C15H17NO5 CAS Number: 1516551-46-4 Molecular Weight: 291.30 PubChem Substance ID: 329765714 NACRES: NA.22
Кат. номер 744867-10MG 744867-100MG Application(1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-ylmethyl N-succinimidyl carbonate may be used to functionalize the primary amines of the lysine residue of recombinant elastin-like proteins (ELPs). These functionalized ELPs quickly undergo cross-linking via bio-orthogonal strain-promoted azide-alkyne cycloaddition reactions to form hydrogels with high gelation kinetics and tunable mechanics, making them useful biomaterials for cell encapsulation.{67
It may also be used to synthesize bicyclononyne functionalized poly(ethylene glycol) polymer coatings with anti-fouling properties towards protein adhesion and cell adhesion for supramolecular ureidopyrimidinone (UPy) based materials.
Succinimidyl ester/NHS functionalized cyclooctyne derivative for incorporation of the cyclooctyne moiety into amine containing compounds or biomolecules. Cyclooctynes are useful in strain-promoted copper-free azide-alkyne cycloaddition reactions. This strained cyclooctyne will react with azide functionalized compounds or biomolecules without the need for a copper catalyst to result in a stable triazole linkage.PackagingBottomless glass bottle. Contents are inside inserted fused cone.ПараметрыQuality Level 100 composition carbon content, 61.85% , hydrogen content, 5.88% , nitrogen content, 4.81% reaction suitability reaction type: click chemistry, reagent type: cross-linking reagent storage temp. 20°C SMILES string O=C(OCC1[C@@H]2CCC#CCC[C@H]12)ON3C(=O)CCC3=O InChI 1S/C15H17NO5/c17-13-7-8-14(18)16(13)21-15(19)20-9-12-10-5-3-1-2-4-6-11(10)12/h10-12H,3-9H2/t10-,11+,12- InChI key SKTDJYHCSCYLQU-ZSBIGDGJSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
(1S,4S,8S)-5-Benzyl-2-isobutyl-8-methoxy-1,8-dimethylbicyclo[2.2.2]octa-2,5-diene 709492-100MG
Empirical Formula (Hill Notation): C22H30O CAS Number: 862499-50-1 Molecular Weight: 310.47 MDL number: MFCD09265063 PubChem Substance ID: 329762875 General description(1S,4S,8S)-5-Benzyl-2-isobutyl-8-methoxy-1,8-dimethylbicyclo[2.2.2]octa-2,5-diene, an enantiopure diene ligand developed by Carreira, is most commonly used in asymmetric catalysis. It is generally prepared from commercially available (R)-carvone.Application(1S,4S,8S)-5-Benzyl-2-isobutyl-8-methoxy-1,8-dimethylbicyclo[2.2.2]octa-2,5-diene is mainly useful for the stereoselective synthesis of diarylmethine stereogenic centers.
Carreira DOLEFIN Ligands,
Packaging
100 mg in clear glass bottleПараметрыQuality Level 100, assay 97% optical activity []/D 84±5°, c = 0.5 in chloroform reaction suitability reaction type: click chemistry refractive index n20/D 1.522 SMILES string CO[C@@]1(C)C[C@@]2(C)C=C(Cc3ccccc3)[C@@H]1C=C2CC(C)C InChI 1S/C22H30O/c1-16(2)11-19-13-20-18(12-17-9-7-6-8-10-17)14-21(19,3)15-22(20,4)23-5/h6-10,13-14,16,20H,11-12,15H2,1-5H3/t20-,21+,22-/m0/s1 InChI key ACWLDJOHMGJACE-BDTNDASRSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
(2S)-2-Deoxy-2-fluoro-5-ethynyluridine, (F-ara-EdU) T511293-5MG
Empirical Formula (Hill Notation): C11H11FN2O5 CAS Number: 95740-26-4 Molecular Weight: 270.21 MDL number: MFCD22417248 PubChem Substance ID: 329826809 ApplicationA probe for DNA synthesis in vivo that is less toxic than both EdU and BrdU. Ideally suited for metabolic DNA labeling when prolonged cell survival and undisturbed cell cycle progression are required.Other NotesPlease note that Sigma-Aldrich provides this product to early discovery researchers as part of a collection of unique chemicals. Sigma-Aldrich does not collect analytical data for this product. Buyer assumes responsibility to confirm product identity and/or purity. All sales are final.
NOTWITHSTANDING ANY CONTRARY PROVISION CONTAINED IN SIGMA-ALDRICHS STANDARD TERMS AND CONDITIONS OF SALE OR AN AGREEMENT BETWEEN SIGMA-ALDRICH AND BUYER, SIGMA-ALDRICH SELLS THIS PRODUCT "AS-IS" AND MAKES NO REPRESENTATION OR WARRANTY WHATSOEVER WITH RESPECT TO THIS PRODUCT, INCLUDING ANY (A) WARRANTY OF MERCHANTABILITY; (B) WARRANTY OF FITNESS FOR A PARTICULAR PURPOSE; OR (C) WARRANTY AGAINST INFRINGEMENT OF INTELLECTUAL PROPERTY RIGHTS OF A THIRD PARTY; WHETHER ARISING BY LAW, COURSE OF DEALING, COURSE OF PERFORMANCE, USAGE OF TRADE OR OTHERWISE.ПараметрыQuality Level 100, reaction suitability reaction type: click chemistry SMILES string OC[C@H]1O[C@H]([C@@H](F)[C@@H]1O)N2C=C(C#C)C(=O)NC2=O InChI 1S/C11H11FN2O5/c1-2-5-3-14(11(18)13-9(5)17)10-7(12)8(16)6(4-15)19-10/h1,3,6-8,10,15-16H,4H2,(H,13,17,18)/t6-,7+,8-,10-/m1/s1 InChI key YEEGMPUOCRQFRV-IBCQBUCCSA-N
Safety Informationpictograms GHS06 signalword Danger hcodes H300 + H310 + H330 pcodes P262 - P280 - P301 + P310 + P330 - P302 + P352 + P310 - P304 + P340 + P310 RIDADR UN 2811 6.1 / PGII WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
(3-Hydroxyphenyl)(4-(prop-2-yn-1-yloxy)phenyl)methanone 900611-50MG
Empirical Formula (Hill Notation): C16H12O3 CAS Number: 2140866-78-8 Molecular Weight: 252.26 NACRES: NA.22 Application(3-Hydroxyphenyl)(4-(prop-2-yn-1-yloxy)phenyl)methanone is used for chemical probe synthesis, this trifunctional building block contains a light-activated benzophenone, alkyne tag, and hydroxyl synthetic handle. When appended to a ligand or pharmacophore through its hydroxyl linker, this building block allows for UV light-induced covalent modification of a biological target with potential for downstream applications via the alkyne tag. Use alone or in parallel with other multi-functional building blocks, to discover the optimal probe for your chemical biology experiments.
Packaging
50 mg in glass bottleOther Notes
Technology Spotlight: Trifuctional Probe Building Blocks,
A library approach to rapidly discover photoaffinity probes of the mRNA decapping scavenger enzyme DcpS,ПараметрыQuality Level 100, assay ≥95% form solid reaction suitability reaction type: click chemistry storage temp. −20°C
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
(4-(1,2,4,5-Tetrazin-3-yl)phenyl)methanamine hydrochloride
Empirical Formula (Hill Notation): C9H9N5 · xHCl CAS Number: 1345866-68-3 Molecular Weight: 187.20 (free base basis) MDL number: MFCD23097050 PubChem Substance ID: 329766561 NACRES: NA.22
Кат. номер 761591-25MG 761591-10MG General description4-(1,2,4,5-Tetrazin-3-yl)phenyl)methanamine is a 1,2,4,5-tetrazine derivative capable of undergoing [4+2] Diels-Alder cycloaddition reactions with strained alkenes, which makes it highly useful in bioorthogonal labeling and cell detection applications.ApplicationAmine functionalized tetrazine for inverse electron demand Diels-Alder cycloaddition reactions. The tetrazine will react with strained alkenes such as transcyclooctene, norbornene and cyclopropene to yield a stable covalent linkage. Tetrazines have proven useful in bioorthogonal reactions for many biological imaging and bioconjugation applications.
