Amitriptyline hydrochloride

Empirical Formula (Hill Notation):	C20H23N · HCl
CAS Number:	549-18-8
Molecular Weight:	313.86
EC Number:	208-964-6
MDL number:	MFCD00012537
PubChem Substance ID:	329823361
NACRES:	NA.24

Кат. номер

PHR1384-1G

PHR1384-1G-PW

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Amitriptyline hydrochloride is a drug, and a tricyclic antidepressant with anticholinergic activity. It is widely used in combination with chlordiazepoxide 7-chloro-2-(methyl-amino)-5-phenyl-3H-1,4-benzodiazepine-4-oxide for the treatment of patients with moderate to severe depression associated with moderate to severe anxiety.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Amitriptyline hydrochloride may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using spectrophotometric technique and reversed-phase high-performance liquid chromatography.
Tricyclic antidepressant; inhibits the norepinephrine and serotonin transporters with Kis of 100 nM and 14.7 nM, respectively; high in vitro affinity for 1-adrenoceptors, serotonin and muscarinic acetylcholine receptors.
These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA1640 in the slot below. This is an example certificate only and may not be the lot that you receive.

Quality Level	300
grade	certified reference material, pharmaceutical secondary standard
form	neat
CofA	current certificate can be downloaded
application(s)	HPLC: suitable, gas chromatography (GC): suitable
Featured Industry	Pharmaceutical (small molecule)
format	neat
pharmacopeia traceability	traceable to BP 16, traceable to PhEur Y0000563, traceable to USP 1029002
SMILES string	Cl[H].CN(C)CC\C=C1\c2ccccc2CCc3ccccc13
InChI	1S/C20H23N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-12H,7,13-15H2,1-2H3;1H
InChI key	KFYRPLNVJVHZGT-UHFFFAOYSA-N
Gene Information	human ... SLC6A2(6530), SLC6A4(6532)

pictograms	GHS06,GHS08,GHS09
signalword	Danger
hcodes	H301 - H319 - H361d - H410
pcodes	P201 - P273 - P301 + P310 + P330 - P305 + P351 + P338
RIDADR	UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., HI: all
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable