Antibiotics

Cell permeable fungal toxin; potent inhibitor of actin polymerization. Disrupts actin microfilaments and activates the p53-dependent pathways causing arrest of the cell cycle at the G1-S transition. Inhibits smooth muscle contraction. Inhibits insulin-stimulated, but not basal, transport of glucose.
Cytochalasin B is a cell permeable fungal toxin and potent inhibitor of actin polymerization. It disrupts actin microfilaments and activates the p53-dependent pathways causing arrest of the cell cycle at the G1-S transition. It inhibits smooth muscle contraction and insulin-stimulated, but not basal, transport of glucose.
Potent inhibitor of actin polymerization; disrupts actin microfilaments; activates the p53-dependent pathways; inhibits smooth muscle contraction; inhibits insulin-stimulated glucose transport.

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

biological source	Zygosporium mansonii
Quality Level	300,
sterility	0.2 µm filtered
form	solution
concentration	5 mg/mL in DMSO
Mode of action	enzyme \| interferes
antibiotic activity spectrum	fungi
shipped in	wet ice
storage temp.	20°C
SMILES string	[H][C@@]12[C@H](C)C(=C)[C@@H](O)[C@@H]3\C=C\C[C@H](C)C(=O)[C@](C)(O)\C=C\[C@@H](OC(C)=O)[C@@]13C(=O)N[C@H]2Cc4ccccc4
InChI	1S/C30H37NO6/c1-17-10-9-13-22-26(33)19(3)18(2)25-23(16-21-11-7-6-8-12-21)31-28(35)30(22,25)24(37-20(4)32)14-15-29(5,36)27(17)34/h6-9,11-15,17-18,22-26,33,36H,3,10,16H2,1-2,4-5H3,(H,31,35)/b13-9+,15-14+/t17-,18+,22-,23-,24+,25-,26+,29+,30+/m0/s1
InChI key	SDZRWUKZFQQKKV-JHADDHBZSA-N

Chemical structure: amino acid derivatives

Personal Protective Equipment	Eyeshields,, Gloves,, multi-purpose combination respirator cartridge (US),
RIDADR	UN 1993 / PGIII
WGK Germany	WGK 2
Flash Point F	188.6 °F - closed cup - Solvent
Flash Point C	87 °C - closed cup - Solvent

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D-Cycloserine

Empirical Formula (Hill Notation):	C₃H₆N₂O₂
CAS Number:	68-41-7
Molecular Weight:	102.09
Beilstein/REAXYS Number:	80798
EC Number:	200-688-4
MDL number:	MFCD00005353
PubChem Substance ID:	57648401
NACRES:	NA.85

D-Cycloserine acts as inhibitor of various enzymes.

Mode of Action: Inhibits cell wall biosynthesis (D-Ala peptide bond formation). Also prevents conversion of D-Ala to L-Ala. Bacteriostatic. Mode of Resistance: D-Ala transport interference.
Mode of Action: Inhibits cell wall biosynthesis (D-Ala peptide bond formation). Also prevents conversion of D-Ala to L-Ala. Bacteriostatic.
Partial agonist at the glycine modulatory site of NMDA glutamatergic receptors; antibiotic against Gram-negative bacteria.
Mode of Resistance: D-Ala transport interference.

1g, 5g, 25g

Keep container tightly closed in a dry and well-ventilated place. Store under inert gas. Air sensitive. Keep in a dry place.

Quality Level	100,
biological source	synthetic
assay	98.0% (On Dried Basis)
form	powder
color	white to off-white
mp	147 °C (dec.) (lit.)
Mode of action	cell wall synthesis \| interferes
antibiotic activity spectrum	Gram-negative bacteria, Gram-positive bacteria, mycobacteria
storage temp.	20°C
SMILES string	N[C@@H]1CONC1=O
InChI	1S/C3H6N2O2/c4-2-1-7-5-3(2)6/h2H,1,4H2,(H,5,6)/t2-/m1/s1
InChI key	DYDCUQKUCUHJBH-UWTATZPHSA-N

D-Penicillamine contains a β-lactam chemical structure.

Personal Protective Equipment	Eyeshields,, Gloves,, type N95 (US),
RIDADR	NONH for all modes of transport
WGK Germany	WGK 2
Flash Point F	Not applicable
Flash Point C	Not applicable

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D-Penicillamine

Empirical Formula (Hill Notation):	C₅H₁₁NO₂S
Linear Formula:	(CH₃)₂C(SH)CH(NH₂)CO₂H
CAS Number:	52-67-5
Molecular Weight:	149.21
Beilstein/REAXYS Number:	1722375
EC Number:	200-148-8
MDL number:	MFCD00064302
PubChem Substance ID:	24898564

It is used as an antirheumatic and as a chelating agent in Wilson′s disease. It is used as a copper chelator to form mixed disulfides with cysteine or other sulfide media components. It is used to inactivate protein-1 DNA binding and to inhibit the growth of asynchronous cultures of rabbit articular chondrocytes.

5, 25 g in poly bottle

Penicillamine is a characteristic degradation product of penicillin type antibiotics. One atom of copper combines with two molecules of penicillamine. Penicillamine reduces excess cystine excretion in cystinuria. This is by disulfide interchange between penicillamine and cystine, which results in formation of a readily excreted penicillamine-cysteine disulfide. Penicillamine interferes with the formation of cross-links between tropocollagen molecules and cleaves them when newly formed. Penicillamine lowers IgM rheumatoid factor and depresses T-cell activity.

Keep container tightly closed in a dry and well-ventilated place.

Quality Level	100,
assay	98-101%
mp	210 °C (dec.) (lit.)
solubility	H₂O: 100 mg/mL
Mode of action	cell wall synthesis \| interferes
storage temp.	2-8°C
SMILES string	CC(C)(S)[C@@H](N)C(O)=O
InChI	1S/C5H11NO2S/c1-5(2,9)3(6)4(7)8/h3,9H,6H2,1-2H3,(H,7,8)/t3-/m0/s1
InChI key	VVNCNSJFMMFHPL-VKHMYHEASA-N
Gene Information	mouse ... Oprk1(18387)

Dacarbazine is a triazine antineoplastic agent that is used for DNA methylation via formation of methyl adducts. It is used to treat metastatic malignant melanomas and Hodgkin′s when used in combination with other antineoplastic agents.

pictograms	GHS08
signalword	Warning
hcodes	H361d
pcodes	P201 - P308 + P313
Personal Protective Equipment	dust mask type N95 (US),, Eyeshields,, Gloves,
RIDADR	NONH for all modes of transport
WGK Germany	WGK 2

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Dacarbazine

Empirical Formula (Hill Notation):	C₆H₁₀N₆O
CAS Number:	4342-03-4
Molecular Weight:	182.18
EC Number:	224-396-1
MDL number:	MFCD00057167
PubChem Substance ID:	24893683
NACRES:	NA.85

1 g in glass bottle
100 mg in glass bottle

Dacarbazine is a purine analog of naturally occurring purine precursor 5-amino-1H-imidazole-4-carboxamide (AIC). It is a synthetic triazine antineoplastic agent that exerts cytotoxic effects by acting as an alkylating agent and by inhibiting DNA synthesis and inducing apoptosis. It is known to induce hepatotoxicity in mice. Dacarbazine is not cell cycle-phase specific.

Keep container tightly closed in a dry and well-ventilated place.

Quality Level	100,
form	powder or crystals
solubility	1 M HCl: 50 mg/mL
Mode of action	DNA synthesis \| interferes
antibiotic activity spectrum	neoplastics
storage temp.	2-8°C
SMILES string	CN(C)\N=N\c1[nH]cnc1C(N)=O
InChI	1S/C6H10N6O/c1-12(2)11-10-6-4(5(7)13)8-3-9-6/h3H,1-2H3,(H2,7,13)(H,8,9)/b11-10+
InChI key	FDKXTQMXEQVLRF-ZHACJKMWSA-N

pictograms	GHS07,GHS08
signalword	Danger
hcodes	H302 + H312 + H332 - H315 - H319 - H335 - H340 - H350
pcodes	P201 - P280 - P301 + P312 + P330 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313
Target Organs	Respiratory system
Personal Protective Equipment	Eyeshields,, Gloves,, type P1 (EN143) respirator filter,, type P3 (EN 143) respirator cartridges,
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Daptomycin D2446-1MG

Empirical Formula (Hill Notation):	C₇₂H₁₀₁N₁₇O₂₆
CAS Number:	103060-53-3
Molecular Weight:	1620.67
PubChem Substance ID:	329798741

Daptomycin has been studied as a potential therapy for Streptococcus pneumoniae infections. It has also been used to study the impact of sarA on daptomycin susceptibility of Staphylococcus aureus.

1 mg in glass bottle

Daptomycin is a cyclic lipopeptide antibiotic. isolated from Streptomyces sp. It is effective against Gram-positive bacteria. It disrupts the plasma membrane causes rapid depolarization and inhibits the synthesis of protein, RNA and DNA. It is potent against Staphylococcus aureus infections, including MRSA (methicillin-resistant Staphylococcus aureus).

Keep container tightly closed in a dry and well-ventilated place.

Quality Level	100,
assay	≥90% (HPLC)
form	powder
solubility	methanol: 5 mg/mL, DMSO: soluble, ethanol: soluble, methanol: soluble
Mode of action	DNA synthesis \| interferes, protein synthesis \| interferes
antibiotic activity spectrum	Gram-positive bacteria
storage temp.	−20°C
SMILES string	CCCCCCCCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H]3[C@@H](C)OC(=O)[C@H](CC(=O)c4ccccc4N)NC(=O)[C@@H](NC(=O)[C@@H](CO)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](CCCN)NC(=O)CNC3=O)[C@H](C)CC(O)=O
InChI	1S/C72H101N17O26/c1-5-6-7-8-9-10-11-22-53(93)81-44(25-38-31-76-42-20-15-13-17-39(38)42)66(108)84-45(27-52(75)92)67(109)86-48(30-59(102)103)68(110)89-61-37(4)115-72(114)49(26-51(91)40-18-12-14-19-41(40)74)87-71(113)60(35(2)24-56(96)97)88-69(111)50(34-90)82-55(95)32-77-63(105)46(28-57(98)99)83-62(104)36(3)79-65(107)47(29-58(100)101)85-64(106)43(21-16-23-73)80-54(94)33-78-70(61)112/h12-15,17-20,31,35-37,43-50,60-61,76,90H,5-11,16,21-30,32-34,73-74H2,1-4H3,(H2,75,92)(H,77,105)(H,78,112)(H,79,107)(H,80,94)(H,81,93)(H,82,95)(H,83,104)(H,84,108)(H,85,106)(H,86,109)(H,87,113)(H,88,111)(H,89,110)(H,96,97)(H,98,99)(H,100,101)(H,102,103)/t35-,36-,37-,43-,44+,45-,46+,47+,48+,49+,50-,60+,61+/m1/s1
InChI key	DOAKLVKFURWEDJ-FAZHXZQASA-N

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Daptomycin Ready Made Solution

Empirical Formula (Hill Notation):	C₇₂H₁₀₁N₁₇O₂₆
CAS Number:	103060-53-3
Molecular Weight:	1620.67
MDL number:	MFCD28968054

Кат. номер

SBR00014-0.5ML

SBR00014-0.5ML-PW

Daptomycin is a natural cyclic lipopeptide antibiotic found in Streptomyces roseosporus. It is has been found to be effective in treating infections caused by aerobic Gram-positive bacteria. Daptomycin inhibits many antibiotic resistant strains such as methicillin-resistant S. aureus (MRSA), vancomycin-intermediate S. aureus (VISA) and vancomycin-resistant S. aureus (VRSA).

The mode of action of daptomycin is quite different from that of any other antibiotic. Daptomycin binds to bacterial membranes and causes a rapid depolarization of membrane potential. This loss of membrane potential causes inhibition of protein, DNA, and RNA synthesis, which results in bacterial cell death.

0.5ML

The 1 mg/mL solution may be further diluted in an appropriate buffer prior to use. It is recommended that a fresh dilution be made on the day of use.

Keep container tightly closed in a dry and well-ventilated place.

biological source	Streptomyces roseosporus
Quality Level	200,
description	Ready Made Solution
form	liquid
storage condition	(Keep container tightly closed in a dry and well-ventilated place.)
concentration	1 mg/mL in DMSO
color	colorless to faint yellow
Mode of action	DNA synthesis \| interferes, protein synthesis \| interferes
antibiotic activity spectrum	Gram-positive bacteria
shipped in	dry ice
storage temp.	20°C
SMILES string	O=C(NCC(N[C@H](CCCN)C(N[C@@H](CC(O)=O)C(N[C@H](C)C(N[C@@H](CC(O)=O)C(NC1)=O)=O)=O)=O)=O)[C@@H](NC([C@H](CC(O)=O)NC([C@@H](CC(N)=O)NC([C@H](CC2=CNC3=C2C=CC=C3)NC(CCCCCCCCC)=O)=O)=O)=O)[C@@H](C)OC([C@H](CC(C4=C(N)C=CC=C4)=O)NC([C@@]([C@H](C)CC(O)=O)([H])NC(
InChI	1S/C72H101N17O26/c1-5-6-7-8-9-10-11-22-53(93)81-44(25-38-31-76-42-20-15-13-17-39(38)42)66(108)84-45(27-52(75)92)67(109)86-48(30-59(102)103)68(110)89-61-37(4)115-72(114)49(26-51(91)40-18-12-14-19-41(40)74)87-71(113)60(35(2)24-56(96)97)88-69(111)50(34-90)82-55(95)32-77-63(105)46(28-57(98)99)83-62(104)36(3)79-65(107)47(29-58(100)101)85-64(106)43(21-16-23-73)80-54(94)33-78-70(61)112/h12-15,17-20,31,35-37,43-50,60-61,76,90H,5-11,16,21-30,32-34,73-74H2,1-4H3,(H2,75,92)(H,77,105)(H,78,112)(H,79,107)(H,80,94)(H,81,93)(H,82,95)(H,83,104)(H,84,108)(H,85,106)(H,86,109)(H,87,113)(H,88,111)(H,89,110)(H,96,97)(H,98,99)(H,100,101)(H,102,103)/t35?,36-,37?,43+,44+,45+,46+,47+,48+,49+,50-,60+,61?/m1/s1
InChI key	DOAKLVKFURWEDJ-OFNKPWESSA-N

WGK Germany	WGK 1
Flash Point F	188.6 °F
Flash Point C	87 °C

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Daunorubicin hydrochloride

Empirical Formula (Hill Notation):	C₂₇H₂₉NO₁₀ · HCl
CAS Number:	23541-50-6
Molecular Weight:	563.98
Beilstein/REAXYS Number:	4229221
EC Number:	245-723-4
MDL number:	MFCD04974507
PubChem Substance ID:	57648441
NACRES:	NA.85

Daunorubicin hydrochloride is used in photostability, antileukemic, and drug metabolism studies.

On binding to DNA, daunomycin intercalates, with its daunosamine residue directed toward the minor groove. Daunomycin effectively binds to every 3 base pairs which causes unwinding.
Potent anticancer agent. Inhibits DNA and RNA synthesis as sequence specific ds-DNA intercalating agent.

5 mg, 25 mg

Keep container tightly closed in a dry and well-ventilated place. Hygroscopic. Store under inert gas.

Quality Level	200,
biological source	synthetic
assay	≥90% (HPLC)
form	solid
color	red to deep red
Mode of action	DNA synthesis \| interferes
antibiotic activity spectrum	neoplastics
storage temp.	2-8°C
SMILES string	Cl.COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(C)=O
InChI	1S/C27H29NO10.ClH/c1-10-22(30)14(28)7-17(37-10)38-16-9-27(35,11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33;/h4-6,10,14,16-17,22,30,32,34-35H,7-9,28H2,1-3H3;1H/t10-,14-,16-,17-,22+,27-;/m0./s1
InChI key	GUGHGUXZJWAIAS-QQYBVWGSSA-N
Gene Information	human ... TOP2A(7153)

Chemical structure: tetracycline

pictograms	GHS06,GHS08
signalword	Danger
hcodes	H301 - H341 - H351 - H360FD
pcodes	P201 - P202 - P264 - P270 - P280 - P301 + P310
Personal Protective Equipment	Eyeshields,, Faceshields,, Gloves,, type P1 (EN143) respirator filter,, type P3 (EN 143) respirator cartridges,
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	WGK 3

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Demeclocycline hydrochloride

Empirical Formula (Hill Notation):	C₂₁H₂₁ClN₂O₈ · HCl
CAS Number:	64-73-3
Molecular Weight:	501.31
Beilstein/REAXYS Number:	3849198
EC Number:	200-592-2
MDL number:	MFCD00082371
PubChem Substance ID:	24278380
NACRES:	NA.75

Used to study mechanisms of bacterial protein synthesis inhibition at the level of the 30S subunit and aminoacy-tRNA A-site binding.
Demeclocycline hydrochloride is a tetracycline antibiotic derived from a strain of Streptomyces aureofaciens. DMC protects neurons from glutamate induced toxicity by suppressing calpain I and II activities.
Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time.

assay	≥92% (HPLC)
Quality Level	200,
form	powder or crystals
application(s)	cell culture \| mammalian: suitable
solubility	soluble (1 mg/mL of Demeclocycline Hydrochloride in 0.01 N hydrochloric acid)
Mode of action	protein synthesis \| interferes
antibiotic activity spectrum	Gram-negative bacteria, Gram-positive bacteria
storage temp.	−20°C
SMILES string	Cl[H].[H][C@]12C[C@@]3([H])[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C(=O)c4c(O)ccc(Cl)c4[C@H]2O
InChI	1S/C21H21ClN2O8.ClH/c1-24(2)14-7-5-6-10(16(27)12-9(25)4-3-8(22)11(12)15(6)26)18(29)21(7,32)19(30)13(17(14)28)20(23)31;/h3-4,6-7,14-15,25-26,28-29,32H,5H2,1-2H3,(H2,23,31);1H/t6-,7-,14-,15-,21-;/m0./s1
InChI key	GVSJQNRGSCOSNJ-KBHRXELFSA-N

Chemical structure: -lactam

pictograms	GHS07,GHS08
signalword	Warning
hcodes	H302 + H312 + H332 - H315 - H319 - H335 - H341
pcodes	P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338 - P308 + P313
Target Organs	Respiratory system
Personal Protective Equipment	dust mask type N95 (US),, Eyeshields,, Faceshields,, Gloves,
RIDADR	NONH for all modes of transport
WGK Germany	WGK 2
Flash Point F	Not applicable
Flash Point C	Not applicable

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Dicloxacillin sodium salt monohydrate

Empirical Formula (Hill Notation):	C₁₉H₁₆Cl₂N₃NaO₅S·H₂O
CAS Number:	13412-64-1
Molecular Weight:	510.32
EC Number:	206-444-3
MDL number:	MFCD00167147
PubChem Substance ID:	24894242
NACRES:	NA.85

Dicloxacillin is a -lactamase resistant penicillin similar to oxacillin. Dicloxacillin has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. It is resistant to penicillinase. It is used to study bacterial cell wall biosynthesis at the level of peptidogylcan cross-linking and to study mechanisms of penicillinase (-lactamase) resistance. It is used to study phenylbutazone plasma binding and extracellular and intracellular killing of Staphylococcus aureus

Docloxacillin binds to specific penicillin-binding proteins (PBPs) in the bacterial cell wall and therefore inhibits the last stage of bacterial cell wall synthesis. Cell lysis, mediated by bacterial cell wall autolytic enzymes, is the result. Dicloxacillin may interfere with autolysin inhibitors .

Quality Level	200,
form	powder or crystals
color	white to off-white
solubility	H₂O: 100 mg/mL
Mode of action	cell wall synthesis \| interferes
antibiotic activity spectrum	Gram-negative bacteria, Gram-positive bacteria
storage temp.	2-8°C
SMILES string	O.[Na+].Cc1onc(c1C(=O)N[C@H]2[C@H]3SC(C)(C)[C@@H](N3C2=O)C([O-])=O)-c4c(Cl)cccc4Cl
InChI	1S/C19H17Cl2N3O5S.Na.H2O/c1-7-10(12(23-29-7)11-8(20)5-4-6-9(11)21)15(25)22-13-16(26)24-14(18(27)28)19(2,3)30-17(13)24;;/h4-6,13-14,17H,1-3H3,(H,22,25)(H,27,28);;1H2/q;+1;/p-1/t13-,14+,17-;;/m1../s1
InChI key	SIGZQNJITOWQEF-VICXVTCVSA-M

pictograms	GHS07,GHS08
signalword	Danger
hcodes	H315 - H319 - H334 - H335
pcodes	P302 + P352 - P305 + P351 + P338
Target Organs	Respiratory system
Personal Protective Equipment	dust mask type N95 (US),, Eyeshields,, Faceshields,, Gloves,
RIDADR	NONH for all modes of transport
WGK Germany	WGK 2
Flash Point F	Not applicable
Flash Point C	Not applicable

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Dihydralazine sulfate

Empirical Formula (Hill Notation):	C₈H₁₂N₆O₄S
CAS Number:	7327-87-9
Molecular Weight:	288.28
EC Number:	230-808-0
PubChem Substance ID:	329798750
NACRES:	NA.85

Кат. номер

D2697-100MG

D2697-100MG-PW

Dihydralazine sulfate is a vasodilator and an antihypertensive agent. It relaxes arterial smooth muscle by inhibiting the accumulation of intracellular free calcium. By relaxing vascular smooth muscle, vasodilators act to decrease peripheral resistance.

Keep container tightly closed in a dry and well-ventilated place.

form	powder
Quality Level	200,
solubility	DMSO: 1 mg/mL
Mode of action	cell membrane \| interferes
storage temp.	−20°C
SMILES string	OS(O)(=O)=O.NNC1=NNC(=N/N)\c2ccccc12
InChI	1S/C8H10N6.H2O4S/c9-11-7-5-3-1-2-4-6(5)8(12-10)14-13-7;1-5(2,3)4/h1-4H,9-10H2,(H,11,13)(H,12,14);(H2,1,2,3,4)
InChI key	BWHAMWGGORIDBK-UHFFFAOYSA-N

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Dihydrostreptomycin sesquisulfate

Empirical Formula (Hill Notation):	C₂₁H₄₁N₇O₁₂·1.5H₂SO₄
Linear Formula:	C₂₁H₄₁N₇O₁₂ · 3/2H₂SO₄
CAS Number:	5490-27-7
Molecular Weight:	730.71
Beilstein/REAXYS Number:	3894221
EC Number:	226-823-7
MDL number:	MFCD00070252
PubChem Substance ID:	24894093
NACRES:	NA.85

Dihydrostreptomycin sesquisulfate is a derivative of streptomycin used in aminoglycoside uptake studies. It has also been used as an electrode for a cochlear amplifier in the hair-cell bundle of lizards.

Mode of Action: Dihydrostreptomycin sesquisulfate inhibits protein synthesis at the level of the 30s ribosomal subunit and the 16s rRNA.

biological source	microbial
Quality Level	200,
form	powder
color	white to off-white
Mode of action	protein synthesis \| interferes
antibiotic activity spectrum	Gram-negative bacteria, Gram-positive bacteria, mycobacteria
storage temp.	2-8°C
SMILES string	OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@H]2[C@@H](O[C@@H](C)[C@]2(O)CO)O[C@@H]3[C@@H](O)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]3NC(N)=N.CN[C@H]4[C@H](O)[C@@H](O)[C@H](CO)O[C@H]4O[C@H]5[C@@H](O[C@@H](C)[C@]5(O)CO)O[C@@H]6[C@@H](O)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]6NC(N)=N
InChI	1S/2C21H41N7O12.3H2O4S/c21-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35;31-5(2,3)4/h25-18,26,29-36H,3-4H2,1-2H3,(H4,22,23,27)(H4,24,25,28);3(H2,1,2,3,4)/t2*5-,6-,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,21+;;;/m00.../s1
InChI key	CZWJCQXZZJHHRH-YZTFXSNBSA-N

Dimetridazole has been used in the treatment and prevention of blackhead, a life-threatening disease in turkeys. It is a potential antimicrobial agent against Campylobacter spp. from pigs. It has been used to study antitrichomonad action on Tritrichomonas foetus. Dimetridazole is used to study mechanisms of anti-protozoan nitroimidazole drugs.

pictograms	GHS07,GHS08
signalword	Warning
hcodes	H302 - H361fd
pcodes	P201 - P301 + P312 + P330 - P308 + P313
Personal Protective Equipment	Eyeshields,, Gloves,, type N95 (US),
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Dimetridazole

Empirical Formula (Hill Notation):	C₅H₇N₃O₂
CAS Number:	551-92-8
Molecular Weight:	141.13
Beilstein/REAXYS Number:	130665
EC Number:	209-001-2
MDL number:	MFCD00047046
PubChem Substance ID:	24893809
NACRES:	NA.85

form	powder
Quality Level	200,
color	almost white to brownish-yellow
solubility	ethanol: sparingly soluble 96%, H₂O: slightly soluble, chloroform: freely soluble, ether: slightly soluble
Mode of action	DNA synthesis \| interferes
antibiotic activity spectrum	Gram-negative bacteria, parasites
storage temp.	2-8°C
SMILES string	Cc1ncc(n1C)[N+]([O-])=O
InChI	1S/C5H7N3O2/c1-4-6-3-5(7(4)2)8(9)10/h3H,1-2H3
InChI key	IBXPYPUJPLLOIN-UHFFFAOYSA-N

pictograms	GHS07
signalword	Warning
hcodes	H315 - H319 - H335
pcodes	P302 + P352 - P305 + P351 + P338
Target Organs	Respiratory system
Personal Protective Equipment	dust mask type N95 (US),, Eyeshields,, Gloves,
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3

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Dirithromycin

Empirical Formula (Hill Notation):	C₄₂H₇₈N₂O₁₄
CAS Number:	62013-04-1
Molecular Weight:	835.07
MDL number:	MFCD00865041
PubChem Substance ID:	329825077

Кат. номер

SMB00606-1G

SMB00606-1G-PW

Dirithromycin is a macrolide antibiotic. It is a prodrug of erythromycylamine that has outstanding activity against Campylobacter. Dirithromycin is a group 3 agent with respect to its interaction with cytochrome P450 (CYP) isoform 3A4, as it interferes poorly with CYP3A4 in vitro and generally does not alter drug metabolism in vivo.