Packaging
10, 25 mg in clear glass bottleПараметрыassay 95% reaction suitability reaction type: click chemistry mp 206-225 °C (decomposition) storage temp. −20°C SMILES string NCC1=CC=C(C2=NN=CN=N2)C=C1.[H]Cl InChI 1S/C9H9N5.ClH/c10-5-7-1-3-8(4-2-7)9-13-11-6-12-14-9;/h1-4,6H,5,10H2;1H InChI key FAAUXGMWUKVOPI-UHFFFAOYSA-N
Safety Informationpictograms GHS06 signalword Danger hcodes H301 - H315 - H319 - H335 pcodes P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338 Target Organs Respiratory system RIDADR UN 2811 6.1 / PGIII WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
(4-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)phenyl)(4-(prop-2-yn-1-yloxy)phenyl)methanone HCl salt 900750-100MG
Empirical Formula (Hill Notation): C22H25NO5 · HCl Molecular Weight: 419.90 NACRES: NA.22 Application(4-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)phenyl)(4-(prop-2-yn-1-yloxy)phenyl)methanone HCl salt is used for chemical probe synthesis, this trifunctional building block contains a light-activated benzophenone, alkyne tag, and amine synthetic handle. When appended to a ligand or pharmacophore through its PEGylated amine linker, this building block allows for UV light-induced covalent modification of a biological target with potential for downstream applications via the alkyne tag. Use alone or in parallel with other multi-functional building blocks, to discover the optimal probe for your chemical biology experiments.
Packaging
100 mg in glass bottleOther NotesTechnology Spotlight: Trifuctional Probe Building Blocks,
A library approach to rapidly discover photoaffinity probes of the mRNA decapping scavenger enzyme DcpS,
Investigating -secretase protein interactions in live cells using active site-directed clickable dual-photoaffinity probes,ПараметрыQuality Level 100, assay ≥95% form powder reaction suitability reaction type: click chemistry storage temp. −20°C SMILES string [H]Cl.O=C(C1=CC=C(OCC#C)C=C1)C2=CC=C(OCCOCCOCCN)C=C2
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
(4-(2-(2-Aminoethoxy)ethoxy)phenyl)(4-(prop-2-yn-1-yloxy)phenyl)methanone 900603-100MG
Empirical Formula (Hill Notation): C20H21NO4 CAS Number: 1632401-22-9 Molecular Weight: 339.39 Application(4-(2-(2-Aminoethoxy)ethoxy)phenyl)(4-(prop-2-yn-1-yloxy)phenyl)methanone is used for chemical probe synthesis, this trifunctional building block contains a light-activated benzophenone, alkyne tag, and amine synthetic handle. When appended to a ligand or pharmacophore through its PEGylated amine linker, this building block allows for UV light-induced covalent modification of a biological target with potential for downstream applications via the alkyne tag. Use alone or in parallel with other multi-functional building blocks, to discover the optimal probe for your chemical biology experiments.
Packaging
100 mg in glass bottleOther NotesTechnology Spotlight: Trifuctional Probe Building Blocks,
A library approach to rapidly discover photoaffinity probes of the mRNA decapping scavenger enzyme DcpS,
Chemoproteomics Demonstrates Target Engagement and Exquisite Selectivity of the Clinical Phosphodiesterase 10A Inhibitor MP-10 in Its Native Environment,ПараметрыQuality Level 100, assay ≥95% form powder or crystals reaction suitability reaction type: click chemistry storage temp. −20°C
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
(4-(Aminomethyl)phenyl)(4-(prop-2-yn-1-yloxy)phenyl)methanone 900599-100MG
Empirical Formula (Hill Notation): C17H15NO2 Molecular Weight: 265.31 NACRES: NA.22 Application(4-(Aminomethyl)phenyl)(4-(prop-2-yn-1-yloxy)phenyl)methanone is used for chemical probe synthesis, this trifunctional building block contains a light-activated benzophenone, alkyne tag, and amine synthetic handle. When appended to a ligand or pharmacophore through its amine linker, this building block allows for UV light-induced covalent modification of a biological target with potential for downstream applications via the alkyne tag. Use alone or in parallel with other multi-functional building blocks, to discover the optimal probe for your chemical biology experiments.
Packaging
100 mg in glass insertOther Notes
Technology Spotlight: Trifuctional Probe Building Blocks,
A library approach to rapidly discover photoaffinity probes of the mRNA decapping scavenger enzyme DcpS,ПараметрыQuality Level 100, assay 95% form solid reaction suitability reaction type: click chemistry storage temp. −20°C
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
(4-(Bromomethyl)phenyl)(4-(prop-2-yn-1-yloxy)phenyl)methanone 900598-100MG
Empirical Formula (Hill Notation): C17H13BrO2 CAS Number: 1695554-80-3 Molecular Weight: 329.19 MDL number: MFCD30737994 ApplicationUsed for chemical probe synthesis, this trifunctional building block contains a light-activated benzophenone, alkyne tag, and bromine synthetic handle. When appended to a ligand or pharmacophore through its brominated linker, this building block allows for UV light-induced covalent modification of a biological target with potential for downstream applications via the alkyne tag. Use alone or in parallel with other multi-functional building blocks, to discover the optimal probe for your chemical biology experiments.
Packaging
100 mg in glass bottleOther NotesTechnology Spotlight: Trifuctional Probe Building Blocks,
Development of Sulfonamide Photoaffinity Inhibitors for Probing Cellular -Secretase,
A library approach to rapidly discover photoaffinity probes of the mRNA decapping scavenger enzyme DcpS,ПараметрыQuality Level 100, assay ≥95% form solid reaction suitability reaction type: click chemistry storage temp. −20°C SMILES string O=C(C1=CC=C(OCC#C)C=C1)C2=CC=C(CBr)C=C2
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
(4-(Hydroxymethyl)phenyl)(4-(prop-2-yn-1-yloxy)phenyl)methanone 900617-50MG
Empirical Formula (Hill Notation): C17H14O3 CAS Number: 1940176-39-5 Molecular Weight: 266.29 Application(4-(Hydroxymethyl)phenyl)(4-(prop-2-yn-1-yloxy)phenyl)methanone is used for chemical probe synthesis, this trifunctional building block contains a light-activated benzophenone, alkyne tag, and hydroxyl synthetic handle. When appended to a ligand or pharmacophore through its hydroxyl linker, this building block allows for UV light-induced covalent modification of a biological target with potential for downstream applications via the alkyne tag. Use alone or in parallel with other multi-functional building blocks, to discover the optimal probe for your chemical biology experiments.
Packaging
50 mg in glass bottleOther NotesTechnology Spotlight: Trifuctional Probe Building Blocks,
A library approach to rapidly discover photoaffinity probes of the mRNA decapping scavenger enzyme DcpS,
Development of Sulfonamide Photoaffinity Inhibitors for Probing Cellular -Secretase,ПараметрыQuality Level 100, assay ≥95% form powder or crystals reaction suitability reaction type: click chemistry storage temp. −20°C
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
(4-Hydroxyphenyl)(4-(prop-2-yn-1-yloxy)phenyl)methanone 900615-100MG
Empirical Formula (Hill Notation): C16H12O3 CAS Number: 1208395-99-6 Molecular Weight: 252.26 MDL number: MFCD28124082 Application(4-Hydroxyphenyl)(4-(prop-2-yn-1-yloxy)phenyl)methanone is used for chemical probe synthesis, this trifunctional building block contains a light-activated benzophenone, alkyne tag, and hydroxyl synthetic handle. When appended to a ligand or pharmacophore through its hydroxyl linker, this building block allows for UV light-induced covalent modification of a biological target with potential for downstream applications via the alkyne tag. Use alone or in parallel with other multi-functional building blocks, to discover the optimal probe for your chemical biology experiments.
Packaging
100 mg in glass bottleOther NotesTechnology Spotlight: Trifuctional Probe Building Blocks,
A library approach to rapidly discover photoaffinity probes of the mRNA decapping scavenger enzyme DcpS,
Design, synthesis and biological evaluation of photoaffinity probes of antiangiogenic homoisoflavonoids,
Clickable Photoaffinity Ligands for Metabotropic Glutamate Receptor 5 Based on Select Acetylenic Negative Allosteric Modulators,
-Secretase Modulator (GSM) Photoaffinity Probes Reveal Distinct Allosteric Binding Sites on Presenilin,ПараметрыQuality Level 100, assay ≥95% form solid reaction suitability reaction type: click chemistry storage temp. −20°C
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
(E)-Cyclooct-4-enol
Empirical Formula (Hill Notation): C8H14O CAS Number: 85081-69-2 Molecular Weight: 126.20 PubChem Substance ID: 329767115 NACRES: NA.22
Кат. номер 764396-50MG 764396-10MG ApplicationHydroxyl modified cyclooctene derivative. Cyclooctenes are useful in strain-promoted copper-free click chemistry cycloaddition reactions with 1,2,4,5-tetrazines. This cyclooctene will react with tetrazine functionalized compounds or biomolecules without the need for a catalyst to result in a stable covalent linkage. The 4+2 inverse electron demand Diels-Alder cycloaddition between trans-cyclooctene and tetrazines is the fastest biologically compatible ligation technology reported and has had many applications in biological labeling and imaging.
