Antibiotics

Gentamicn-Glutamine solution is used for selection of transformed cells that contain the aacA.aphD gene, and is recommended for use in cell culture applications at 10 mL/L.

Mode of Action: The product inhibits protein synthesis by binding to L6 protein of the 50S ribosomal subunit. Glutamine functions as an essential as an energy source for most mammalian cells in culture because of its amino acid carbon skeletons.

Antimicrobial spectrum: This product acts against both gram-negative and gram-positive bacteria, and mycoplasma.

Components

This solution is formulated to contain 200 mM L-glutamine and 5 mg/mL gentamicin in .9% sodium chloride

This product is stable in solution at 37°C for 5 days. The recommended storage temperature is -20°C.

Quality Level	300,
sterility	0.1 μm filtered
product line	BioReagent
form	liquid
potency	5-6 mg per mL
application(s)	cell culture \| mammalian: suitable
impurities	endotoxin, tested
Mode of action	protein synthesis \| interferes
antibiotic activity spectrum	Gram-negative bacteria, Gram-positive bacteria, mycoplasma
shipped in	dry ice
storage temp.	−20°C

Globomycin is a cyclic peptide antibiotic, which inhibits the growth of enteric Gram-negative bacteria through cell wall synthesis inhibition.

Personal Protective Equipment	Eyeshields,, Gloves,, multi-purpose combination respirator cartridge (US),
RIDADR	NONH for all modes of transport
WGK Germany	WGK 1
Flash Point F	Not applicable
Flash Point C	Not applicable

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Globomycin from Streptomyces hagronensis

Empirical Formula (Hill Notation):	C₃₂H₅₇N₅O₉
CAS Number:	67076-74-8
Molecular Weight:	655.82
MDL number:	MFCD32661892
NACRES:	NA.85

Globomycin was found to inhibit LspA, a lipoprotein signal peptidase. It eliminates the maturation of pro-lipoproteins by inhibition of the enzyme that converts pro-lipoprotein to lipoprotein, acting as a substrate analog of the signal sequence in the outer membrane of Gram-negative bacteria.

biological source	Streptomyces hagronensis
Quality Level	200,
assay	98% (HPLC)
form	powder
color	white
solubility	DMSO: 1 mg/mL
Mode of action	enzyme \| inhibits
antibiotic activity spectrum	Gram-negative bacteria
storage temp.	20°C, 20°C
InChI	1S/C32H57N5O9/c1-9-11-12-13-14-24-20(6)32(45)37(8)23(15-18(3)4)29(42)35-26(19(5)10-2)31(44)34-22(17-38)28(41)36-27(21(7)39)30(43)33-16-25(40)46-24/h18-24,26-27,38-39H,9-17H2,1-8H3,(H,33,43)(H,34,44)(H,35,42)(H,36,41)
InChI key	VFGBXFZXJAWPOE-UHFFFAOYSA-N

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Glycyrrhizic acid ammonium salt from glycyrrhiza root (licorice)

Empirical Formula (Hill Notation):	C₄₂H₆₅NO₁₆
Linear Formula:	C₄₂H₆₂O₁₆ · NH₃
CAS Number:	53956-04-0
Molecular Weight:	839.96
Beilstein/REAXYS Number:	3897076
EC Number:	258-887-7
MDL number:	MFCD00167400
PubChem Substance ID:	57651257

Кат. номер

50531-50G

50531-10G

Biologically active constituent in the sweet root of Glycyrrhiza species (licorice). Antiviral.

Quality Level	100,
assay	95.0% (NT)
optical activity	[]20/D +48±4°, c = 1% in ethanol: water (1:1)
sweetness	50 x sucrose
impurities	7% water
SMILES string	N.CC1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]3(C)[C@@H]2C(=O)C=C4[C@@H]5C[C@](C)(CC[C@]5(C)CC[C@@]34C)C(O)=O)O[C@H]6O[C@@H]([C@@H](O)[C@H](O)[C@H]6O[C@@H]7O[C@@H]([C@@H](O)[C@H](O)[C@H]7O)C(O)=O)C(O)=O
InChI	1S/C42H62O16.H3N/c1-37(2)21-8-11-42(7)31(20(43)16-18-19-17-39(4,36(53)54)13-12-38(19,3)14-15-41(18,42)6)40(21,5)10-9-22(37)55-35-30(26(47)25(46)29(57-35)33(51)52)58-34-27(48)23(44)24(45)28(56-34)32(49)50;/h16,19,21-31,34-35,44-48H,8-15,17H2,1-7H3,(H,49,50)(H,51,52)(H,53,54);1H3/t19-,21-,22-,23-,24-,25-,26-,27+,28-,29-,30+,31+,34-,35-,38+,39-,40-,41+,42+;/m0./s1
InChI key	ILRKKHJEINIICQ-OOFFSTKBSA-N

