Tobramycin
Empirical Formula (Hill Notation): | C18H37N5O9 |
CAS Number: | 32986-56-4 |
Molecular Weight: | 467.51 |
Beilstein/REAXYS Number: | 1357507 |
EC Number: | 251-322-5 |
MDL number: | MFCD00077885 |
PubChem Substance ID: | 329823102 |
NACRES: | NA.24 |
Кат. номер |
PHR1079-1G |
PHR1079-1G-PW |
Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards. Tobramycin is an aminoglycoside antibiotic effective in treating infections caused by Gram negative bacteria.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Tobramycin may be used as a pharmaceutical reference standard for the determination of the analyte in drug dosage forms by high performance liquid chromatography.
Tobramycin is an aminoglycoside.
Mode of Action: Binds to 70S ribosomal subunit; inhibits translocation; elicits miscoding.
Spectrum of Activity: Gram negative bacteria. Not effective against
Enterococci. These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.
Values of analytes vary lot to lot.
This Certified Reference Material (CRM) is produced and certified in accordance with
ISO 17034 and
ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA5713 in the slot below. This is an example certificate only and may not be the lot that you receive.
Quality Level | 300 |
grade | certified reference material, pharmaceutical secondary standard |
form | neat |
CofA | current certificate can be downloaded |
application(s) | HPLC: suitable, gas chromatography (GC): suitable |
Featured Industry | Pharmaceutical (small molecule) |
format | neat |
pharmacopeia traceability | traceable to BP 333, traceable to PhEur T1500000, traceable to USP 1667508 |
SMILES string | NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@@H](N)[C@H]3O)[C@H]2O)[C@H](N)C[C@@H]1O |
InChI | 1S/C18H37N5O9/c19-3-9-8(25)2-7(22)17(29-9)31-15-5(20)1-6(21)16(14(15)28)32-18-13(27)11(23)12(26)10(4-24)30-18/h5-18,24-28H,1-4,19-23H2/t5-,6+,7+,8-,9+,10+,11+,12+,13+,14-,15+,16-,17+,18+/m0/s1 |
InChI key | NLVFBUXFDBBNBW-SNGYORCQSA-N |
pictograms | GHS08,GHS08 |
signalword | Warning-Warning |
hcodes | H361f - H361f |
pcodes | P201 - P202 - P280 - P201 - P202 - P280 - P308 + P313 - P308 + P313 - P405 - P405 - P501 - P501 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |