Antibiotics

Telithromycin is a ketolide antibiotic, the first to enter clinical use. It is used to treat mild to moderate respiratory infections. Telithromycin binds to the subunit 50S of the bacterial ribosome, interfering with bacterial protein synthesis.

assay	≥90% (HPLC)
form	powder
color	white to beige
solubility	DMSO: 2 mg/mL, clear
storage temp.	−20°C
SMILES string	O=C(N1CCCCN2C=NC(C3=CC=CN=C3)=C2)O[C@]4([C@@]1([H])[C@H](C([C@@H](C[C@]([C@@H]([C@H](C([C@H](C(O[C@@H]4CC)=O)C)=O)C)O[C@H]5[C@@H]([C@H](C[C@H](O5)C)N(C)C)O)(OC)C)C)=O)C)C

pictograms	GHS08
signalword	Danger
hcodes	H370
pcodes	P308 + P311
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Terbinafine hydrochloride

Empirical Formula (Hill Notation):	C₂₁H₂₅N · HCl
CAS Number:	78628-80-5
Molecular Weight:	327.89
MDL number:	MFCD00145430
PubChem Substance ID:	329826887
NACRES:	NA.85

Allylamine derivative.

Terbinafine hydrochloride is a synthetic allylamine antifungal. It is used to treat dermatophyte infections of the toenail/fingernail, ringworm and jock itch. It is used in adsorption, partition and stability studies.

100, 250 mg in poly bottle

Terbinafine inhibits squalene monooxygenase thereby blocking the biosynthesis of ergosterol, which is an essential component of fungal cell membranes. The inhibition of squalene monooxygenase also results in the accumulation of squalene. Terbinafine hydrochloride is highly lipophilic and tends to accumulate in skin, nails, and fatty tissues. It is antifungal and antimycotic. It is fungicidal against dermatopytes and some yeasts and is fungistatic against Candida albicans.
Mode of Action: Inhibits squalene epoxidase, preventing biosynthesis of ergosterol.
Antimicrobial spectrum: Antifungal and antimycotic. Fungicidal against dermatopytes and some yeasts; fungistatic against Candida albicans.

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.

Quality Level	200,
biological source	synthetic
assay	≥98% (HPLC)
form	powder
color	white
solubility	methanol: soluble 50 mg/mL
Mode of action	enzyme \| inhibits
antibiotic activity spectrum	fungi, yeast
SMILES string	Cl[H].[H]\C(CN(C)Cc1cccc2ccccc12)=C(\[H])C#CC(C)(C)C
InChI	1S/C21H25N.ClH/c1-21(2,3)15-8-5-9-16-22(4)17-19-13-10-12-18-11-6-7-14-20(18)19;/h5-7,9-14H,16-17H2,1-4H3;1H/b9-5+;
InChI key	BWMISRWJRUSYEX-SZKNIZGXSA-N

Terconazole is a traizole ketal derivative, which is antifungal in nature. It is especially effective against Candidal spp.

pictograms	GHS07,GHS09
signalword	Warning
hcodes	H315 - H319 - H335 - H410
pcodes	P273 - P302 + P352 - P305 + P351 + P338
Target Organs	Respiratory system
Personal Protective Equipment	dust mask type N95 (US),, Eyeshields,, Gloves,
RIDADR	UN 3077 9 / PGIII
WGK Germany	WGK 3

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Terconazole

Empirical Formula (Hill Notation):	C₂₆H₃₁Cl₂N₅O₃
CAS Number:	67915-31-5
Molecular Weight:	532.46
EC Number:	267-751-6
NACRES:	NA.85

Terconazole could be used for the assessment of the effect of terconazole on transduction efficiency of host cells by glycoprotein of Ebola virus (EBOV), and for the assessment of the effect of terconazole on transduction efficiency of embryonic kidney cell line 293T by human coronaviruses.

Terconazole suppresses the growth of various types of yeats and mycelium-forming fungi in in vitro conditions. Its antifungal activity is an outcome of the accumulation of the membrane-disrupting 14-demethylsterols and ergosterol depletion. This is result of inactivation of cytochrome P-450-dependent 14-demethylase by terconazole. It is a rapidly-acting and well-tolerated antifungal used for the treatment of vulvovaginal candidiasis. It is also used for the treatment of dermatophytosis and candidosis. The drug may facilitate the accumulation of cholesterol in late endosomes.

2MG

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place. Storage class (TRGS 510): Non Combustible Solids

Quality Level	200,
assay	≥98%
form	powder
storage condition	(Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Non Combustible Solids)
color	white
solubility	DMSO: 1 mg/mL
Mode of action	enzyme \| interferes
antibiotic activity spectrum	fungi
storage temp.	2-8°C
InChI	1S/C26H31Cl2N5O3/c1-19(2)31-9-11-32(12-10-31)21-4-6-22(7-5-21)34-14-23-15-35-26(36-23,16-33-18-29-17-30-33)24-8-3-20(27)13-25(24)28/h3-8,13,17-19,23H,9-12,14-16H2,1-2H3/t23-,26-/m0/s1
InChI key	BLSQLHNBWJLIBQ-OZXSUGGESA-N

Chemical structure: tetracycline

pictograms	GHS07
signalword	Warning
hcodes	H315 - H319 - H335 - H413
pcodes	P273 - P302 + P352 - P305 + P351 + P338
Target Organs	Respiratory system
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Tetracycline

Empirical Formula (Hill Notation):	C₂₂H₂₄N₂O₈ · xH₂O
CAS Number:	60-54-8
Molecular Weight:	444.43 (anhydrous basis)
Beilstein/REAXYS Number:	2230417
EC Number:	200-481-9
MDL number:	MFCD00151232
PubChem Substance ID:	57653229
NACRES:	NA.85

Mode of Action: Tetracycline passively diffuses through proin channels in the cell membrane, binding to 30S ribosomes and inhibits protein synthesis by preventing access of aminoacyl tRNA to the acceptor site on the mRNA-ribosome complex. It also binds to the bacterial 50S ribosomal subunit, altering the membrane and causing intracellular components to leak from bacterial cells. The inhibitory effects can be reversed by washing, suggesting that it is the reversibly bound antibiotic, and not the irreversibly bound drug, that is responsible for antibacterial action.

Mode of Resistance: The effects are inactivated via a loss of cell wall permeability.

Antimicrobial spectrum: Includes a wide range of antimicrobial activity against gram-positive and gram-negative bacteria.

25g, 100g

Keep container tightly closed in a dry and well-ventilated place.Hygroscopic. Light sensitive. Keep in a dry place.

Quality Level	200,
biological source	synthetic
assay	98.0-102.0% (HPLC)
form	powder or crystals
color	faint yellow to dark yellow
mp	172-174 °C (dec.)
Mode of action	protein synthesis \| interferes
antibiotic activity spectrum	Gram-negative bacteria, Gram-positive bacteria
storage temp.	2-8°C
SMILES string	CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c4c(O)cccc4[C@@]3(C)O
InChI	1S/C22H24N2O8/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28/h4-6,9-10,15,25,27-28,31-32H,7H2,1-3H3,(H2,23,30)/t9-,10-,15-,21+,22-/m0/s1
InChI key	OFVLGDICTFRJMM-WESIUVDSSA-N
Gene Information	human ... CYP1A2(1544), TERT(7015)

Chemical structure: tetracycline

pictograms	GHS07
signalword	Warning
hcodes	H302
pcodes	P264 - P270 - P301 + P312 - P501
Personal Protective Equipment	dust mask type N95 (US),, Eyeshields,, Gloves,
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Tetracycline hydrochloride

Empirical Formula (Hill Notation):	C₂₂H₂₄N₂O₈ · HCl
CAS Number:	64-75-5
Molecular Weight:	480.90
Beilstein/REAXYS Number:	3844873
EC Number:	200-593-8
MDL number:	MFCD00078142
PubChem Substance ID:	24900468

5, 25 g in poly bottle

Tetracycline is a broad spectrum polyketide antibiotic with clinical uses in treating bacterial infections such as Rocky Mountain spotted fever, typush fever, tick fevers, Q fever, and Brill-Zinsser disease and to treat upper respiratory infections and acne. It has been used in studies of multidrug resistance and potential side effects including acute pancreatitis. It is recommended for use in cell culture applications at 10 mg/L.

Mode of Action: Tetracycline passively diffuses through proin channels in the cell membrane, binding to 30S ribosomes and inhibits protein synthesis by preventing access of aminoacyl tRNA to the acceptor site on the mRNA-ribosome complex. It also binds to the bacterial 50S ribosomal subunit, altering the membrane and causing intracellular components to leak from bacterial cells. The inhibitory effects can be reversed by washing, suggesting that it is the reversibly bound antibiotic, and not the irreversibly bound drug, that is responsible for antibacterial action.
Mode of Resistance: The effects are inactivated via a loss of cell wall permeability.
Antimicrobial spectrum: Includes a wide range of antimicrobial activity against gram-positive and gram-negative bacteria.