HCO-X-Gly-L-Ala-D-Leu-L-Ala-D-Val-L-Val-D-Val-L-Trp-D-Leu-L-Trp-D-Leu-L-Trp-D-Leu-L-Trp-NHCH2CH2OH

pictograms	GHS07
signalword	Warning
hcodes	H319
pcodes	P264 - P280 - P305 + P351 + P338 - P337 + P313
Personal Protective Equipment	Eyeshields,, Gloves,, type N95 (US),
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Gramicidin A from Bacillus brevis

CAS Number:	11029-61-1
Beilstein/REAXYS Number:	6461131
EC Number:	234-259-8
MDL number:	MFCD00466944
PubChem Substance ID:	329757641
NACRES:	NA.85

Gramicidin A is a linear pentadecapeptide antibiotic produced by Bacillus brevis. The transmembrane protein contains a left-handed helix with alternating L and D residues.
Chemical structure: peptide

Gramicidin A is used for studies on bacterial cell wall permeabilization and monovalent cation channel formation. Gramicidin has also been shown to inhibit transcription of T7 phage DNA, inhibit membrane-bound epidennal adenosine triphosphatase, suppress human lymphocyte blastogenesis in vitro and prolong heart allograft survival in the rat model <

Gramicidin A increases the permeability of bacterial cell membranes, which allows inorganic monovalent cations to travel through unrestricted. This destroys the ion gradient between the cytoplasm and the extracellular environment . Gramicidin A acts as neutral carrier and helps in the establishment of ion flux across the lipid bilayer.
Gramicidin A is a polypeptide antibiotic that forms single ion monovalent cation channels in biological membranes.

100mg

Keep container tightly closed in a dry and well-ventilated place.Moisture sensitive. Store under inert gas. Keep in a dry place.

biological source	Bacillus brevis
Quality Level	100,
form	solid
color	white to off-white
Mode of action	cell membrane \| interferes, enzyme \| inhibits
antibiotic activity spectrum	Gram-negative bacteria, Gram-positive bacteria
storage temp.	2-8°C
SMILES string	CC(C)C[C@@H](NC(=O)[C@H](C)NC(=O)CNC(=O)[C@@H](NC=O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](Cc5c[nH]c6ccccc56)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](Cc7c[nH]c8ccccc78)C(=O)NCCO
InChI	1S/C99H140N20O17/c1-51(2)37-73(109-86(123)59(17)107-81(122)49-105-96(133)82(55(9)10)106-50-121)89(126)108-60(18)87(124)117-84(57(13)14)98(135)119-85(58(15)16)99(136)118-83(56(11)12)97(134)116-80(44-64-48-104-72-34-26-22-30-68(64)72)95(132)112-76(40-54(7)8)92(129)115-79(43-63-47-103-71-33-25-21-29-67(63)71)94(131)111-75(39-53(5)6)91(128)114-78(42-62-46-102-70-32-24-20-28-66(62)70)93(130)110-74(38-52(3)4)90(127)113-77(88(125)100-35-36-120)41-61-45-101-69-31-23-19-27-65(61)69/h19-34,45-48,50-60,73-80,82-85,101-104,120H,35-44,49H2,1-18H3,(H,100,125)(H,105,133)(H,106,121)(H,107,122)(H,108,126)(H,109,123)(H,110,130)(H,111,131)(H,112,132)(H,113,127)(H,114,128)(H,115,129)(H,116,134)(H,117,124)(H,118,136)(H,119,135)/t59-,60-,73+,74+,75+,76+,77-,78-,79-,80-,82-,83+,84+,85-/m0/s1
InChI key	ZWCXYZRRTRDGQE-LUPIJMBPSA-N

Chemical structure: peptide

pictograms	GHS07
signalword	Warning
hcodes	H302
pcodes	P264 - P270 - P301 + P312 + P330 - P501
Personal Protective Equipment	dust mask type N95 (US),, Eyeshields,, Gloves,
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Gramicidin C from Bacillus brevis

CAS Number:	9062-61-7
NACRES:	NA.85

Gramicidin is a naturally occuring polypeptide antibiotic. It functions as a transmembrane ion channel and is used for studies on phospholipid bilayer membrane fluidity measured by lateral diffusion.

