Bioactive Small Molecules
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NI-42
Empirical Formula (Hill Notation): C18H15N3O3S CAS Number: 1884640-99-6 Molecular Weight: 353.40 MDL number: MFCD30290161
PackagingКат. номер PZ0348-5MG PZ0348-25MG
5, 25 mg in glass bottle
Biochem/physiol Actions
NI-42 is a biased potent small molecule inhibitor of the bromodomain of the BRPF (bromodomain and PHD finger-containing) proteins, which are scaffolding proteins that assemble histone acetyltransferase (HAT) complexes of the MYST transcriptional coactivator family. NI-42 has an IC50 value of of 7.9 nM and is suitable for cellular and in vivo studies.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 5 mg/mL, clear (warmed) originator Pfizer storage temp. room temp SMILES string CC1=CC2=CC(NS(=O)(C3=CC=C(C#N)C=C3)=O)=CC=C2N(C)C1=O
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
OSU6162 hydrochloride
Empirical Formula (Hill Notation): C15H23NO2S·HCl CAS Number: 156907-84-5 Molecular Weight: 317.87 MDL number: MFCD09753276 PubChem Substance ID: 329823751 NACRES: NA.77
Кат. номер PZ0177-5MG PZ0177-25MG
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
OSU6162 (PNU-96391) is a dopamine stabilizer, a drug that can stimulate or inhibit dopaminergic signaling depending on the dopaminergic tone. Dopaminergic stabilizers have been proposed to act as partial dopamine receptor agonists or as antagonists with both dopamine and behavioral stabilizing activity. Although affinity is not high (in vitro binding affinity for dopamine D2 receptor has a Ki of 447 nM), OSU6162 shows a high level of receptor occupancy.
Features and Benefits
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here, to learn more.
This compound is featured on the Dopamine Receptors, page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here,.Other NotesThis compound was developed by Pfizer for Neuroscience research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder optical activity []/D -5 to -7°, c = 1 in methanol Торговая марка Pfizer® color white to tan solubility H2O: 16 mg/mL originator Pfizer storage temp. 20°C SMILES string Cl.CCCN1CCC[C@H](C1)c2cccc(c2)S(C)(=O)=O InChI 1S/C15H23NO2S.ClH/c1-3-9-16-10-5-7-14(12-16)13-6-4-8-15(11-13)19(2,17)18;/h4,6,8,11,14H,3,5,7,9-10,12H2,1-2H3;1H/t14-;/m1./s1 InChI key LEMGVHZVBREXAD-PFEQFJNWSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H302 - H319 pcodes P301 + P312 + P330 - P305 + P351 + P338 RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Oxamniquine
Empirical Formula (Hill Notation): C14H21N3O3 CAS Number: 21738-42-1 Molecular Weight: 279.33 MDL number: MFCD00866725
Biochem/physiol ActionsКат. номер PZ0393-5MG PZ0393-25MG
Oxamniquine is an anthelmintic agent with schistosomicidal activity against Schistosoma mansoni.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.Параметрыassay 98% (HPLC) form powder Торговая марка Pfizer® color faint yellow to dark brown solubility DMSO: 2 mg/mL, clear originator Pfizer storage temp. room temp InChI 1S/C14H21N3O3/c1-9(2)15-7-12-4-3-10-5-11(8-18)14(17(19)20)6-13(10)16-12/h5-6,9,12,15-16,18H,3-4,7-8H2,1-2H3 InChI key XCGYUJZMCCFSRP-UHFFFAOYSA-N
Safety Informationpictograms GHS06 signalword Danger hcodes H300 pcodes P301 + P310 + P330 WGK Germany WGK 1 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Oxaprozin O9637-5MG
Empirical Formula (Hill Notation): C18H15NO3 CAS Number: 21256-18-8 Molecular Weight: 293.32 EC Number: 244-296-1 MDL number: MFCD00215977 PubChem Substance ID: 24278617 NACRES: NA.77 General descriptionOxaprozin is a non-steroidal anti-inflammatory drug prescribed for rheumatoid arthritis (RA) and osteoarthritis (OA). Oxaprozin binds to albumin. It inhibits arachidonic acid pathway. Oxaprozin has anti-inflammatory property and is an effective inhibitor of cyclooxygenase enzymes, COX-1 and COX-2.
Packaging
5 mg in glass bottleApplicationAnti-inflammatory
Features and Benefits
This compound was developed by Pfizer,. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here, to learn more.Other NotesTandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. O9637.pdf , Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.,Legal InformationLOPAC is a registered trademark of Sigma-Aldrich Co. LLCПараметрыQuality Level 200, form solid originator Pfizer SMILES string OC(=O)CCc1nc(-c2ccccc2)c(o1)-c3ccccc3 InChI 1S/C18H15NO3/c20-16(21)12-11-15-19-17(13-7-3-1-4-8-13)18(22-15)14-9-5-2-6-10-14/h1-10H,11-12H2,(H,20,21) InChI key OFPXSFXSNFPTHF-UHFFFAOYSA-N Gene Information human ... PTGIR(5739), PTGS1(5742), PTGS2(5743)
Safety InformationPersonal Protective Equipment Eyeshields,, Gloves,, type N95 (US), RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Palbociclib
Empirical Formula (Hill Notation): C24H29N7O2 CAS Number: 571190-30-2 Molecular Weight: 447.53 NACRES: NA.77
Кат. номер PZ0383-5MG PZ0383-25MG Biochem/physiol ActionsPF-00080665 (Palbociclib; PD 0332991) is an orally active and highly specific inhibitor against cyclin-dependent kinase 4 & 6 (IC50 = 9, 11, 15 nM, respectively, using CDK4/cycD3, CDK4/cycD1, CDK6/cycD2; IC50 >10 µM against 36 other kinases) that potently suppresses Cdk4/6-dependent cellular Rb phosphorylation (IC50 = 66 nM/pSer780 & 63 nM/pSer795; MDA-MB-435). PF-00080665 exhibits selective antiproliferation activity against Rb-positive human breast/colon/lung/leukemia cancer cultures (IC50 = 40-400 nM; IC50 >3 µM/Rb-negative MDA-MB-468 & H2009) and displays in vivo efficacy against various advanced stage human tumor xenografts in mice (12.5-150 mg/kg/day p.o.).Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.Параметрыassay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility 0.1 M HCl: 2 mg/mL, clear originator Pfizer storage temp. room temp SMILES string CC(C1=C(N2C3CCCC3)N=C(NC4=CC=C(N5CCNCC5)C=N4)N=C1)=C(C(C)=O)C2=O
Safety Informationpictograms GHS08,GHS09 signalword Warning hcodes H341 - H361f - H373 - H411 pcodes P201 - P202 - P260 - P273 - P280 - P308 + P313 RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PD 0325901
Empirical Formula (Hill Notation): C16H14F3IN2O4 CAS Number: 391210-10-9 Molecular Weight: 482.19 MDL number: MFCD08435926 PubChem Substance ID: 329823743
Кат. номер PZ0162-5MG PZ0162-25MG ApplicationPD 0325901 has been used as an inhibitor in extracellular signal-regulated kinase (ERK) inhibition assay in primed induced pluripotent stem cells, RKO colorectal cancer cell line and human embryonic stem cells(hESCs).Packaging5, 25 mg in glass bottleBiochem/physiol ActionsPD 0325901 is a potent MKK1 (MEK1) and MKK2 (MEK2) inhibitor. The Ki is 1.1 and 0.79 nM for MEK1 and MEK2, respectively. PD 0325901 was inactive against a panel of 27 other kinases. PD 0325901 inhibited C26 tumor pERK by 75% when dosed at 25 mg/kg in mice.
PD 0325901 by inhibiting mitogen-activated protein kinases (MAPKs) elicits growth-inhibitory and antiangiogenic effects on glioblastoma and melanoma tumor progression.Features and BenefitsThis compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here to learn more.
This compound is featured on the MAPKKKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.Other NotesThis compound was developed by Pfizer for Kinase Phosphatase Biology research. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.Legal InformationSold for research purposes under agreement from Pfizer Inc.