Caution

This product should be frozen below 0°C and protected from light and moisture. In these conditions, the product has been shown to retain activity for 4 years. Stock solutions should be stored at -20°C and are stable at 37°C for 4 days.

The product is freely soluble in water, slightly soluble in 96% ethanol, and is practically insoluble in acetone. Tetracycline is rapidly destroyed by alkali hydroxide solutions and standing water solutions become turbid due to hydrolysis and precipitation. The potency of tetracycline is reduced in solutions with pH below 2.

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place

Quality Level	200,
biological source	synthetic
product line	BioReagent
form	powder
storage condition	(Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)
application(s)	cell culture \| mammalian: suitable
impurities	endotoxin, tested
color	yellow
mp	220-223 °C (lit.)
Mode of action	protein synthesis \| interferes
antibiotic activity spectrum	Gram-negative bacteria, Gram-positive bacteria
storage temp.	−20°C
SMILES string	Cl.CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c4c(O)cccc4[C@@]3(C)O
InChI	1S/C22H24N2O8.ClH/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28;/h4-6,9-10,15,25,27-28,31-32H,7H2,1-3H3,(H2,23,30);1H/t9-,10-,15-,21+,22-;/m0./s1
InChI key	XMEVHPAGJVLHIG-FMZCEJRJSA-N

Chemical structure: imidazole

pictograms	GHS07,GHS08,GHS09
signalword	Warning
hcodes	H315 - H319 - H335 - H361fd - H410
pcodes	P202 - P261 - P273 - P302 + P352 - P305 + P351 + P338 - P308 + P313
Target Organs	Respiratory system
Personal Protective Equipment	dust mask type N95 (US),, Eyeshields,, Gloves,
RIDADR	UN 3077 9 / PGIII
WGK Germany	WGK 2
Flash Point F	Not applicable
Flash Point C	Not applicable

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Thiabendazole

Empirical Formula (Hill Notation):	C₁₀H₇N₃S
CAS Number:	148-79-8
Molecular Weight:	201.25
Beilstein/REAXYS Number:	611403
EC Number:	205-725-8
MDL number:	MFCD00005587
PubChem Substance ID:	24900571
NACRES:	NA.85

Thiabendazole (TBZ) is a broad-spectrum antihelminthic and is used to treat parasitic infections in humans. It is used as an agricultural fungicide and as a food preservative. Thiabendazole has been used as a heavy metal chelating detoxification agent. It is used clinically to treat threadworm, cutaneous larva migrans, visceral larva migrans, and trichinosis.

100, 500 g in glass bottle

Thiabendazole inhibits anaerobic respiration at the level of mitochondrial helminth-specific enzyme. It acts as a quinol-fumarate reductase (QFR) inhibitor in ,C. jejuni and H. pylori, blocking quinol oxidation to quinone. Thiabendazole suppresses egg and larval production and may inhibit the subsequent development of eggs and larvae which are passed in feces. A proposed route of biotransformation of thiabendazole is the CYP1A2-catalyzed hydroxylation to 5-hydroxythiabendazole, which is metabolized to glucuronide and sulfate conjugates.

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.Storage class (TRGS 510): Non Combustible Solids

Quality Level	200,
assay	≥99%
form	powder
color	white to off-white
solubility	DMF: soluble 50 mg/mL
Mode of action	enzyme \| inhibits
antibiotic activity spectrum	fungi, parasites
SMILES string	c1ccc2[nH]c(nc2c1)-c3cscn3
InChI	1S/C10H7N3S/c1-2-4-8-7(3-1)12-10(13-8)9-5-14-6-11-9/h1-6H,(H,12,13)
InChI key	WJCNZQLZVWNLKY-UHFFFAOYSA-N
Gene Information	human ... CYP2C9(1559)

Chemical structure: phenicole

pictograms	GHS09
signalword	Warning
hcodes	H410
pcodes	P273 - P501
Personal Protective Equipment	Eyeshields,, Gloves,
RIDADR	UN 3077 9 / PGIII
WGK Germany	WGK 2
Flash Point F	Not applicable
Flash Point C	Not applicable

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Thiamphenicol

Empirical Formula (Hill Notation):	C₁₂H₁₅Cl₂NO₅S
CAS Number:	15318-45-3
Molecular Weight:	356.22
Beilstein/REAXYS Number:	2819542
EC Number:	239-355-3
MDL number:	MFCD00467983
PubChem Substance ID:	24899874
NACRES:	NA.85

Thiamphenicol is an antibiotic that has been used to treat chancroid in men and uncomplicated gonorrhea. It is used in studies of bacterial protein synthesis at the level of peptidyl transferase activity associated with the 23S rRNA of the 50S ribosomal subunit. It is used to study chloraniphenicol-thiamphenicol-resistance and the use of fluorinated analogs when resistance is encountered.

Thiamphenicol inhibits mitochondrial protein synthesis of proteins such as cytochrome c oxidase.

1G,5G,25G

Keep container tightly closed in a dry and well-ventilated place.

form	powder
Quality Level	100,
color	white to off-white
solubility	ethanol: soluble 50 mg/mL
Mode of action	protein synthesis \| interferes
antibiotic activity spectrum	Gram-negative bacteria, Gram-positive bacteria
SMILES string	CS(=O)(=O)c1ccc(cc1)[C@@H](O)[C@@H](CO)NC(=O)C(Cl)Cl
InChI	1S/C12H15Cl2NO5S/c1-21(19,20)8-4-2-7(3-5-8)10(17)9(6-16)15-12(18)11(13)14/h2-5,9-11,16-17H,6H2,1H3,(H,15,18)/t9-,10-/m1/s1
InChI key	OTVAEFIXJLOWRX-NXEZZACHSA-N

Personal Protective Equipment	Eyeshields,, Gloves,, type N95 (US),
RIDADR	NONH for all modes of transport
WGK Germany	WGK 2
Flash Point F	Not applicable
Flash Point C	Not applicable

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Thio-TEPA T6069-1G

Empirical Formula (Hill Notation):	C₆H₁₂N₃PS
CAS Number:	52-24-4
Molecular Weight:	189.22
EC Number:	200-135-7
MDL number:	MFCD00145452
PubChem Substance ID:	24900346
NACRES:	NA.85

Chemical structure: aziridine

Thio-TEPA (N,NN-triethylenethiophosphoramide) is used as a cancer chemotherapeutic, alkylating agent. It is used to treat various kinds of cancer such as breast, ovarian and bladder cancer. It is also used as conditioning treatment prior to haematopoietic progenitor cell transplantation (HPCT).

1 g in poly bottle

The unstable nitrogen-carbon groups alkylate with DNA which causes irreversible DNA damage. They stop tumor growth by crosslinking guanine nucleobases in DNA double-helix strands, directly attacking DNA. The DNA strands are unable to uncoil and separate which halts cell division.

Analysis Note

Solubility - freely soluble in water , in chloroform and in ethanol (96%)

Keep container tightly closed in a dry and well-ventilated place.

Quality Level	200,
assay	97.0-102.0% (titration)
form	powder or crystals
storage condition	(Keep container tightly closed in a dry and well-ventilated place.)
color	white
solubility	methanol: soluble 10 mg/mL
Mode of action	DNA synthesis \| interferes
antibiotic activity spectrum	neoplastics
storage temp.	2-8°C
SMILES string	S=P(N1CC1)(N2CC2)N3CC3
InChI	1S/C6H12N3PS/c11-10(7-1-2-7,8-3-4-8)9-5-6-9/h1-6H2
InChI key	FOCVUCIESVLUNU-UHFFFAOYSA-N

pictograms	GHS06,GHS08
signalword	Danger
hcodes	H300 - H350
pcodes	P201 - P301 + P310 + P330
Personal Protective Equipment	Eyeshields,, Faceshields,, Gloves,, type P1 (EN143) respirator filter,, type P3 (EN 143) respirator cartridges,
RIDADR	UN 2811 6.1 / PGII
WGK Germany	WGK 3

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Ticarcillin disodium salt T5639-1G

Empirical Formula (Hill Notation):	C₁₅H₁₄N₂Na₂O₆S₂
CAS Number:	4697-14-7
Molecular Weight:	428.39
MDL number:	MFCD07787410
PubChem Substance ID:	24900306
NACRES:	NA.85

Chemical structure: -lactam

Ticarcillin is a semisynthetic antibiotic with a broad spectrum of bactericidal activity against many gram-positive and gram-negative aerobic and anaerobic bacteria. It is commonly used in combination with clavulanate in order to improve it′s efficacy. It is used to study appropriate dosing in pediatric patients who have cystic fibrosis.