(E)-Cyclooct-4-enol may be used in the multi-step synthesis of trans-cyclooctene geranyl diphosphate, a novel strained-ring containing protein farnesyltransferase (PFTase) substrate that can be used in site-specific modification technologies.
Packaging
10, 50 mg in glass bottleПараметрыreaction suitability reaction type: click chemistry storage temp. 20°C SMILES string O[C@H]1CC/C=C/CCC1 InChI 1S/C8H14O/c9-8-6-4-2-1-3-5-7-8/h1-2,8-9H,3-7H2/b2-1+/t8-/m0/s1 InChI key UCPDHOTYYDHPEN-CMLYIYFCSA-N
Safety Informationpictograms GHS05 signalword Danger hcodes H318 pcodes P280 - P305 + P351 + P338 RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
(E)-Cyclooct-4-enyl 2,5-dioxo-1-pyrrolidinyl carbonate
Empirical Formula (Hill Notation): C13H17NO5 CAS Number: 1191901-33-3 Molecular Weight: 267.28 PubChem Substance ID: 329767127 NACRES: NA.22
Кат. номер 764523-1MG 764523-5MG 764523-25MG ApplicationSuccinimidyl carbonate/NHS functionalized cyclooctene derivative for incorporation of the cyclooctene moiety into amine containing compounds or biomolecules. Cyclooctenes are useful in strain-promoted copper-free click chemistry cycloaddition reactions with 1,2,4,5-tetrazines. This cyclooctene will react with tetrazine functionalized compounds or biomolecules without the need for a catalyst to result in a stable covalent linkage. The 4+2 inverse electron demand Diels-Alder cycloaddition between trans-cyclooctene and tetrazines is the fastest biologically compatible ligation technology reported and has had many applications in biological labeling and imaging.
(E)-Cyclooct-4-enyl 2,5-dioxo-1-pyrrolidinyl carbonate may be used in the synthesis of vancomycin-TCO that can bind to the cell wall of gram-positive bacteria, which can subsequently react with tetrazine (Tz) decorated magneto-fluorescent nanoparticles orthogonally. This bioorthogonal labeling method is useful for the detection of gram-positive bacteria.
Packaging
1, 5, 25 mg in amber glass bottleПараметрыQuality Level 100, reaction suitability reaction type: click chemistry mp 90-105 °C storage temp. 20°C SMILES string O=C(ON1C(CCC1=O)=O)O[C@@H]2CC/C=C/CCC2 InChI 1S/C13H17NO5/c15-11-8-9-12(16)14(11)19-13(17)18-10-6-4-2-1-3-5-7-10/h1-2,10H,3-9H2/b2-1+/t10-/m1/s1 InChI key OUGQJOKGFAIFAQ-TXXBHVLJSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
(R)-2-(Boc-amino)-5-hexynoic acid 714232-250MG
PackagingEmpirical Formula (Hill Notation): C11H17NO4 CAS Number: 1217464-82-8 Molecular Weight: 227.26 MDL number: MFCD11052901 PubChem Substance ID: 329763264 NACRES: NA.22
250 mg in glass bottle
Bottomless glass bottle. Contents are inside inserted fused cone.ПараметрыQuality Level 100, assay 96% (HPLC) optical activity []/D 80.0±2.0°, c = 1 in DMF composition carbon, 57.0-59.3% , nitrogen, 5.9-6.4% reaction suitability reaction type: Boc solid-phase peptide synthesis, reaction type: click chemistry application(s) peptide synthesis: suitable SMILES string CC(C)(C)OC(=O)N[C@H](CCC#C)C(O)=O InChI 1S/C11H17NO4/c1-5-6-7-8(9(13)14)12-10(15)16-11(2,3)4/h1,8H,6-7H2,2-4H3,(H,12,15)(H,13,14)/t8-/m1/s1 InChI key DPHIBCOGEUVKGB-MRVPVSSYSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H315 - H319 - H335 pcodes P302 + P352 - P305 + P351 + P338 Target Organs Respiratory system Personal Protective Equipment dust mask type N95 (US),, Eyeshields,, Gloves, RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
(R)-3-Amino-5-hexynoic acid hydrochloride 711926-250MG
PackagingEmpirical Formula (Hill Notation): C6H9NO2 · HCl CAS Number: 332064-87-6 Molecular Weight: 163.60 MDL number: MFCD01860908 PubChem Substance ID: 329763097
250 mg in glass bottle
Bottomless glass bottle. Contents are inside inserted fused cone.ПараметрыQuality Level 100, assay 94.5% (TLC), 95% optical activity []/D -12.0±1°, c = 1 in H2O reaction suitability reaction type: click chemistry, reaction type: solution phase peptide synthesis application(s) peptide synthesis: suitable storage temp. 2-8°C SMILES string Cl.N[C@H](CC#C)CC(O)=O InChI 1S/C6H9NO2.ClH/c1-2-3-5(7)4-6(8)9;/h1,5H,3-4,7H2,(H,8,9);1H/t5-;/m1./s1 InChI key FVKOZZHCHSRKJA-NUBCRITNSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H315 - H319 pcodes P305 + P351 + P338 Personal Protective Equipment dust mask type N95 (US),, Eyeshields,, Gloves, RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
(S)-2-Azido-3-methylbutyric acid cyclohexylammonium salt 714275-100MG
PackagingEmpirical Formula (Hill Notation): C5H9N3O2·C6H13N CAS Number: 1217462-63-9 Molecular Weight: 242.32 MDL number: MFCD11223823 PubChem Substance ID: 329763268
Bottomless glass bottle. Contents are inside inserted fused cone.Параметрыassay 98% (CE) optical activity []/D -34.0±2.0°, c = 1 in methanol composition carbon, 53.4-55.6% , nitrogen, 22.5-23.7% reaction suitability reaction type: click chemistry, reaction type: solution phase peptide synthesis application(s) peptide synthesis: suitable storage temp. 2-8°C SMILES string NC1CCCCC1.CC(C)[C@H](N=[N+]=[N-])C(O)=O InChI 1S/C6H13N.C5H9N3O2/c7-6-4-2-1-3-5-6;1-3(2)4(5(9)10)7-8-6/h6H,1-5,7H2;3-4H,1-2H3,(H,9,10)/t;4-/m.0/s1 InChI key YMXXCNHHCIMTCV-VWMHFEHESA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H315-H319-H335 pcodes P261-P305 + P351 + P338 Personal Protective Equipment dust mask type N95 (US),, Eyeshields,, Gloves, RIDADR NONH for all modes of transport WGK Germany 3 Узнать цену -
(S)-2-Azido-3-phenylpropionic acid (dicyclohexylammonium) salt
Empirical Formula (Hill Notation): C9H9N3O2 · C12H23N CAS Number: 79410-36-9 Molecular Weight: 372.50 Beilstein/REAXYS Number: 3651627 MDL number: MFCD12546002 PubChem Substance ID: 329761361 NACRES: NA.22
Кат. номер 690767-5G 690767-1G Параметрыassay 98%, 98.0% (HPLC), 98.0-102.0% (with NaOH, T) optical activity []/D -44±2°, c = 1% in ethanol reaction suitability reaction type: click chemistry storage temp. 2-8°C SMILES string C1CCC(CC1)NC2CCCCC2.OC(=O)[C@H](Cc3ccccc3)N=[N+]=[N-] InChI 1S/C12H23N.C9H9N3O2/c1-3-7-11(8-4-1)13-12-9-5-2-6-10-12;10-12-11-8(9(13)14)6-7-4-2-1-3-5-7/h11-13H,1-10H2;1-5,8H,6H2,(H,13,14)/t;8-/m.0/s1 InChI key AKAIZEHUGUEJRK-WDBKTSHHSA-N
Safety InformationPersonal Protective Equipment Eyeshields,, Gloves,, type N95 (US), RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
(S)-3-(Boc-amino)-5-hexynoic acid 711934-250MG
PackagingEmpirical Formula (Hill Notation): C11H17NO4 CAS Number: 270596-47-9 Molecular Weight: 227.26 MDL number: MFCD01861007 PubChem Substance ID: 329763099 NACRES: NA.22
250 mg in glass bottle
Bottomless glass bottle. Contents are inside inserted fused cone.ПараметрыQuality Level 100, assay 97.5-102.5% (with NaOH, T), 98% optical activity []/D +26±2°, c = 1 in ethanol optical purity enantiomeric excess: 99.0% (HPLC) reaction suitability reaction type: click chemistry application(s) peptide synthesis: suitable SMILES string CC(C)(C)OC(=O)N[C@@H](CC#C)CC(O)=O InChI 1S/C11H17NO4/c1-5-6-8(7-9(13)14)12-10(15)16-11(2,3)4/h1,8H,6-7H2,2-4H3,(H,12,15)(H,13,14)/t8-/m0/s1 InChI key QZRLAJLEZVWLOV-QMMMGPOBSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H302 Personal Protective Equipment dust mask type N95 (US),, Eyeshields,, Faceshields,, Gloves, RIDADR UN 2811 6.1 / PGIII WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
(S)-3-Amino-5-hexynoic acid hydrochloride 711918-100MG
PackagingEmpirical Formula (Hill Notation): C6H9NO2 · HCl CAS Number: 332064-85-4 Molecular Weight: 163.60 MDL number: MFCD01861006 PubChem Substance ID: 329763096 NACRES: NA.22
100 mg in glass bottle
Bottomless glass bottle. Contents are inside inserted fused cone.ПараметрыQuality Level 100, assay 94.0% (TLC), 94% optical activity []/D +13±1.5°, c = 1 in H2O reaction suitability reaction type: click chemistry, reaction type: solution phase peptide synthesis application(s) peptide synthesis: suitable storage temp. 2-8°C SMILES string Cl.N[C@@H](CC#C)CC(O)=O InChI 1S/C6H9NO2.ClH/c1-2-3-5(7)4-6(8)9;/h1,5H,3-4,7H2,(H,8,9);1H/t5-;/m0./s1 InChI key FVKOZZHCHSRKJA-JEDNCBNOSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H315 - H319 pcodes P302 + P352 - P305 + P351 + P338 Personal Protective Equipment dust mask type N95 (US),, Eyeshields,, Gloves, RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
(S)-5-Azido-2-(Fmoc-amino)pentanoic acid 714291-250MG
PackagingEmpirical Formula (Hill Notation): C20H20N4O4 CAS Number: 1097192-04-5 Molecular Weight: 380.40 MDL number: MFCD11052921 PubChem Substance ID: 329763270 NACRES: NA.26
250 mg in glass bottle