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100 assay 98% (HPLC) form powder optical activity []/D -1.8 to -3.5°, c = 1 mg/mL in methanol Торговая марка Pfizer® color white to off-white solubility DMSO: 20 mg/mL, clear originator Pfizer storage temp. 2-8°C SMILES string OC[C@@H](O)CONC(=O)c1ccc(F)c(F)c1Nc2ccc(I)cc2F InChI 1S/C16H14F3IN2O4/c17-11-3-2-10(16(25)22-26-7-9(24)6-23)15(14(11)19)21-13-4-1-8(20)5-12(13)18/h1-5,9,21,23-24H,6-7H2,(H,22,25)/t9-/m1/s1 InChI key SUDAHWBOROXANE-SECBINFHSA-N Gene Information human ... MAP2K1(5604), MAP2K2(5605)
Safety Informationpictograms GHS06,GHS08 signalword Danger hcodes H301 - H373 - H413 pcodes P260 - P264 - P270 - P273 - P301 + P310 - P314 RIDADR UN 2811 6.1 / PGIII WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PD 0332991 isethionate
Empirical Formula (Hill Notation): C24H29N7O2 · C2H6O4S CAS Number: 827022-33-3 Molecular Weight: 573.66 MDL number: MFCD22666589 PubChem Substance ID: 329823771 NACRES: NA.77
Кат. номер PZ0199-5MG PZ0199-25MG ApplicationPD 0332991 isethionate has been used:- to incubate MCF10A cells to verify cyclin D1 inhibition of autophagy involved cyclin-dependent kinase activity
- as a cyclin dependent kinase 4 (CDK4) inhibitor to study its anticonvulsive property in Drosophila
- to mimic the inhibitory effect of 5-dihydrotestosterone (DHT) on HPr-1AR cell cycle progression and growth
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PD 0332991 is a potent selective inhibitor of cyclin dependent kinases CDK4 and CDK6 with in vitro IC50 = 11 nM (CDK4) and 16 nM (CDK6). PD 0332991 induces G1 arrest in retinoblastoma (Rb)-positive tumor cells.
PD 0332991 might act as a chemsensitizer. It is useful in the treatment of breast cancer along with antioestrogens. PD 0332991 is also known to possess antitumor action.
Features and Benefits
This compound is featured on the CDKs, page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here,.Other NotesPD0332991 has been expertly reviewed and recommended by the Chemical Probes Portal. This compound was developed by Pfizer for Kinase Phosphatase Biology research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility H2O: 5 mg/mL, clear originator Pfizer storage temp. room temp SMILES string OCCS(O)(=O)=O.CC(=O)C1=C(C)c2cnc(Nc3ccc(cn3)N4CCNCC4)nc2N(C5CCCC5)C1=O InChI 1S/C24H29N7O2.C2H6O4S/c1-15-19-14-27-24(28-20-8-7-18(13-26-20)30-11-9-25-10-12-30)29-22(19)31(17-5-3-4-6-17)23(33)21(15)16(2)32;3-1-2-7(4,5)6/h7-8,13-14,17,25H,3-6,9-12H2,1-2H3,(H,26,27,28,29);3H,1-2H2,(H,4,5,6) InChI key LYYVFHRFIJKPOV-UHFFFAOYSA-N Gene Information human ... CCND1(595), CDK4(1019), CDK6(1021)
Safety Informationpictograms GHS06 signalword Danger hcodes H301 pcodes P301 + P310 RIDADR UN 2811 6.1 / PGIII WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PD 146176
Empirical Formula (Hill Notation): C15H11NS CAS Number: 4079-26-9 Molecular Weight: 237.32 MDL number: MFCD05664738 PubChem Substance ID: 24724579
Кат. номер P4620-5MG P4620-25MG ApplicationPD 146176 has been used to study its influence on ex vivo leukotriene B4 (LTB4) and lipoxin A4 (LXA4) secretion in adipose tissue.
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PD 146176 blocks neuroprotectin D1 (NPD1) and eicosanoid synthesis by inhibiting the 5-lipoxygenase-1 (15-LOX-1) enzyme.
15-Lipoxygenase inhibitor
Features and Benefits
This compound was developed by Pfizer,. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.ПараметрыQuality Level 100, assay 98% (HPLC) form solid color white to beige solubility DMSO: soluble >10 mg/mL, H2O: insoluble originator Pfizer SMILES string C1Sc2ccccc2-c3[nH]c4ccccc4c13 InChI 1S/C15H11NS/c1-3-7-13-10(5-1)12-9-17-14-8-4-2-6-11(14)15(12)16-13/h1-8,16H,9H2 InChI key ZGOOPZVQMLHPFM-UHFFFAOYSA-N Gene Information human ... ALOX15(246)
mouse ... ALOX15(11687)
rat ... ALOX15(81639)
Safety InformationPersonal Protective Equipment Eyeshields,, Gloves,, type N95 (US), RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PD 149163 tetrahydrochloride hydrate
Empirical Formula (Hill Notation): C42H71N9O6·4HCl · xH2O Molecular Weight: 943.91 (anhydrous basis) MDL number: MFCD20527308 PubChem Substance ID: 329823749 NACRES: NA.77
Кат. номер PZ0175-5MG PZ0175-25MG
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PD 149163 is a Neurotensin NTR1 receptor agonist; a Neurotensin (8-13) analog. PD149163 is a selective, brain penetrating NT1 receptor agonist with pro-cognitive, antipsychotic and anxiolytic effects.
Features and Benefits
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here, to learn more.
This compound is featured on the Neurotensin Receptors, page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here,.Other NotesThis compound was developed by Pfizer for Neuroscience research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 90% (HPLC) form powder Торговая марка Pfizer® color white to tan solubility H2O: 12 mg/mL originator Pfizer storage temp. 2-8°C SMILES string O.Cl.Cl.Cl.Cl.CCOC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CCCCN)NC[C@@H](N)CCCCN)C(C)(C)C InChI 1S/C42H71N9O6.4ClH.H2O/c1-7-57-41(56)34(23-27(2)3)49-39(54)36(42(4,5)6)50-37(52)33(24-28-25-46-31-17-9-8-16-30(28)31)48-38(53)35-19-14-22-51(35)40(55)32(18-11-13-21-44)47-26-29(45)15-10-12-20-43;;;;;/h8-9,16-17,25,27,29,32-36,46-47H,7,10-15,18-24,26,43-45H2,1-6H3,(H,48,53)(H,49,54)(H,50,52);4*1H;1H2/t29-,32-,33-,34-,35-,36+;;;;;/m0...../s1 InChI key PIFVEGOSSWCHFK-AEPODNBTSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H302 - H315 - H319 - H335 pcodes P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338 Target Organs Respiratory system RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PD-156707
Empirical Formula (Hill Notation): C28H25O9·Na CAS Number: 162412-70-6 Molecular Weight: 528.48 PubChem Substance ID: 329823726 NACRES: NA.77
Кат. номер PZ0141-5MG PZ0141-25MG
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PD-156707 is a selective endothelin receptor (ETA) antagonist.
Features and Benefits
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here, to learn more.
This compound is featured on the Endothelin Receptors, page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here,.
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here, to learn more.Other NotesThis compound was developed by Pfizer for Neuroscience research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to off-white solubility DMSO: 20 mg/mL originator Pfizer storage temp. room temp SMILES string COc1ccc(cc1)C(=O)\C(Cc2cc(OC)c(OC)c(OC)c2)=C(/C(=O)O[Na])c3ccc4OCOc4c3 InChI 1S/C28H26O9.Na/c1-32-19-8-5-17(6-9-19)26(29)20(11-16-12-23(33-2)27(35-4)24(13-16)34-3)25(28(30)31)18-7-10-21-22(14-18)37-15-36-21;/h5-10,12-14H,11,15H2,1-4H3,(H,30,31);/q;+1/p-1/b25-20-; InChI key ZLHQEGFYBMZQGM-RKVLWQGQSA-M
Safety Informationpictograms GHS09 signalword Warning hcodes H410 pcodes P273 - P501 RIDADR UN 3077 9 / PGIII WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PD-161570
Empirical Formula (Hill Notation): C26H35Cl2N7O CAS Number: 192705-80-9 Molecular Weight: 532.51 MDL number: MFCD16618403 PubChem Substance ID: 329823701 NACRES: NA.77
Кат. номер PZ0109-5MG PZ0109-25MG
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PD-161570 is an inhibitor of human FGF-1 receptor tyrosine kinase.