Ticarcillin is a β-Lactam antibiotic that prevents bacterial cell wall biosynthesis at the level of peptidogylcan cross-linking by inhibiting peptidoglycan transpeptidases. It is derived from penicillin and is similar to carbenicillin in action. Ticarcillin is susceptible to degradation by -lactamases.

β-Lactam antibiotic
Keep container tightly closed in a dry and well-ventilated place. Moisture sensitive. Keep in a dry place.

biological source	semisynthetic
Quality Level	200,
form	powder or crystals
storage condition	(Keep container tightly closed in a dry and well-ventilated place. Moisture sensitive. Keep in a dry place.)
color	white to light yellow
Mode of action	cell wall synthesis \| interferes
antibiotic activity spectrum	Gram-negative bacteria, Gram-positive bacteria
storage temp.	2-8°C
SMILES string	[Na+].[Na+].CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](C([O-])=O)c3ccsc3)C(=O)N2[C@H]1C([O-])=O
InChI	1S/C15H16N2O6S2.2Na/c1-15(2)9(14(22)23)17-11(19)8(12(17)25-15)16-10(18)7(13(20)21)6-3-4-24-5-6;;/h3-5,7-9,12H,1-2H3,(H,16,18)(H,20,21)(H,22,23);;/q;2*+1/p-2/t7-,8-,9+,12-;;/m1../s1
InChI key	ZBBCUBMBMZNEME-QBGWIPKPSA-L

pictograms	GHS07,GHS08
signalword	Danger
hcodes	H315 - H319 - H334 - H335
pcodes	P302 + P352 - P305 + P351 + P338
Target Organs	Respiratory system
Personal Protective Equipment	dust mask type N95 (US),, Eyeshields,, Faceshields,, Gloves,
RIDADR	NONH for all modes of transport
WGK Germany	WGK 2
Flash Point F	Not applicable
Flash Point C	Not applicable

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Tioconazole 3907-10G

Empirical Formula (Hill Notation):	C₁₆H₁₃Cl₃N₂OS
CAS Number:	65899-73-2
Molecular Weight:	387.71
EC Number:	265-973-8
MDL number:	MFCD00057276
PubChem Substance ID:	329747834
NACRES:	NA.85

Chemical structure: pyrimidine

Tioconazole was used to study the synergistic mechanisms of antifungals on Candida albicans as well as significant drug-drug interactions in vivo.

Tioconazole is an antifungal medication of the imidazole class used to treat infections caused by fungus and yeast.It is more active than fluconazole or voriconazole against Candida glabrata mutant strains. It acts by membrane disruption and loss of intracellular ATP.

10G

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. 03907.pdf, Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.,

Quality Level	100,
assay	96.5% (HPLC), 96.5-103.5% (NT), 97%
form	powder
color	white to off-white
Mode of action	cell membrane \| interferes
antibiotic activity spectrum	fungi, yeast
SMILES string	Clc1ccc(C(Cn2ccnc2)OCc3ccsc3Cl)c(Cl)c1
InChI	1S/C16H13Cl3N2OS/c17-12-1-2-13(14(18)7-12)15(8-21-5-4-20-10-21)22-9-11-3-6-23-16(11)19/h1-7,10,15H,8-9H2
InChI key	QXHHHPZILQDDPS-UHFFFAOYSA-N

Tobramycin is an aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the Pseudomonas species.
Chemical structure: aminoglycoside

pictograms	GHS07
signalword	Warning
hcodes	H302
Personal Protective Equipment	dust mask type N95 (US),, Eyeshields,, Gloves,
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Tobramycin

Empirical Formula (Hill Notation):	C₁₈H₃₇N₅O₉
CAS Number:	32986-56-4
Molecular Weight:	467.51
Beilstein/REAXYS Number:	1357507
EC Number:	251-322-5
MDL number:	MFCD00077885
PubChem Substance ID:	24900188
NACRES:	NA.85

Tobramycin has been used:

to study the effect of tobramycin on bacteriophage infected biofilms
to study the effects of antibiotics on Pseudomonas aeruginosa strain
as a comparator antibiotic

100, 500 mg in glass bottle

Tobramycin binds irreversibly to one of two aminoglycoside binding sites on the 30S ribosomal subunit, inhibiting bacterial protein synthesis. Tobramycin may also destabilize bacterial membranes by binding to 16S rRNA (ribosomal RNA). It inhibits translocation and elicits miscoding.
Tobramycin is used to treat Pseudomonas aeruginosa lung infections and is used in combination with other antibiotics to treat urinary tract infections, gynecologic infections, peritonitis, endocarditis, pneumonia, sepsis, respiratory infections, osteomyelitis, and other soft-tissue infections. It is a potential therapy for sinus infections.
Tobramycin is an aminoglycoside.
Mode of Action: Binds to 70S ribosomal subunit; inhibits translocation; elicits miscoding.
Spectrum of Activity: Gram negative bacteria. Not effective against Enterococci.

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

biological source	Streptomyces tenebrarius
Quality Level	200,
assay	900 µg/mg anhydrous basis
form	powder
storage condition	(Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)
color	white to off-white
Mode of action	protein synthesis \| interferes
antibiotic activity spectrum	Gram-negative bacteria
storage temp.	2-8°C
SMILES string	NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@@H](N)[C@H]3O)[C@H]2O)[C@H](N)C[C@@H]1O
InChI	1S/C18H37N5O9/c19-3-9-8(25)2-7(22)17(29-9)31-15-5(20)1-6(21)16(14(15)28)32-18-13(27)11(23)12(26)10(4-24)30-18/h5-18,24-28H,1-4,19-23H2/t5-,6+,7+,8-,9+,10+,11+,12+,13+,14-,15+,16-,17+,18+/m0/s1
InChI key	NLVFBUXFDBBNBW-SNGYORCQSA-N

Chemical structure: aminoglycoside

pictograms	GHS08
signalword	Warning
hcodes	H361f
pcodes	P201 - P202 - P280 - P308 + P313 - P405 - P501
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3

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Tobramycin sulfate salt

Empirical Formula (Hill Notation):	C₁₈H₃₇N₅O₉ · xH₂SO₄
Molecular Weight:	467.51 (free base basis)
MDL number:	MFCD00133864
PubChem Substance ID:	329826686
NACRES:	NA.85

Tobramycin is an aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the pseudomonas species. It is not effective against Enterococci. It is used to inhibit bacterial protein synthesis at the level of 30S (16S rRNA) and 70S ribosomal complex assembly. It is used to treat pseudomonas aeruginosa lung infections and is used in combination with other antibiotics to treat urinary tract infections, gynecologic infections, peritonitis, endocarditis, pneumonia, sepsis, respiratory infections, osteomyelitis and other soft-tissue infections. It is a potential therapy for sinus infections. Product T1783 has been used to study antibiotic resistance.

100, 500 mg in glass bottle
100MG,500MG

Caution

Hygroscopic

Keep container tightly closed in a dry and well-ventilated place. Hygroscopic.

biological source	Streptomyces tenebrarius
Quality Level	200,
form	powder
potency	634-739 µg per mg
storage condition	(Keep container tightly closed in a dry and well-ventilated place. Hygroscopic.)
color	white to off-white
solubility	H₂O: soluble 50 mg/mL
Mode of action	protein synthesis \| interferes
antibiotic activity spectrum	Gram-negative bacteria
storage temp.	2-8°C
SMILES string	OS(O)(=O)=O.NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](N)C[C@@H]1O
InChI	1S/C18H37N5O9.H2O4S/c19-3-9-8(25)2-7(22)17(29-9)31-15-5(20)1-6(21)16(14(15)28)32-18-13(27)11(23)12(26)10(4-24)30-18;1-5(2,3)4/h5-18,24-28H,1-4,19-23H2;(H2,1,2,3,4)/t5-,6+,7+,8-,9+,10+,11-,12+,13+,14-,15+,16-,17+,18+;/m0./s1
InChI key	ZEUUPKVZFKBXPW-TWDWGCDDSA-N

Tolnaftate is used to study the mechanism of ergosterol (sterol) biosynthesis at the rate-limiting step of squalene epoxidase inhibition. Tolnaftate is clinically used to treat cutaneous infections such as athlete′s foot, jock itch, and ringworm. It also has been used as a comparator compound for antifungal efficiency studies.

pictograms	GHS07,GHS08
signalword	Danger
hcodes	H312 + H332 - H360
pcodes	P201 - P202 - P280 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313
Personal Protective Equipment	Eyeshields,, Gloves,, type P1 (EN143) respirator filter,, type P3 (EN 143) respirator cartridges,
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Tolnaftate

Empirical Formula (Hill Notation):	C₁₉H₁₇NOS
CAS Number:	2398-96-1
Molecular Weight:	307.41
EC Number:	219-266-6
MDL number:	MFCD00056611
PubChem Substance ID:	24900394
NACRES:	NA.85

Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. It has also been reported to distort the hyphae and to stunt mycelial growth in susceptible organisms. Tolnaftate inhibits biosynthesis of aflatoxin.