Gramicidin′s bactericidal activity is a result of increasing the permeability of the bacterial cell membrane. This allows inorganic monovalent cations to travel through unrestricted which thereby destroys the ion gradient between the cytoplasm and the extracellular environment .
Naturally occuring polypeptide antibiotic with Tyr at position 11; functions as a transmembrane ion channel.

10mg

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place. Keep in a dry place.

biological source	Bacillus brevis
Quality Level	100,
assay	~90% (HPLC)
form	powder
impurities	5% water
color	white to off-white
Mode of action	cell membrane \| interferes, enzyme \| inhibits
antibiotic activity spectrum	Gram-negative bacteria, Gram-positive bacteria
storage temp.	2-8°C
SMILES string	CC(C)C[C@@H]1NC(=O)[C@H](CCCN)NC(=O)[C@@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN)NC(=O)[C@@H](NC(=O)[C@@H]4CCCN4C(=O)[C@@H](Cc5ccccc5)NC1=O)C(C)C)C(C)C

Gramicidin from Bacillus aneurinolyticus (Bacillus brevis) has been used as a control to measure the rate of diffusion of protonated -lactams through the lipid bilayer in liposome swelling assay. It has also been used as an analyte for the purpose of infrared laser desorption or ionization from silicon.

Personal Protective Equipment	Eyeshields,, Gloves,, type N95 (US),
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Gramicidin from Bacillus aneurinolyticus (Bacillus brevis)

CAS Number:	1405-97-6
EC Number:	215-790-4
MDL number:	MFCD00131232
NACRES:	NA.77

1, 5 g in glass bottle
100, 500 mg in glass bottle

Linear polypeptide antibiotic mixture of gramicidin A, B, C, and D. Gramicidin A acts as neutral carrier and helps in the establishment of ion flux across the lipid bilayer.
Linear polypeptide antibiotic, a mixture of gramicidin A, B, C, and D. Gramicidin D, a channel-forming ionophore that flip-flops slowly across the membrane is a known Pgp substrate and surprisingly was found to inhibit Pgp ATPase activity. This inhibition was reversed by other Pgp substrates suggesting a common drug binding site among MDR substrate-type drugs and chemosensitizers.

Quality Level	200,
Mode of action	cell membrane \| interferes, enzyme \| inhibits
antibiotic activity spectrum	Gram-negative bacteria, Gram-positive bacteria
storage temp.	2-8°C
InChI	1S/C99H140N20O17/c1-51(2)37-73(109-86(123)59(17)107-81(122)49-105-96(133)82(55(9)10)106-50-121)89(126)108-60(18)87(124)117-84(57(13)14)98(135)119-85(58(15)16)99(136)118-83(56(11)12)97(134)116-80(44-64-48-104-72-34-26-22-30-68(64)72)95(132)112-76(40-54(7)8)92(129)115-79(43-63-47-103-71-33-25-21-29-67(63)71)94(131)111-75(39-53(5)6)91(128)114-78(42-62-46-102-70-32-24-20-28-66(62)70)93(130)110-74(38-52(3)4)90(127)113-77(88(125)100-35-36-120)41-61-45-101-69-31-23-19-27-65(61)69/h19-34,45-48,50-60,73-80,82-85,101-104,120H,35-44,49H2,1-18H3,(H,100,125)(H,105,133)(H,106,121)(H,107,122)(H,108,126)(H,109,123)(H,110,130)(H,111,131)(H,112,132)(H,113,127)(H,114,128)(H,115,129)(H,116,134)(H,117,124)(H,118,136)(H,119,135)/t59-,60-,73+,74+,75+,76+,77-,78-,79-,80-,82-,83-,84+,85-/m0/s1
InChI key	ZWCXYZRRTRDGQE-SORVKSEFSA-N

HAT Media Supplement (50x) Hybri-Max™ has been used:

Personal Protective Equipment	Eyeshields,, Gloves,, type N95 (US),
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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HAT Media Supplement (50) Hybri-Max™

in the selection and validation of hypoxanthine-guanine phosophoribosyltransferase (HPRT)-deficient clones
in the generation of mAbs (monoclonal antibodies)
in the luciferase-based bioassay (LUC) assay

Reconstitution

Reconstitute contents of vial with 10 ml sterile cell culture medium. Stock solution is sufficient to prepare 500 ml medium. Final working concentration: 100 μM hypoxanthine, 0.4 μM aminopterin, 16 μM thymidine.

Legal Information

Hybri-Max is a trademark of Sigma-Aldrich Co. LLC

Quality Level	200,
sterility	-irradiated
product line	BioXtra
form	lyophilized powder
application(s)	cell culture \| hybridoma: suitable
impurities	endotoxin, tested
shipped in	dry ice
storage temp.	20°C

pictograms	GHS07,GHS08
signalword	Danger
hcodes	H302 - H360
pcodes	P201 - P301 + P312 + P330 - P308 + P313
Personal Protective Equipment	Eyeshields,, Gloves,, type P2 (EN 143) respirator cartridges,
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Hexamethylenetetramine

Empirical Formula (Hill Notation):	C₆H₁₂N₄
CAS Number:	100-97-0
Molecular Weight:	140.19
Beilstein/REAXYS Number:	2018
EC Number:	202-905-8
MDL number:	MFCD00006895
PubChem Substance ID:	57647507
NACRES:	NA.21

vapor pressure	<0.01 mmHg ( 20 °C)
Quality Level	200,
assay	99-100.5% (calc. to the dried substance)
autoignition temp.	770 °F
quality	meets analytical specification of Ph. Eur., BP
impurities	acidic and alkalic reac. substances, complies, residual solvents, in accordance, 0.002% heavy metals (as Pb), 0.005% free formaldehyde
loss	2% loss on drying
mp	280 °C (subl.) (lit.)
solubility	H₂O: soluble
anion traces	chloride (Cl^-): 100 mg/kg, sulfate (SO₄^2-): 100 mg/kg
suitability	complies for appearance of solution
Featured Industry	Pharmaceutical (small molecule)
SMILES string	C1N2CN3CN1CN(C2)C3
InChI	1S/C6H12N4/c1-7-2-9-4-8(1)5-10(3-7)6-9/h1-6H2
InChI key	VKYKSIONXSXAKP-UHFFFAOYSA-N

Chemical structure: aminoglycoside
Aminoglycosides are the most widely used class of antibiotics that target ribosome. Hygromycin B is an aminocyclitol antibiotic. The organism, S. hygroscopicus contains phosphotransferase (HPH) activity, which phosphorylates hygromycin B helping in autoimmunity against the toxic effects of the drug.

pictograms	GHS02,GHS07
signalword	Warning
hcodes	H228 - H317
pcodes	P210 - P280 - P302 + P352
Personal Protective Equipment	Eyeshields,, Faceshields,, Gloves,, type P1 (EN143) respirator filter,, type P3 (EN 143) respirator cartridges,
RIDADR	UN1328 - class 4.1 - PG 3 - Hexamethylenetetramine
WGK Germany	WGK 1
Flash Point F	482.0 °F - closed cup
Flash Point C	250 °C - closed cup

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HT Media Supplement (50) Hybri-Max™

Кат. номер

H0137-PH

H0137-10VL-PW

H0137-1VL

H0137-10VL

H0137-1VL-KC

Application
HT Media supplement is a cocktail hypoxanthine and thymidine qualified for use in hybridoma selection and cell culture applications. HT Media Supplement (50x) Hybri-Max™ has been used as a supplement in INS-1 -cells co-culture medium. It is suitable for use as medium for hybridoma cells and as Dulbeccos Modified Eagle Medium (DMEM) for HeLa S3 and MTH1-KO cells.
Reconstitution
Reconstitute contents of vial with 10 ml sterile cell culture medium. Stock solution is sufficient to prepare 500 ml medium. Final working concentration: 100 μM hypoxanthine, 16 μM thymidine.
Legal Information
Hybri-Max is a trademark of Sigma-Aldrich Co. LLC
Параметры

Quality Level 200,

sterility -irradiated

product line BioXtra

form lyophilized powder

application(s) cell culture | hybridoma: suitable

impurities endotoxin, tested

storage temp. 20°C

Safety Information

Personal Protective Equipment Eyeshields,, Gloves,, type N95 (US),

RIDADR NONH for all modes of transport

WGK Germany WGK 3

Flash Point F Not applicable

Flash Point C Not applicable

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Hygromycin B from Streptomyces hygroscopicus

Empirical Formula (Hill Notation):	C₂₀H₃₇N₃O₁₃
CAS Number:	31282-04-9
Molecular Weight:	527.52
EC Number:	250-545-5
MDL number:	MFCD06795479
PubChem Substance ID:	24895568
NACRES:	NA.76

Hygromycin B antibiotic was used for hygro resistance effect in the following cells:

transfected 293T cells with mixture of plasmids at 160 µg/ml.
MCF-7ALOX12 cells at 150 µg/ml.
MSCV Luciferase PGK-hygro plasmid.
STAT3 Reporter HeLa Stable Cell Line (stably transfected with Luciferase gene under the control of STAT3 promoter) maintained in DMEM supplemented with 10% FBS.

