18:1 PI(4,5)P2

Empirical Formula (Hill Notation):	C45H94N3O19P3
CAS Number:	799268-56-7
Molecular Weight:	1074.16
NACRES:	NA.25

Кат. номер

850155P-500UG

850155P-100UG

Phosphatidylinositol is a structural phospholipid. Phosphatidylinositol phosphate (PIP) is located in the plasma membrane.
Although PI(4,5)P2 is a minor component of cell membranes, it plays a critical role as a substrate for a number of important signaling proteins. PI(4,5)P2 is an intermediate in the IP3/DAG pathway where it is hydrolyzed by phospholipase C to liberate the second messengers, inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). PI(4,5)P2 is also a substrate for PI 3-kinase where it is phosphorylated to PI(3,4,5)P3, an activator of downstream signaling components such as the protein kinase AKT.
18:1 PI(4,5)P2 is suitable to use as a supplement in native macrophage membranes to generate phospholipid enriched membrane liposome.s It has also been used:

• in the preparation of anionic phospholipid liposomes
• as a component in supported membrane tube (SMrT) templates
• in liposome preparation

Phosphatidylinositol bisphosphate (PIP2) can effectively stimulate the ATPase.
2 mL Amber Serum Vial with Stopper and Crimp Cap (850155P-100ug)
2 mL Amber Serum Vial with Stopper and Crimp Cap (850155P-500ug)

assay	>99% (TLC)
form	powder
packaging	pkg of 1 x 100 µg (with stopper and crimp cap (850155P-100ug)), pkg of 1 x 500 µg (with stopper and crimp cap (850155P-500ug))
Торговая марка	Avanti Polar Lipids
shipped in	dry ice
storage temp.	20°C
SMILES string	[H][C@@](COP([O-])(O[C@H]1[C@H](O)[C@@H](OP(O)([O-])=O)[C@H](OP([O-])(O)=O)[C@@H](O)[C@H]1O)=O)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O.[NH4+].[NH4+].[NH4+]

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3