When dissolving dirithromycin in organic solvents, first purge the solvent with inert gas.

To prepare in aqueous buffer, dirithromycin should first be dissolved in ethanol and then diluted with aqueous buffer. The solution is stable for one day.

Dirithromycin is soluble in ethanol at approximately 20 mg/mL, DMF at approximately 10 mg/mL, and DMSO at approximately 15 mg/mL.

Keep container tightly closed in a dry and well-ventilated place.

Quality Level	200,
assay	≥96%
form	powder
storage condition	(Keep container tightly closed in a dry and well-ventilated place.)
color	white to off-white
Mode of action	protein synthesis \| interferes
antibiotic activity spectrum	Gram-negative bacteria
storage temp.	2-8°C
SMILES string	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)C4N[C@@H](COCCOC)OC([C@H]4C)[C@]1(C)O
InChI	1S/C42H78N2O14/c1-15-29-42(10,49)37-24(4)32(43-30(56-37)21-52-17-16-50-13)22(2)19-40(8,48)36(58-39-33(45)28(44(11)12)18-23(3)53-39)25(5)34(26(6)38(47)55-29)57-31-20-41(9,51-14)35(46)27(7)54-31/h22-37,39,43,45-46,48-49H,15-21H2,1-14H3/t22-,23-,24+,25+,26-,27+,28+,29-,30-,31+,32+,33-,34+,35+,36-,37-,39+,40-,41+,42-/m1/s1
InChI key	WLOHNSSYAXHWNR-KZYCBHIHSA-N

A cell-permeable, stable benzimidazolylpropanehydrazone that acts as a potent bacteriostatic agent and reduces the growth rate and transmembrane potential of bacterial cells without altering their membrane permeability. Blocks bacterial cell division by disturbing divisome assembly and causing dissociation of late division proteins from the divisome (MIC = 3, 5, 12.5, and 12.5 µM against V. cholerae, C. crescentus CB15N strain and JW5503 and YJE24 strains of E. coli, respectively). Also shown to reduce peptidoglycan remodeling and arrest the constriction in dividing cells. Does neither affect the tubulin homologue, FtsZ, nor interfere with replication, partitioning, and orientation of chromosomes. Exhibits low toxicity in mammalian cells.

pictograms	GHS07
signalword	Warning
hcodes	H317
pcodes	P280
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Divin - Calbiochem

Empirical Formula (Hill Notation):	C₂₂H₂₀N₄O₂
Molecular Weight:	372.42

Cell permeable: yes
Primary Target
bacteria

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Eun, Y.J., et al. 2013. J. Am. Chem. Soc.135, 9768.

Legal Information

storage conditions	+2C to +8C
Quality Level	200,
assay	95% (HPLC)
form	powder
Торговая марка	Calbiochem^®
storage condition	OK to freeze, protect from light
color	yellow
solubility	DMSO: 50 mg/mL
storage temp.	2-8°C

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Doramectin synthetic D6696-100MG

Empirical Formula (Hill Notation):	C₅₀H₇₄O₁₄
CAS Number:	117704-25-3
Molecular Weight:	899.11
MDL number:	MFCD00894747
PubChem Substance ID:	329798834
NACRES:	NA.85

Doramectin is commonly used in veterinary medicine for the treatment of parasites such as gastrointestinal roundworms, lungworms, eyeworms, grubs, sucking lice and mange mites. It is effective against Haemonchus spp., Ostertagia spp., Trichostrongylus spp., Cooperia spp., Oesophagostomum spp., Dyctiocaulus viviparus, Dermatobia hominis, Boophilus microplus, Psoroptes bovis, as well as other internal and external parasites.

100 mg in poly bottle

Doramectin is a derivative of ivermectin. It is thought to work like other macrocyclic lactones by opening glutamate-gated chloride channels in the nerve cells, causing paralysis.

Quality Level	200,
biological source	synthetic
assay	≥90%
form	solid
impurities	≤5% water (Karl Fischer)
color	white
solubility	methanol: soluble
Mode of action	cell membrane \| interferes
antibiotic activity spectrum	parasites
storage temp.	−20°C
SMILES string	[H][C@@]12OC/C3=C\C=C\[C@H](C)[C@H](O[C@@H]4C[C@H](OC)[C@@H](O[C@@H]5C[C@H](OC)[C@@H](O)[C@H](C)O5)[C@H](C)O4)\C(C)=C\CC6C[C@@H](C[C@]7(O6)O[C@@H]([C@@H](C)C=C7)C8CCCCC8)OC(=O)[C@H](C=C(C)[C@H]1O)[C@@]23O
InChI	1S/C50H74O14/c1-27-13-12-16-34-26-57-47-42(51)30(4)21-37(50(34,47)54)48(53)60-36-22-35(63-49(25-36)20-19-29(3)45(64-49)33-14-10-9-11-15-33)18-17-28(2)44(27)61-41-24-39(56-8)46(32(6)59-41)62-40-23-38(55-7)43(52)31(5)58-40/h12-13,16-17,19-21,27,29,31-33,35-47,51-52,54H,9-11,14-15,18,22-26H2,1-8H3/b13-12+,28-17+,34-16+/t27-,29-,31-,32-,35?,36-,37-,38-,39-,40+,41+,42+,43-,44-,45-,46-,47+,49+,50+/m0/s1
InChI key	QLFZZSKTJWDQOS-TTXKVKCHSA-N

pictograms	GHS07,GHS08,GHS09
signalword	Warning
hcodes	H302 - H361fd - H362 - H410
pcodes	P202 - P260 - P263 - P273 - P301 + P312 - P308 + P313
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	WGK 3

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Doxorubicin hydrochloride D1515-10MG

Empirical Formula (Hill Notation):	C₂₇H₂₉NO₁₁ · HCl
CAS Number:	25316-40-9
Molecular Weight:	579.98
Beilstein/REAXYS Number:	4229251
EC Number:	246-818-3
MDL number:	MFCD00077757
PubChem Substance ID:	24893465
NACRES:	NA.76

Doxorubicin hydrochloride (DOX) is an anthracycline antibiotic isolated from Streptomyces peucetius var. caesius. The water soluble anti-cancer agent DOX is a hydroxy derivative of daunorubicin.
Chemical structure: tetracycline

Doxorubicin hydrochloride has been used:

in cell viability assays
MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay
as a drug in polymeric PLGA-based microparticulate drug delivery
to develop doxorubicin-resistant HepG2 cells (HepG2-DR) and K562 cells (K562-DR)

10 mg in glass bottle

Naturally fluorescent anthracycline antibiotic, anticancer drug. Doxorubicin is a substrate of MRP1 which was first cloned from a DOX-resistant lung cancer cell line. Fluorescent property has been exploited for the measurement of drug efflux pump activities as well as resolving the important question of intracellular localization of various multidrug resistance proteins and the role of subcellular organelles (Golgi and lysosome) in the sequestration of drugs and its implication in drug resistant phenotypes.
Substrate of MRP1; used for measurement of drug efflux pump activities. Doxorubicin hydrochloride (DOX) inhibits topoisomerase II by intercalating between base pairs and by inducing strand breaks, resulting in the inhibition of nucleic acid and protein synthesis. It also contributes to the formation of free radicals for the disruption of membrane lipids and DNA strands. DOX is used in the treatment of non-Hodgkin′s lymphoma and other cancers.

Soluble in water and in isotonic sodium chloride solution, slightly soluble in methanol. Practically insoluble in chloroform, ether, and in other organic solvents.

Keep container tightly closed in a dry and well-ventilated place. Moisture sensitive. Light sensitive.

Quality Level	200
biological source	synthetic (organic)
assay	98.0-102.0% (HPLC)
form	powder
mp	216 °C (dec.) (lit.)
solubility	water: 50.0-52.0 mg/mL, clear, orange to red
Mode of action	DNA synthesis \| interferes
antibiotic activity spectrum	viruses
storage temp.	2-8°C
SMILES string	Cl[H].COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO
InChI	1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1
InChI key	MWWSFMDVAYGXBV-RUELKSSGSA-N
Gene Information	human ... TOP2A(7153)

Doxycycline hyclate belongs to the second generation of tetracycline antibiotics family. Doxycycline hyclate shows minimal side effects upon usage. It is effective for the treatment of recurrent aphthous stomatitis (RAS) and promotes speedy recovery.
Chemical structure: tetracycline

Pictograms	GHS07,GHS08
Signal Word	Danger
Hazard Statements	H302 - H340 - H350 - H360FD
Precautionary Statements	P201 - P202 - P264 - P270 - P301 + P312 - P308 + P313
Personal Protective Equipment	Eyeshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

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Doxycycline hyclate

Empirical Formula (Hill Notation):	C₂₂H₂₄N₂O₈ · HCl · 0.5H₂O · 0.5C₂H₆O
CAS Number:	24390-14-5
Molecular Weight:	512.94
Beilstein/REAXYS Number:	5702728
MDL number:	MFCD07357237
PubChem Substance ID:	57654124
NACRES:	NA.85

Doxycycline hyclate has been used for the induction of glioma cells and human embryonic kidney 293T cells (HEK293T).
Doxycycline hyclate is a synthetic oxytetracycline derivative. It has been used to eliminate Borrelia burgdorferi and Anaplasma phagocytophilum in rodent reservoirs and to eliminate Ixodes scapularis ticks. It is a broad spectrum inhibitor used to inhibit matrix metalloproteinases (MMP), such as type 1 collagenase in studies on wound healing and tissue remodeling.

1, 5, 10, 25, 100 g in glass bottle

Doxycycline hyclate inhibits the inflammatory response to the Lyme Disease Spirochete Borrelia burgdorferi. It is a broad spectrum inhibitor of matrix metalloproteinases in vivo.

Quality Level	200
biological source	synthetic
assay	≥93.5% (HPLC), 95.0-102.0% anhydrous basis (ethanol free based)
form	powder
color	yellow to yellow-green
mp	~201 °C
solubility	water: soluble 50 mg/mL, clear, yellow-green
Mode of action	protein synthesis \| interferes
antibiotic activity spectrum	Gram-negative bacteria, Gram-positive bacteria, mycoplasma, parasites
storage temp.	2-8°C
SMILES string	Cl[H].Cl[H].[H]O[H].CCO.C[C@@H]1C2[C@H](O)C3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C2C(=O)c4c(O)cccc14.C[C@@H]5C6[C@H](O)C7[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]7(O)C(O)=C6C(=O)c8c(O)cccc58
InChI	1S/2C22H24N2O8.C2H6O.2ClH.H2O/c21-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;1-2-3;;;/h24-7,10,14-15,17,25,27-29,32H,1-3H3,(H2,23,31);3H,2H2,1H3;21H;1H2/t27-,10?,14?,15-,17-,22-;;;;/m00..../s1
InChI key	HALQELOKLVRWRI-ZVACAFRPSA-N

Doxycycline is a member of the tetracycline antibiotics group, and is commonly used to treat a variety of infections. It is a Broad spectrum antibiotic and bacteriostatic. Doxycycline shows antiprotozoal properties and is a potent inhibitor of MMPs (matrix metalloproteinases) in vivo. Doxycycline is frequently used to treat Lyme disease, chronic prostatitis, sinusitis, pelvic inflammatory disease acne, rosacea, and rickettsial infections and prophylaxis of anthrax (caused by Bacillus anthracis). It is also effective against Yersinia pestis. Treatment with doxycycline inhibits collagen synthesis.

Personal Protective Equipment	dust mask type N95 (US), Eyeshields, Gloves
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

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Doxycycline hydrochloride

Empirical Formula (Hill Notation):	C₂₂H₂₄N₂O₈ · HCl
CAS Number:	10592-13-9
Molecular Weight:	480.90
NACRES:	NA.85

Doxycycline hydrochloride has been used for the induction of shRNA expression and induction of expression vectors.

