16:0-5 Doxyl PC 810601C-1MG
Empirical Formula (Hill Notation): | C46H90N2O10P |
CAS Number: | 188004-24-2 |
Molecular Weight: | 862.19 |
NACRES: | NA.25 |
Avantis nitroxide spin product listing is a group of compounds designed to act as membrane probes. A variety of positions down the hydrophobic chain are labeled with the nitroxide functional groups to allow probing the membrane at various depths. These compounds have been synthesized from 1-palmitoyl-2-hydroxy-
sn-glycerol-3-phosphocholine with the product being purified by column chromatography. Various
n-doxyl phosphocholines have been recently used as biophysical tools to elucidate membrane trafficking with phosphatidylinositol transfer proteins and as fluorescent quenchers in lipid bilayer structural studies.
Phosphatidylcholine (PC), a strong bilayer-forming lipid is the most common phospholipid in mammalian membranes. It is also an important component of the mucosal layer of the colon. The 5th carbon of the
sn-2 stearic acid chain of 1-palmitoyl-2-stearoyl-(5-doxyl)-
sn-glycero-3-phosphocholine analog has a Doxyl PC, a spin probe attached to it covalently.
16:0-5 Doxyl PC may be used:
- as a component in virus-like large unilamellar vesicles (VL LUVs) to quench 4-chloro-7-nitrobenz-2-oxa-1,3-diazole (NBD) fluorescence emission
- in the preparation of multi-lamellar vesicles (MLVs) as a site-specific quencher to perform fluorescence quenching studies
- in the preparation of spin-labelled multi-lamellar vesicles (MLVs)
Phosphatidylcholine (PC) functions as a surfactant within the mucus to form a hydrophobic surface to inhibit bacterial penetrance. It is used to treat fat embolism. Phosphatidylcholine lowers the levels of cholesterol and triglycerides.
5 mL Clear Glass Sealed Ampule (810601C-1mg)
To prevent aggregation, prepare water-based solutions of 2 mM stock solutions of n-DOXYL PCs and store in plastic. Dilute stock solutions to 0.03- 0.1 mM solutions for EPR studies. For liposome preparations in fluorescent quenching measurements, dissolve the doxyl lipid in 150 μl absolute ethanol for a concentration of 40.3 mM., Supplemental information,
assay | >99% (TLC) |
packaging | pkg of 1 x 1 mL (810601C-1mg) |
Торговая марка | Avanti Polar Lipids |
concentration | 1 mg/mL (810601C-1mg) |
shipped in | dry ice |
storage temp. | 20°C |
pictograms | GHS06,GHS08 |
signalword | Danger |
hcodes | H302 - H315 - H319 - H331 - H336 - H351 - H361d - H372 - H412 |
pcodes | P201 - P273 - P301 + P312 + P330 - P302 + P352 - P304 + P340 + P311 - P308 + P313 |
Target Organs | Central nervous system |
RIDADR | UN 1888 6.1 / PGIII |
WGK Germany | WGK 3 |
Flash Point F | does not flash |
Flash Point C | does not flash |