Citric acid, Anhydrous
Empirical Formula (Hill Notation): | C6H8O7 |
Linear Formula: | HOC(COOH)(CH2COOH)2 |
CAS Number: | 77-92-9 |
Molecular Weight: | 192.12 |
Beilstein/REAXYS Number: | 782061 |
EC Number: | 201-069-1 |
MDL number: | MFCD00011669 |
eCl@ss: | 39021801 |
PubChem Substance ID: | 329823094 |
NACRES: | NA.24 |
Кат. номер |
PHR1071-1G-PW |
PHR1071-1G |
PHR1071-500MG-PW |
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Citric acid is a common ingredient in pharmaceutical formulations. It finds use in antacids and dentrifices because of the effervescent effect it generates upon combination with carbonates or bicarbonates. Citric acid may also be used as a buffering agent and it assists in the dispersion of suspensions in order to ensure the stability of the active ingredients and enhance the efficacy of antioxidants.
Anhydrous citric acid may be used as a reference standard in determining the concentration of citric acid present in biological fluids using spectrophotometric method.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Citric acid, Anhydrous may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and milk samples by various chromatography techniques.
These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.
This Certified Reference Material (CRM) is produced and certified in accordance with
ISO 17034 and
ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAB7603 in the slot below. This is an example certificate only and may not be the lot that you receive.
Quality Level | 300 |
grade | certified reference material, pharmaceutical secondary standard |
form | neat |
CofA | current certificate can be downloaded |
expl. lim. | 8 %, 65 °F |
application(s) | HPLC: suitable, gas chromatography (GC): suitable |
pKa A | (1) 3.13, (2) 4.76, (3) 6.4 |
mp | 153-159 °C (lit.) |
Featured Industry | Pharmaceutical (small molecule) |
format | neat |
pharmacopeia traceability | traceable to PhEur A1202000, traceable to USP 1134368 |
SMILES string | OC(=O)CC(O)(CC(O)=O)C(O)=O |
InChI | 1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12) |
InChI key | KRKNYBCHXYNGOX-UHFFFAOYSA-N |
pictograms | GHS07 |
signalword | Warning |
hcodes | H319 |
pcodes | P264 - P280 - P305 + P351 + P338 - P337 + P313 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 1 |
Flash Point F | Not applicable |
Flash Point C | Not applicable |