Hygromycin B is an aminoglycoside antibiotic isolated from Streptomyces hygroscopicus. It has been used to study protein synthesis at the level of the 70S ribosome translocation and mRNA template misreading, as an antiviral agent by selectively penetrating cells rendered permeable by virus infection and inhibiting translation, and as a selection agent for hygromycin resistance gene transformed cells. It is recommended for use as a selection agent at 100-800 µg/mL, specifically at 100 µg/mL for prokaryotes, 200 µg/mL for lower eukaryotes and 150-400 µg/mL for higher eukaryotes.

Mode of Action: The product acts by inhibiting protein synthesis by inducing the misreading of the m-RNA template in the prokaryote, with the potency to inhibit translation.
Antimicrobial Spectrum: Hygromycin B acts against bacteria, fungi and higher eukaryotic cells.

Hygromycin B products should be stored as supplied at 2-8°C, and the dry solid is table for at least 5 years if stored at 2-8°C. It is stable at 37°C for 30 days. (For solutions) This solution is stable as supplied for two years if stored at 2-8°C.

This product is purified by ion exchange chromatography. Hygromycin B is soluble in water at concentrations >50 mg/mL, and also soluble in methanol or ethanol. Solutions should be sterilized by filtration, not by autoclaving. Additionally, Hygromycin B solutions have been reported to lose activity on freezing, and since they are stable refrigerated, freezing should be avoided.

biological source	Streptomyces hygroscopicus
Quality Level	200,
product line	BioReagent
assay	60% (HPLC)
form	powder
application(s)	cell culture \| insect: suitable, cell culture \| mammalian: suitable
color	faintly brown to brown, white to beige
A	(1) 7.1, (2) 8.8
mp	160-180 °C
solubility	H₂O: 50 mg/mL (As a stock solution. Stock solutions should be stored at 2-8°C. Stable at 37°C for 30 days.)
Mode of action	protein synthesis \| interferes
antibiotic activity spectrum	fungi
storage temp.	2-8°C
SMILES string	CN[C@H]1C[C@@H](N)[C@H](O)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O)[C@@H]3O[C@]4(O[C@H]([C@H](N)CO)[C@H](O)[C@H](O)[C@H]4O)O[C@H]23)[C@@H]1O
InChI	1S/C20H37N3O13/c1-23-7-2-5(21)9(26)15(10(7)27)33-19-17-16(11(28)8(4-25)32-19)35-20(36-17)18(31)13(30)12(29)14(34-20)6(22)3-24/h5-19,23-31H,2-4,21-22H2,1H3/t5-,6-,7+,8-,9+,10-,11+,12-,13+,14-,15-,16+,17+,18-,19+,20+/m1/s1
InChI key	GRRNUXAQVGOGFE-XKIAHZFYSA-N

pictograms	GHS06
signalword	Danger
hcodes	H300 + H310 + H330
pcodes	P260 - P262 - P264 - P280 - P302 + P352 + P310 - P304 + P340 + P310
RIDADR	UN3462 - class 6.1 - PG 1 - Toxins, extracted from living sources, solid, n.o.s., HI: all (not BR)
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Hygromycin B solution from Streptomyces hygroscopicus

Empirical Formula (Hill Notation):	C₂₀H₃₇N₃O₁₃
CAS Number:	31282-04-9
Molecular Weight:	527.52
Beilstein/REAXYS Number:	6755837
MDL number:	MFCD06795479
PubChem Substance ID:	24895410
NACRES:	NA.85

Mode of action: The product acts by inhibiting protein synthesis by inducing the misreading of the m-RNA template in the prokaryote, with the potency to inhibit translation.
Antimicrobial Spectrum: Hygromycin B acts against bacteria, fungi and higher eukaryotic cells.

Hygromycin B products should be stored as supplied at 2-8°C, and the dry solid is stable for at least 5 years if stored at 2-8°C. It is stable at 37°C for 30 days.

This product is a solution that comes =60% (HPAE) and 45-60 mg/mL in H2O.