Keep container tightly closed in a dry and well-ventilated place.

Quality Level	200,
biological source	synthetic
form	powder
color	yellow
solubility	DMSO: 50 mg/mL
Mode of action	protein synthesis \| interferes
antibiotic activity spectrum	Gram-negative bacteria, Gram-positive bacteria, mycoplasma, parasites
storage temp.	−20°C
InChI	1S/C22H24N2O8.ClH/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;/h4-7,10,14-15,17,25-27,31-32H,23H2,1-3H3;1H/b21-13-;/t7-,10+,14+,15-,17-,22-;/m0./s1
InChI key	VLUQVUWDECWBTL-UQVCFKGQSA-N

Doxycycline is a member of the tetracycline antibiotics group, and is commonly used to treat a variety of infections. It is a Broad spectrum antibiotic and bacteriostatic. Doxycycline shows antiprotozoal properties and is a potent inhibitor of MMPs (matrix metalloproteinases) in vivo. Doxycycline is frequently used to treat Lyme disease, chronic prostatitis, sinusitis, pelvic inflammatory disease acne, rosacea, and rickettsial infections and prophylaxis of anthrax (caused by Bacillus anthracis). It is also effective against Yersinia pestis . Treatment with doxycycline inhibits collagen synthesis.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Doxycycline Hydrochloride, Ready Made Solution

Empirical Formula (Hill Notation):	C₂₂H₂₄N₂O₈ · HCl
CAS Number:	10592-13-9
Molecular Weight:	480.90
MDL number:	MFCD03427564
NACRES:	NA.85

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Quality Level	200,
biological source	synthetic
sterility	0.22 μm filtered
form	liquid
concentration	100 mg/mL in DMSO
solubility	DMSO: 100 mg/mL
Mode of action	protein synthesis \| interferes
antibiotic activity spectrum	Gram-negative bacteria, Gram-positive bacteria, mycoplasma, parasites
storage temp.	−20°C
InChI	1S/C22H24N2O8.ClH/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;/h4-7,10,14-15,17,25-27,31-32H,23H2,1-3H3;1H/b21-13-;/t7-,10+,14+,15-,17-,22-;/m0./s1
InChI key	VLUQVUWDECWBTL-UQVCFKGQSA-N

RIDADR	NA 1993 / PGIII
WGK Germany	WGK 3
Flash Point F	188.6 °F - closed cup
Flash Point C	87 °C - closed cup

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Doxycycline monohydrate

Empirical Formula (Hill Notation):	C₂₂H₂₄N₂O₈· H₂O
CAS Number:	17086-28-1
Molecular Weight:	462.45
MDL number:	MFCD02682958
PubChem Substance ID:	329798712
NACRES:	NA.85

In yeast cells, doxycycline has been used in doxycycline-inducible system for overexpression of methyltransferase Hmt1 (hnRNP methyltransferase 1).
It has been used in the doxycycline-inducible IFITM (interferon-induced transmembrane) cell lines.
It has also been used as an antimicrobial agent.

Doxycycline is a semisynthetic tetracycline that is active against bacteria, mycoplasma and protozoan parasites. It inhibits the bacterial protein synthesis by inhibiting the interaction of aminoacyl-tRNA and the bacterial ribosome.

Keep container tightly closed in a dry and well-ventilated place.

Quality Level	200,
form	powder or crystals
Mode of action	protein synthesis \| interferes
antibiotic activity spectrum	Gram-negative bacteria, Gram-positive bacteria, mycoplasma, parasites
storage temp.	−20°C
SMILES string	O.C[C@@H]1[C@H]2[C@H](O)[C@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C2C(=O)c4c(O)cccc14
InChI	1S/C22H24N2O8.H2O/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;/h4-7,10,14-15,17,25,27-29,32H,1-3H3,(H2,23,31);1H2/t7-,10+,14+,15-,17-,22-;/m0./s1
InChI key	XQTWDDCIUJNLTR-CVHRZJFOSA-N
Gene Information	human ... MMP1(4312), MMP13(4322), MMP7(4316), MMP8(4317)

Chemical structure: tetracycline

pictograms	GHS07
signalword	Warning
hcodes	H302
pcodes	P264 - P270 - P301 + P312 + P330 - P501
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Duramycin from Streptoverticillium cinnamoneus

Empirical Formula (Hill Notation):	C₈₉H₁₂₅N₂₃O₂₅S₃
CAS Number:	1391-36-2
Molecular Weight:	2013.28
MDL number:	MFCD00133301
NACRES:	NA.85

Duramycin is used to study chloride secretion by cardial, pancreatic and airway epithelial voltage-gated ion channels. It is used to study cystic fibrosis and as a novel phosphatidylethanolamine-binding molecular probe. It is used to stimulate sodium transport in cultured human colonic epithelia.

10 mg in poly bottle

Duramycin is the smallest known polypeptide since it has only 19 amino acids. It has a defined 3-dimensional binding structure. Duramycin binds phosphatidylethanolamine (PtdE) at a 1:1 ratio with high affinity and exclusive specificity. It enhances chloride secretion in airway epithelium.

Keep container tightly closed in a dry and well-ventilated place.

Quality Level	200,
assay	90.0%
form	powder
solubility	0.1 M HCl: 10 mg/mL
Mode of action	protein synthesis \| interferes
antibiotic activity spectrum	Gram-negative bacteria, Gram-positive bacteria
storage temp.	2-8°C

Chemical structure: imidazole

Personal Protective Equipment	Eyeshields,, Gloves,, type N95 (US),
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Econazole nitrate salt

Empirical Formula (Hill Notation):	C₁₈H₁₅Cl₃N₂O · HNO₃
CAS Number:	24169-02-6
Molecular Weight:	444.70
EC Number:	246-053-5
MDL number:	MFCD00058160
PubChem Substance ID:	24894567
NACRES:	NA.85

Econazole is a broad spectrum antimycotic similar to ketoconazole. It has some action against Gram positive bacteria. It is used topically in dermatomycoses as well as orally and parenterally. It is used for studies on processes such as platelet serotonin uptake, prostanoid biosynthesis, EDHF-mediated relaxation, and Ca2+ transport pathways in thymic lymphocytes.

Econazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. Inhibition of ergosterol results in increased cellular permeability causing leakage of cellular contents. Econazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and phospholipid biosynthesis.

Quality Level	200,
form	powder or crystals
color	white to off-white
Mode of action	cell membrane \| interferes, cell wall synthesis \| interferes, enzyme \| inhibits
antibiotic activity spectrum	Gram-positive bacteria, fungi
SMILES string	O[N+]([O-])=O.Clc1ccc(COC(Cn2ccnc2)c3ccc(Cl)cc3Cl)cc1
InChI	1S/C18H15Cl3N2O.HNO3/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)16-6-5-15(20)9-17(16)21;2-1(3)4/h1-9,12,18H,10-11H2;(H,2,3,4)
InChI key	DDXORDQKGIZAME-UHFFFAOYSA-N

pictograms	GHS07
signalword	Warning
hcodes	H302 - H315 - H319
pcodes	P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US),, Eyeshields,, Gloves,
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Elmycin A SMB00039-1MG

Empirical Formula (Hill Notation):	C₁₉H₂₀O₆
CAS Number:	128061-13-2
Molecular Weight:	344.36
MDL number:	MFCD00892568
PubChem Substance ID:	329824676
NACRES:	NA.25

Natural product derived from fungal source.

assay	≥95% (LC/MS-ELSD)
form	solid
storage temp.	−20°C
SMILES string	CC1CC(=O)C2=C(C1)CC(O)C3(O)C(O)c4c(O)cccc4C(=O)C23
InChI	1S/C19H20O6/c1-8-5-9-7-13(22)19(25)16(14(9)12(21)6-8)17(23)10-3-2-4-11(20)15(10)18(19)24/h2-4,8,13,16,18,20,22,24-25H,5-7H2,1H3
InChI key	PKPHZFVECLENRP-UHFFFAOYSA-N

Lquid, containing 10,000 Units Penicillin and 10,000 µg Streptomycin per mL.

pictograms	GHS07,GHS09
signalword	Warning
hcodes	H302 - H410
pcodes	P273 - P501
RIDADR	UN 3077 9 / PGIII
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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EmbryoMax™ Penicillin-Streptomycin Solution, 100X TMS-AB2-C

eCl@ss:	32160801
NACRES:	NA.75

Physical form

Storage and Stability

Store at -20°C upto 1 year.

Legal Information

EmbryoMax is a trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Quality Level	200,
form	liquid
Торговая марка	EmbryoMax^™, Specialty Media
application(s)	cell culture \| stem cell: suitable
input	sample type: mouse embryonic stem cell(s) sample type induced pluripotent stem cell(s)

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Enrofloxacin Extraction Kit MAK226-1KT

NACRES:

NA.25

Enrofloxacin is a fluoroquinolone antibiotic used for the treatment of pets and domestic animals and in fish farming. Minimum acceptable limits have been set for enrofloxacin residues in food samples. The enrofloxacin extraction kit enables the simultaneous separation of enrofloxacin from tissue, and the defatting of the sample during extraction in an accurate and quick manner.
We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. This product reduces solvent waste over traditional methods. Find details here,.

Enrofloxacin concentrations (ng/g) can be derived from biological specimens. Can be used for any biological food sample-shrimp, meat, liver, crab fish, etc. This kit enables the extraction of enrofloxacin for quantitation by ELISA.
Click on the following link for a video demonstration of how the kit works,

Features and Benefits

The streamlined process bypasses the centrifugation, vortexing, pipetting and solvent addition steps associated with extracting and defatting the sample. The extracted enrofloxacin can then be detected and quantified by enzyme-linked immunosorbent assay (ELISA) followed by spectrophotometric analysis.

Suitability

This kit is suitable for the extraction of enroflaxacin from a variety of samples such as biological tissue and food samples.

Principle

The Enrofloxacin Extraction Kit enables the simultaneous separation of enrofloxacin from tissue, and the defatting of the sample during extraction in an accurate and quick manner. The streamlined process bypasses the centrifugation, vortexing, pipetting and solvent addition steps associated with extracting and defatting the sample. The extracted enrofloxacin can then be detected and quantified by enzyme-linked immunosorbent assay (ELISA) followed by spectrophotometric analysis.
Enrofloxacin is typically extracted using a single solvent system containing 80% methanol in buffer. In the standard procedure, methanol containing the enrofloxacin is separated from tissue by centrifugation for 10 minutes followed by manual pipetting. The extract is then dried and reconstituted into 1 mL of 8% methanol in sample dilution buffer. The extract is subsequently defatted by adding 1 mL hexane and centrifuging. A 50 µL aliquot is taken from the bottom layer containing the defatted enrofloxacin extract and used for analysis by ELISA and spectrophotometry.
The Enrofloxacin Extraction Kit shortcuts the extraction process by eliminating the need for centrifugation, manual pipetting, and post-extraction defatting with hexane or another lipophilic solvent. After adding 80% methanol to the sample, it can be mixed manually for 15 minutes or with sonication for 5 minutes and poured through the syringe containing a filter. The eluted solution containing the enrofloxacin extract is then reconstituted in 8% methanol and a 50 µL aliquot is used for analysis by ELISA and spectrophotometry.

greener alternative product characteristics	Waste Prevention Learn more about the Principles of Green Chemistry,.
storage temp.	room temp

Epirubicin is used to inhibit topoisomerase II and DNA helicase activity. Epirubicin is used to study metastatic breast cancerand cardiac toxicity.

pictograms	GHS02,GHS06,GHS08
signalword	Danger
hcodes	H225 - H301 + H311 + H331 - H370
pcodes	P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311
Target Organs	Eyes
RIDADR	UN 3316 9
WGK Germany	WGK 2
Flash Point F	49.5 °F
Flash Point C	9.7 °C

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Epirubicin hydrochloride

Empirical Formula (Hill Notation):	C₂₇H₂₉NO₁₁ · HCl
CAS Number:	56390-09-1
Molecular Weight:	579.98
EC Number:	260-145-2
MDL number:	MFCD00941448
PubChem Substance ID:	329799084
NACRES:	NA.85

5, 10 mg in glass bottle

Epirubicin is antimitotic and cytotoxic. It inhibits nucleic acid and protein synthesis. Epirubicin may do so by forming complexes with DNA and intercalation between base pairs, by inhibiting topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, and by preventing the religation portion of the ligation-religation reaction that topoisomerase II catalyzes.
Cell-permeable anthracycline antitumor antibiotic. Antineoplastic. A stereoisomer of doxorubicin that exhibits reduced cardiotoxicity. Its antitumor actions are mediated by targeting topoisomerase II.