1G,5G

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. T6638.pdf , Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.,
Keep container tightly closed in a dry and well-ventilated place.

form	powder
Quality Level	200,
storage condition	(Keep container tightly closed in a dry and well-ventilated place.)
color	white to off-white
solubility	chloroform: soluble 50 mg/mL
Mode of action	enzyme \| inhibits
antibiotic activity spectrum	fungi
storage temp.	2-8°C
SMILES string	CN(C(=S)Oc1ccc2ccccc2c1)c3cccc(C)c3
InChI	1S/C19H17NOS/c1-14-6-5-9-17(12-14)20(2)19(22)21-18-11-10-15-7-3-4-8-16(15)13-18/h3-13H,1-2H3
InChI key	FUSNMLFNXJSCDI-UHFFFAOYSA-N

Personal Protective Equipment	Eyeshields,, Gloves,, type N95 (US),
RIDADR	NONH for all modes of transport
WGK Germany	WGK 2
Flash Point F	Not applicable
Flash Point C	Not applicable

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Toyocamycin

Empirical Formula (Hill Notation):	C₁₂H₁₃N₅O₄
CAS Number:	606-58-6
Molecular Weight:	291.26
MDL number:	MFCD00866513
PubChem Substance ID:	329826772
NACRES:	NA.77

Кат. номер

T3580-10MG

T3580-10MG-PW

Studies have implicated that toyocamycin blocks the replication of fowl plague virus.
Toyocamycin is a nucleoside- type antibiotic analogue of adenosine, isolated from Streptomyces species. Toyocamycin is an anti-tumor antibiotic with various target activities. Toyocamycin is a potent inhibitor of RNA self-cleavage in mammalian cells. It also inhibits phosphatidylinositol kinase, a cell proliferation regulator. Toyocamycin was also found to inhibit Auxin signaling. Auxins are plant hormones with a crucial role in plant development regulation, and Toyocamycin was found to specifically inhibit auxin-responsive gene expression.

Features and Benefits

This compound is featured on the Adenosine Receptors, page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here,.

Toyocamycin is soluble in DMSO at 0.90 - 1.10 mg/ml and yields a clear, colorless solution. It is also soluble in acidic solutions and is moderately soluble in water, methanol and ethanol. Solutions prepared in DMSO can be diluted 10-fold in water.

biological source	Streptomyces rimosus
Quality Level	200,
assay	98% (HPLC)
form	solid
solubility	DMSO: soluble 0.90-1.10 mg/mL, clear, colorless, H₂O: moderately soluble, aqueous acid: moderately soluble, ethanol: moderately soluble, methanol: moderately soluble
Mode of action	DNA synthesis \| interferes
antibiotic activity spectrum	fungi
storage temp.	2-8°C
SMILES string	Nc1ncnc2n(cc(C#N)c12)[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O
InChI	1S/C12H13N5O4/c13-1-5-2-17(11-7(5)10(14)15-4-16-11)12-9(20)8(19)6(3-18)21-12/h2,4,6,8-9,12,18-20H,3H2,(H2,14,15,16)/t6-,8-,9-,12-/m1/s1
InChI key	XOKJUSAYZUAMGJ-WOUKDFQISA-N

Chemical structure: diphenyl ether derivative

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Triclosan

Empirical Formula (Hill Notation):	C₁₂H₇Cl₃O₂
CAS Number:	3380-34-5
Molecular Weight:	289.54
Beilstein/REAXYS Number:	2057142
EC Number:	222-182-2
MDL number:	MFCD00800992
PubChem Substance ID:	57652433
NACRES:	NA.85

5, 25 g in poly bottle

A component of cefsulodin-irgasan-novobiocin selection medium for Yersinia, a human pathogen that may contaminate animal-source food products. Because of its low antigenicity, irgasan is also a component of many antibacterial consumer products.

Irgasan is a broad spectrum antimicrobial agent. It is an inhibitor of the enoyl-ACP (acyl-carrier protein) reductase component of type II fatty acid synthase (FAS-II) in bacteria and Plasmodium. It also inhibits mammalian fatty acid synthase (FASN), and may have anticarcinogenic activity.

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Quality Level	200,
biological source	synthetic
assay	97.0-103.0% (active substance, GC)
form	powder or crystals
impurities	≤0.1% Water (Karl Fischer)
color	white
mp	55-59 °C
solubility	1 M NaOH: 5% at 25 °C, faintly turbid to clear (colorless solution)
Mode of action	enzyme \| inhibits
antibiotic activity spectrum	fungi
SMILES string	Oc1cc(Cl)ccc1Oc2ccc(Cl)cc2Cl
InChI	1S/C12H7Cl3O2/c13-7-1-3-11(9(15)5-7)17-12-4-2-8(14)6-10(12)16/h1-6,16H
InChI key	XEFQLINVKFYRCS-UHFFFAOYSA-N

Chemical structure: pyrimidine

pictograms	GHS07,GHS09
signalword	Warning
hcodes	H315 - H319 - H410
pcodes	P264 - P273 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313
Personal Protective Equipment	dust mask type N95 (US),, Eyeshields,, Gloves,
RIDADR	UN 3077 9 / PGIII
WGK Germany	WGK 2
Flash Point F	Not applicable
Flash Point C	Not applicable

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Trimethoprim

Empirical Formula (Hill Notation):	C₁₄H₁₈N₄O₃
CAS Number:	738-70-5
Molecular Weight:	290.32
Beilstein/REAXYS Number:	625127
EC Number:	212-006-2
MDL number:	MFCD00036761
PubChem Substance ID:	24278201
NACRES:	NA.85

Trimethoprim is primarily used as an antibacterial agent. It has dihydrofolate reductase inhibitor activity with selectivity for the prokaryote enzyme. It is used to treat urinary tract infections, mild acute prostatitis, recurrent cystitis, asymptomatic bacteriuria during pregnancy and respiratory tract infections.
Primarily used as an antibacterial agent. Dihydrofolate reductase inhibitor with selectivity for the prokaryote enzyme.

The combination of trimethoprim and sulfamethoxazole interferes with the cellular metabolism of folic acid in the bacterial cell by blocking the biosynthesis of nucleotides. Trimethoprim binds to dihydrofolate reductase and inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF). THF is an essential precursor in the thymidine synthesis pathway and interference with this pathway inhibits bacterial DNA synthesis.

5G,25G,100G

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Quality Level	200,
assay	98% (HPLC)
form	white powder
storage condition	(Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)
color	white to off-white
solubility	chloroform/ethanol (1:1): soluble 50 mg/mL, DMSO: soluble
Mode of action	DNA synthesis \| interferes, enzyme \| inhibits
antibiotic activity spectrum	Gram-negative bacteria, Gram-positive bacteria, mycobacteria
storage temp.	2-8°C
SMILES string	COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC
InChI	1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18)
InChI key	IEDVJHCEMCRBQM-UHFFFAOYSA-N
Gene Information	human ... DHFRP1(573971), KCNH1(3756) rat ... Dhfr(24312)

Chemical structure: pyrimidine

pictograms	GHS06,GHS08
signalword	Danger
hcodes	H301 - H361d
pcodes	P202 - P264 - P270 - P280 - P301 + P310 - P405
Personal Protective Equipment	Eyeshields,, Gloves,, type N95 (US),
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Trimethoprim lactate salt

Empirical Formula (Hill Notation):	C₁₄H₁₈N₄O₃ · C₃H₆O₃
CAS Number:	23256-42-0
Molecular Weight:	380.40
EC Number:	245-533-1
MDL number:	MFCD00171722
PubChem Substance ID:	329826610
NACRES:	NA.85

Trimethoprim is primarily used as an antibacterial agent. It has dihydrofolate reductase inhibitor activity with selectivity for the prokaryote enzyme. It is used clinically to treat urinary tract infections, mild acute prostatitis, recurrent cystitis, asymptomatic bacteriuria during pregnancy and respiratory tract infections. Trimethoprim lactate salt is used as a selection agent.

250 mg in glass bottle

The combination of trimethoprim and sulfamethoxazole interferes with the cellular metabolism of folic acid in the bacterial cell by blocking the biosynthesis of nucleotides. Trimethoprim binds to prokaryote-specific dihydrofolate reductase (DHFR) and inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF). THF is an essential precursor in the thymidine synthesis pathway and interference with this pathway inhibits bacterial DNA synthesis.