biological source	Streptomyces hygroscopicus
Quality Level	200,
sterility	0.22 µm filtered
assay	60% (HPLC)
concentration	45-60 mg/mL in H₂O
color	brown-yellow, light orange to dark orange, light yellow to dark yellow
Mode of action	protein synthesis \| interferes
antibiotic activity spectrum	viruses
storage temp.	2-8°C
SMILES string	CN[C@H]1C[C@@H](N)[C@H](O)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O)[C@@H]3OC4(O[C@H]([C@H](N)CO)[C@H](O)[C@H](O)[C@H]4O)O[C@H]23)[C@@H]1O
InChI	1S/C20H37N3O13/c1-23-7-2-5(21)9(26)15(10(7)27)33-19-17-16(11(28)8(4-25)32-19)35-20(36-17)18(31)13(30)12(29)14(34-20)6(22)3-24/h5-19,23-31H,2-4,21-22H2,1H3/t5-,6-,7+,8-,9+,10-,11+,12-,13+,14-,15-,16+,17+,18-,19+,20+/m1/s1
InChI key	GRRNUXAQVGOGFE-XKIAHZFYSA-N

pictograms	GHS06
signalword	Danger
hcodes	H301 + H311 - H330
pcodes	P260 - P264 - P270 - P280 - P302 + P352 + P312 - P304 + P340 + P310
Personal Protective Equipment	Eyeshields,, Faceshields,, Gloves,, type ABEK (EN14387) respirator filter,
RIDADR	UN2810 - class 6.1 - PG 1 - PAX forbidden - Toxic, liquids, organic, n.o.s., HI: all
WGK Germany	WGK 3

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Hypericin from Hypericum perforatum 56690-1MG

Empirical Formula (Hill Notation):	C₃₀H₁₆O₈
CAS Number:	548-04-9
Molecular Weight:	504.44
Beilstein/REAXYS Number:	1917913
EC Number:	208-941-0
MDL number:	MFCD00016683
PubChem Substance ID:	57651594
NACRES:	NA.77

Hypericin hydrophobic is a red color pigment occurring naturally in Hypericum perforatum. Its fluorescence is measured at 600 nm. It is localized in the intracellular membranes including nuclear membrane, mitochondrial membrane, Golgi apparatus, lysosomes and endoplasmic reticulum.

Hypericin from Hypericum perforatum has been used:

in the broth macrodilution test and antibacterial assay against bacterial strains
as a medium supplement for human malignant melanoma cells for irradiation and localization studies
as a ligand for pregnane X receptor (PXR) and as defatting medium supplement for primary human hepatocytes culture

Hypericin is a potent inhibitor of protein kinase C (PKC), telomerase, cytochrome P450 and reverse transcriptase. It is exploited for its photosensitizing functionality in photodynamic therapy (PDT) and photodynamic diagnosis (PDD) in cancer cells.
Anthraquinone-derivative within St. John′s wort. Antibacterial effective against Gram-positive and Gram-negative bacteria.

Bottomless glass bottle. Contents are inside inserted fused cone.

assay	~95% (HPLC)
Quality Level	100,
solubility	1 M NaOH: 10 mg/mL, turbid, dark green
SMILES string	Cc1cc(O)c2C(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6C(=O)c7c(O)cc(C)c8c1c2c(c34)c(c78)c56
InChI	1S/C30H16O8/c1-7-3-9(31)19-23-15(7)16-8(2)4-10(32)20-24(16)28-26-18(12(34)6-14(36)22(26)30(20)38)17-11(33)5-13(35)21(29(19)37)25(17)27(23)28/h3-6,31-36H,1-2H3
InChI key	BTXNYTINYBABQR-UHFFFAOYSA-N

Hypoxanthine (6-hydroxypurine), a purine derivative is a naturally occurring compound. It is the deaminated form of adenine and a breakdown product of adenosine monophosphate (AMP).

pictograms	GHS07
signalword	Warning
hcodes	H302
pcodes	P301 + P312 + P330
Personal Protective Equipment	dust mask type N95 (US),, Eyeshields,, Gloves,
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Hypoxanthine

Empirical Formula (Hill Notation):	C₅H₄N₄O
CAS Number:	68-94-0
Molecular Weight:	136.11
Beilstein/REAXYS Number:	5811
EC Number:	200-697-3
MDL number:	MFCD00005725
PubChem Substance ID:	24895864
NACRES:	NA.75

Hypoxanthine is a nutrient additive for a variety of cell culture applications involving bacterial, parasite (Plasmodium falciparum) and animal cells. Hypoxanthine is a component of selection media used in hybridoma technologies.
Hypoxanthine has been used:

as a supplement in HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid) -buffered Roswell park memorial institute (RPMI) to culture Plasmodium falciparum strain IT/FCR3
in the preparation of Dulbeccos modified eagles medium (DMEM) + MXH for the selection of chimeric modified vaccinia virus ankara (MVA)
to generate superoxide anions
to prepare hybridoma selection and maintenance media.

1, 5, 25 g in poly bottle

Hypoxanthine is capable of stimulating cell death. It can also induce reactive oxygen species (ROS). It results in endothelial dysfunction via apoptosis, stimulated by oxidative stress.