Quality Level	100,
biological source	synthetic
assay	90% (HPLC)
form	powder
color	red to deep red
solubility	H₂O: soluble
Mode of action	DNA synthesis \| interferes, enzyme \| inhibits
antibiotic activity spectrum	neoplastics
storage temp.	20°C
SMILES string	Cl.COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO
InChI	1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22-,27-;/m0./s1
InChI key	MWWSFMDVAYGXBV-FGBSZODSSA-N

Chemical structure: macrolide
Erythromycin is an antibiotic produced by growth of certain strains of Streptomyces erythreus. This product is composed largely of erythromycin A with small amounts of erythromycins B and C and is recommended for concentration at 100 mg/L. Concentrations between 50 and 200 mg/L have also proven effective in controlling bacterial growth. Erythromycin has been used as a motilin receptor agonist, to block respiratory glycoconjugate secretion in human airways in vitro, and for selecting plasmid-cured and recombinant lactococcus lactis MG1363 strains.

pictograms	GHS07,GHS08
signalword	Danger
hcodes	H302 - H340 - H350 - H360
pcodes	P201 - P301 + P312 + P330 - P308 + P313
Personal Protective Equipment	dust mask type N95 (US),, Eyeshields,, Gloves,
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3

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Erythromycin

Empirical Formula (Hill Notation):	C₃₇H₆₇NO₁₃
CAS Number:	114-07-8
Molecular Weight:	733.93
Beilstein/REAXYS Number:	75279
EC Number:	204-040-1
MDL number:	MFCD00084654
PubChem Substance ID:	24894612
NACRES:	NA.76

Erythromycin has been used:

as a supplement for nutrient broth medium for culturing green fluorescent protein (GFP)- expressing E. coli
as a model drug to determine small intestinal (SMI) microtissue viability using the MTT assay{254
as an antibiotic to study the treatment strategies of chronic infections

1, 5 g in poly bottle

Mode of Action: Erythromycin acts by inhibiting elongation at the transpeptidation step, specifically aminoacyl translocation from the A-site to P-site by binding to the 50s subunit of the bacterial 70s rRNA complex.
Antimicrobial Spectrum: This product acts against both gram-negative and gram-positive bacteria.

This product is stable in solution at 37°C for 3 days. Stock solutions should be stored at 2-8°C.

This product is soluble in water at 2 mg/mL, with a 0.067% solution in water yielding a pH of 8.0-10.5. It is also soluble in ethanol at 50 mg/mL, yielding a clear, colorless to faint yellow solution. It is freely soluble in alcohol, acetone, chloroform, acetonitrile and ethyl acetate but forms salts with acids. All solutions should be protected from light.

Quality Level	200,
product line	BioReagent
form	powder
potency	850 µg per mg
application(s)	cell culture \| mammalian: suitable
impurities	0.1 EU/mg endotoxin
color	white
mp	133 °C
solubility	2 M HCl: 50 mg/mL (Stock solutions should be stored at 2-8 °C. Stable at 37 °C for 3 days.), ethanol: soluble (Stock solutions should be stored at 2-8 °C. Stable at 37 °C for 3 days.)
Mode of action	protein synthesis \| interferes
antibiotic activity spectrum	Gram-negative bacteria, Gram-positive bacteria
SMILES string	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O
InChI	1S/C37H67NO13/c1-14-25-37(10,45)30(41)20(4)27(39)18(2)16-35(8,44)32(51-34-28(40)24(38(11)12)15-19(3)47-34)21(5)29(22(6)33(43)49-25)50-26-17-36(9,46-13)31(42)23(7)48-26/h18-26,28-32,34,40-42,44-45H,14-17H2,1-13H3/t18-,19-,20+,21+,22-,23+,24+,25-,26+,28-,29+,30-,31+,32-,34+,35-,36-,37-/m1/s1
InChI key	ULGZDMOVFRHVEP-RWJQBGPGSA-N
Gene Information	human ... ABCB1(5243), CYP3A4(1576), MLNR(2862) mouse ... Abcb1a(18671), Abcb1b(18669)

Chemical structure: macrolide

Personal Protective Equipment	Eyeshields,, Gloves,, type N95 (US),
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Erythromycin ethyl succinate

Empirical Formula (Hill Notation):	C₄₃H₇₅NO₁₆
CAS Number:	1264-62-6
Molecular Weight:	862.05
EC Number:	215-033-8
MDL number:	MFCD00084692
PubChem Substance ID:	24894684
NACRES:	NA.85

Erythromycin ethyl succinate is used to study erythromycin-resistant Streptococcus pyogenes and Streptococcus pneumoniae. It has been used to study down-regulation of motilin receptors on rabbit colon myocytes and lethal mutations in outer membrane genes omsA and firA in Salmonella typhimurium.

Erythromycin inhibits protein synthesis (elongation) at the level of transpeptidation (aminoacyl translocation A-site to P-site) by binding to the 50s subunit of the bacterial 70s rRNA complex.

Quality Level	100,
biological source	microbial
form	solid
potency	≥780 μg per mg
color	white
solubility	ethanol: 50 mg/mL
Mode of action	protein synthesis \| interferes
antibiotic activity spectrum	Gram-positive bacteria
SMILES string	CCOC(=O)CCC(=O)OC1C(CC(C)OC1OC2C(C)C(OC3CC(C)(OC)C(O)C(C)O3)C(C)C(=O)OC(CC)C(C)(O)C(O)C(C)C(=O)C(C)CC2(C)O)N(C)C
InChI	1S/C43H75NO16/c1-15-29-43(11,52)36(48)24(5)33(47)22(3)20-41(9,51)38(25(6)34(26(7)39(50)57-29)59-32-21-42(10,53-14)37(49)27(8)56-32)60-40-35(28(44(12)13)19-23(4)55-40)58-31(46)18-17-30(45)54-16-2/h22-29,32,34-38,40,48-49,51-52H,15-21H2,1-14H3
InChI key	NSYZCCDSJNWWJL-UHFFFAOYSA-N

pictograms	GHS08
signalword	Danger
hcodes	H317 - H334
pcodes	P261 - P280 - P342 + P311
Personal Protective Equipment	dust mask type N95 (US),, Eyeshields,, Faceshields,, Gloves,
RIDADR	NONH for all modes of transport
WGK Germany	WGK 2

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Erythromycin standard solution 45703-10ML-F

Empirical Formula (Hill Notation):	C₃₇H₆₇NO₁₃
CAS Number:	114-07-8
Molecular Weight:	733.93
Beilstein/REAXYS Number:	8183758
MDL number:	MFCD00084654
PubChem Substance ID:	329756912
NACRES:	NA.85

Chemical structure: macrolide

Erythromycin is an antibiotic produced by growth of certain strains of Streptomyces erythreus. This product is composed largely of erythromycin A with small amounts of erythromycins B and C and is recommended for concentration at 100 mg/L. Concentrations between 50 and 200 mg/L have also proven effective in controlling bacterial growth. Erythromycin has been used as a motilin receptor agonist, to block respiratory glycoconjugate secretion in human airways in vitro, and for selecting plasmid-cured and recombinant lactococcus lactis MG1363 strains. .

10 ml

This Erythromycin solution is concentrated at 1 mg/mL in H2O and is stable in solution at 37°C for 3 days. Stock solutions should be stored at 2-8°C.

Keep container tightly closed in a dry and well-ventilated place. Store under inert gas.

biological source	Streptomyces erythreus (strains)
Agency/Method	EPA 1694
form	liquid
concentration	1 mg/mL in H₂O
color	colorless
Featured Industry	Environmental
Mode of action	protein synthesis \| interferes
antibiotic activity spectrum	Gram-positive bacteria
storage temp.	2-8°C
SMILES string	CC[C@H]1OC(=O)[C@H](C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)C(C)C(OC3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)C(O)[C@]1(C)O
InChI	1S/C37H67NO13/c1-14-25-37(10,45)30(41)20(4)27(39)18(2)16-35(8,44)32(51-34-28(40)24(38(11)12)15-19(3)47-34)21(5)29(22(6)33(43)49-25)50-26-17-36(9,46-13)31(42)23(7)48-26/h18-26,28-32,34,40-42,44-45H,14-17H2,1-13H3/t18-,19-,20+,21+,22-,23+,24+,25-,26+,28-,29+,30-,31+,32-,34+,35-,36-,37-/m1/s1
InChI key	ULGZDMOVFRHVEP-RWJQBGPGSA-N

Ethambutol is an antimycobacterial used to treat tuberculosis in combination with other antibiotics to reduce the development of drug resistance. It has been used to study multidrug-resistant tuberculosis (MDR-TB) in highest-incidence-rate areas in China.

Personal Protective Equipment	Eyeshields,, Gloves,
RIDADR	NONH for all modes of transport
Flash Point F	Not applicable
Flash Point C	Not applicable

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Ethambutol dihydrochloride

Empirical Formula (Hill Notation):	C₁₀H₂₄N₂O₂ · 2HCl
CAS Number:	1070-11-7
Molecular Weight:	277.23
EC Number:	213-970-7
MDL number:	MFCD21364080
PubChem Substance ID:	24894566
NACRES:	NA.85

25, 100 g in poly bottle

Ethambutol is bacteriostatic against actively growing TB bacilli. Mycolic acids attach to the 5-hydroxyl groups of D-arabinose residues of arabinogalactan and form mycolyl-arabinogalactan-peptidoglycan complex in the cell wall. Ethambutol disrupts arabinogalactan synthesis by inhibiting arabinosyltransferases, specifically those in Mycobacterium, interfering with the biosynthesis of arabinogalactans found in the cell wall of mycobacteria and leading to increased cell wall permeability.

Quality Level	200,
form	powder
optical activity	[]25/D 6.0 to 6.7°, c = 10 in water
color	white
solubility	H₂O: 50 mg/mL
Mode of action	cell wall synthesis \| interferes
antibiotic activity spectrum	mycobacteria
SMILES string	CC[C@@H](CO)NCCN[C@H](CO)CC.Cl.Cl
InChI	1S/C10H24N2O2.2ClH/c1-3-9(7-13)11-5-6-12-10(4-2)8-14;;/h9-14H,3-8H2,1-2H3;2*1H/t9-,10-;;/m0../s1
InChI key	AUAHHJJRFHRVPV-BZDVOYDHSA-N

pictograms	GHS07
signalword	Warning
hcodes	H302
pcodes	P264 - P270 - P301 + P312 - P501
Personal Protective Equipment	Eyeshields,, Gloves,, type P1 (EN143) respirator filter,, type P3 (EN 143) respirator cartridges,
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Fengycin SMB00292-5MG

Empirical Formula (Hill Notation):	C₇₂H₁₁₀N₁₂O₂₀
Molecular Weight:	1463.71
NACRES:	NA.85

Chemical structure: peptide
Fengycin is a lipopeptide complex which is synthesized by Bacillus subtilis strain F-29-3. It is an antifungal compound, and is made up of two components namely, fengycin A and fengycin B. Fengycin A contains 1 D-Ala, 1 L-Ile, 1 L-Pro, 1 D-allo-Thr, 3 L-Glx, 1 D-Tyr, 1 L-Tyr, 1 D-Orn, whereas fengycin B contains D-Val instead of D-Ala.

Fengycin may be used for the sterilization of E. coli., and for the inactivation of spores of Bacillus cereus.

Fengycin shows antifungal properties against filamentous fungi, but has no action against yeast and bacteria. Certain unsaturated fatty acids facilitate the antifungal property, whereas sterols, phospholipids and oleic acid act as antagonists. It produces morphological abnormalities in fungi including curling, bulging and empyting of hyphae. Thus, it mainly functions through its effects on the plasma membrane.

Store at 2 to 8 °C. (Keep container tightly closed in a dry and well-ventilated place. Light sensitive.)

5MG

Storage and Stability

Keep container tightly closed in a dry and well-ventilated place. Light sensitive.

Quality Level	200,
biological source	Bacillus subtilis
assay	90%
form	powder
color	faintly yellow to light brown
Mode of action	cell membrane \| interferes
antibiotic activity spectrum	fungi
storage temp.	2-8°C

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Fleroxacin F6807-1G

Empirical Formula (Hill Notation):	C₁₇H₁₈F₃N₃O₃
CAS Number:	79660-72-3
Molecular Weight:	369.34
MDL number:	MFCD00864880
PubChem Substance ID:	329799758
NACRES:	NA.85

Fleroxacin is a broad-spectrum antimicrobial fluoroquinolone. It is used in pharmacokinetic studies and is used to study the treatment of intra-abdominal abscesses and travellers diarrhea.