Keep container tightly closed in a dry and well-ventilated place.

Quality Level	200,
assay	98%
form	powder
storage condition	(Keep container tightly closed in a dry and well-ventilated place.)
color	white
solubility	H₂O: soluble 20 mg/mL
Mode of action	DNA synthesis \| interferes, enzyme \| inhibits
antibiotic activity spectrum	Gram-negative bacteria, Gram-positive bacteria, mycobacteria
storage temp.	2-8°C
SMILES string	CC(O)C(O)=O.COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC
InChI	1S/C14H18N4O3.C3H6O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15;1-2(4)3(5)6/h5-7H,4H2,1-3H3,(H4,15,16,17,18);2,4H,1H3,(H,5,6)
InChI key	IIZVTUWSIKTFKO-UHFFFAOYSA-N

pictograms	GHS06,GHS08
signalword	Danger
hcodes	H301 - H361d
pcodes	P202 - P264 - P270 - P280 - P301 + P310 - P405
Personal Protective Equipment	Eyeshields,, Gloves,, type N95 (US),
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Trimethoprim Ready Made Solution SBR00024-1ML

Empirical Formula (Hill Notation):	C₁₄H₁₈N₄O₃
Molecular Weight:	290.32

Trimethoprim is used at a final concentration of ~4µg/mL for antibacterial activty.

Trimethoprim is a synthetic derivative of pyrimidine with antibacterial and antiprotozoal properties. Trimethoprim is an inhibitor of bacterial dihydrofolate reductase (DHFR), interfering with the conversion of dihydrofolate (DHF) to tetrahydrofolate (THF). THF is an essential precursor in the thymidine synthesis pathway, interference with this pathway inhibits bacterial DNA synthesis. Trimethoprims affinity for bacterial DHFR is several thousand times greater than its affinity for human DHFR. Trimethoprim is potentiated by Sulfonamides and the Trimethoprim-sulfamethazole combination is the most used form.

biological source	synthetic
assay	≥98% (HPLC)
form	liquid
concentration	25 mg/mL in DMSO
Mode of action	DNA synthesis \| interferes, enzyme \| inhibits
antibiotic activity spectrum	Gram-negative bacteria, Gram-positive bacteria, mycobacteria
storage temp.	−20°C

Chemical structure: nucleoside

WGK Germany	WGK 2
Flash Point F	188.6 °F
Flash Point C	87 °C

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Tubercidin

Empirical Formula (Hill Notation):	C₁₁H₁₄N₄O₄
CAS Number:	69-33-0
Molecular Weight:	266.25
Beilstein/REAXYS Number:	38498
EC Number:	200-703-4
MDL number:	MFCD00056012
PubChem Substance ID:	24899902
NACRES:	NA.85

It is used to study tubercidins mechanism of toxicity, tubercidin resistance and is used as a selection agent. Tubercidin is used to study RNAi silencing. It is used to study the role of transmethylation in chemotaxis of eukaryotic cells.

10 mg in poly bottle
50, 250 mg in glass bottle

Tubercidin is a toxic adenosine analog with antiviral, antitrypanosomal, and antifungal functions. It inhibits multiple metabolic processes, including RNA processing, nucleic acid synthesis, protein synthesis, and methylation of tRNA through intracellular incorporation into nucleic acids. Tubercidin acts as a plant antifungal, inhibits mammalian SAH hydrolase (SAHH), and blocks purine biosynthesis in Candida famata. Tubercidin inhibits glycolysis in Trypanosoma brucei. Tubercidin inhibits both chemotaxis and chemotaxis-dependent cell streaming of Dictyostelium, and chemotaxis of neutrophils at concentrations that have little effect on cell viability.
Toxic adenosine analog with antiviral, antitrypanosomal, and antifungal functions. Mode of action: Inhibits multiple metabolic processes, including RNA processing, nucleic acid synthesis, protein synthesis, and methylation of tRNA through intracellular incorporation into nucleic acids. Tubercidin acts as a plant antifungal, inhibits mammalian SAH hydrolase (SAHH), and blocks purine biosynthesis in Candida famata.

Keep container tightly closed in a dry and well-ventilated place.

biological source	Streptomyces tubercidicus
Quality Level	200,
assay	~95%
form	powder
color	off-white
Mode of action	DNA synthesis \| interferes
antibiotic activity spectrum	fungi, parasites, viruses
SMILES string	O[C@H]1[C@@H](O)[C@H](N2C=CC3=C2N=CN=C3N)O[C@@H]1CO
InChI	1S/C11H14N4O4/c12-9-5-1-2-15(10(5)14-4-13-9)11-8(18)7(17)6(3-16)19-11/h1-2,4,6-8,11,16-18H,3H2,(H2,12,13,14)/t6-,7-,8-,11-/m1/s1
InChI key	HDZZVAMISRMYHH-KCGFPETGSA-N
Gene Information	rat ... Adora1(29290)

Chemical structure: nucleoside
Contains homologues A,B,C, and D. Composition may vary from lot to lot. Actual content given on label.

pictograms	GHS06
signalword	Danger
hcodes	H300
pcodes	P264 - P301 + P310
Personal Protective Equipment	Eyeshields,, Faceshields,, Gloves,, type P2 (EN 143) respirator cartridges,
RIDADR	UN 3462 6.1 / PGII
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Tunicamycin from Streptomyces sp.

CAS Number:	11089-65-9
Beilstein/REAXYS Number:	6888090
MDL number:	MFCD00065709
PubChem Substance ID:	57654701
NACRES:	NA.77

Tunicamycin has been used to study the effect of N-linked glycosylation of human proton-coupled folate transporter (HsPCFT) in HeLa cells. Tunicamycin has also been used to study the functional effects of coxsackievirus and adenovirus receptor (CAR) glycosylation in COS-7 cells.

1, 5, 10, 50 mg in glass bottle

Antibacterial and antifungal. Blocks the formation of protein N-glycosidic linkages by inhibiting the transfer of N-acetylglucosamine 1-phosphate to dolichol monophosphate. Inhibits bacterial and eukaryote N-acetylglucosamine transferases and prevents formation of N-acetylglucosamine lipid intermediates.

Tunicamycin dissolves in DMSO at 4.9-5.1 mg/ml and yields a clear to very slightly hazy, colorless to yellow solution. Furthermore, tunicamycin is soluble in DMF (>10 mg/ml), pyridine (>10 mg/ml), water (<5 mg/ml, pH 9.0), dioxane (<1 mg/ml) and THF. However, it is insoluble in other organic solvents such as acetone, chloroform, and ethyl acetate, and in aqueous solutions with pH <6. Aqueous solutions can be prepared from stock solutions by diluting with water at pH 8-10 or with buffers with pH >7, preferably >8. Tunicamycin will not dissolve in phosphate buffer, pH 8, at 1 mg/ml, even with heating, but solubility can be achieved by raising the pH to 9 and back titrating to pH 7-8.

Quality Level	300,
solubility	95% ethanol: soluble 1 mg/mL, clear to faintly hazy, THF: soluble <1 mg/mL, dioxane: soluble <1 mg/mL, DMF: soluble >10 mg/mL, pyridine: >10 mg/mL, DMSO: soluble 4.9-5.1 mg/mL, clear to slightly hazy, colorless to yellow, methanol: slightly soluble 4.9-5.1 mg/mL, methanol: soluble 4.9-5.1 mg/mL, clear to slightly hazy, colorless to yellow, acetone: insoluble, aqueous base: insoluble, chloroform: insoluble, ethyl acetate: insoluble
Mode of action	protein synthesis \| interferes
antibiotic activity spectrum	fungi, viruses
storage temp.	2-8°C
SMILES string	CC(C)CCCCCCCC\C=C\C(=O)N[C@@H]1[C@@H](O)[C@@H](O)[C@@H](C[C@@H](O)[C@H]2O[C@H]([C@H](O)[C@@H]2O)N3C=CC(=O)NC3=O)O[C@H]1O[C@@H]4O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]4NC(C)=O
InChI	1S/C37H60N4O16/c1-18(2)12-10-8-6-4-5-7-9-11-13-23(45)39-26-30(50)27(47)21(54-36(26)57-35-25(38-19(3)43)29(49)28(48)22(17-42)55-35)16-20(44)33-31(51)32(52)34(56-33)41-15-14-24(46)40-37(41)53/h11,13-15,18,20-22,25-36,42,44,47-52H,4-10,12,16-17H2,1-3H3,(H,38,43)(H,39,45)(H,40,46,53)/b13-11+/t20-,21-,22+,25+,26-,27+,28+,29+,30-,31+,32-,33-,34-,35+,36+/m1/s1
InChI key	YJQCOFNZVFGCAF-WPTOCQRYSA-N

pictograms	GHS06
signalword	Danger
hcodes	H300
pcodes	P264 - P270 - P301 + P310 - P405 - P501
Personal Protective Equipment	Eyeshields,, Faceshields,, Gloves,, type P1 (EN143) respirator filter,, type P3 (EN 143) respirator cartridges,
RIDADR	UN 3462 6.1 / PGII
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Tunicamycin V SMB00071-1MG