Quality Level	200,
product line	BioReagent
assay	≥99%
form	powder
application(s)	cell culture \| mammalian: suitable
mp	>300 °C (lit.)
solubility	formic acid: water (2:1): 50 mg/mL
SMILES string	O=C1NC=Nc2nc[nH]c12
InChI	1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10)
InChI key	FDGQSTZJBFJUBT-UHFFFAOYSA-N

5, 25, 100 g in glass bottle

Personal Protective Equipment	Eyeshields,, Gloves,, type N95 (US),
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Indomethacin

Empirical Formula (Hill Notation):	C₁₉H₁₆ClNO₄
CAS Number:	53-86-1
Molecular Weight:	357.79
Beilstein/REAXYS Number:	497341
EC Number:	200-186-5
MDL number:	MFCD00057095
PubChem Substance ID:	24896136
NACRES:	NA.21

Cyclooxygenase (COX) inhibitor that is relatively selective for COX-1.
Used as a non-selective inhibitor of cyclooxygenases, COX1 and COX2, leading to reduced prostaglandin biosynthesis from arachidonic acid.

Quality Level	200,
Agency/Method	USP/NF, meets USP testing specifications
assay	98.0-102.0%
form	powder
Mode of action	enzyme \| inhibits
SMILES string	COc1ccc2n(c(C)c(CC(O)=O)c2c1)C(=O)c3ccc(Cl)cc3
InChI	1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)
InChI key	CGIGDMFJXJATDK-UHFFFAOYSA-N
Gene Information	human ... ALB(213), ALOX5(240), ELA2(1991), GPR44(11251), IL1A(3552), PLA2G1B(5319), PTGDR(5729), PTGS1(5742), PTGS2(5743) mouse ... Alox5(11689), Ptgdr(19214), Ptger1(19216), Ptger2(19217), Ptger3(19218), Ptger4(19219), Ptgs1(19224), Ptgs2(19225) rat ... Alox5(25290), Ptgs1(24693), Ptgs2(29527)

Ionomycin is an ionophore produced by the bacterium Streptomyces conglobatus. It has been shown to induce central demyelination , inhibit adrenal bovine TREK-1 channels , and to regulate cell division of mature human B cells . It is used to study the effects of calcium flux on endoplasmic reticulum (ER) stress, mitochodrial stress and intrinsic apoptosis mechanisms. It is also used to stimulate the intracellular production of the cytokines, interferon, perforin, IL-2, and IL-4 usually in conjunction with PMA.

pictograms	GHS06
signalword	Danger
hcodes	H300
pcodes	P264 - P301 + P310
Personal Protective Equipment	Eyeshields,, Faceshields,, Gloves,, type P2 (EN 143) respirator cartridges,
RIDADR	UN 2811 6.1 / PGI
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Ionomycin calcium salt

Empirical Formula (Hill Notation):	C₄₁H₇₀CaO₉
Molecular Weight:	747.07
EC Number:	200-664-3
MDL number:	MFCD00083634
PubChem Substance ID:	329815372
NACRES:	NA.85

Ca2+ ionophore that is more effective than A23187 as a mobile ion carrier for Ca2+; non-fluorescent; used to study Ca2+ transport across biological membranes; induces apoptotic degeneration of embryonic cortical neurons.
Ionomycin is a Ca2+ ionophore that is more effective than A23187 as a mobile ion carrier for Ca2+. It is non-fluorescent. It is used to study Ca2+ transport across biological membranes and induces apoptotic degeneration of embryonic cortical neurons.

biological source	Streptomyces conglobatus
Quality Level	300,
sterility	0.2 µm filtered
assay	98% (HPLC)
shelf life	2 yr
concentration	1 mM in DMSO
color	colorless
mp	18.4 °C
Mode of action	cell membrane \| interferes
antibiotic activity spectrum	Gram-positive bacteria
shipped in	wet ice
storage temp.	20°C
SMILES string	C[C@@H]1CCC(=O)O[Ca]OC(=CC(=O)[C@@H](C)C[C@@H](C)C1)[C@H](C)C[C@H](C)C\C=C\[C@@H](C)[C@@H](O)[C@@H](C)[C@@H](O)C[C@@H]2CC[C@](C)(O2)[C@H]3CC[C@](C)(O3)[C@@H](C)O
InChI	1S/C41H72O9.Ca/c1-25(21-29(5)34(43)24-35(44)30(6)22-27(3)20-26(2)14-15-38(46)47)12-11-13-28(4)39(48)31(7)36(45)23-33-16-18-41(10,49-33)37-17-19-40(9,50-37)32(8)42;/h11,13,24-33,36-37,39,42-43,45,48H,12,14-23H2,1-10H3,(H,46,47);/q;+2/p-2/b13-11+,34-24-;/t25-,26-,27+,28-,29-,30+,31+,32-,33+,36+,37-,39-,40+,41+;/m1./s1
InChI key	WKRWUYKLUMMAKG-WYGBAUISSA-L