1 g in poly bottle

Fleroxacin is a synthetic trifluorinated quinolone with antimicrobial activity against a variety of pathogens, including mycobacteria, mycoplasmas, chlamydiae, and legionellae. It strongly inhibits the DNA-supercoiling activity of DNA gyrase and DNA topoisomerase 2, which results in cell death.

assay	≥98% (HPLC)
Quality Level	100,
form	solid
color	white to off-white
solubility	0.1 M NaOH: 10 mg/mL
Mode of action	DNA synthesis \| interferes, enzyme \| inhibits
antibiotic activity spectrum	Gram-negative bacteria, Gram-positive bacteria, mycobacteria, mycoplasma
storage temp.	−20°C
SMILES string	CN1CCN(CC1)c2c(F)cc3C(=O)C(=CN(CCF)c3c2F)C(O)=O
InChI	1S/C17H18F3N3O3/c1-21-4-6-22(7-5-21)15-12(19)8-10-14(13(15)20)23(3-2-18)9-11(16(10)24)17(25)26/h8-9H,2-7H2,1H3,(H,25,26)
InChI key	XBJBPGROQZJDOJ-UHFFFAOYSA-N

Fludarabine is a purine analog included in the category of DNA-damaging drugs with well-known efficacy in B-cell chronic lymphocytic leukemia (B-CLL).

RIDADR	NONH for all modes of transport
WGK Germany	WGK 2
Flash Point F	Not applicable
Flash Point C	Not applicable

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Fludarabine phosphate

Empirical Formula (Hill Notation):	C₁₀H₁₃FN₅O₇P
CAS Number:	75607-67-9
Molecular Weight:	365.21
NACRES:	NA.85

Fludarabine represses DNA replication and suppresses the nucleotide metabolism by inhibiting the enzyme ribonucleotide reductase.

form	powder
Quality Level	200,
color	white
solubility	DMSO: 1 mg/mL
Mode of action	DNA synthesis \| interferes
antibiotic activity spectrum	neoplastics
storage temp.	−20°C
InChI	1S/C10H13FN5O7P/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(18)5(17)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,17-18H,1H2,(H2,12,14,15)(H2,19,20,21)
InChI key	GIUYCYHIANZCFB-UHFFFAOYSA-N

Chemical structure: fluoroquinolone

pictograms	GHS08
signalword	Warning
hcodes	H341 - H361d
pcodes	P201 - P202 - P280 - P308 + P313 - P405 - P501
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Flumequine

Empirical Formula (Hill Notation):	C₁₄H₁₂FNO₃
CAS Number:	42835-25-6
Molecular Weight:	261.25
Beilstein/REAXYS Number:	490724
EC Number:	255-962-6
MDL number:	MFCD00079298
PubChem Substance ID:	24894926
NACRES:	NA.85

Flumequine inhibits topoisomerases, which are needed for the transcription and replication of bacterial DNA. The inhibition of the topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. Therefore, DNA replication and transcription is inhibited .

Quality Level	200,
assay	≥97.0% (HPLC)
form	powder
color	white to off-white
Mode of action	DNA synthesis \| interferes, enzyme \| inhibits
antibiotic activity spectrum	Gram-negative bacteria, Gram-positive bacteria
SMILES string	CC1CCc2cc(F)cc3C(=O)C(=CN1c23)C(O)=O
InChI	1S/C14H12FNO3/c1-7-2-3-8-4-9(15)5-10-12(8)16(7)6-11(13(10)17)14(18)19/h4-7H,2-3H2,1H3,(H,18,19)
InChI key	DPSPPJIUMHPXMA-UHFFFAOYSA-N

Flumethasone pivalate is a topical difluorinated corticosteroid ester with anti-inflammatory, antipruritic and vasoconstrictive properties. A prompt decrease in inflammation, exudation and itching is experienced after application. It is commonly used in veterinary practice and has been used in cortisol assays to study early porcine conceptus development.

Personal Protective Equipment	Eyeshields,, Gloves,, type N95 (US),
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Flumethasone

Empirical Formula (Hill Notation):	C₂₂H₂₈F₂O₅
CAS Number:	2135-17-3
Molecular Weight:	410.45
EC Number:	218-370-9
MDL number:	MFCD00056464
PubChem Substance ID:	24894998
NACRES:	NA.85

Flumethasone is a glucocorticoid receptor agonist used in studies on plasma transcortin binding. It binds to the nucleus causing a variety of genetic activation and repressions. The anti-inflammatory actions of flumethasone is thought to involve lipocortins and phospholipase A2 inhibitory proteins, which results in the inhibition of arachidonic acid and the control of prostaglandin and leukotriene biosynthesis. Flumethasone suppresses the immune system due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding .

Bottomless glass bottle. Contents are inside inserted fused cone.

form	powder
Quality Level	200,
color	white to off-white
solubility	acetic acid: 10 mg/mL
Mode of action	cell membrane \| interferes
storage temp.	2-8°C
SMILES string	[H][C@@]12C[C@@H](C)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]3(F)[C@@]2([H])C[C@H](F)C4=CC(=O)C=C[C@]34C
InChI	1S/C22H28F2O5/c1-11-6-13-14-8-16(23)15-7-12(26)4-5-19(15,2)21(14,24)17(27)9-20(13,3)22(11,29)18(28)10-25/h4-5,7,11,13-14,16-17,25,27,29H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19+,20+,21+,22+/m1/s1
InChI key	WXURHACBFYSXBI-GQKYHHCASA-N

Flumethasone pivalate is a topical difluorinated corticosteroid ester with anti-inflammatory, antipruritic and vasoconstrictive properties. A prompt decrease in inflammation, exudation and itching is experienced after application. It is used to study adrenocortical suppression, plasma transcortin binding, and cutaneous atrophy and telangiectasia.

pictograms	GHS08
signalword	Warning
hcodes	H351
pcodes	P281
Personal Protective Equipment	Eyeshields,, Gloves,, type P1 (EN143) respirator filter,, type P3 (EN 143) respirator cartridges,
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Flumethasone pivalate

Empirical Formula (Hill Notation):	C₂₇H₃₆F₂O₆
CAS Number:	2002-29-1
Molecular Weight:	494.57
EC Number:	217-901-1
MDL number:	MFCD00079287
PubChem Substance ID:	24894735
NACRES:	NA.85

100 mg in poly bottle

Flumethasone pivalate is a glucocorticoid receptor agonist used in studies on plasma transcortin binding. It binds to the nucleus causing a variety of genetic activations and repressions. The anti-inflammatory action of flumethasone is thought to involve lipocortins and phospholipase A2 inhibitory proteins, which results in the inhibition of arachidonic acid and the control of prostaglandin and leukotriene biosynthesis. Flumethasone suppresses the immune system due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding.

Quality Level	100,
form	solid
optical activity	[α]25/D 71.0 to 82.0°, c = 1 in dioxane
solubility	dioxane: 4.0 mL, clear, colorless to very faintly yellow (50 mg + 4.0 mL dioxane)
Mode of action	cell membrane \| interferes
SMILES string	[H][C@@]12C[C@@H](C)[C@](O)(C(=O)COC(=O)C(C)(C)C)[C@@]1(C)C[C@H](O)[C@@]3(F)[C@@]2([H])C[C@H](F)C4=CC(=O)C=C[C@]34C
InChI	1S/C27H36F2O6/c1-14-9-16-17-11-19(28)18-10-15(30)7-8-24(18,5)26(17,29)20(31)12-25(16,6)27(14,34)21(32)13-35-22(33)23(2,3)4/h7-8,10,14,16-17,19-20,31,34H,9,11-13H2,1-6H3/t14-,16+,17+,19+,20+,24+,25+,26+,27+/m1/s1
InChI key	JWRMHDSINXPDHB-OJAGFMMFSA-N
Gene Information	human ... NR3C1(2908)

Flurbiprofen is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic, analgesic, and antifungal activity. Oral formulations of flurbiprofen may be used to treat rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen is also used topically during ocular surgery to prevent or reduce intraoperative miosis. Flurbiprofen is structurally and pharmacologically related to ibuprofen. It is used to study the pathophysiological steps of NSAID enteropathy in the rat and the biotransformation of flurbiprofen by Cunninghamella species.

pictograms	GHS08
signalword	Warning
hcodes	H351
pcodes	P280
Personal Protective Equipment	Eyeshields,, Gloves,, type P1 (EN143) respirator filter,, type P3 (EN 143) respirator cartridges,
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Flurbiprofen

Empirical Formula (Hill Notation):	C₁₅H₁₃FO₂
Linear Formula:	C₆H₅C₆H₃(F)CH(CH₃)CO₂H
CAS Number:	5104-49-4
Molecular Weight:	244.26
EC Number:	225-827-6
MDL number:	MFCD00079303
PubChem Substance ID:	24894968

1, 5, 25 g in poly bottle

Fluibiprofen is a cyclooxygenase (COX) inhibitor, which is an enzyme responsible for the conversion of arachidonic acid to prostaglandin G2 (PGG2) and PGG2 to prostaglandin H2 (PGH2) in the prostaglandin synthesis pathway. This decreases the prostaglandins which cause inflammation, pain, swelling and fever. Flurbiprofen inhibits the activity of both COX-1 and -2. The S enantiomer inhibits prostaglandin synthesis and has both anti-inflammatory and analgesic activity, while the R enantiomer does not inhibit prostaglandin synthesis and displays only analgesic activity.

Quality Level	100,
biological source	synthetic
assay	98.5% (HPLC)
form	powder
color	white to off-white
mp	110-112 °C (lit.)
solubility	methanol: 50 mg/mL
Mode of action	enzyme \| inhibits
antibiotic activity spectrum	fungi
SMILES string	CC(C(O)=O)c1ccc(c(F)c1)-c2ccccc2
InChI	1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18)
InChI key	SYTBZMRGLBWNTM-UHFFFAOYSA-N
Gene Information	human ... ALB(213), APP(351), CYP1A2(1544), CYP2C9(1559), PTGS1(5742), PTGS2(5743) rat ... Ptgs1(24693)

Formycin A is an adenosine analog, and is cytotoxic in nature. It acts as a substrate for the human enzymes human erythrocytic adenosine deaminase and adenosine kinase.
Chemical structure: nucleoside

pictograms	GHS06
signalword	Danger
hcodes	H301
pcodes	P264 - P270 - P301 + P310 + P330 - P405 - P501
Personal Protective Equipment	Eyeshields,, Faceshields,, Gloves,, type P2 (EN 143) respirator cartridges,
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Formycin A

Empirical Formula (Hill Notation):	C₁₀H₁₃N₅O₄
CAS Number:	6742-12-7
Molecular Weight:	267.24
Beilstein/REAXYS Number:	624229
MDL number:	MFCD00036807
PubChem Substance ID:	329824924
NACRES:	NA.85

Formycin A possess antitumor function, along with its antibacterial and antiviral activity.
Formycin A (FA) is a C-nucleoside that inhibits the E.coli enzyme purine nucleoside phosphorylase (PNP). FA was found to upsurge insulin release elevated by glucose, and was also shown to inhibit 5-Methylthioadenosine/S-adenosylhomocysteine (MTA/AdoHcy) nucleosidase, an enzyme important in the recycling of methionine. Research has shown FA is an antiretroviral agent against HIV-1, targeting reverse transcription.

10MG

Store the product sealed at –20 °C. Under these conditions the product is stable for at least 4 years.
Keep container tightly closed in a dry and well-ventilated place.

biological source	Streptomyces kaniharaensis
Quality Level	200,
assay	98% (HPLC)
form	powder
storage condition	(Keep container tightly closed in a dry and well-ventilated place.)
color	white to off-white
solubility	DMSO: soluble 1 mg/mL, H₂O: soluble 3 mg/mL
Mode of action	enzyme \| inhibits
antibiotic activity spectrum	viruses (Antiretroviral)
storage temp.	20°C
SMILES string	Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O
InChI	1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1
InChI key	OIRDTQYFTABQOQ-KQYNXXCUSA-N
Gene Information	human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140)

Furazolidone is a nitrofuran derivative with antiprotozoal and antibacterial activity. Furazolidone binds bacterial DNA, which leads to the gradual inhibition of monoamine oxidase. It is used to treat anorexia and antagonism of thiamin utilization in poultry. Furazolidone increases thapsigargin-sensitive Ca2+-ATPase in chick cardiac myocytes.

pictograms	GHS07
signalword	Warning
hcodes	H302
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Furazolidone

Empirical Formula (Hill Notation):	C₈H₇N₃O₅
CAS Number:	67-45-8
Molecular Weight:	225.16
Beilstein/REAXYS Number:	8317414
EC Number:	200-653-3
MDL number:	MFCD00010550
PubChem Substance ID:	24894997
NACRES:	NA.85

10, 25, 100 g in glass bottle

Furazolidone and its generated free radicals, may bind to DNA and induce cross-links. Bacterial DNA is particularly susceptible to this drug, which results in high levels of mutations (transitions and transversions) in the bacterial chromosome. Its mechanism of action minimizes the development of resistant organisms. Furazolidone is a monoamine oxidase (MAO) inhibitor and is used as a DNA interstrand cross-linking agent.