Empirical Formula (Hill Notation):	C₃₈H₆₂N₄O₁₆
CAS Number:	66054-36-2
Molecular Weight:	830.92
MDL number:	MFCD24849301
PubChem Substance ID:	329824750
NACRES:	NA.25

Natural product derived from fungal source.

assay	≥95% (LC/MS-ELSD)
form	solid
storage temp.	−20°C
SMILES string	CC(C)CCCCCCCCC\C=C\C(=O)N[C@@H]1[C@@H](O)[C@@H](O)[C@@H](C[C@@H](O)[C@H]2O[C@H]([C@H](O)[C@@H]2O)N3C=CC(=O)NC3=O)O[C@H]1O[C@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4NC(C)=O
InChI	1S/C38H62N4O16/c1-19(2)13-11-9-7-5-4-6-8-10-12-14-24(46)40-27-31(51)28(48)22(55-37(27)58-36-26(39-20(3)44)30(50)29(49)23(18-43)56-36)17-21(45)34-32(52)33(53)35(57-34)42-16-15-25(47)41-38(42)54/h12,14-16,19,21-23,26-37,43,45,48-53H,4-11,13,17-18H2,1-3H3,(H,39,44)(H,40,46)(H,41,47,54)/b14-12+/t21-,22-,23-,26-,27-,28+,29-,30-,31-,32+,33-,34-,35-,36-,37+/m1/s1
InChI key	MEYZYGMYMLNUHJ-DIRMKAHISA-N

Chemical structure: macrolide
Tylosin is a macrolide antibiotic, which comprises of a 16-member lactone ring. This solution is recommended for use at 1 mL/L.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Tylosin solution

CAS Number:	74610-55-2
MDL number:	MFCD07783824
PubChem Substance ID:	329826751
NACRES:	NA.76

Tylosin solution has been used as an antimicrobial agent in antibiotic susceptibility minimal inhibitory concentration(MIC) of E. coli and S. aureus isolates. It has also been used as a component of Dulbeccos modified Eagles (DMEM) medium for self-inactivating lentivirus production and skin fibroblast cultivation.

Tylosin inhibits bacterial protein synthesis by binding to the large subunit 50S. It is effective against Gram-positive bacteria and mycoplasma and is used in veterinary medicine. It has been used to study implant site abscess prevention in cattle and Mycoplasma gallisepticum and Mycoplasma meleagridis infections.

20ML

This product was formulated to contain 8 mg/ml tylosin in 0.9% sodium chloride.

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Quality Level	200,
sterility	0.1 μm filtered
product line	BioReagent
form	solution
storage condition	(Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and keep upright to prevent leakage.)
concentration	8 mg/mL in 0.9% NaCl
application(s)	cell culture \| mammalian: suitable
impurities	endotoxin, tested
color	colorless to yellow
Mode of action	protein synthesis \| interferes
antibiotic activity spectrum	Gram-positive bacteria, mycoplasma
storage temp.	2-8°C
SMILES string	O[C@H]([C@@H](O)C(O)=O)C(O)=O.CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@@H]([C@H]2O)N(C)C)[C@@H](CC=O)C[C@@H](C)C(=O)\C=C\C(C)=C\[C@@H]1CO[C@@H]4O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]4OC
InChI	1S/C46H77NO17.C4H6O6/c1-13-33-30(22-58-45-42(57-12)41(56-11)37(52)26(5)60-45)18-23(2)14-15-31(49)24(3)19-29(16-17-48)39(25(4)32(50)20-34(51)62-33)64-44-38(53)36(47(9)10)40(27(6)61-44)63-35-21-46(8,55)43(54)28(7)59-35;5-1(3(7)8)2(6)4(9)10/h14-15,17-18,24-30,32-33,35-45,50,52-55H,13,16,19-22H2,1-12H3;1-2,5-6H,(H,7,8)(H,9,10)/b15-14+,23-18+;/t24-,25+,26-,27-,28+,29+,30-,32-,33-,35+,36-,37-,38-,39-,40-,41-,42-,43+,44+,45-,46-;1-,2-/m11/s1
InChI key	ICVKYYINQHWDLM-KBEWXLTPSA-N

Chemical structure: macrolide

RIDADR	NONH for all modes of transport
WGK Germany	WGK 2
Flash Point F	Not applicable
Flash Point C	Not applicable

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Tylosin tartrate

MDL number:	MFCD07783824
PubChem Substance ID:	24900364
NACRES:	NA.76

1, 5, 10 g in poly bottle

Tylosin is a mcrolide antibiotic commonly used in veterinary medicine. It has been used to study protein synthesis at the 50S ribosome, implant site abscess prevention in cattle, disposition kinetics and Mycoplasma gallisepticumand Mycoplasma meleagridis infections. It is recommended for use in cell culture applications at 8 mg/L.

Mode of Action: Tylosin Tartrate inhibits bacterial protein synthesis by binding to the 50S (L27 protein) ribosome.
Antimicrobial Spectrum: This product acts against gram-positive bacteria and mycoplasma.

Components

This product is a mixture of tylosin A, B, C, and D tartrates.

Caution

Stock solutions should be filter sterilized and stored at 2-8°C. These solutions are stable at 37°C for 3 days.

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Quality Level	200,
product line	BioReagent
form	powder
potency	800 units/mg tylosin
storage condition	(Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)
application(s)	cell culture \| mammalian: suitable
color	off-white to yellow
solubility	H₂O: 50 mg/mL
Mode of action	protein synthesis \| interferes
antibiotic activity spectrum	Gram-positive bacteria, mycoplasma
storage temp.	2-8°C
SMILES string	O[C@H]([C@@H](O)C(O)=O)C(O)=O.CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@@H]([C@H]2O)N(C)C)[C@@H](CC=O)C[C@@H](C)C(=O)\C=C\C(C)=C\[C@@H]1CO[C@@H]4O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]4OC
InChI	1S/C46H77NO17.C4H6O6/c1-13-33-30(22-58-45-42(57-12)41(56-11)37(52)26(5)60-45)18-23(2)14-15-31(49)24(3)19-29(16-17-48)39(25(4)32(50)20-34(51)62-33)64-44-38(53)36(47(9)10)40(27(6)61-44)63-35-21-46(8,55)43(54)28(7)59-35;5-1(3(7)8)2(6)4(9)10/h14-15,17-18,24-30,32-33,35-45,50,52-55H,13,16,19-22H2,1-12H3;1-2,5-6H,(H,7,8)(H,9,10)/b15-14+,23-18+;/t24-,25+,26-,27-,28+,29+,30-,32-,33-,35+,36-,37-,38-,39-,40-,41-,42-,43+,44+,45-,46-;1-,2-/m11/s1
InChI key	ICVKYYINQHWDLM-KBEWXLTPSA-N

Chemical structure: peptide

pictograms	GHS08
signalword	Danger
hcodes	H317 - H334
pcodes	P280 - P302 + P352
Personal Protective Equipment	dust mask type N95 (US),, Eyeshields,, Faceshields,, Gloves,
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Valinomycin

Empirical Formula (Hill Notation):	C₅₄H₉₀N₆O₁₈
CAS Number:	2001-95-8
Molecular Weight:	1111.32
Beilstein/REAXYS Number:	78657
EC Number:	217-896-6
MDL number:	MFCD00005114
PubChem Substance ID:	24900697
NACRES:	NA.77

K+-selective ionophoric cyclodepsipeptide; potassium ionophore which uncouples oxidative phosphorylation, induces apoptosis in murine thymocytes, inhibits NGF-induced neuronal differentiation and antagonizes ET-induced vasoconstriction.

10MG,25MG,100MG,500MG

Keep container tightly closed in a dry and well-ventilated place.