Bottomless glass bottle. Contents are inside inserted fused cone.ПараметрыQuality Level 100, assay 97.0% (HPLC) optical activity []/D 3.5±0.3°, c = 1 in ethyl acetate composition carbon, 62.5-63.9% , nitrogen, 14.3-15.1% reaction suitability reaction type: Fmoc solid-phase peptide synthesis, reaction type: click chemistry application(s) peptide synthesis: suitable functional group Fmoc storage temp. 2-8°C SMILES string OC(=O)[C@H](CCCN=[N+]=[N-])NC(=O)OCC1c2ccccc2-c3ccccc13 InChI 1S/C20H20N4O4/c21-24-22-11-5-10-18(19(25)26)23-20(27)28-12-17-15-8-3-1-6-13(15)14-7-2-4-9-16(14)17/h1-4,6-9,17-18H,5,10-12H2,(H,23,27)(H,25,26)/t18-/m0/s1 InChI key TVPIDQLSARDIPX-SFHVURJKSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H315 - H319 - H335 pcodes P302 + P352 - P305 + P351 + P338 Target Organs Respiratory system Personal Protective Equipment dust mask type N95 (US),, Eyeshields,, Gloves, RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
(S,R,S)-AHPC-C6-PEG1-C3-PEG1-butyl azide 905178-50MG
Empirical Formula (Hill Notation): C39H61N7O6S Molecular Weight: 756.01 ApplicationProtein degrader builiding block (S,R,S)-AHPC-C6-PEG1-C3-PEG1-butyl azide enables the synthesis of molecules for targeted protein degradation, and PROTAC (proteolysis-targeting chimeras) technology,. This conjugate contains a von Hippel–Lindau (VHL)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks, with a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Other NotesTechnology Spotlight: Degrader Building Blocks for Targeted Protein Degradation,
Portal: Building PROTAC® Degraders for Targeted Protein Degradation,
Targeted Protein Degradation by Small Molecules,
Small-Molecule PROTACS: New Approaches to Protein Degradation,
Targeted Protein Degradation: from Chemical Biology to Drug Discovery,
Impact of linker length on the activity of PROTACs,Legal InformationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under licenseПараметрыassay 95% form solid reaction suitability reaction type: click chemistry storage temp. 2-8°C SMILES string O=C(N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C)CCCCCOCCCCCOCCCCCCN=[N+]=[N-], O=C(N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C)CCCCCOCCCCCOCCCCCCN=[N+]=[N-]
Safety InformationWGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
(S,R,S)-AHPC-C6-PEG3-butyl azide 904821-50MG
Empirical Formula (Hill Notation): C38H59N7O7S CAS Number: 2300155-90-0 Molecular Weight: 757.98 ApplicationProtein degrader builiding block (S,R,S)-AHPC-C6-PEG3-butyl azide enables the synthesis of molecules for targeted protein degradation, and PROTAC (proteolysis-targeting chimeras) technology,. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks, with a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Other NotesTechnology Spotlight: Degrader Building Blocks for Targeted Protein Degradation,
Portal: Building PROTAC® Degraders for Targeted Protein Degradation,
Targeted Protein Degradation by Small Molecules,
Small-Molecule PROTACS: New Approaches to Protein Degradation,
Targeted Protein Degradation: from Chemical Biology to Drug Discovery,
Impact of linker length on the activity of PROTACs,Legal InformationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under licenseПараметрыassay 95% form powder or crystals reaction suitability reaction type: click chemistry storage temp. 2-8°C SMILES string O=C(N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C)CCCCCOCCOCCOCCCCCCN=[N+]=[N-], O=C(N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C)CCCCCOCCOCCOCCCCCCN=[N+]=[N-]
Safety InformationWGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
(S,R,S)-AHPC-PEG1-Alkyne 901503-50MG
Empirical Formula (Hill Notation): C28H36N4O5S Molecular Weight: 540.67 ApplicationProtein degrader builiding block (S,R,S)-AHPC-PEG1-NH2 (HCl salt) enables the synthesis of molecules for targeted protein degradation, and PROTAC (proteolysis-targeting chimeras) technology,. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant amine for reactivity with a carboxyl group on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks, with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Other NotesTechnology Spotlight: Degrader Building Blocks for Targeted Protein Degradation,
Portal: Building PROTAC® Degraders for Targeted Protein Degradation,
Targeted Protein Degradation by Small Molecules,
Small-Molecule PROTACS: New Approaches to Protein Degradation,
Targeted Protein Degradation: from Chemical Biology to Drug Discovery,
Impact of linker length on the activity of PROTACs,Legal InformationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under licenseПараметрыQuality Level 100, assay 95% form powder or crystals reaction suitability reaction type: click chemistry storage temp. 2-8°C SMILES string O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H](C[C@@H](O)C3)N3C([C@H](C(C)(C)C)NC(CCOCC#C)=O)=O, O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H](C[C@@H](O)C3)N3C([C@H](C(C)(C)C)NC(CCOCC#C)=O)=O
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
(S,R,S)-AHPC-PEG1-azide 903957-50MG
Empirical Formula (Hill Notation): C26H35N7O5S CAS Number: 2101200-09-1 Molecular Weight: 557.67 ApplicationProtein degrader builiding block (S,R,S)-AHPC-PEG1-azide enables the synthesis of molecules for targeted protein degradation, and PROTAC (proteolysis-targeting chimeras) technology,. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks, with a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Other NotesTechnology Spotlight: Degrader Building Blocks for Targeted Protein Degradation,
Portal: Building PROTAC® Degraders for Targeted Protein Degradation,
Targeted Protein Degradation by Small Molecules,
Small-Molecule PROTACS: New Approaches to Protein Degradation,
Targeted Protein Degradation: from Chemical Biology to Drug Discovery,
Impact of linker length on the activity of PROTACs,Legal InformationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under licenseПараметрыassay 95% form powder reaction suitability reaction type: click chemistry storage temp. 2-8°C SMILES string O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H](C[C@@H](O)C3)N3C([C@H](C(C)(C)C)NC(COCCN=[N+]=[N-])=O)=O, O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H](C[C@@H](O)C3)N3C([C@H](C(C)(C)C)NC(COCCN=[N+]=[N-])=O)=O
Safety InformationWGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
(S,R,S)-AHPC-PEG2-Alkyne 901517-50MG
Empirical Formula (Hill Notation): C30H40N4O6S Molecular Weight: 584.73 NACRES: NA.22 ApplicationProtein degrader builiding block (S,R,S)-AHPC-PEG2-Alkyne enables the synthesis of molecules for targeted protein degradation, and PROTAC (proteolysis-targeting chimeras) technology,. This conjugate contains a Von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant alkyne for click chemistry with an azide on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks, with a pendant alkyne group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Other NotesTechnology Spotlight: Degrader Building Blocks for Targeted Protein Degradation,
Portal: Building PROTAC® Degraders for Targeted Protein Degradation,
Targeted Protein Degradation by Small Molecules,
Small-Molecule PROTACS: New Approaches to Protein Degradation,
Targeted Protein Degradation: from Chemical Biology to Drug Discovery,
Impact of linker length on the activity of PROTACs,Legal InformationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under licenseПараметрыQuality Level 100, assay 95% form powder reaction suitability reaction type: click chemistry storage temp. 2-8°C SMILES string O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H](C[C@@H](O)C3)N3C([C@H](C(C)(C)C)NC(CCOCCOCC#C)=O)=O, O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H](C[C@@H](O)C3)N3C([C@H](C(C)(C)C)NC(CCOCCOCC#C)=O)=O
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
(S,R,S)-AHPC-PEG2-azide 904813-50MG
Empirical Formula (Hill Notation): C28H39N7O6S CAS Number: 2010159-45-0 Molecular Weight: 601.72 ApplicationProtein degrader builiding block (S,R,S)-AHPC-PEG2-azide enables the synthesis of molecules for targeted protein degradation, and PROTAC (proteolysis-targeting chimeras) technology,. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks, with a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Other NotesTechnology Spotlight: Degrader Building Blocks for Targeted Protein Degradation,
Portal: Building PROTAC® Degraders for Targeted Protein Degradation,
Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds,
Structural basis of PROTAC cooperative recognition for selective protein degradation,
Targeted Protein Degradation by Small Molecules,
Small-Molecule PROTACS: New Approaches to Protein Degradation,
Targeted Protein Degradation: from Chemical Biology to Drug Discovery,
Impact of linker length on the activity of PROTACs,Legal InformationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under licenseПараметрыassay 95% form solid reaction suitability reaction type: click chemistry storage temp. 2-8°C SMILES string O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H](C[C@@H](O)C3)N3C([C@H](C(C)(C)C)NC(COCCOCCN=[N+]=[N-])=O)=O, O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H](C[C@@H](O)C3)N3C([C@H](C(C)(C)C)NC(COCCOCCN=[N+]=[N-])=O)=O