Features and Benefits
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here, to learn more.
This compound is featured on the FGFR, page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here,.
This compound is a featured product for Kinase Phosphatase Biology research. Click here, to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm,.Other NotesThis compound was developed by Pfizer for Kinase Phosphatase Biology research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to off-white solubility DMSO: >10 mg/mL originator Pfizer storage temp. 2-8°C SMILES string CCN(CC)CCCCNc1ncc2cc(c(NC(=O)NC(C)(C)C)nc2n1)-c3c(Cl)cccc3Cl InChI 1S/C26H35Cl2N7O/c1-6-35(7-2)14-9-8-13-29-24-30-16-17-15-18(21-19(27)11-10-12-20(21)28)23(31-22(17)32-24)33-25(36)34-26(3,4)5/h10-12,15-16H,6-9,13-14H2,1-5H3,(H3,29,30,31,32,33,34,36) InChI key MKVMEJKNLUWFSQ-UHFFFAOYSA-N
Safety Informationpictograms GHS06 signalword Danger hcodes H301 - H315 - H319 - H335 pcodes P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338 Target Organs Respiratory system RIDADR UN 2811 6.1 / PGIII WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PD-161989 2-Hydroxyethanesulfonate
Empirical Formula (Hill Notation): C14H16N4O4 · C2H6O4S CAS Number: 186268-07-5 Molecular Weight: 430.43 MDL number: MFCD18452848 PubChem Substance ID: 329823729 NACRES: NA.77
Кат. номер PZ0144-25MG PZ0144-5MG
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PD-161989 is an AMPA receptor antagonist.
Features and Benefits
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here, to learn more.
This compound is featured on the Glutamate Receptors (Ion Channel Family), page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here,.Other NotesThis compound was developed by Pfizer for Neuroscience research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to off-white solubility H2O: 10 mg/mL originator Pfizer storage temp. 2-8°C SMILES string OCCS(O)(=O)=O.Cc1c(CN2CCCC2)c3NC(=O)C(=O)Nc3cc1[N+]([O-])=O InChI 1S/C14H16N4O4.C2H6O4S/c1-8-9(7-17-4-2-3-5-17)12-10(6-11(8)18(21)22)15-13(19)14(20)16-12;3-1-2-7(4,5)6/h6H,2-5,7H2,1H3,(H,15,19)(H,16,20);3H,1-2H2,(H,4,5,6) InChI key KFHUCRVOUVNJSQ-UHFFFAOYSA-N
Safety Informationpictograms GHS06 signalword Danger hcodes H301 pcodes P301 + P310 RIDADR UN 2811 6.1 / PGIII WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PD-166285 hydrate
Empirical Formula (Hill Notation): C26H27Cl2N5O2·2HCl Molecular Weight: 585.35 MDL number: MFCD17215957 PubChem Substance ID: 329823708 NACRES: NA.77
Кат. номер PZ0116-5MG PZ0116-25MG ApplicationPD-166285 Hydrate has been used as a fibroblast growth factor (FGF) signaling inhibitor to study its effects on LIM-homeodomain gene 9 (Lhx9) expression during limb development in mice.
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PD-166285 is also a potent inhibitor of Wee-1, epidermal growth factor receptor, and platelet-derived growth factor receptor β subunit (PDGFR-β). It also exhibits its inhibitory effects against mitogen-activated protein kinase (MAPK) and protein kinase C (PKC). PD-166285 shows antiproliferative and anti-migratory effects due to which it may be used as a therapeutic agent against atherosclerosis, restenosis, and cancer.
PD-166285 hydrate is a broad spectrum protein tyrosine kinase inhibitor; Src and FGFR kinase inhibitor.
Features and Benefits
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here, to learn more.
This compound is featured on the FGFR, page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here,.
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here, to learn more.Other NotesThis compound was developed by Pfizer for Kinase Phosphatase Biology research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color yellow solubility DMSO: 20 mg/mL, H2O: 5 mg/mL originator Pfizer storage temp. room temp SMILES string O.Cl.Cl.CCN(CC)CCOc1ccc(Nc2ncc3C=C(C(=O)N(C)c3n2)c4c(Cl)cccc4Cl)cc1 InChI 1S/C26H27Cl2N5O2.2ClH.H2O/c1-4-33(5-2)13-14-35-19-11-9-18(10-12-19)30-26-29-16-17-15-20(25(34)32(3)24(17)31-26)23-21(27)7-6-8-22(23)28;;;/h6-12,15-16H,4-5,13-14H2,1-3H3,(H,29,30,31);2*1H;1H2 InChI key FHIIMEXCWLFXBU-UHFFFAOYSA-N
Safety Informationpictograms GHS06 signalword Danger hcodes H301 - H413 pcodes P273 - P301 + P310 + P330 RIDADR UN 2811 6.1 / PGIII WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PD-166866
Empirical Formula (Hill Notation): C20H24N6O3 CAS Number: 192705-79-6 Molecular Weight: 396.44 MDL number: MFCD12922514 PubChem Substance ID: 329823706 NACRES: NA.77
Кат. номер PZ0114-5MG PZ0114-25MG
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PD-166866 is a selective inhibitor of the FGF-1 receptor tyrosine kinase (FGFR1) with IC50 = 55 nM, and no effect on c-Src, PDGFR-b, EGFR or insulin receptor tyrosine kinases or MEK, PKC, and CDK4.
Features and Benefits
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here, to learn more.
This compound is featured on the FGFR, page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here,.
This compound is a featured product for Kinase Phosphatase Biology research. Click here, to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm,.
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here, to learn more.Other NotesThis compound was developed by Pfizer for Kinase Phosphatase Biology research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) Торговая марка Pfizer® color off-white to light tan solubility DMSO: 10 mg/mL originator Pfizer storage temp. 2-8°C SMILES string COc1cc(OC)cc(c1)-c2cc3cnc(N)nc3nc2NC(=O)NC(C)(C)C InChI 1S/C20H24N6O3/c1-20(2,3)26-19(27)25-17-15(8-12-10-22-18(21)24-16(12)23-17)11-6-13(28-4)9-14(7-11)29-5/h6-10H,1-5H3,(H4,21,22,23,24,25,26,27) InChI key NHJSWORVNIOXIT-UHFFFAOYSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 1 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PD-180970
Empirical Formula (Hill Notation): C21H15Cl2FN4O CAS Number: 287204-45-9 Molecular Weight: 429.27 MDL number: MFCD10565929 PubChem Substance ID: 329823727 NACRES: NA.77
Кат. номер PZ0142-5MG PZ0142-25MG
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PD-180970 is a potent inhibitor of the p210 Bcr-Abl tyrosine kinase.
Features and Benefits
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here, to learn more.
This compound is a featured product for Kinase Phosphatase Biology research. Click here, to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm,.
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here, to learn more.Other NotesThis compound was developed by Pfizer for Kinase Phosphatase Biology research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationLOPAC is a registered trademark of Sigma-Aldrich Co. LLC
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) Торговая марка Pfizer® color yellow solubility DMSO: >20 mg/mL originator Pfizer storage temp. 2-8°C SMILES string CN1C(=O)C(=Cc2cnc(Nc3ccc(F)c(C)c3)nc12)c4c(Cl)cccc4Cl InChI 1S/C21H15Cl2FN4O/c1-11-8-13(6-7-17(11)24)26-21-25-10-12-9-14(20(29)28(2)19(12)27-21)18-15(22)4-3-5-16(18)23/h3-10H,1-2H3,(H,25,26,27) InChI key SLCFEJAMCRLYRG-UHFFFAOYSA-N
Safety Informationpictograms GHS06 signalword Danger hcodes H301 - H413 pcodes P273 - P301 + P310 + P330 RIDADR UN 2811 6.1 / PGIII WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PD-184161
Empirical Formula (Hill Notation): C17H13BrClF2IN2O2 CAS Number: 212631-67-9 Molecular Weight: 557.56 MDL number: MFCD16038897 PubChem Substance ID: 329823704
Кат. номер PZ0112-5MG PZ0112-25MG
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PD-184161 is a MEK inhibitor.