Quality Level	300,
assay	90% (HPLC), 98% (TLC)
form	powder
storage condition	(Keep container tightly closed in a dry and well-ventilated place.)
color	white
solubility	DMSO: 50 mg/mL, H₂O: insoluble
Mode of action	cell membrane \| interferes
antibiotic activity spectrum	Gram-positive bacteria, parasites, viruses
storage temp.	2-8°C
SMILES string	CC(C)[C@@H]1NC(=O)[C@H](C)OC(=O)[C@@H](NC(=O)[C@H](OC(=O)[C@@H](NC(=O)[C@H](C)OC(=O)[C@H](NC(=O)[C@H](OC(=O)[C@@H](NC(=O)[C@H](C)OC(=O)[C@H](NC(=O)[C@H](OC1=O)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C
InChI	1S/C54H90N6O18/c1-22(2)34-49(67)73-31(19)43(61)55-38(26(9)10)53(71)77-41(29(15)16)47(65)59-36(24(5)6)51(69)75-33(21)45(63)57-39(27(11)12)54(72)78-42(30(17)18)48(66)60-35(23(3)4)50(68)74-32(20)44(62)56-37(25(7)8)52(70)76-40(28(13)14)46(64)58-34/h22-42H,1-21H3,(H,55,61)(H,56,62)(H,57,63)(H,58,64)(H,59,65)(H,60,66)/t31-,32-,33-,34-,35+,36+,37-,38-,39-,40+,41+,42+/m0/s1
InChI key	FCFNRCROJUBPLU-RPUZOQEISA-N

Vancomycin is a glycopeptide antibiotic, which was initially isolated from Streptomyces orientalis. It is effective against multidrug-resistant MRSA strain (methicillin-resistant Staphylococcus aureus). However, it is nephrotoxic as it is mainly excreted by the kidneys. It has a core heptapeptide having aliphatic amino acids at positions 1 and 3. It is mainly effective against gram-positive bacteria.

pictograms	GHS06
signalword	Danger
hcodes	H300 + H310
pcodes	P262 - P280 - P301 + P310 + P330 - P302 + P352 + P310
Personal Protective Equipment	Eyeshields,, Faceshields,, Gloves,, type P1 (EN143) respirator filter,, type P3 (EN 143) respirator cartridges,
RIDADR	UN 2811 6.1 / PGI
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Vancomycin hydrochloride

Empirical Formula (Hill Notation):	C₆₆H₇₅Cl₂N₉O₂₄ · xHCl
CAS Number:	1404-93-9
Molecular Weight:	1449.25 (free base basis)
NACRES:	NA.85

Vancomycin hydrochloride may be used-

for the assessment of the antimicrobial activity of vancomycin hydrochloride against Mycobacterium tuberculosis in nonreplicating persistence (NRP) using low-oxygen-recovery assay (LORA) and against a luciferase reporter strain of M. tuberculosis in a fermentor-grown culture adapted to low oxygen conditions
for the estimation of biomass in a culture of various strains of bacteria
as a positive control for E. coli and Staphylococcus aureus in antibacterial activity assay.

Vancomycin is bactericidal in nature, where it inhibits the synthesis of peptidoglycan. It forms hydrogen bond with the peptidoglycan precursor UDP-N-acetylmuramylpentapeptide, and forms a stoichiometric 1:1 complex. Thus, it prevents the growth of the glycan polymer of peptidoglycan by transglycosylase enzyme. It is a frequently used antibiotic for the treatment of peritonitis caused by gram-positive bacteria in patients with continuous ambulatory peritoneal dialysis. In patients with cirrhosis, it is used to control portal systemic encephalopathy. Mice with Clostridium difficile infection (CDI) had better clinical outcome when treated with vancomycin as opposed to the outcome on treatment with metronidazole.

10ML

Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Combustible liquids

Quality Level	200,
biological source	Streptomyces orientalis
form	liquid
storage condition	(Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510) Combustible liquids.)
concentration	100 mg/mL in DMSO
color	colorless to faint tan
Mode of action	cell wall synthesis \| interferes
antibiotic activity spectrum	Gram-positive bacteria
storage temp.	20°C

Chemical structure: glycopeptide

pictograms	GHS08
signalword	Danger
hcodes	H317 - H334
pcodes	P261 - P272 - P280 - P284 - P302 + P352 - P304 + P340 + P312
WGK Germany	WGK 2
Flash Point F	188.6 °F - closed cup
Flash Point C	87 °C - closed cup

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Vancomycin hydrochloride from Streptomyces orientalis

Empirical Formula (Hill Notation):	C₆₆H₇₅Cl₂N₉O₂₄ · HCl
CAS Number:	1404-93-9
Molecular Weight:	1485.71
Beilstein/REAXYS Number:	3704657
PubChem Substance ID:	24900723
NACRES:	NA.85

Vancomycin, from Streptomyces orientalis, is used for the treatment of serious or severe infections caused by susceptible strains of methicillin-resistant (-lactam-resistant) staphylococci. It is used to block bacterial cell wall biosynthesis at the level of peptidoglycan biosynthesis. It is widely studied in cancer patients. Vancomycins overuse has been studied, which has resulted in recommended guidelines.

1, 5 g in glass bottle
100, 250 mg in glass bottle
Bottomless glass bottle. Contents are inside inserted fused cone.

Vancomycin is a glycopeptide antibiotic that blocks bacterial cell wall biosynthesis at the level of peptidoglycan biosynthesis. It inhibits incorporation of terminal D-alanyl-D-alanine moieties of the NAM/NAG-peptides. It is effective against Gram-positive bacteria. Vancomycin also alters bacterial-cell-membrane permeability and RNA synthesis.
Glycopeptide antibiotic
Mode of action: Used to block bacterial cell wall biosynthesis at the level of peptidoglycan biosynthesis by inhibiting incorporation of terminal D-alanyl-D-alanine moieties of the NAM/NAG-peptides.
Antimicrobial spectrum: Gram-positive bacteria

Keep container tightly closed in a dry and well-ventilated place.

Quality Level	200,
biological source	Streptomyces orientalis
form	powder
potency	900 µg per mg (as vancomycin base)
storage condition	(Keep container tightly closed in a dry and well-ventilated place.)
color	white to brown
solubility	H₂O: 50 mg/mL
Mode of action	cell wall synthesis \| interferes
antibiotic activity spectrum	Gram-positive bacteria
storage temp.	2-8°C
SMILES string	Cl[H].CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]1O[C@H]2C[C@](C)(N)[C@@H](O)[C@@H](C)O2.CN[C@H](CC(C)C)C(=O)NC3[C@H](O)c4ccc(Oc5cc6Oc7ccc(cc7Cl)[C@@H](O)[C@H]8NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CC(N)=O)NC3=O)c(c5)c6)c9ccc(O)c(c9)-c%10c(O)cc(O)cc%10[C@@H](NC8=O)C(O)=O)c(Cl)c4

Vincristine sulfate is an alkaloid present in Cantharanthus roseus.

pictograms	GHS08
signalword	Danger
hcodes	H317 - H334
pcodes	P261 - P272 - P280 - P284 - P302 + P352 - P304 + P340 + P312
Personal Protective Equipment	dust mask type N95 (US),, Eyeshields,, Faceshields,, Gloves,
RIDADR	NONH for all modes of transport
WGK Germany	WGK 2
Flash Point F	Not applicable
Flash Point C	Not applicable

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Vincristine sulfate

Empirical Formula (Hill Notation):	C₄₆H₅₆N₄O₁₀ · H₂SO₄
CAS Number:	2068-78-2
Molecular Weight:	923.04
Beilstein/REAXYS Number:	3924631
EC Number:	218-190-0
MDL number:	MFCD00084729
PubChem Substance ID:	24900771
NACRES:	NA.21

Vincristine sulfate has been used:

as a positive control in potato disc anti-tumor bioassay
as a standard cytotoxic agent
to treat cells for manipulation of the microtubule network

Widely used in cancer research. In studies on multi-drug resistance. Used to inhibit cell cycle progression at M-phase. Used to inhibit monoamine oxidase (MAO).

25 mg in poly bottle
1, 5 mg in glass bottle

Vincristine sulfate possesses antitumor action targeting cell cycle. It prevents the action of tubulin by inhibiting microtubule polymerization. It also causes cell death and blocks metaphase in mitosis by preventing chromosome segregation. Vincristine sulfate inhibits angiogenesis mediated by factors such as vasculature endothelial growth factor. It decreases vascularization in tumors and normal tissues.