Safety InformationWGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
(S,R,S)-AHPC-PEG2-butyl alkyne 910538-50MG
Empirical Formula (Hill Notation): C34H48N4O6S Molecular Weight: 640.83 ApplicationProtein degrader builiding block (S,R,S)-AHPC-PEG2-butyl alkyne enables the synthesis of molecules for targeted protein degradation, and PROTAC (proteolysis-targeting chimeras) technology,. This conjugate contains a von Hippel–Lindau (VHL)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant alkyne for click chemistry with an azide on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks, with a pendant alkyne group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Other NotesTechnology Spotlight: Degrader Building Blocks for Targeted Protein Degradation,
Portal: Building PROTAC® Degraders for Targeted Protein Degradation,
Targeted Protein Degradation by Small Molecules,
Small-Molecule PROTACS: New Approaches to Protein Degradation,
Targeted Protein Degradation: from Chemical Biology to Drug Discovery,
Impact of linker length on the activity of PROTACs,Legal InformationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under licenseПараметрыassay 95% form (Liquid or Semi-solid or Paste or Solid) reaction suitability reaction type: click chemistry storage temp. 2-8°C SMILES string O=C(N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C)COCCOCCCCCCC#C, O=C(N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C)COCCOCCCCCCC#C
Safety InformationWGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
(S,R,S)-AHPC-PEG2-butyl azide 905216-50MG
Empirical Formula (Hill Notation): C32H47N7O6S Molecular Weight: 657.82 ApplicationProtein degrader builiding block (S,R,S)-AHPC-PEG2-Butyl Azide enables the synthesis of molecules for targeted protein degradation, and PROTAC (proteolysis-targeting chimeras) technology,. This conjugate contains a von Hippel–Lindau (VHL)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks, with a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Other NotesTechnology Spotlight: Degrader Building Blocks for Targeted Protein Degradation,
Portal: Building PROTAC® Degraders for Targeted Protein Degradation,
Targeted Protein Degradation by Small Molecules,
Small-Molecule PROTACS: New Approaches to Protein Degradation,
Targeted Protein Degradation: from Chemical Biology to Drug Discovery,
Impact of linker length on the activity of PROTACs,Legal InformationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under licenseПараметрыassay 95% form liquid reaction suitability reaction type: click chemistry storage temp. 2-8°C SMILES string O=C(N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C)COCCOCCCCCCN=[N+]=[N-], O=C(N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C)COCCOCCCCCCN=[N+]=[N-]
Safety InformationWGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
(S,R,S)-AHPC-PEG3-Alkyne 901533-50MG
Empirical Formula (Hill Notation): C32H44N4O7S CAS Number: 2374122-30-0 Molecular Weight: 628.78 NACRES: NA.22 ApplicationProtein degrader builiding block (S,R,S)-AHPC-PEG4-Alkyne enables the synthesis of molecules for targeted protein degradation, and PROTAC (proteolysis-targeting chimeras) technology,. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant alkyne for click chemistry with an azide on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks, with a pendant alkyne group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Other NotesTechnology Spotlight: Degrader Building Blocks for Targeted Protein Degradation,
Portal: Building PROTAC® Degraders for Targeted Protein Degradation,
Targeted Protein Degradation by Small Molecules,
Small-Molecule PROTACS: New Approaches to Protein Degradation,
Targeted Protein Degradation: from Chemical Biology to Drug Discovery,
Impact of linker length on the activity of PROTACs,Legal InformationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under licenseПараметрыQuality Level 100, assay 95% form powder or crystals reaction suitability reaction type: click chemistry storage temp. 2-8°C SMILES string O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H](C[C@@H](O)C3)N3C([C@H](C(C)(C)C)NC(CCOCCOCCOCC#C)=O)=O, O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H](C[C@@H](O)C3)N3C([C@H](C(C)(C)C)NC(CCOCCOCCOCC#C)=O)=O
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
(S,R,S)-AHPC-PEG3-azide 904651-50MG
Empirical Formula (Hill Notation): C30H43N7O7S CAS Number: 1797406-80-4 Molecular Weight: 645.77 ApplicationProtein degrader builiding block (S,R,S)-AHPC-PEG3-Azide enables the synthesis of molecules for targeted protein degradation, and PROTAC (proteolysis-targeting chimeras) technology,. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks, with a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Other NotesTechnology Spotlight: Degrader Building Blocks for Targeted Protein Degradation,
Portal: Building PROTAC® Degraders for Targeted Protein Degradation,
Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds,
Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4,
Targeted Protein Degradation by Small Molecules,
Small-Molecule PROTACS: New Approaches to Protein Degradation,
Targeted Protein Degradation: from Chemical Biology to Drug Discovery,
Impact of linker length on the activity of PROTACs,Legal InformationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under licenseПараметрыassay 95% form solid or liquid reaction suitability reaction type: click chemistry storage temp. 2-8°C SMILES string O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H](C[C@@H](O)C3)N3C([C@H](C(C)(C)C)NC(COCCOCCOCCN=[N+]=[N-])=O)=O, O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H](C[C@@H](O)C3)N3C([C@H](C(C)(C)C)NC(COCCOCCOCCN=[N+]=[N-])=O)=O
Safety InformationWGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
(S,R,S)-AHPC-PEG4-Alkyne 901851-50MG
Empirical Formula (Hill Notation): C34H48N4O8S Molecular Weight: 672.83 NACRES: NA.22 ApplicationProtein degrader builiding block (S,R,S)-AHPC-PEG4-Alkyne enables the synthesis of molecules for targeted protein degradation, and PROTAC (proteolysis-targeting chimeras) technology,. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant alkyne for click chemistry with an azide on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks, with a pendant alkyne group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Other NotesTechnology Spotlight: Degrader Building Blocks for Targeted Protein Degradation,
Portal: Building PROTAC® Degraders for Targeted Protein Degradation,
Targeted Protein Degradation by Small Molecules,
Small-Molecule PROTACS: New Approaches to Protein Degradation,
Targeted Protein Degradation: from Chemical Biology to Drug Discovery,
Impact of linker length on the activity of PROTACs,Legal InformationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under licenseПараметрыreaction suitability reaction type: click chemistry storage temp. 2-8°C SMILES string O=C(CCOCCOCCOCCOCC#C)N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
(S,R,S)-AHPC-PEG4-Azide 909262-50MG
Empirical Formula (Hill Notation): C32H47N7O8S CAS Number: 1797406-81-5 Molecular Weight: 689.82 ApplicationProtein degrader builiding block (S,R,S)-AHPC-PEG4-Azide enables the synthesis of molecules for targeted protein degradation, and PROTAC (proteolysis-targeting chimeras) technology,. This conjugate contains a von Hippel–Lindau (VHL)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant azide for click chemistry with an alkyne on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks, with a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Other NotesTechnology Spotlight: Degrader Building Blocks for Targeted Protein Degradation,
Portal: Building PROTAC® Degraders for Targeted Protein Degradation,
Targeted Protein Degradation by Small Molecules,
Small-Molecule PROTACS: New Approaches to Protein Degradation,
Targeted Protein Degradation: from Chemical Biology to Drug Discovery,
Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds,
Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4,Legal InformationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under licenseПараметрыassay 95% form liquid reaction suitability reaction type: click chemistry storage temp. 2-8°C SMILES string O=C(COCCOCCOCCOCCN=[N+]=[N-])N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C, O=C(COCCOCCOCCOCCN=[N+]=[N-])N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C
Safety InformationWGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
(S,R,S)-AHPC-PEG5-Alkyne 901855-50MG