Features and Benefits
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here, to learn more.
This compound is featured on the MAPKKKs, page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here,.
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here, to learn more.Other NotesThis compound was developed by Pfizer for Kinase Phosphatase Biology research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to off-white solubility DMSO: >10 mg/mL originator Pfizer storage temp. 2-8°C SMILES string Fc1c(F)c(Nc2ccc(I)cc2Cl)c(cc1Br)C(=O)NOCC3CC3 InChI 1S/C17H13BrClF2IN2O2/c18-11-6-10(17(25)24-26-7-8-1-2-8)16(15(21)14(11)20)23-13-4-3-9(22)5-12(13)19/h3-6,8,23H,1-2,7H2,(H,24,25) InChI key VJNZMSLGVUSPCF-UHFFFAOYSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PD-407824
Empirical Formula (Hill Notation): C20H12N2O3 CAS Number: 622864-54-4 Molecular Weight: 328.32 MDL number: MFCD09753286 PubChem Substance ID: 329823703 NACRES: NA.77
Кат. номер PZ0111-5MG PZ0111-25MG ApplicationPD-407824 has been used as a wee-1 inhibitor to study its effects on Xenopus laevis embryos. It has also been used as a checkpoint-1 (Chk-1) inhibitor to study its effects on the sensitivity of head and neck squamous carcinoma cells to gemcitabine.
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PD-407824 is a Wee1/Chk1 inhibitor.
Features and Benefits
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here, to learn more.
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here, to learn more.Other NotesThis compound was developed by Pfizer for Kinase Phosphatase Biology research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color yellow to orange solubility DMSO: >10 mg/mL originator Pfizer storage temp. 2-8°C SMILES string Oc1ccc2[nH]c3cc(-c4ccccc4)c5C(=O)NC(=O)c5c3c2c1 InChI 1S/C20H12N2O3/c23-11-6-7-14-13(8-11)16-15(21-14)9-12(10-4-2-1-3-5-10)17-18(16)20(25)22-19(17)24/h1-9,21,23H,(H,22,24,25) InChI key IAUZTOZLTFSMIE-UHFFFAOYSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H315 - H319 - H335 pcodes P261 - P305 + P351 + P338 Target Organs Respiratory system RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PD-85639
Empirical Formula (Hill Notation): C24H32N2O CAS Number: 149838-21-1 Molecular Weight: 364.52 MDL number: MFCD14635427 NACRES: NA.77
Biochem/physiol ActionsКат. номер PZ0370-5MG PZ0370-25MG
PD-85639 (PD85,639) is a voltage-gated sodium (Na+) channel blocker (75% in 10 min & >95% in 25 min blockage of Na+ current by 25 μM PD85,639; whole-cell patch clamp using primary rat brain neurons) that is shown to target rat brain Nav1.2 with simultaneous high- and low-affinity modes of binding (EC50 = 56 nM/40% & 20 μM/60% at pH 9.0, 5 nM/28% & 3 μM/72% at pH 7.4, against 2 nM [3H]-PD85,639 for binding rat brain synaptosomes; EC50 = 17 nM/39% & 10 μM/61% using at pH 9.0 using rat brain synaptosome membranes) and a fast kinetic (t1/2 = 1.2 at 4°C, <0.5 min at 25°C), competitive against the local anesthetic Na+ channel blockers tetracaine, bupivacaine, and mepivacaine, as well as Na+ channel activators veratridine and batrachotoxin (K1 = 0.26 μM against 5 nM [3H]-BTX for binding rat neocrotical membranes).Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.Параметрыassay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 2 mg/mL, clear (warmed) originator Pfizer storage temp. room temp SMILES string CC1CCCC(C)N1CCCNC(C(C2=CC=CC=C2)C3=CC=CC=C3)=O InChI 1S/C23H31N3O/c1-4-13-23(22(24)27,19-9-6-5-7-10-19)20-11-8-12-21(14-20)26-17(2)15-25-16-18(26)3/h5-12,14,17-18,25H,4,13,15-16H2,1-3H3,(H2,24,27) InChI key QNZVKSNHNMBPSR-UHFFFAOYSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H302 pcodes P301 + P312 + P330 RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PD166326
Empirical Formula (Hill Notation): C21H16Cl2N4O2 CAS Number: 185039-91-2 Molecular Weight: 427.28 NACRES: NA.77
Biochem/physiol ActionsКат. номер PZ0366-25MG PZ0366-5MG
ATP-competitive dual BCR-ABL and Src kinase inhibitor
PD166326 is an ATP-competitive dual BCR-ABL and Src kinase inhibitor. In some studies it has been found to be more potent than imatinib with inhibition of cancer growth in the low nanomolar range or even picomolar range in various biological systems.Legal InformationPfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to light brown solubility DMSO: 2 mg/mL, clear originator Pfizer storage temp. room temp SMILES string O=C1N(C)C2=C(C=NC(NC3=CC=CC(CO)=C3)=N2)C=C1C4=C(Cl)C=CC=C4Cl
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PD166793 hydrate
Empirical Formula (Hill Notation): C17H18BrNO4S · xH2O Molecular Weight: 412.30 (anhydrous basis) MDL number: MFCD12912437 PubChem Substance ID: 329819997 NACRES: NA.77
Кат. номер P0047-5MG P0047-25MG
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PD166793 is a broad spectrum, but class-selective, MMP inhibitor (low nM at MMP-2 & 3 and low μM at MMP-1, 7 & 9). Adding PD166793 to the high-fat diet substantially reduced the rise in blood glucose. The improvement of glucose homeostasis in PD166793-treated ZDF rats was a result of the enhancement of β-cell function. It prevents β-cell dysfunction and diabetes in female ZDF rats on a high-fat diet. It has been shown to block left ventricular remodeling and dysfunction in a rat model of heart failure. Preservation of normoglycemia and normal glucose tolerance in compound PD166793-treated animals is accompanied by preservation of the high serum insulin levels that are a consequence of the insulin resistance present in these animals. It is not reversing insulin resistance these animals. The most striking effect of the compound is on pancreatic insulin content and β-cell volume.
Features and Benefits
This compound was developed by Pfizer,. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.ПараметрыQuality Level 100, assay ≥98% (HPLC) form solid originator Pfizer storage temp. 2-8°C SMILES string O.CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c2ccc(Br)cc2)C(O)=O InChI 1S/C17H18BrNO4S.H2O/c1-11(2)16(17(20)21)19-24(22,23)15-9-5-13(6-10-15)12-3-7-14(18)8-4-12;/h3-11,16,19H,1-2H3,(H,20,21);1H2/t16-;/m0./s1 InChI key LUKRECOTGXWIDO-NTISSMGPSA-N Gene Information
Safety InformationPersonal Protective Equipment Eyeshields,, Gloves,, type N95 (US), RIDADR NONH for all modes of transport WGK Germany WGK 2 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PD168393
Empirical Formula (Hill Notation): C17H13BrN4O CAS Number: 194423-15-9 Molecular Weight: 369.22 MDL number: MFCD02179207 PubChem Substance ID: 329823812 NACRES: NA.77
Кат. номер PZ0285-5MG PZ0285-25MG ApplicationPD168393 has been used in the acute inhibition of ErbB4.
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PD168393 is a 6-acrylamido-4-anilinoquinazoline compound. It increases apoptosis in malignant peripheral nerve sheath tumor cells, stimulated by lysosomal dysfunction.