Quality Level	200,
biological source	synthetic
form	powder
color	yellow
mp	256-256 °C
solubility	formic acid: 50 mg/mL
Mode of action	enzyme \| inhibits
antibiotic activity spectrum	Gram-positive bacteria, parasites
SMILES string	[O-][N+](=O)c1ccc(\C=N\N2CCOC2=O)o1
InChI	1S/C8H7N3O5/c12-8-10(3-4-15-8)9-5-6-1-2-7(16-6)11(13)14/h1-2,5H,3-4H2/b9-5+
InChI key	PLHJDBGFXBMTGZ-WEVVVXLNSA-N

Chemical structure: aminoglycoside
G-418 is an aminoglycoside antibiotic, which is produced by Micromonospora rhodorangea NRRL 5326 strain. It has a broad range of antibacterial activity both in vivo and in vitro. It also shows activity against protozoa, cecal amoebiasis, and helminthes. It is commonly known as geneticin selective antibiotic.

pictograms	GHS08
signalword	Warning
hcodes	H361
pcodes	P281
Personal Protective Equipment	Eyeshields,, Gloves,, type P1 (EN143) respirator filter,, type P3 (EN 143) respirator cartridges,
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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G 418 disulfate salt

Empirical Formula (Hill Notation):	C₂₀H₄₀N₄O₁₀ · 2H₂SO₄
CAS Number:	108321-42-2
Molecular Weight:	692.71
MDL number:	MFCD00058314
PubChem Substance ID:	24890581
NACRES:	NA.76

G418 disulfate salt is an aminoglycoside antibiotic similar in structure to gentamicin used for selection and maintenance of prokaryotic and eukaryotic cells transfected with a iNOS promoter construct and neomycin resistance gene†. Optimal concentrations for selection and maintenance vary by cell lines. Bacteria and algae require 5 μg/mL or less while animal cells may require 300-500 μg/mL.

1, 5, 25 g in glass bottle

G-418 inhibits protein synthesis at the early stages of elongation, post-initiation, at the initiation stage of translation as well as just before the initiation stage of translation.

The product is stable for two years when stored at 2-8°C. Stock solutions are stable at 37°C for 8 days.

G418 powder is soluble in water at 100 mg/mL.

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Quality Level	200
product line	BioReagent
form	powder
optical activity	[]/D (Specific Rotation: +104.4^o(c=0.3% in H₂O at 26^oC))
potency	720 µg per mg (Dried basis)
mol wt	692.7
packaging	pkg of 1 g, pkg of 25 g, pkg of 5 g
application(s)	cell culture \| mammalian: suitable
color	white to off-white
solubility	H₂O: 100 mg/mL (As a stock solution. Stock solutions should be stored at 2-8°C. Stable at 37°C for 8 days.)
Mode of action	protein synthesis \| interferes
antibiotic activity spectrum	Gram-negative bacteria
storage temp.	2-8°C
SMILES string	OS(O)(=O)=O.OS(O)(=O)=O.CN[C@H]1[C@H](O)[C@@H](OC[C@@]1(C)O)O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@H]3O[C@H]([C@H](C)O)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O
InChI	1S/C20H40N4O10.2H2O4S/c1-6(25)14-11(27)10(26)9(23)18(32-14)33-15-7(21)4-8(22)16(12(15)28)34-19-13(29)17(24-3)20(2,30)5-31-19;21-5(2,3)4/h6-19,24-30H,4-5,21-23H2,1-3H3;2(H2,1,2,3,4)/t6?,7-,8+,9+,10+,11-,12-,13-,14+,15+,16-,17-,18+,19-,20+;;/m0../s1
InChI key	UHEPSJJJMTWUCP-NKCAIAFTSA-N

Pictograms	GHS08
Signal Word	Danger
Hazard Statements	H317 - H334
Precautionary Statements	P261 - P272 - P280 - P284 - P302 + P352 - P304 + P340 + P312
Personal Protective Equipment	Eyeshields, Gloves, type N95 (US)
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3

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G 418 disulfate salt solution

Empirical Formula (Hill Notation):	C₂₀H₄₀N₄O₁₀ · 2H₂SO₄
CAS Number:	108321-42-2
Molecular Weight:	692.71
MDL number:	MFCD00058314
PubChem Substance ID:	24895333
NACRES:	NA.76

G418 disulfate is an aminoglycoside antibiotic similar in structure to gentamicin used for selection and maintenance of prokaryotic and eukaryotic cells. Optimal concentrations for selection and maintenance vary by cell lines. Bacteria and algae require 5 μg/mL or less while animal cells may require 300-500 μg/mL.

Mode of Action: G418 blocks polypeptide synthesis and protein elongation by inhibiting synthesis at the 70S and 80S ribosomes.

Antimicrobial Spectrum: G418 selects for cells stably transfected with an iNOS promoter construct and neomycin resistance gene and shows activity against protozoa and helminthes.

The product is stable for two years when stored at 2-8°C.

biological source	Micromonospora echinospora
Quality Level	200,
sterility	0.1 µm filtered
product line	BioReagent
form	solution
potency	50-60 mg per mL
mol wt	692.7
packaging	pkg of 10 and 100 mL
concentration	50 mg/mL in H₂O
application(s)	cell culture \| mammalian: suitable
impurities	endotoxin, tested
color	colorless
solubility	H₂O: 50 mg/mL, clear
Mode of action	protein synthesis \| interferes
antibiotic activity spectrum	parasites
storage temp.	2-8°C
SMILES string	OS(O)(=O)=O.OS(O)(=O)=O.CN[C@H]1[C@H](O)[C@@H](OC[C@@]1(C)O)O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@H]3O[C@H]([C@H](C)O)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O
InChI	1S/C20H40N4O10.2H2O4S/c1-6(25)14-11(27)10(26)9(23)18(32-14)33-15-7(21)4-8(22)16(12(15)28)34-19-13(29)17(24-3)20(2,30)5-31-19;21-5(2,3)4/h6-19,24-30H,4-5,21-23H2,1-3H3;2(H2,1,2,3,4)/t6?,7-,8+,9+,10+,11-,12-,13-,14+,15+,16-,17-,18+,19-,20+;;/m0../s1
InChI key	UHEPSJJJMTWUCP-NKCAIAFTSA-N

Chemical structure: benzenoid

pictograms	GHS08
signalword	Danger
hcodes	H317 - H334
pcodes	P261 - P272 - P280 - P284 - P302 + P352 - P333 + P313
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Geldanamycin from Streptomyces hygroscopicus

Empirical Formula (Hill Notation):	C₂₉H₄₀N₂O₉
CAS Number:	30562-34-6
Molecular Weight:	560.64
MDL number:	MFCD00274570
PubChem Substance ID:	329799914
NACRES:	NA.77

1 mg in glass bottle

This compound is featured on the Met, page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here,.
This compound is a featured product for Kinase Phosphatase Biology research. Click here, to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm,.

Features and Benefits

sterility	non-sterile
Quality Level	300,
assay	98% (HPLC)
form	powder
color	yellow to orange
solubility	DMSO: soluble
Mode of action	enzyme \| inhibits
antibiotic activity spectrum	neoplastics
storage temp.	20°C
SMILES string	CO[C@H]1C[C@H](C)CC2=C(OC)C(=O)C=C(NC(=O)\C(C)=C\C=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)C2=O
InChI	1S/C29H40N2O9/c1-15-11-19-25(34)20(14-21(32)27(19)39-7)31-28(35)16(2)9-8-10-22(37-5)26(40-29(30)36)18(4)13-17(3)24(33)23(12-15)38-6/h8-10,13-15,17,22-24,26,33H,11-12H2,1-7H3,(H2,30,36)(H,31,35)/b10-8-,16-9+,18-13+/t15-,17+,22+,23+,24-,26+/m1/s1
InChI key	QTQAWLPCGQOSGP-KSRBKZBZSA-N

Chemical structure: benzenoid

Personal Protective Equipment	Eyeshields,, Gloves,, type N95 (US),
RIDADR	NONH for all modes of transport
WGK Germany	WGK 2
Flash Point F	Not applicable
Flash Point C	Not applicable

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Geldanamycin Ready Made Solution

Empirical Formula (Hill Notation):	C₂₉H₄₀N₂O₉
CAS Number:	30562-34-6
Molecular Weight:	560.64
NACRES:	NA.77

Geldanamycin Ready-Made Solution has been used as a heat shock protein 90 (Hsp90) inhibitor to pre-treat proteosome holo-enzyme during proteasome assay to study the role of proteasome on fibril fragmentation.

Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines. Geldanamycin binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation of proteins and the cellular stress response. In addition, Geldanamycin is a potent inhibitor of the nuclear hormone receptor family.
Geldanamycin is a benzoquinone ansamycin and is a well known tyrosine kinase inhibitor. It possesses anticancer effects and shows therapeutic effects against osteosarcoma.

biological source	Streptomyces hygroscopicus
Quality Level	200,
form	DMSO solution
storage condition	protect from light
concentration	1 mg/mL
Mode of action	enzyme \| inhibits
antibiotic activity spectrum	neoplastics
shipped in	dry ice
storage temp.	20°C

Chemical structure: benzenoid

WGK Germany	WGK 1
Flash Point F	188.6 °F
Flash Point C	87 °C

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Geldanamycin-FITC

Empirical Formula (Hill Notation):	C₅₅H₆₃N₅O₁₃S
Molecular Weight:	1034.18
NACRES:	NA.77

Geldanamycin-FITC is a fluorescent derivative of geldanamycin. It is used as a fluorescent tracer for heat shock protein 90 (HSP90) inhibitors in fluorescence polarization (FP) competition binding assay.
Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines. Geldanamycin binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation of proteins and the cellular stress response. In addition, Geldanamycin is a potent inhibitor of the nuclear hormone receptor family.

biological source	Streptomyces hygroscopicus
Quality Level	200,
assay	98% (HPLC)
form	powder
storage condition	protect from light
color	yellow to yellow-orange
solubility	DMSO: soluble 5 mg/mL
Mode of action	enzyme \| inhibits
antibiotic activity spectrum	neoplastics
storage temp.	20°C

Gentamicin, also known as gentiomycin C, is an aminoglycoside, which is naturally produced by Gram-negative bacteria. This antibiotic functions by preventing protein synthesis. Gentamicin sulfate prevents the growth of both Gram positive and Gram negative bacteria, in vivo and in vitro. In tissue culture, gentamicin sulfate is used to inhibit the growth of various strains of mycoplasma.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Gentamicin solution

CAS Number:	1405-41-0
MDL number:	MFCD00270181
eCl@ss:	42020823
PubChem Substance ID:	329799839
NACRES:	NA.76

Gentamicin solution has been used as an antibiotic component in eukaryotic cell culture and bacterial culture.
Gentamicin sulfate is a broad-spectrum antibiotic used as a selection agent (gentamicin-resistance gene) in molecular biology and cell culture applications. This product is formulated to contain 50 mg/mL Gentamicin in deionized water and is recommended for use in eukaryotic cell culture at a volume of 1 milliliter per liter.
Gentamicin sulfate solution has been used as a component of different types of culture media.

Gentamicin is recommended for treating sepsis during emergency treatment. It is an alternate to ceftriaxone for treating genital infection.
Mode of Action: Gentamicin inhibits protein synthesis by binding to the 30S subunit of the ribosome.
Antimicrobial spectrum: Includes Gram-negative and Gram-positive bacteria, including strains resistant to tetracycline, chloramphenicol, kanamycin and colistin, particularly strains of Pseudomonas, Proteus, Staphylococcus and Streptococcus.

Components

Gentamicin is an aminoglycoside complex produced by fermentation of Micromonospora purpurea or M. echinospora. It is used as the sulfate salt. There are three components, each consisting of five basic nitrogens and requiresing five equivalents of sulfuric acid per mole of gentamicin base.

The product is stable at 37° for 5 days and is stored at 2-8°C.