Empirical Formula (Hill Notation): C36H52N4O9S Molecular Weight: 716.88 NACRES: NA.22 ApplicationProtein degrader builiding block (S,R,S)-AHPC-PEG5-Alkyne enables the synthesis of molecules for targeted protein degradation, and PROTAC (proteolysis-targeting chimeras) technology,. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant alkyne for click chemistry with an azide on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks, with a pendant alkyne group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Other NotesTechnology Spotlight: Degrader Building Blocks for Targeted Protein Degradation,
Portal: Building PROTAC® Degraders for Targeted Protein Degradation,
Targeted Protein Degradation by Small Molecules,
Small-Molecule PROTACS: New Approaches to Protein Degradation,
Targeted Protein Degradation: from Chemical Biology to Drug Discovery,
Impact of linker length on the activity of PROTACs,Legal InformationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under licenseПараметрыreaction suitability reaction type: click chemistry storage temp. 2-8°C SMILES string O=C(CCOCCOCCOCCOCCOCC#C)N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
(S,R,S)-AHPC-PEG5-azide 909351-50MG
Empirical Formula (Hill Notation): C34H51N7O9S Molecular Weight: 733.88 ApplicationProtein degrader builiding block (S,R,S)-AHPC-PEG5-azide enables the synthesis of molecules for targeted protein degradation, and PROTAC (proteolysis-targeting chimeras) technology,. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant azide for click chemistry with an alkyne on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks, with a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Other NotesTechnology Spotlight: Degrader Building Blocks for Targeted Protein Degradation,
Portal: Building PROTAC® Degraders for Targeted Protein Degradation,
Targeted Protein Degradation by Small Molecules,
Small-Molecule PROTACS: New Approaches to Protein Degradation,
Targeted Protein Degradation: from Chemical Biology to Drug Discovery,
Impact of linker length on the activity of PROTACs,Legal InformationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under licenseПараметрыassay 98% form (Liquid or Semi-Solid or Paste or Solid) reaction suitability reaction type: click chemistry storage temp. 2-8°C SMILES string O=C(COCCOCCOCCOCCOCCN=[N+]=[N-])N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C, O=C(COCCOCCOCCOCCOCCN=[N+]=[N-])N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C
Safety InformationWGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
(S,R,S)-AHPC-PEG6-Alkyne 901873-50MG
Empirical Formula (Hill Notation): C38H56N4O10S Molecular Weight: 760.94 NACRES: NA.22 ApplicationProtein degrader builiding block (S,R,S)-AHPC-PEG6-Alkyne enables the synthesis of molecules for targeted protein degradation, and PROTAC (proteolysis-targeting chimeras) technology,. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant alkyne for click chemistry with an azide on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks, with a pendant alkyne group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Other NotesTechnology Spotlight: Degrader Building Blocks for Targeted Protein Degradation,
Portal: Building PROTAC® Degraders for Targeted Protein Degradation,
Targeted Protein Degradation by Small Molecules,
Small-Molecule PROTACS: New Approaches to Protein Degradation,
Targeted Protein Degradation: from Chemical Biology to Drug Discovery,
Impact of linker length on the activity of PROTACs,Legal InformationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under licenseПараметрыform powder reaction suitability reaction type: click chemistry storage temp. 2-8°C SMILES string O=C(CCOCCOCCOCCOCCOCCOCC#C)N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C, O=C(CCOCCOCCOCCOCCOCCOCC#C)N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
(S,R,S)-AHPC-PEG6-Azide 909378-50MG
Empirical Formula (Hill Notation): C36H55N7O10S CAS Number: 2086298-71-5 Molecular Weight: 777.93 ApplicationProtein degrader builiding block (S,R,S)-AHPC-PEG6-Azide enables the synthesis of molecules for targeted protein degradation, and PROTAC (proteolysis-targeting chimeras) technology,. This conjugate contains a von Hippel–Lindau (VHL)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant azide for click chemistry with an alkyne on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks, with a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Other NotesTechnology Spotlight: Degrader Building Blocks for Targeted Protein Degradation,
Portal: Building PROTAC® Degraders for Targeted Protein Degradation,
Targeted Protein Degradation by Small Molecules,
Small-Molecule PROTACS: New Approaches to Protein Degradation,
Targeted Protein Degradation: from Chemical Biology to Drug Discovery,
Impact of linker length on the activity of PROTACs,Legal InformationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under licenseПараметрыassay 95% form (Liquid or Semi-Solid or Paste or Solid) reaction suitability reaction type: click chemistry storage temp. 2-8°C SMILES string O=C(COCCOCCOCCOCCOCCOCCN=[N+]=[N-])N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C, O=C(COCCOCCOCCOCCOCCOCCN=[N+]=[N-])N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C
Safety InformationWGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
(S,R,S)-AHPC-PEG6-butyl alkyne 910597-50MG
Empirical Formula (Hill Notation): C42H64N4O10S Molecular Weight: 817.04 ApplicationProtein degrader builiding block (S,R,S)-AHPC-PEG6-butyl alkyne enables the synthesis of molecules for targeted protein degradation, and PROTAC (proteolysis-targeting chimeras) technology,. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant alkyne for click chemistry with an azide on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks, with a pendant alkyne group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Other NotesTechnology Spotlight: Degrader Building Blocks for Targeted Protein Degradation,
Portal: Building PROTAC® Degraders for Targeted Protein Degradation,
Targeted Protein Degradation by Small Molecules,
Small-Molecule PROTACS: New Approaches to Protein Degradation,
Targeted Protein Degradation: from Chemical Biology to Drug Discovery,
Impact of linker length on the activity of PROTACs,Legal InformationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under licenseПараметрыassay 95% form (Liquid or Semi-Solid or Paste or Solid) reaction suitability reaction type: click chemistry storage temp. 2-8°C SMILES string O=C(N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C)COCCOCCOCCOCCOCCOCCCCCCC#C, O=C(N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C)COCCOCCOCCOCCOCCOCCCCCCC#C
Safety InformationWGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
(S,R,S)-AHPC-PEG6-butyl azide 904864-50MG
Empirical Formula (Hill Notation): C40H63N7O10S Molecular Weight: 834.03 ApplicationProtein degrader builiding block (S,R,S)-AHPC-PEG6-butyl azide enables the synthesis of molecules for targeted protein degradation, and PROTAC (proteolysis-targeting chimeras) technology,. This conjugate contains a von Hippel–Lindau (VHL)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks, with a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Other NotesTechnology Spotlight: Degrader Building Blocks for Targeted Protein Degradation,
Portal: Building PROTAC® Degraders for Targeted Protein Degradation,
Targeted Protein Degradation by Small Molecules,
Small-Molecule PROTACS: New Approaches to Protein Degradation,
Targeted Protein Degradation: from Chemical Biology to Drug Discovery,
Impact of linker length on the activity of PROTACs,Legal InformationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under licenseПараметрыassay 95% form liquid reaction suitability reaction type: click chemistry storage temp. 2-8°C SMILES string O=C(N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C)COCCOCCOCCOCCOCCOCCCCCCN=[N+]=[N-], O=C(N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C)COCCOCCOCCOCCOCCOCCCCCCN=[N+]=[N-]
Safety InformationWGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
-(2-Azidoethyl)-ATP sodium salt solution 808539-100UL
Empirical Formula (Hill Notation): C12H19N8O13P3 · xNa+ Molecular Weight: 576.25 (free acid basis) PubChem Substance ID: 329769106 NACRES: NA.22 ApplicationLee, et al., reported a non-radioactive version of in vitro phosphorylation where -[2-Azidoethyl]-ATP (compound 8) was successfully used instead of -32P-modified ATP to phosphorylate GST-tagged recombinant p27kip1 with protein kinase cdk2. The phosphorylated, azide-modified protein substrate can be labeled with alkynes of biotin or fluorescent dyes using Cu(I)- catalyzed click chemistry or DBCO-containing biotin or fluorescent dyes using Cu(I)-free click chemistry.