PD168393 is potent, cell-permeable, irreversible and selective inhibitor of EGF receptor (EGFR) tyrosine kinase and ErbB2. PD168393 has an IC50 value of 0.70 nM for EGFR, and is inactive against insulin, PDGFR, FGFR and PKC.Other NotesThis compound was developed by Pfizer for Kinase Phosphatase Biology research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 25 mg/mL, clear originator Pfizer storage temp. room temp SMILES string C=CC(NC1=CC2=C(NC3=CC=CC(Br)=C3)N=CN=C2C=C1)=O InChI 1S/C17H13BrN4O/c1-2-16(23)21-13-6-7-15-14(9-13)17(20-10-19-15)22-12-5-3-4-11(18)8-12/h2-10H,1H2,(H,21,23)(H,19,20,22) InChI key HTUBKQUPEREOGA-UHFFFAOYSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PD173952
Empirical Formula (Hill Notation): C24H21Cl2N5O2 CAS Number: 305820-75-1 Molecular Weight: 482.36 MDL number: MFCD16875428 PubChem Substance ID: 329823705 NACRES: NA.77
Кат. номер PZ0113-5MG PZ0113-25MG
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PD173952 is a Src family kinase inhibitor.
Features and Benefits
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here, to learn more.
This compound is a featured product for Kinase Phosphatase Biology research. Click here, to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm,.
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here, to learn more.Other NotesThis compound was developed by Pfizer for Kinase Phosphatase Biology research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color yellow to green solubility DMSO: >10 mg/mL originator Pfizer storage temp. 2-8°C SMILES string CN1C(=O)C(=Cc2cnc(Nc3ccc(cc3)N4CCOCC4)nc12)c5c(Cl)cccc5Cl InChI 1S/C24H21Cl2N5O2/c1-30-22-15(13-18(23(30)32)21-19(25)3-2-4-20(21)26)14-27-24(29-22)28-16-5-7-17(8-6-16)31-9-11-33-12-10-31/h2-8,13-14H,9-12H2,1H3,(H,27,28,29) InChI key XZEJMVDCQZRHLN-UHFFFAOYSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany nwg Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PD184352
Empirical Formula (Hill Notation): C17H14ClF2IN2O2 CAS Number: 212631-79-3 Molecular Weight: 478.66 MDL number: MFCD02683961 PubChem Substance ID: 329823755 NACRES: NA.77
Кат. номер PZ0181-25MG PZ0181-5MG
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PD184352 (CI-1040) is a highly selective non-competitive inhibitor of MEK (MKK1; MAPK kinase) and the closely related MKK2. It has anti-cancer activity, suppresses the ERK pathway, and has been used along with other classes of inhibitors to establish embryonic stem cell lines.
Features and Benefits
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here, to learn more.
This compound is featured on the MAPKs, page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here,.Other NotesThis compound was developed by Pfizer for Kinase Phosphatase Biology research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to tan solubility DMSO: 30 mg/mL originator Pfizer storage temp. room temp SMILES string Fc1ccc(C(=O)NOCC2CC2)c(Nc3ccc(I)cc3Cl)c1F InChI 1S/C17H14ClF2IN2O2/c18-12-7-10(21)3-6-14(12)22-16-11(4-5-13(19)15(16)20)17(24)23-25-8-9-1-2-9/h3-7,9,22H,1-2,8H2,(H,23,24) InChI key GFMMXOIFOQCCGU-UHFFFAOYSA-N Gene Information human ... MAP2K1(5604), MAP2K2(5605)
Safety Informationpictograms GHS09 signalword Warning hcodes H400 pcodes P273 RIDADR UN 3077 9 / PGIII WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Pelitinib
Empirical Formula (Hill Notation): C24H23ClFN5O2 CAS Number: 257933-82-7 Molecular Weight: 467.92 NACRES: NA.77
Кат. номер PZ0197-5MG PZ0197-25MG
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
Pelitinib (EKB-569) is an orally active, potent, second generation irreversible epidermal growth factor receptor tyrosine kinase (EGFR TK) inhibitor. Pelitinib is selective for EGFR (ErbB-1) with an IC50 about 80 nM, but also covalently binds to ErbB-2 (HER2/c-neu) and ErbB-4 (Her 4) with much lower potency. Pelitinib has been shown to inhibit the growth of EGFR-overexpressing tumor cell lines.Other NotesLight sensitive
This compound was developed by Pfizer for Kinase Phosphatase Biology research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® storage condition desiccated, protect from light color white to beige solubility DMSO: 5 mg/mL, clear (warmed) originator Pfizer storage temp. 20°C InChI 1S/C24H23ClFN5O2/c1-4-33-22-12-20-17(11-21(22)30-23(32)6-5-9-31(2)3)24(15(13-27)14-28-20)29-16-7-8-19(26)18(25)10-16/h5-8,10-12,14H,4,9H2,1-3H3,(H,28,29)(H,30,32)/b6-5+ InChI key WVUNYSQLFKLYNI-AATRIKPKSA-N
Safety Informationpictograms GHS06 signalword Danger hcodes H301 pcodes P301 + P310 RIDADR UN 2811 6.1 / PGIII WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF 3845 hydrate
Empirical Formula (Hill Notation): C24H23F3N4O2 · xH2O CAS Number: 1196109-52-0 Molecular Weight: 456.46 (anhydrous basis) MDL number: MFCD21365072 PubChem Substance ID: 329823740 NACRES: NA.77
Кат. номер PZ0158-5MG PZ0158-25MG
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PF 3845 is a potent, irreversible inhibitor of fatty acid amide hydrolase (FAAH), the principle enzyme involved in the degradation of the endocannabinoid anandamide. The endocannabinoid system is a target for therapeutic pain relief. PF-3845 is a covalent inhibitor that carbamylates FAAH′s serine nucleophile. It high selectivity over other enzymes including FAAH-2. In mouse studies, PF-3845 has been shown to raise brain anandamide levels for up to 24 hr; and in a rat model it produced significant reduction of inflammatory pain..
Features and Benefits
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here, to learn more.
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here, to learn more.Other NotesThis compound was developed by Pfizer for Neuroscience research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® storage condition desiccated color white to tan solubility DMSO: 45 mg/mL originator Pfizer storage temp. 2-8°C SMILES string O.FC(F)(F)c1ccc(Oc2cccc(CC3CCN(CC3)C(=O)Nc4cccnc4)c2)nc1 InChI 1S/C24H23F3N4O2.H2O/c25-24(26,27)19-6-7-22(29-15-19)33-21-5-1-3-18(14-21)13-17-8-11-31(12-9-17)23(32)30-20-4-2-10-28-16-20;/h1-7,10,14-17H,8-9,11-13H2,(H,30,32);1H2 InChI key CVQMBUCCSAKASE-UHFFFAOYSA-N
Safety Informationpictograms GHS06 signalword Danger hcodes H301 pcodes P301 + P310 RIDADR UN 2811 6.1 / PGIII WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-01247324
Empirical Formula (Hill Notation): C13H10Cl3N3O CAS Number: 875051-72-2 Molecular Weight: 330.60 NACRES: NA.77
Кат. номер PZ0274-5MG PZ0274-25MG
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
In humans, PF-01247324 [6-amino-5-(2, 3, 5-trichloro-phenyl)-pyridine-2-carboxylic acid methylamide] prevents native tetrodotoxin-resistant (TTX-R) currents in dorsal root ganglion (DRG) neurons.