Quality Level	300
biological source	microbial
sterility	0.1 µm filtered
product line	BioReagent
form	liquid
potency	50-60 mg per mL
concentration	50 mg/mL in deionized water
application(s)	cell culture \| mammalian: suitable
impurities	endotoxin, tested
color	colorless to light yellow
density	1.000 g/cm³
Mode of action	protein synthesis \| interferes
antibiotic activity spectrum	Gram-negative bacteria, Gram-positive bacteria, mycoplasma
storage temp.	2-8°C
SMILES string	OS(O)(=O)=O.CN[C@@H]1[C@@H](O)[C@H](OC[C@]1(C)O)O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@H]3O[C@H](CN)CC[C@H]3N)[C@@H]2O.CN[C@@H]4[C@@H](O)[C@H](OC[C@]4(C)O)O[C@H]5[C@H](N)C[C@H](N)[C@@H](O[C@H]6O[C@@H](CC[C@H]6N)[C@@H](C)N)[C@@H]5O.CN[C@H](C)[C@@H]7CC[C@@H](N)[C@H](O7)O[C@@H]8[C@@H](N)C[C@@H](N)[C@H](O[C@H]9OC[C@](C)(O)[C@H](NC)[C@H]9O)[C@H]8O
InChI	1S/C21H43N5O7.C20H41N5O7.C19H39N5O7.H2O4S/c1-9(25-3)13-6-5-10(22)19(31-13)32-16-11(23)7-12(24)17(14(16)27)33-20-15(28)18(26-4)21(2,29)8-30-20;1-8(21)12-5-4-9(22)18(30-12)31-15-10(23)6-11(24)16(13(15)26)32-19-14(27)17(25-3)20(2,28)7-29-19;1-19(27)7-28-18(13(26)16(19)24-2)31-15-11(23)5-10(22)14(12(15)25)30-17-9(21)4-3-8(6-20)29-17;1-5(2,3)4/h9-20,25-29H,5-8,22-24H2,1-4H3;8-19,25-28H,4-7,21-24H2,1-3H3;8-18,24-27H,3-7,20-23H2,1-2H3;(H2,1,2,3,4)/t9-,10-,11+,12-,13+,14+,15-,16-,17+,18-,19-,20-,21+;8-,9-,10+,11-,12+,13+,14-,15-,16+,17-,18-,19-,20+;8-,9+,10-,11+,12-,13+,14+,15-,16+,17+,18+,19-;/m110./s1
InChI key	RDEIXVOBVLKYNT-HDZPSJEVSA-N

Pictograms	GHS07
Signal Word	Warning
Hazard Statements	H317
Precautionary Statements	P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
RIDADR	NONH for all modes of transport
WGK Germany	WGK 2
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

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Gentamicin sulfate

CAS Number:	1405-41-0
EC Number:	215-778-9
MDL number:	MFCD00270181
eCl@ss:	42020823
PubChem Substance ID:	329799849
NACRES:	NA.76

250 mg in glass bottle
5, 25 g in glass bottle

Gentamicin sulfate, a broad-spectrum antibiotic, used as a selection agent (gentamicin-resistance gene) in cell culture and molecular biology applications. This product is recommended for use at 50 mg/L.

Mode of action: Gentamicin causes codon misreading by binding to the 30S ribosomal subunit, blocking the translocation of peptidyl-tRNA from the acceptor site to the donor site. The bactericidal effect of gentamicin on Pseudomonas aeruginosa is exerted by the binding of gentamicin to the outer membrane, where it displaces natural cations, destabilizes the membrane, and forms holes in the cell surface.
Antimicrobial spectrum: Includes Gram-negative and Gram-positive bacteria, including strains resistant to tetracycline, chloramphenicol, kanamycin and colistin, particularly strains of Pseudomonas, Proteus, Staphylococcus and Streptococcus.

Components

Sterile solutions should be stored at 2-8°C. Solutions have also been shown to be stable at room temperature and in boiling aqueous buffers of pH 2-142.

biological source	Micromonospora purpurea
Quality Level	200,
Agency/Method	USP/NF, meets USP testing specifications
form	powder
Featured Industry	Pharmaceutical (small molecule)
Mode of action	protein synthesis \| interferes
antibiotic activity spectrum	Gram-negative bacteria, Gram-positive bacteria, mycoplasma
storage temp.	2-8°C
SMILES string	O=S(O)(O)=O.O[C@]1(C)[C@@H]([C@@H](O)[C@@H](O[C@@H]2[C@@H](O)[C@H](O[C@H]3O[C@@](CC[C@H]3N)([C@@H](C)NC)[H])[C@@H](N)C[C@H]2N)OC1)NC.O[C@]4(C)[C@@H]([C@@H](O)[C@@H](O[C@@H]5[C@@H](O)[C@H](O[C@H]6O[C@@](CC[C@H]6N)([C@@H](C)N)[H])[C@@H](N)C[C@H]5N)OC4)NC.O[
InChI	1S/C21H43N5O7.C20H41N5O7.C19H39N5O7.H2O4S/c1-9(25-3)13-6-5-10(22)19(31-13)32-16-11(23)7-12(24)17(14(16)27)33-20-15(28)18(26-4)21(2,29)8-30-20;1-8(21)12-5-4-9(22)18(30-12)31-15-10(23)6-11(24)16(13(15)26)32-19-14(27)17(25-3)20(2,28)7-29-19;1-19(27)7-28-18(13(26)16(19)24-2)31-15-11(23)5-10(22)14(12(15)25)30-17-9(21)4-3-8(6-20)29-17;1-5(2,3)4/h9-20,25-29H,5-8,22-24H2,1-4H3;8-19,25-28H,4-7,21-24H2,1-3H3;8-18,24-27H,3-7,20-23H2,1-2H3;(H2,1,2,3,4)/t9-,10-,11+,12-,13+,14+,15-,16-,17+,18-,19-,20-,21+;8-,9-,10+,11-,12+,13+,14-,15-,16+,17-,18-,19-,20+;8-,9+,10-,11+,12-,13+,14+,15-,16+,17+,18+,19-;/m110./s1
InChI key	RDEIXVOBVLKYNT-HDZPSJEVSA-N

pictograms	GHS07
signalword	Warning
hcodes	H317
pcodes	P280 - P302 + P352
Personal Protective Equipment	dust mask type N95 (US),, Eyeshields,, Faceshields,, Gloves,
RIDADR	NONH for all modes of transport
WGK Germany	WGK 2
Flash Point F	Not applicable
Flash Point C	Not applicable

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Gentamicin sulfate from Micromonospora purpurea

Linear Formula:	C_19-21H_39-43N₅O₇ · 2.5H₂SO₄
CAS Number:	1405-41-0
EC Number:	215-778-9
MDL number:	MFCD00270181
eCl@ss:	42020823
PubChem Substance ID:	329757401

Used as a selection agent (gentamicin-resistance gene) in molecular biology applications. It inhibits the growth of a wide variety of grampositive and gram-negative microorganisms including strains resistant to tetracycline, chloramphenicol, kanamycin and colistin, particularly strains of Pseudomonas, Proteus, Staphylococcus and Streptococcus.

Mode of Action: Inhibits protein synthesis by binding to L6 protein of 50S ribosomal subunit.
Antimicrobial spectrum: Gram-negative and Gram-positive bacteria, and mycoplasma.

1 U corresponds to 1 μg of the USP gentamicin sulfate reference standard

1g, 5g, 25g

Unit Definition

Freely soluble in water, practically insoluble in alcohol and ether.

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

biological source	Micromonospora purpurea
Quality Level	200,
form	powder
optical activity	[]/D 107.0 to 121.0°, c = 10% in H₂O
specific activity	590 µg/mg of gentamicin
mol wt	M_r 694-723
loss	18.0% loss on drying
color	white to off-white
pH	3.5-5.5 (4% in H₂O)
Mode of action	protein synthesis \| interferes
antibiotic activity spectrum	Gram-negative bacteria, Gram-positive bacteria, mycoplasma
storage temp.	2-8°C
SMILES string	OS(O)(=O)=O.CN[C@@H]1[C@@H](O)[C@H](OC[C@]1(C)O)O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@H]3O[C@H](CN)CC[C@H]3N)[C@@H]2O.CN[C@@H]4[C@@H](O)[C@H](OC[C@]4(C)O)O[C@H]5[C@H](N)C[C@H](N)[C@@H](O[C@H]6O[C@@H](CC[C@H]6N)[C@@H](C)N)[C@@H]5O.CN[C@H](C)[C@@H]7CC[C@@H](N)[C@H](O7)O[C@@H]8[C@@H](N)C[C@@H](N)[C@H](O[C@H]9OC[C@](C)(O)[C@H](NC)[C@H]9O)[C@H]8O
InChI	1S/C21H43N5O7.C20H41N5O7.C19H39N5O7.H2O4S/c1-9(25-3)13-6-5-10(22)19(31-13)32-16-11(23)7-12(24)17(14(16)27)33-20-15(28)18(26-4)21(2,29)8-30-20;1-8(21)12-5-4-9(22)18(30-12)31-15-10(23)6-11(24)16(13(15)26)32-19-14(27)17(25-3)20(2,28)7-29-19;1-19(27)7-28-18(13(26)16(19)24-2)31-15-11(23)5-10(22)14(12(15)25)30-17-9(21)4-3-8(6-20)29-17;1-5(2,3)4/h9-20,25-29H,5-8,22-24H2,1-4H3;8-19,25-28H,4-7,21-24H2,1-3H3;8-18,24-27H,3-7,20-23H2,1-2H3;(H2,1,2,3,4)/t9-,10-,11+,12-,13+,14+,15-,16-,17+,18-,19-,20-,21+;8-,9-,10+,11-,12+,13+,14-,15-,16+,17-,18-,19-,20+;8-,9+,10-,11+,12-,13+,14+,15-,16+,17+,18+,19-;/m110./s1
InChI key	RDEIXVOBVLKYNT-HDZPSJEVSA-N

Chemical structure: aminoglycoside
Gentamicin, also known as gentiomycin C, is an aminoglycoside, which is naturally produced by Gram-negative bacteria. This antibiotic functions by preventing protein synthesis. Gentamicin sulfate prevents the growth of both Gram positive and Gram negative bacteria, in vivo and in vitro. In tissue culture, gentamicin sulfate is used to inhibit the growth of various strains of mycoplasma.

pictograms	GHS07
signalword	Warning
hcodes	H317
pcodes	P280 - P302 + P352
Personal Protective Equipment	dust mask type N95 (US),, Eyeshields,, Faceshields,, Gloves,
RIDADR	NONH for all modes of transport
WGK Germany	WGK 2
Flash Point F	Not applicable
Flash Point C	Not applicable

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Gentamicin sulfate salt

CAS Number:	1405-41-0
EC Number:	215-778-9
MDL number:	MFCD00270181
eCl@ss:	42020823
PubChem Substance ID:	329799833
NACRES:	NA.76

Gentamicin sulfate, a broad-spectrum antibiotic, has been used as a selection agent (gentamicin-resistance gene) in cell culture and molecular biology applications. This product is recommended for use at 50 mg/L.

50, 250 mg in poly bottle
1, 5, 100 g in poly bottle

Gentamicin is an aminoglycoside complex produced by fermentation of Micromonospora purpurea or M. echinospora. It is used as the sulfate salt. There are three components, each consisting of five basic nitrogens and requiring five equivalents of sulfuric acid per mole of gentamicin base.

Components

Sterile solutions should be stored at 2-8°C. Solutions have also been shown to be stable at room temperature and in boiling aqueous buffers of pH 2-142.

Analysis Note

Solubility- freely soluble in water, practically insoluble in ethanol

biological source	Micromonospora purpurea
Quality Level	200,
product line	BioReagent
form	powder
potency	~600 µg Gentamicin per mg
application(s)	cell culture \| mammalian: suitable
color	white to off-white
Mode of action	protein synthesis \| interferes
antibiotic activity spectrum	Gram-negative bacteria, Gram-positive bacteria, mycoplasma
storage temp.	2-8°C
SMILES string	O=S(O)(O)=O.O[C@]1(C)[C@@H]([C@@H](O)[C@@H](O[C@@H]2[C@@H](O)[C@H](O[C@H]3O[C@@](CC[C@H]3N)([C@@H](C)NC)[H])[C@@H](N)C[C@H]2N)OC1)NC.O[C@]4(C)[C@@H]([C@@H](O)[C@@H](O[C@@H]5[C@@H](O)[C@H](O[C@H]6O[C@@](CC[C@H]6N)([C@@H](C)N)[H])[C@@H](N)C[C@H]5N)OC4)NC.O[
InChI	1S/C21H43N5O7.C20H41N5O7.C19H39N5O7.H2O4S/c1-9(25-3)13-6-5-10(22)19(31-13)32-16-11(23)7-12(24)17(14(16)27)33-20-15(28)18(26-4)21(2,29)8-30-20;1-8(21)12-5-4-9(22)18(30-12)31-15-10(23)6-11(24)16(13(15)26)32-19-14(27)17(25-3)20(2,28)7-29-19;1-19(27)7-28-18(13(26)16(19)24-2)31-15-11(23)5-10(22)14(12(15)25)30-17-9(21)4-3-8(6-20)29-17;1-5(2,3)4/h9-20,25-29H,5-8,22-24H2,1-4H3;8-19,25-28H,4-7,21-24H2,1-3H3;8-18,24-27H,3-7,20-23H2,1-2H3;(H2,1,2,3,4)/t9-,10-,11+,12-,13+,14+,15-,16-,17+,18-,19-,20-,21+;8-,9-,10+,11-,12+,13+,14-,15-,16+,17-,18-,19-,20+;8-,9+,10-,11+,12-,13+,14+,15-,16+,17+,18+,19-;/m110./s1
InChI key	RDEIXVOBVLKYNT-HDZPSJEVSA-N