Packaging
100 μL in poly bottleLegal InformationThe purchase of this product for use in applications relating to copper catalyzed azide-alkyne cycloaddition chemistry ("Click Chemistry") includes a limited, nontransferable license to intellectual property owned by The Scripps Research Institute to use this product solely for internal non-commercial research activities and specifically excludes clinical, therapeutic, or diagnostic use in humans or animals and manufacturing purposes. Information regarding a license for commercial use in Click Chemistry may be obtained directly from The Scripps Research Institute, 10550 N. Torrey Pines Rd., La Jolla, CA 92037, or by contacting 858-784-8140 or click@scripps.edu.ПараметрыQuality Level 200, assay 95% (HPLC) form aqueous solution (pH 7.5) reaction suitability reaction type: click chemistry concentration 10 mM in H2O shipped in wet ice storage temp. 20°C SMILES string O[C@H]1[C@@H](O)[C@H](N2C(N=CN=C3N)=C3N=C2)O[C@@H]1COP(OP(OP(OCCN=[N+]=[N-])(O)=O)(O)=O)(O)=O.C
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 2 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
-[(6-Azidohexyl)-imido]-ATP sodium salt 808520-1MG
Empirical Formula (Hill Notation): C16H28N9O12P3 · xNa+ Molecular Weight: 631.37 (free acid basis) PubChem Substance ID: 329769105 ApplicationLee, et al., reported a non-radioactive version of in vitro phosphorylation where -[(6-Azidohexyl)-imido]-ATP (compound 6) was successfully used instead of -32P-modified ATP to phosphorylate GST-tagged recombinant p27kip1 with protein kinase cdk2. The phosphorylated, azide-modified protein substrate can be labeled with alkynes of biotin or fluorescent dyes using Cu(I)-catalyzed click chemistry or DBCO-containing biotin or fluorescent dyes using Cu(I)-free click chemistry.
Packaging
1 mg in glass bottleLegal InformationThe purchase of this product for use in applications relating to copper catalyzed azide-alkyne cycloaddition chemistry ("Click Chemistry") includes a limited, nontransferable license to intellectual property owned by The Scripps Research Institute to use this product solely for internal non-commercial research activities and specifically excludes clinical, therapeutic, or diagnostic use in humans or animals and manufacturing purposes. Information regarding a license for commercial use in Click Chemistry may be obtained directly from The Scripps Research Institute, 10550 N. Torrey Pines Rd., La Jolla, CA 92037, or by contacting 858-784-8140 or click@scripps.edu.ПараметрыQuality Level 200, assay ≥95% (HPLC) reaction suitability reaction type: click chemistry solubility 10 mM Tris-HCl, pH 7.5: soluble shipped in wet ice storage temp. −20°C SMILES string O[C@@H]([C@H]1O)[C@@H](COP(O)(OP(O)(OP(NCCCCCCN=[N+]=[N-])(O)=O)=O)=O)O[C@@H]1N2C=NC3=C2N=CN=C3N InChI 1S/C16H28N9O12P3/c17-14-11-15(20-8-19-14)25(9-21-11)16-13(27)12(26)10(35-16)7-34-39(30,31)37-40(32,33)36-38(28,29)23-6-4-2-1-3-5-22-24-18/h8-10,12-13,16,26-27H,1-7H2,(H,30,31)(H,32,33)(H2,17,19,20)(H2,23,28,29)/t10-,12-,13-,16?/m1/s1 InChI key FZLLGYSKHRTLRX-AARXTDBFSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
-[(Propargyl)-imido]-ATP sodium salt 808512-1MG
Empirical Formula (Hill Notation): C13H19N6O12P3 · xNa+ Molecular Weight: 544.24 (free acid basis) PubChem Substance ID: 329769104 NACRES: NA.22 ApplicationLee, et al,. reported a non-radioactive version of in vitro phosphorylation where -[(Propargyl)-imido]-ATP (compound 1) was successfully used instead of -32P-modified ATP to phosphorylate GST-tagged recombinant p27kip1 with protein kinase cdk2. The phosphorylated, alkyne-modified protein substrate can be labeled with azides of biotin or fluorescent dyes using Cu(I)-catalyzed click chemistry.
Packaging
1 mg in glass bottleLegal InformationThe purchase of this product for use in applications relating to copper catalyzed azide-alkyne cycloaddition chemistry ("Click Chemistry") includes a limited, nontransferable license to intellectual property owned by The Scripps Research Institute to use this product solely for internal non-commercial research activities and specifically excludes clinical, therapeutic, or diagnostic use in humans or animals and manufacturing purposes. Information regarding a license for commercial use in Click Chemistry may be obtained directly from The Scripps Research Institute, 10550 N. Torrey Pines Rd., La Jolla, CA 92037, or by contacting 858-784-8140 or click@scripps.edu.ПараметрыQuality Level 200, assay ≥95% (HPLC) form solid reaction suitability reaction type: click chemistry solubility 10 mM Tris-HCl, pH 7.5: soluble shipped in wet ice storage temp. −20°C SMILES string NC1=NC=NC2=C1N=CN2[C@H]3O[C@H](COP(OP(O)(OP(O)(NCC#C)=O)=O)(O)=O)[C@@H](O)[C@H]3O InChI 1S/C13H19N6O12P3/c1-2-3-18-32(22,23)30-34(26,27)31-33(24,25)28-4-7-9(20)10(21)13(29-7)19-6-17-8-11(14)15-5-16-12(8)19/h1,5-7,9-10,13,20-21H,3-4H2,(H,24,25)(H,26,27)(H2,14,15,16)(H2,18,22,23)/t7-,9-,10-,13?/m1/s1 InChI key PIPOEUYSJJTELD-RJNFYWFKSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
1, 2-Benzenedisulfonyl fluoride ALD00170-1G
Empirical Formula (Hill Notation): C6H4F2O4S2 CAS Number: 115560-96-8 Molecular Weight: 242.22 PubChem Substance ID: 329772621 NACRES: NA.22 ApplicationSulfonyl fluoride motif can be used as a connector for the assembly of -SO2- linked small molecules with proteins or nucleic acids. This new click chemistry approach through sulfates is a complimentary approach to using amides and phosphate groups as linkers.