PF-01247324 is an orally bioavailable, selective and potent NaV1.8 channel blocker that inhibits that exhibits analgesic efficacy in rodent behavioral models of pain.Other NotesThis compound was developed by Pfizer for Ion Channel research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 20 mg/mL, clear originator Pfizer storage temp. room temp
Safety Informationpictograms GHS06 signalword Danger hcodes H301 - H315 - H319 - H335 pcodes P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338 Target Organs Respiratory system RIDADR UN 2811 6.1 / PGIII WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-02413873
Empirical Formula (Hill Notation): C18H21N3O3S CAS Number: 936345-35-6 Molecular Weight: 359.44 MDL number: MFCD16987601 NACRES: NA.77
Biochem/physiol ActionsКат. номер PZ0367-5MG PZ0367-25MG
PF-02413873 is a potent, selective and fully competitive non-steroidal progesterone receptor (PR) antagonist that blocks progesterone binding and PR nuclear translocation. PF-02413873 suppresses endometrial growth in the macaque and human.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 2 mg/mL, clear originator Pfizer storage temp. room temp SMILES string CC1=C(C#N)C(C)=CC(OC2=C(C)N(CS(=O)(C)=O)N=C2C3CC3)=C1
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-03049423
Empirical Formula (Hill Notation): C24H32N6O4 · xHCl CAS Number: 402955-58-2 Molecular Weight: 468.55 (free base basis) PubChem Substance ID: 329823803 NACRES: NA.77
PackagingКат. номер PZ0269-5MG PZ0269-25MG
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-03049423 is an orally active, brain penetrant phosphodiesterase 5 (PDE5) inihbitor.Other NotesThis compound was developed by Pfizer for Cyclic Nucleotides research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility H2O: 20 mg/mL, clear originator Pfizer storage temp. room temp SMILES string CCCOCCN1C2=C(C=NC(C3=CN=C(OC)C=C3)=C2)N=C(N4CCN(CCO)CC4)C1=O.C InChI 1S/C24H32N6O4.CH4/c1-3-13-34-14-11-30-21-15-19(18-4-5-22(33-2)26-16-18)25-17-20(21)27-23(24(30)32)29-8-6-28(7-9-29)10-12-31;/h4-5,15-17,31H,3,6-14H2,1-2H3;1H4 InChI key BXMDZHBYGYPATN-UHFFFAOYSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H302 pcodes P301 + P312 + P330 RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-03084014 hydrobromide
Empirical Formula (Hill Notation): C27H41F2N5O · HBr CAS Number: 1290543-63-3 Molecular Weight: 570.56 PubChem Substance ID: 329823821 NACRES: NA.77
Кат. номер PZ0298-5MG PZ0298-25MG
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-03084014 inhibits the Notch signalling pathway. It contributes totumor suppression in breast, pancreatic carcinoma, hepatocellular carcinoma and progressive desmoid tumors. PF-03084014 in combination with dexamethasone elicits antileukemic effects in T-cell acute lymphoblastic leukemias (T-ALL).
PF-03084014 is a highly potent -secretase inhibitor that reduces A production in vitro. PF-03084014 does not show a paradoxical increase in plasma A at low concentrations in both preclinical species and humans.Other NotesThis compound was developed by Pfizer for Neuroscience research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility H2O: 1 mg/mL, clear originator Pfizer storage temp. room temp SMILES string FC1=C2C(CC[C@H](N[C@@H](CCC)C(NC3=CN(C(C)(C)CNCC(C)(C)C)C=N3)=O)C2)=CC(F)=C1.C InChI 1S/C27H41F2N5O.CH4/c1-7-8-23(32-20-10-9-18-11-19(28)12-22(29)21(18)13-20)25(35)33-24-14-34(17-31-24)27(5,6)16-30-15-26(2,3)4;/h11-12,14,17,20,23,30,32H,7-10,13,15-16H2,1-6H3,(H,33,35);1H4/t20-,23-;/m0./s1 InChI key GLEYBLZDOTUZJH-WCRWPNQISA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H315 - H319 - H335 pcodes P280 - P304 + P340 + P312 - P305 + P351 + P338 - P337 + P313 Target Organs Respiratory system RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-03246799 hydrochloride
Empirical Formula (Hill Notation): C15H17N3 · xHCl CAS Number: 1065114-52-4 Molecular Weight: 239.32 (free base basis) PubChem Substance ID: 329823781 NACRES: NA.77
Кат. номер PZ0229-5MG PZ0229-25MG
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-3246799 is a potent serotonin 5-HT2C receptor agonist with an EC50 of 4.5 nM and minimal activity at 5-HT2A and 5-HT2B receptors. PF-3246799 had good efficacy in a preclinical canine model of stress urinary incontinence.
Features and Benefits
This compound is a featured product for Neuroscience research. Click here, to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm,.Other NotesThis compound was developed by Pfizer for Neuroscience research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility H2O: 20 mg/mL, clear originator Pfizer storage temp. room temp SMILES string C1(CC2=NC(CCNCC3)=C3C=N2)=CC=CC=C1.Cl InChI 1S/C15H17N3.ClH/c1-2-4-12(5-3-1)10-15-17-11-13-6-8-16-9-7-14(13)18-15;/h1-5,11,16H,6-10H2;1H InChI key ICVPRIZGSIUCOE-UHFFFAOYSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-03549184
Empirical Formula (Hill Notation): C21H14Cl2N2O4S CAS Number: 1221971-47-6 Molecular Weight: 461.32
Кат. номер PZ0326-5MG PZ0326-25MG
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-03549184 (PF-9184) is a potent inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1) with an IC50 value of 16.5 nM in recombinant human mPGES-1. mPEGS-1 is the terminal enzyme that synthesizes prostaglandin E2 (PGE2) from PGH2 to PGE2 downstream of cyclooxygenase-2 (COX-2). Its expression is induced in response to pro-inflammatory mediators, similar to COX-2. Unlike the effects of COX inhibition, PF-9184 does not inhibit the production of other PGH2-derived products such as 6-keto-PGF or PGF2. PF-9184 inhibits PGE2 production in cell based assays with IC50 ranges from 0.5 to 5 µM. IC50 concentrations for rhCOX1 and rHCOX2 are 118 µM and 236 µM, respectively.
PGE2 is involved in inflammation and is one of the most abundant prostanoid.Other NotesThis compound was developed by Pfizer for Lipid Signaling research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 5 mg/mL, clear (warmed) originator Pfizer storage temp. 2-8°C
Safety Informationpictograms GHS07 signalword Warning hcodes H315 - H319 - H335 pcodes P305 + P351 + P338 Target Organs Respiratory system RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-03716556
Empirical Formula (Hill Notation): C22H26N4O3 CAS Number: 928774-43-0 Molecular Weight: 394.47 MDL number: MFCD19690947 PubChem Substance ID: 329823738 NACRES: NA.77
Кат. номер PZ0155-25MG PZ0155-5MG
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
potent, selective and reversible acid pump antagonist (H, K-ATPase)
Features and Benefits
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here, to learn more.
