14:1 Cardiolipin
Empirical Formula (Hill Notation): | C65H116Na2O17P2 |
Molecular Weight: | 1277.53 |
NACRES: | NA.25 |
Кат. номер |
710337C-5MG |
710337C-25MG |
Cardiolipin is localized in the inner membrane of mitochondria. It contains 18 carbon atoms, 3-phosphatidyl groups connected via a glycerol bridge. It is an important component of ATP synthase enzyme.
Cardiolipin is an anionic phospholipid containing four acyl chains and small headgroup.
3β,7α-dihydroxy-5-cholestenoic acid is a sterol derived from cholestenoic acid.
14:1 Cardiolipin may be used as reference standard in liquid chromatography with tandem mass spectrometry (LC-MS-MS). It may also be used in the quantification of mitochondrial phospholipids and yeast respiratory chain complex using mass spectrometry.
TMCL (1,1,2,2-tetramyristoyl cardiolipin) bilayers are useful in generating multilamellar vesicles. Defects in the metabolic pathway of cardiolipin is associated with Barth syndrome patients. Liposomes of TMCL with 1,2-dioleoyl-
sn-glycero-3-phosphocholine (DOPC) and cholesterol are potential drug-delivery systems. TMCL displays temperature dependant thermotropic phase transitions.
Cardiolipin and cytochrome c interaction determines the function of proteins involved in oxidative phosphorylation and apoptosis. Cardiolipin involved in proton uptake pathway maintains the structure of enzymes participating. Cardiolipin controls the mitochondrial function and membrane potential. It offers structural support for the inner mitochondrial membrane and proteins in it. Altered cardiolipin concentration and composition have been implicated in pathological conditions including ischemia, hypothyroidism, aging, heart failure and cardioskeletal myopathy.
ST503: 3 Vial/Ampule Tray with Outer Cardboard Box (3-1/8" x 29/32" x 2-15/16") (710337C-5mg)
5 mL Clear Glass Sealed Ampule (710337C-5mg)
5 mL Clear Glass Sealed Ampule (710337C-25mg)
assay | >99% (TLC) |
packaging | pkg of 1 x 1 mL (710337C-5mg), pkg of 1 x 2.5 mL (710337C-25mg) |
Торговая марка | Avanti Polar Lipids |
concentration | 10 mg/mL (710337C-25mg), 5 mg/mL (710337C-5mg) |
shipped in | dry ice |
storage temp. | 20°C |
SMILES string | O=P([O-])(OC[C@]([H])(OC(CCCCCCC/C=C\CCCC)=O)COC(CCCCCCC/C=C\CCCC)=O)OCC([H])(O)COP([O-])(OC[C@]([H])(OC(CCCCCCC/C=C\CCCC)=O)COC(CCCCCCC/C=C\CCCC)=O)=O.[Na+].[Na+] |
pictograms | GHS06,GHS08 |
signalword | Danger |
hcodes | H302 - H315 - H319 - H331 - H336 - H351 - H361d - H372 - H412 |
pcodes | P201 - P273 - P301 + P312 + P330 - P302 + P352 - P304 + P340 + P311 - P308 + P313 |
Target Organs | Central nervous system |
RIDADR | UN 1888 6.1 / PGIII |
WGK Germany | WGK 3 |
Flash Point F | does not flash |
Flash Point C | does not flash |