Packaging
1 g in poly bottleПараметрыQuality Level 100, assay 97% reaction suitability reaction type: click chemistry mp 127-132 °C SMILES string O=S(C1=C(S(=O)(F)=O)C=CC=C1)(F)=O InChI 1S/C6H4F2O4S2/c7-13(9,10)5-3-1-2-4-6(5)14(8,11)12/h1-4H InChI key DNXLZBKMVRTNHQ-UHFFFAOYSA-N
Safety Informationpictograms GHS05 signalword Danger hcodes H314 pcodes P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 RIDADR UN 3261 8 / PGII WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
1,11-Diazido-3,6,9-trioxaundecane
Empirical Formula (Hill Notation): C8H16N6O3 CAS Number: 101187-39-7 Molecular Weight: 244.25 MDL number: MFCD03425545 PubChem Substance ID: 329767198 NACRES: NA.22
Кат. номер 765953-5G 765953-1G ApplicationHomobifunctional PEG azide click chemistry linker. Azide functional groups will react via a copper catalyzed or strain promoted 1,3-dipolar cycloaddition click reaction with terminal alkynes and cyclooctyne derivatives to yield a stable triazole linkage.
1,11-Diazido-3,6,9-trioxaundecane may be used to synthesize:- 1,11-bis[4-(pyren-1-ylmethoxymethyl)-1H-1,2,3-triazole-1-yl]-3,6,9-trioxaundecane, a fluorogenic chemosensor that can selective detect Hg2+ and Ag+ ions in aqueous methanol solution
- 1-amino-11-azido-3,6,9-trioxaundecane, an intermediate to synthesize tetraethylene glycol based bidentate ligand functionalized with dihydrolipoic acid and biotin (DHLA-TEG-biotin)
Packaging
1, 5 g in glass bottleПараметрыQuality Level 100, reaction suitability reaction type: click chemistry, reagent type: cross-linking reagent refractive index n20/D 1.470 bp 163-196 °C/760 mmHg density 1.170 g/mL at 25 °C storage temp. 20°C SMILES string [N-]=[N+]=NCCOCCOCCOCCN=[N+]=[N-] InChI 1S/C8H16N6O3/c9-13-11-1-3-15-5-7-17-8-6-16-4-2-12-14-10/h1-8H2 InChI key SFMMXKLNFMIUCH-UHFFFAOYSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H302 RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
1,14-Diazido-3,6,9,12-tetraoxatetradecane
Empirical Formula (Hill Notation): C10H20N6O4 CAS Number: 182760-73-2 Molecular Weight: 288.30 MDL number: MFCD08067376
Кат. номер 901140-5G 901140-1G Параметрыform liquid Quality Level 100, reaction suitability reaction type: click chemistry density 1.129 storage temp. 2-8°C SMILES string [N-]=[N+]=NCCOCCOCCOCCOCCN=[N+]=[N-]
Safety Informationpictograms GHS02 signalword Danger hcodes H242 pcodes P210 - P234 - P235 - P240 - P370 + P378 - P403 RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F 230.0 °F Flash Point C 110 °C Узнать цену -
1,17-Diazido-3,6,9,12,15-pentaoxaheptadecane 901136-5G
Empirical Formula (Hill Notation): C12H24N6O5 CAS Number: 356046-26-9 Molecular Weight: 332.36 MDL number: MFCD07369627 Параметрыform liquid Quality Level 100, reaction suitability reaction type: click chemistry refractive index n/D 1.4716 density 1.13194 g/mL storage temp. 2-8°C SMILES string [N-]=[N+]=NCCOCCOCCOCCOCCOCCN=[N+]=[N-]
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F 230.0 °F Flash Point C 110 °C Узнать цену -
1,2-Di-O-acetyl-3-azido-3-deoxy-5-O-(p-toluoyl)-D-ribofuranose 712825-100MG
PackagingEmpirical Formula (Hill Notation): C17H19N3O7 CAS Number: 120143-22-8 Molecular Weight: 377.35 Beilstein/REAXYS Number: 7317070 MDL number: MFCD16621724 PubChem Substance ID: 329763153 NACRES: NA.22
100 mg in glass bottle
Bottomless glass bottle. Contents are inside inserted fused cone.ПараметрыQuality Level 100, assay 95% (HPLC) optical activity []/D +11.0±2.0°, c = 1 in chloroform composition carbon, 53.0-55.2% , nitrogen, 10.5-11.7% reaction suitability reaction type: click chemistry storage temp. 2-8°C SMILES string CC(=O)OC1O[C@H](COC(=O)c2ccc(C)cc2)[C@@H](N=[N+]=[N-])[C@H]1OC(C)=O InChI 1S/C17H19N3O7/c1-9-4-6-12(7-5-9)16(23)24-8-13-14(19-20-18)15(25-10(2)21)17(27-13)26-11(3)22/h4-7,13-15,17H,8H2,1-3H3/t13-,14-,15-,17?/m1/s1 InChI key LNDLSVCWKVEVIX-BOEXNKMNSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H302 - H312 pcodes P280 Personal Protective Equipment Eyeshields,, Faceshields,, Gloves,, type ABEK (EN14387) respirator filter, RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
1,2-Dibromoethane-1-sulfonyl fluoride 906190-250MG
Empirical Formula (Hill Notation): C2H3Br2FO2S CAS Number: 103020-97-9 Molecular Weight: 269.92 MDL number: MFCD31615713 Application1,2-Dibromoethane-1-sulfonyl fluoride (DESF) is a bench-stable precursor to 1-bromoethene-1-sulfonyl fluoride (BESF), a new and robust connective hub for the Sulfur (VI) fluoride exchange (SuFEx,) click reaction. BESF offers similar routes as ethenesulfonyl fluoride (ESF, cat# 746959,) but with additional reactivity due to the embedded bromo group.
Treatment of DESF with triethylamine generates BESF in situ, which has been used to synthesize diverse and unprecented sulfonyl fluorides in good-to-excellent yields. As the resulting molecules possess sulfonyl fluoride handles, further SuFEx reactions are also possible. DESF adds another useful tool for conjugation strategies in chemical biology and organic and polymer synthesis.Other Notes1-Bromoethene-1-sulfonyl fluoride (BESF) is another good connective hub for SuFEx click chemistry,
Regioselective Synthesis of Fluorosulfonyl 1,2,3-Triazoles from Bromovinylsulfonyl Fluoride,
Technology Spotlight: SuFEx: Sulfonyl Fluorides that Participate in the Next Click Reaction,Параметрыform liquid reaction suitability reaction type: click chemistry
Safety Informationpictograms GHS07 signalword Warning hcodes H315 - H319 pcodes P302 + P352 - P305 + P351 + P338 WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
1,3-Benzenedisulfonyl fluoride
Empirical Formula (Hill Notation): C6H4F2O4S2 CAS Number: 7552-55-8 Molecular Weight: 242.22 PubChem Substance ID: 329772622 NACRES: NA.22
Кат. номер ALD00172-1G ALD00172-10G ApplicationSulfonyl fluoride motif can be used as a connector for the assembly of -SO2- linked small molecules with proteins or nucleic acids. This new click chemistry approach through sulfates is a complimentary approach to using amides and phosphate groups as linkers.
Packaging
1, 10 g in poly bottleПараметрыQuality Level 100, assay 95% reaction suitability reaction type: click chemistry mp 37-42 °C SMILES string FS(C1=CC(S(F)(=O)=O)=CC=C1)(=O)=O InChI 1S/C6H4F2O4S2/c7-13(9,10)5-2-1-3-6(4-5)14(8,11)12/h1-4H InChI key VCINFPPPNNZOAD-UHFFFAOYSA-N
Safety Informationpictograms GHS05 signalword Danger hcodes H314 pcodes P280 - P305 + P351 + P338 - P310 RIDADR UN 3261 8 / PGII WGK Germany WGK 3 Узнать цену
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Менеджер по работе с клиентами
С 2010 года мы поставляем оборудование с заводов Европы. Берем на себя все — от подбора оборудования до внедрения на предприятии
Все сотрудники имеют высшее образование, закончили ведущие химические вузы страны, такие как РХТУ им Менделеева.
У большинства компаний срок ожидания составляет 10-12 недель.
Оборудование хранится на сухом отапливаемом складе, где поддерживается ровная температура.
Работаем с PonyExpress и Деловыми линиями. Вы также можете выбрать свою транспортную компанию или забрать товар со склада в Москве.
В случае любых неполадок за свой счет выполним ремонт в сервисном центре или на заводе-изготовителе. Или бесплатно заменим прибор на новый.
Производим пуско-наладку оборудования, валидацию, обучение сотрудников. Если нужно, привлекаем инженеров с заводов- изготовителей.