This compound is featured on the Potassium Channels, page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here,.Other NotesThis compound was developed by Pfizer for Ion Channel research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to tan solubility DMSO: 10 mg/mL originator Pfizer storage temp. 2-8°C SMILES string CN(CCO)C(=O)c1cc(N[C@@H]2CCOc3cccc(C)c23)c4nc(C)cn4c1 InChI 1S/C22H26N4O3/c1-14-5-4-6-19-20(14)17(7-10-29-19)24-18-11-16(22(28)25(3)8-9-27)13-26-12-15(2)23-21(18)26/h4-6,11-13,17,24,27H,7-10H2,1-3H3/t17-/m1/s1 InChI key YBHKBMJREUZHOV-QGZVFWFLSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-03814735
Empirical Formula (Hill Notation): C23H25F3N6O2 CAS Number: 942487-16-3 Molecular Weight: 474.48 NACRES: NA.77
Biochem/physiol ActionsКат. номер PZ0218-5MG PZ0218-25MG
PF-03814735 is a potent inhibitor of Aurora kinase A and B (IC50 = 5 and 0.8 nM, respectively). PF-03814735 inhibits proliferation of tumor cells in culture and in xenograft tumor models. The compound PF-03814735 blocks phosphorylation of Aurora B and Histone H3, and leads to the formation of polyploid cells in culture (HCT116 and MDA-MB-231).Other NotesThis compound was developed by Pfizer for Kinase Phosphatase Biology research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 20 mg/mL, clear originator Pfizer storage temp. 20°C
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-03882845
Empirical Formula (Hill Notation): C24H22ClN3O2 CAS Number: 1023650-66-9 Molecular Weight: 419.90 MDL number: MFCD28124394 PubChem Substance ID: 329823690 NACRES: NA.77
Кат. номер PZ0031-5MG PZ0031-25MG
Biochem/physiol Actions
PF-03882845 is a potent non-steroidal mineralocorticoid antagonist with and IC50 of 0.755 nM, compared to eplerenone with an IC50 of 109 nM. PF-03882845 was tested in a rat model for renal protection against aldosterone-mediated renal disease, and found to be more potent than eplerenone in suppressing the urinary albumin to creatinine ratio (UACR), a measure of renal fibrosis. The therapeutic index, calculated as the ratio of the EC50 for increasing serum K+ to the EC50 for UACR lowering, was 83.8 for PF-03882845 and 1.47 for eplerenone.Other NotesThis compound was developed by Pfizer for Cytokines & Growth Factors research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 10 mg/mL, clear originator Pfizer storage temp. room temp SMILES string OC(C1=CC2=C(C=C1)C3=NN(C4=CC=C(C#N)C(Cl)=C4)[C@@H](C5CCCC5)[C@@]3([H])CC2)=O InChI 1S/C24H22ClN3O2/c25-21-12-18(8-5-17(21)13-26)28-23(14-3-1-2-4-14)20-10-6-15-11-16(24(29)30)7-9-19(15)22(20)27-28/h5,7-9,11-12,14,20,23H,1-4,6,10H2,(H,29,30)/t20-,23-/m0/s1 InChI key XNULRSOGWPFPBL-REWPJTCUSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H315 - H319 - H335 pcodes P302 + P352 - P305 + P351 + P338 Target Organs Respiratory system RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-04217329
Empirical Formula (Hill Notation): C27H28N4O5S CAS Number: 1005549-94-9 Molecular Weight: 520.60 NACRES: NA.77
Biochem/physiol ActionsКат. номер PZ0369-5MG PZ0369-25MG
PF-04217329 is a selective and potent prostaglandin EP2 receptor agonist. PF-04217329 is an ocular bioavailable isopropyl ester prodrug of CP-544326 (active acid metabolite).Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 2 mg/mL, clear originator Pfizer storage temp. room temp SMILES string O=S(N(CC1=CC=C(N2N=CC=C2)C=C1)CC3=CC=CC(OCC(OC(C)C)=O)=C3)(C4=CC=CN=C4)=O
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-04279405
Empirical Formula (Hill Notation): C25H25FN4O4 CAS Number: 955881-01-3 Molecular Weight: 464.49 NACRES: NA.77
Biochem/physiol ActionsКат. номер PZ0224-5MG PZ0224-25MG
PF-04279405 is a potent and selective glucokinase activator.Other NotesThis compound was developed by Pfizer for Cytokines & Growth Factors research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 10 mg/mL, clear originator Pfizer storage temp. room temp
Safety Informationpictograms GHS07 signalword Warning hcodes H315 - H319 - H335 pcodes P261 - P305 + P351 + P338 Target Organs Respiratory system RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-04363467 hydrochloride
Empirical Formula (Hill Notation): C22H30N2O3S · HCl CAS Number: 2040055-81-8 Molecular Weight: 439.01 NACRES: NA.77
PackagingКат. номер PZ0354-5MG PZ0354-25MG
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-4363467 hydrochloride is a Dopamine D3/D2 receptor antagonist. PF-4363467 has 100-fold selectivity for D3 with a Ki value of 3.1 nM for D3R compared to a Ki value of 692 nM for D2R and high selectivity for D3R compared to other biogenic amine receptors. PF-4363467 attenuated opioid drug-seeking behavior in a rat model of addiction without causing the extrapyramidal symptoms often associated with D2R antagonism.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility H2O: 3 mg/mL, clear (warmed) originator Pfizer storage temp. room temp SMILES string [H]Cl.CC1=CC([C@H]2CN(CC)CCO2)=CC=C1NS(C3=CC=C(C(C)C)C=C3)(=O)=O
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-04418948
Empirical Formula (Hill Notation): C23H20FNO5 CAS Number: 1078166-57-0 Molecular Weight: 409.41 NACRES: NA.77
Кат. номер PZ0213-5MG PZ0213-25MG ApplicationPF-04418948 has been used in TG (trigeminal ganglion) explant culture.
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-04418948 is a PGE2 Receptor (EP2) specific antagonist (IC50 = 16 nM) with greater than 2000-fold selectivity over other EP subtypes. PF-04418948 inhibits EP2 activity in smooth muscle preps from human, dog and mouse.
PF-04418948 represses the formation of colorectal tumor.
Features and Benefits
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here, to learn more.Other NotesThis compound was developed by Pfizer for Lipid Signaling research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 20 mg/mL, clear originator Pfizer storage temp. room temp
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-04445597
Empirical Formula (Hill Notation): C29H31F9N6O2 CAS Number: 949099-81-4 Molecular Weight: 666.58
PackagingКат. номер PZ0222-5MG PZ0222-25MG
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-04445597 is a potent, orally bioavailable inhibitor of cholesteryl ester transfer protein (CETP).Other NotesThis compound was developed by Pfizer for Lipid Signaling research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 20 mg/mL, clear originator Pfizer storage temp. 2-8°C
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-04447943
Empirical Formula (Hill Notation): C20H25N7O2 CAS Number: 1082744-20-4 Molecular Weight: 395.46 MDL number: MFCD22665724 NACRES: NA.77
Biochem/physiol ActionsКат. номер PZ0380-5MG PZ0380-25MG
PF-04447943 is a potent selective brain penetrant phosphodiesterase PDE9A inhibitor both potency (8 nM) and selectivity (>10 μM versus all the PDEs except PDE1C at >1 μM). It has been investigated for the treatment of cognitive disorders including Alzheimer′s Disease. PF-04447943 increased neurite outgrowth and synapse formation in hippocampal neurons in culture, exhibited synaptic stabilization in an amyloid precursor protein (APP) transgenic mouse model, and improved memory and enhanced attention in several animal models.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.Параметрыassay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 2 mg/mL, clear originator Pfizer storage temp. room temp SMILES string O=C1C2=C(N(C3CCOCC3)N=C2)N=C([C@H]4[C@H](C)CN(CC5=NC=CC=N5)C4)N1
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-04449613
Empirical Formula (Hill Notation): C21H25N5O3 CAS Number: 1236858-52-8 Molecular Weight: 395.45
PackagingКат. номер PZ0349-5MG PZ0349-25MG
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-04449613 is a potent and selective cGMP-competitive PDE9A inhibitor (IC50 = 24 nM; IC50 >800 nM against other PDE members), displaying more than 1000-fold selectivity over the majority of 79 non-PDE targets investigated with the exception of cytochrome P450 2C19 (IC50 = 1600 nM), dopamine transporter (Ki = 110 nM), µ-opioid receptor (Ki = 3500 nM), and sodium channel binding site 2 (Ki = 470 nM). PF-4449613 is shown to effectively increase cGMP levels in brain (1-10 mg/kg s.c.; mice) and CSF (1-32 mg/kg s.c.; rats and cynomolgus macaques) in vivo with good brain penetration (brain/plasma ratio of 0.8 in mice). PF-04449613 is effective against D-amphetamine-induced auditory gating deficit (by 43% with 1 mg/kg PF-04449613 s.c.; 1 mg/kg AMP i.v.) and transverse aortic constriction-caused cardiac dysfunction (30 mg/kg/12 h p.o.) in mice in a NOS-independent manner.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 10 mg/mL, clear originator Pfizer shipped in wet ice storage temp. 20°C
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-04449913 maleate salt
Empirical Formula (Hill Notation): C21H22N6O · C4H4O4 CAS Number: 1095173-27-5 Molecular Weight: 490.51 MDL number: MFCD29037212 PubChem Substance ID: 329823825 NACRES: NA.77
Кат. номер PZ0303-5MG PZ0303-25MG
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-04449913 maleate salt is also known as 1-((2R,4R)-2-(1H-benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea. It increases the differentiation of blood cells from hematopoietic precursors of the lymph gland medullary zone. This human Smo inhibitor protein is now under clinical trials to treat myeloid malignancies.