Quality Level	200,
Agency/Method	USP/NF, meets USP testing specifications
Featured Industry	Pharmaceutical (small molecule)
Mode of action	protein synthesis \| interferes
antibiotic activity spectrum	neoplastics
storage temp.	−20°C
SMILES string	OS(O)(=O)=O.CC[C@]1(O)CC2CN(CCc3c([nH]c4ccccc34)[C@@](C2)(C(=O)OC)c5cc6c(cc5OC)N(C=O)C7[C@](O)([C@H](OC(C)=O)[C@]8(CC)C=CCN9CC[C@]67C89)C(=O)OC)C1
InChI	1S/C46H56N4O10.H2O4S/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6;1-5(2,3)4/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3;(H2,1,2,3,4)/t28-,37-,38+,39+,42-,43+,44+,45-,46-;/m0./s1
InChI key	AQTQHPDCURKLKT-PNYVAJAMSA-N

Vincristine is an antitumor alkaloid isolated from Vinca Rosea. It is used to treat acute leukaemia, malignant lymphoma, Hodgkin′s disease, acute erythraemia, acute panmyelosis, breast cancer, Kaposis sarcoma and testicular cancer. Vincristine is widely used in cancer research. It is used to study multi-drug resistance. It is used to inhibit cell cycle progression at M-phase and to inhibit monoamine oxidase (MAO) .

pictograms	GHS06,GHS08
signalword	Danger
hcodes	H300 - H341 - H361fd
pcodes	P201 - P301 + P310 + P330
Personal Protective Equipment	Eyeshields,, Gloves,, type N95 (US),
RIDADR	UN 2811 6.1 / PGII
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Vincristine sulfate salt

Empirical Formula (Hill Notation):	C₄₆H₅₆N₄O₁₀ · H₂SO₄
CAS Number:	2068-78-2
Molecular Weight:	923.04
Beilstein/REAXYS Number:	3924631
EC Number:	218-190-0
MDL number:	MFCD00084729
PubChem Substance ID:	57654729
NACRES:	NA.85

1, 5, 25 mg in glass bottle

Vincristine is a plant alkaloid that inhibits microtubule assembly by binding tubulin and inducing coiled spiral aggregate formation. It arrests cell cycle in G2/M-phase by blocking mitotic spindle formation. Vincristine triggers Raf-1 activation, phosphorylation of bcl-2-family proteins, induction of p53 expression, and apoptosis in several tumor cell lines. It inhibits VEGF production in leukemia cell lines. It is a substrate for Pgp and CYP3A4. MRP1 transports vincristine in an ATP- and GSH-dependent manner. Vincristine has some immunosuppressant effect. Vincristine may also interfere with amino acid, cyclic AMP, and glutathione metabolism, calmodulin-dependent Ca2+-transport, cellular respiration, and nucleic acid and lipid biosynthesis.

Analysis Note

Freely soluble in water, Soluble in methanol, slightly soluble in ethanol

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

biological source	Streptomyces roseosporus
Quality Level	200,
assay	95.0-105.0% (HPLC)
form	powder or crystals
storage condition	(Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)
color	white to slightly yellow
Mode of action	protein synthesis \| interferes
antibiotic activity spectrum	neoplastics
storage temp.	20°C
SMILES string	OS(O)(=O)=O.CC[C@]1(O)CC2CN(CCc3c([nH]c4ccccc34)[C@@](C2)(C(=O)OC)c5cc6c(cc5OC)N(C=O)C7[C@](O)([C@H](OC(C)=O)[C@]8(CC)C=CCN9CC[C@]67C89)C(=O)OC)C1
InChI	1S/C46H56N4O10.H2O4S/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6;1-5(2,3)4/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3;(H2,1,2,3,4)/t28-,37-,38+,39+,42-,43+,44+,45-,46-;/m0./s1
InChI key	AQTQHPDCURKLKT-PNYVAJAMSA-N

Chemical structure: macrolide

pictograms	GHS06,GHS08
signalword	Danger
hcodes	H300 - H341 - H361fd
pcodes	P201 - P301 + P310 + P330
RIDADR	UN 2811 6.1 / PGII
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Virginiamycin M1

Empirical Formula (Hill Notation):	C₂₈H₃₅N₃O₇
CAS Number:	21411-53-0
Molecular Weight:	525.59
EC Number:	244-376-6
MDL number:	MFCD00869411
PubChem Substance ID:	24900736
NACRES:	NA.85

The antibiotic virginiamycin is produced by Streptomyces virginiae and is a member of the virginiamycin family. Each member is produced as a mixture of two structurally different compounds that exhibit synergistic antibacterial activity. There are two groups: virginiamycin M1 (VM1) and virginiamycin S (VS). VM1 is a polyunsaturated macrocyclic petolide. VM1 and VS are both used to inhibit protein synthesis since they are bacteriostatic. When used in combination they are more effective. Virginiamycin is used as a performance promoter in animal husbandry. They are chemically modified to make therapeutic drugs such as quinupristin and dalfopristin.

5, 10 mg in serum bottle

Virginiamycin M1 inhibits bacterial protein synthesis at the level of aminoacyl-tRNA binding and peptide bond formation. It inactivates the 50S ribosome. S. virginiae inactivates VM1 by reducing its 16-carbonyl group, forming 16R-dihydroVM1. VM1 reductase participates solely in VM1 inactivation in vivo.

Keep container tightly closed in a dry and well-ventilated place.

biological source	Streptomyces virginiae
Quality Level	200,
assay	95% (HPLC)
form	powder
storage condition	(Keep container tightly closed in a dry and well-ventilated place.)
color	white to yellow
solubility	methanol: soluble 10 mg/mL
Mode of action	protein synthesis \| interferes
antibiotic activity spectrum	Gram-positive bacteria
storage temp.	2-8°C
SMILES string	CC(C)[C@H]1OC(=O)C2=CCCN2C(=O)c3coc(CC(=O)C[C@H](O)C=C(C)C=CCNC(=O)C=C[C@H]1C)n3
InChI	1S/C28H35N3O7/c1-17(2)26-19(4)9-10-24(34)29-11-5-7-18(3)13-20(32)14-21(33)15-25-30-22(16-37-25)27(35)31-12-6-8-23(31)28(36)38-26/h5,7-10,13,16-17,19-20,26,32H,6,11-12,14-15H2,1-4H3,(H,29,34)/b7-5-,10-9-,18-13-/t19-,20-,26-/m1/s1
InChI key	DAIKHDNSXMZDCU-QHKJSJJMSA-N

Personal Protective Equipment	Eyeshields,, Gloves,, type N95 (US),
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Virginiamycin S1 V4140-5MG

Empirical Formula (Hill Notation):	C₄₃H₄₉N₇O₁₀
CAS Number:	23152-29-6
Molecular Weight:	823.89
EC Number:	245-462-6
PubChem Substance ID:	329829048
NACRES:	NA.85

Chemical structure: macrolide

The antibiotic virginiamycin is produced by Streptomyces virginiae and is a member of the virginiamycin family. Each member is produced as a mixture of two structurally different compounds that exhibit synergistic antibacterial activity. There are two groups: virginiamycin M1 (VM1) and virginiamycin S (VS). VS is a cyclic hexadepsipeptide. VS and VM1 are both used to inhibit protein synthesis since they are bacteriostatic. When used in combination they are more effective. Virginiamycin is used as a performance promoter in animal husbandry. It is chemically modified to make therapeutic drugs such as quinupristin and dalfopristin.

5 mg in serum bottle

Virginiamycin S inhibits bacterial protein synthesis at the level of aminoacyl-tRNA binding and peptide bond formation. It inactivates the 50S ribosome. VS is a cyclic hexadepsipeptide containing a nonproteinogenic amino acid, Lphenylglycine (L-pheGly), in its core structure. The visG gene is required for VS biosynthesis. Nonribosomal peptide synthetase (NRPS) may be involved in VS biosynthesis. Virginiamycin S is active against Gram-positive bacteria.
Cyclic polypeptide antibiotic from Streptomyces sp. Acts as a synergist binding to the conformational change in the peptidyl transferase center fo the 50S ribosome.

Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.

Keep container tightly closed in a dry and well-ventilated place.

Quality Level	100,
biological source	Streptomyces virginiae
assay	99% (HPLC)
form	solid
storage condition	(Keep container tightly closed in a dry and well-ventilated place.)
color	white
Mode of action	protein synthesis \| interferes
antibiotic activity spectrum	Gram-positive bacteria
storage temp.	20°C
SMILES string	CC[C@H]1NC(=O)[C@@H](NC(=O)c2ncccc2O)[C@@H](C)OC(=O)[C@@H](NC(=O)[C@@H]3CC(=O)CCN3C(=O)[C@H](Cc4ccccc4)N(C)C(=O)[C@@H]5CCCN5C1=O)c6ccccc6
InChI	1S/C43H49N7O10/c1-4-29-40(56)49-21-12-17-30(49)41(57)48(3)32(23-26-13-7-5-8-14-26)42(58)50-22-19-28(51)24-31(50)37(53)47-35(27-15-9-6-10-16-27)43(59)60-25(2)34(38(54)45-29)46-39(55)36-33(52)18-11-20-44-36/h5-11,13-16,18,20,25,29-32,34-35,52H,4,12,17,19,21-24H2,1-3H3,(H,45,54)(H,46,55)(H,47,53)/t25-,29-,30+,31+,32+,34+,35+/m1/s1
InChI key	FEPMHVLSLDOMQC-IYPFLVAKSA-N