PF-04449913 (Glasdegib) is an orally bioavailable Hedgehog pathway inhibitor. PF-04449913 acts by binidng Smoothened (Smo) and blocking signal transduction. PF-04449913 has an IC50 of 5 nM in the Gli-Luciferase assay. In a Phase I clinical trial in patients with advanced solid tumors, PF-04449913 caused disease stabilization in 34% of patients.Other NotesThis compound was developed by Pfizer for Cytokines & Growth Factors research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 20 mg/mL, clear originator Pfizer storage temp. room temp SMILES string OC(/C=C\C(O)=O)=O.CN1CC[C@@H](NC(NC2=CC=C(C#N)C=C2)=O)C[C@@H]1C3=NC4=CC=CC=C4N3 InChI 1S/C21H22N6O.C4H4O4/c1-27-11-10-16(24-21(28)23-15-8-6-14(13-22)7-9-15)12-19(27)20-25-17-4-2-3-5-18(17)26-20;5-3(6)1-2-4(7)8/h2-9,16,19H,10-12H2,1H3,(H,25,26)(H2,23,24,28);1-2H,(H,5,6)(H,7,8)/b;2-1-/t16-,19-;/m1./s1 InChI key VJCVKWFBWAVYOC-UIXXXISESA-N Gene Information human ... SMO(6608)
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-04455242 hydrochloride
Empirical Formula (Hill Notation): C21H28N2O2S · HCl CAS Number: 1322001-35-3 Molecular Weight: 408.99 MDL number: MFCD22666388 PubChem Substance ID: 329823774 NACRES: NA.77
Кат. номер PZ0206-25MG PZ0206-5MG
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-4455242 is a selective k opioid receptor (KOR) antagonist with 20-fold selectivity for kappa over mu receptors (k Ki = 3 nM, μ Ki =64 nM). PF-4455242 is orally active, has good brain penetration in rats and was able to block the effects of the kappa agonist U50488. Studies indicate that k blockade has afforded antidepressant activity in several animal models. PF-4455242 has been in phase I clinical trials for trial for bipolar depression.
Features and Benefits
This compound is featured on the Opioid Receptors, page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here,.Other NotesThis compound was developed by Pfizer for Neuroscience research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 5 mg/mL (clear solution, warmed) originator Pfizer storage temp. room temp SMILES string Cl.CC(C)CNCc1ccc(cc1)-c2ccccc2S(=O)(=O)N3CCCC3 InChI 1S/C21H28N2O2S.ClH/c1-17(2)15-22-16-18-9-11-19(12-10-18)20-7-3-4-8-21(20)26(24,25)23-13-5-6-14-23;/h3-4,7-12,17,22H,5-6,13-16H2,1-2H3;1H InChI key WRNZYMZEVIVCFL-UHFFFAOYSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-04457845
Empirical Formula (Hill Notation): C23H20F3N5O2 CAS Number: 1020315-31-4 Molecular Weight: 455.43 MDL number: MFCD18782721 PubChem Substance ID: 329823758 NACRES: NA.77
Кат. номер PZ0184-5MG PZ0184-25MG
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-04457845 is a potent, orally active, irreversible inhibitor of fatty acid amide hydrolase (FAAH), the principle enzyme involved in the degradation of the endocannabinoid anandamide. PF-04457845 is a covalent inhibitor that carbamylates FAAH′s serine nucleophile. It was shown to be both potent and selective against other serine hydrolases. It has an IC50 value of 7.2 nM for human FAAH. The endocannabinoid system is a target for therapeutic pain relief. In a rat model of inflammatory pain, PF-04457845 produced significant reduction of inflammatory pain with efficacy comparable to that of naproxen at 10 mg/kg.Other NotesThis compound was developed by Pfizer for Neuroscience research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 20 mg/mL originator Pfizer storage temp. room temp SMILES string O=C(NC1=NN=CC=C1)N(CC2)CCC2=CC3=CC=CC(OC4=NC=C(C(F)(F)F)C=C4)=C3 InChI 1S/C23H20F3N5O2/c24-23(25,26)18-6-7-21(27-15-18)33-19-4-1-3-17(14-19)13-16-8-11-31(12-9-16)22(32)29-20-5-2-10-28-30-20/h1-7,10,13-15H,8-9,11-12H2,(H,29,30,32) InChI key BATCTBJIJJEPHM-UHFFFAOYSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-04471141 hydrochloride
Empirical Formula (Hill Notation): C16H23N3O3 · xHCl Molecular Weight: 305.37 (free base basis) PubChem Substance ID: 329823783 NACRES: NA.77
PackagingКат. номер PZ0232-5MG PZ0232-25MG
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-04471141 is a potent, selective inhibitor of the calcium-activated phosphodiesterase PDE1. (PDE1B IC50 = 35 nM).Other NotesThis compound was developed by Pfizer for Cyclic Nucleotides research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 20 mg/mL, clear originator Pfizer storage temp. 20°C SMILES string CCC(CC)NC1=NC=NC2=C(OC)C(OC)=C(OC)C=C21.Cl InChI 1S/C16H23N3O3.ClH/c1-6-10(7-2)19-16-11-8-12(20-3)14(21-4)15(22-5)13(11)17-9-18-16;/h8-10H,6-7H2,1-5H3,(H,17,18,19);1H InChI key QRHFQSUUJMOIHO-UHFFFAOYSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-04479745
Empirical Formula (Hill Notation): C17H22N4 CAS Number: 1065110-43-1 Molecular Weight: 282.38 MDL number: MFCD28137682 PubChem Substance ID: 329823691 NACRES: NA.77
Кат. номер PZ0032-5MG PZ0032-25MG
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-04479745 (PF-4479745) is a selective serotonin 5HT2C agonist.
Features and Benefits
This compound is a featured product for Neuroscience research. Click here, to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm,.Other NotesThis compound was developed by Pfizer for Neuroscience research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 20 mg/mL, clear originator Pfizer storage temp. room temp SMILES string CNC1=C2C([C@@H](C)CNCC2)=NC(CC3=CC=CC=C3)=N1 InChI 1S/C17H22N4/c1-12-11-19-9-8-14-16(12)20-15(21-17(14)18-2)10-13-6-4-3-5-7-13/h3-7,12,19H,8-11H2,1-2H3,(H,18,20,21)/t12-/m0/s1 InChI key IHHALLDEDARSAL-LBPRGKRZSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-04531083
Empirical Formula (Hill Notation): C17H16ClN5O2 CAS Number: 1079400-07-9 Molecular Weight: 357.79 NACRES: NA.77
PackagingКат. номер PZ0273-5MG PZ0273-25MG
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-04531083 is an orally available, potent and selective sodium channel Nav1.8 blocker. PF-04531083 was designated as a potential treatment of pain.Other NotesThis compound was developed by Pfizer for Ion Channel research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 10 mg/mL, clear originator Pfizer storage temp. room temp
Safety Informationpictograms GHS07 signalword Warning hcodes H302 pcodes P301 + P312 + P330 RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-04620110
Empirical Formula (Hill Notation): C21H24N4O4 CAS Number: 1109276-89-2 Molecular Weight: 396.44 PubChem Substance ID: 329823775 NACRES: NA.77
Кат. номер PZ0207-25MG PZ0207-5MG
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-04620110 is known to regulate gut hormones. Inhibition of DGAT1 might serve as a good approach for the treatment of obesity and type 2 diabetes. DGAT1 inhibition might increase the oxidation of fatty acids, thus it is found to be protective against hepatic steatosis.
PF-04620110 is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that inhibits triacylglycerol synthesis in cells and in rodents.Other NotesThis compound was developed by Pfizer for Lipid Signaling research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 10 mg/mL (clear solution) originator Pfizer storage temp. room temp SMILES string Nc1ncnc2OCCN(C(=O)c12)c3ccc(cc3)[C@@H]4CC[C@H](CC4)CC(O)=O InChI 1S/C21H24N4O4/c22-19-18-20(24-12-23-19)29-10-9-25(21(18)28)16-7-5-15(6-8-16)14-3-1-13(2-4-14)11-17(26)27/h5-8,12-14H,1-4,9-11H2,(H,26,27)(H2,22,23,24)/t13-,14- InChI key GEVVQZHMFVFGLN-HDJSIYSDSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H302 RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену
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