Personal Protective Equipment	Eyeshields,, Gloves,, multi-purpose combination respirator cartridge (US),
RIDADR	NA 1993 / PGIII
WGK Germany	WGK 1
Flash Point F	188.6 °F - closed cup
Flash Point C	87 °C - closed cup

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Ionomycin calcium salt from Streptomyces conglobatus

Empirical Formula (Hill Notation):	C₄₁H₇₀CaO₉
CAS Number:	56092-82-1
Molecular Weight:	747.07
Beilstein/REAXYS Number:	1416163
MDL number:	MFCD00083634
PubChem Substance ID:	329815321
NACRES:	NA.77

1, 5 mg in glass bottle

Store ionomycin in powder form desiccated and protected from light at 2-8 °C. Under these conditions the product is stable for 3 years. Store stock solutions in ethanol or DMSO at -20 °C, protected from light. Under these conditions the stock solutions are stable for several months. For short term use (up to 6 weeks) the stock solutions maybe stored at 2-8 °C protected from light.

Quality Level	300
assay	98% (HPLC)
form	powder
storage condition	desiccated, protect from light
color	white to off-white
solubility	DMSO: 10 mg/mL, ethanol: soluble
Mode of action	cell membrane \| interferes
antibiotic activity spectrum	Gram-positive bacteria
storage temp.	2-8°C
SMILES string	C[C@@H]1CCC(=O)O[Ca]OC(=CC(=O)[C@@H](C)C[C@@H](C)C1)[C@H](C)C[C@H](C)C\C=C\[C@@H](C)[C@@H](O)[C@@H](C)[C@@H](O)C[C@@H]2CC[C@](C)(O2)[C@H]3CC[C@](C)(O3)[C@@H](C)O
InChI	1S/C41H72O9.Ca/c1-25(21-29(5)34(43)24-35(44)30(6)22-27(3)20-26(2)14-15-38(46)47)12-11-13-28(4)39(48)31(7)36(45)23-33-16-18-41(10,49-33)37-17-19-40(9,50-37)32(8)42;/h11,13,24-33,36-37,39,42-43,45,48H,12,14-23H2,1-10H3,(H,46,47);/q;+2/p-2/b13-11+,34-24-;/t25-,26-,27+,28-,29-,30+,31+,32-,33+,36+,37-,39-,40+,41+;/m1./s1
InChI key	WKRWUYKLUMMAKG-WYGBAUISSA-L

Pictograms	GHS07
Signal Word	Warning
Hazard Statements	H302
Precautionary Statements	P264 - P270 - P301 + P312 - P501
Personal Protective Equipment	dust mask type N95 (US), Eyeshields, Gloves
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

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Ionomycin from Streptomyces conglobatus

Empirical Formula (Hill Notation):	C₄₁H₇₂O₉
CAS Number:	56092-81-0
Molecular Weight:	709.00
Beilstein/REAXYS Number:	3642126
MDL number:	MFCD06798385
PubChem Substance ID:	24896159
NACRES:	NA.85

1, 5 mg in glass bottle

Ionomycin is a Ca2+ ionophore that is more effective than A23187 as a mobile ion carrier for Ca2+. It is non-fluorescent. It induces apoptotic degeneration of embryonic cortical neurons.

biological source	Streptomyces conglobatus
Quality Level	300,
assay	98% (HPLC)
solubility	acetonitrile: 10 mg/mL
Mode of action	cell membrane \| interferes
antibiotic activity spectrum	Gram-positive bacteria
storage temp.	20°C
SMILES string	C[C@H](CCC(O)=O)C[C@H](C)C[C@H](C)C(=O)\C=C(/O)[C@H](C)C[C@H](C)C\C=C\[C@@H](C)[C@@H](O)[C@@H](C)[C@@H](O)C[C@@H]1CC[C@](C)(O1)[C@H]2CC[C@](C)(O2)[C@@H](C)O
InChI	1S/C41H72O9/c1-25(21-29(5)34(43)24-35(44)30(6)22-27(3)20-26(2)14-15-38(46)47)12-11-13-28(4)39(48)31(7)36(45)23-33-16-18-41(10,49-33)37-17-19-40(9,50-37)32(8)42/h11,13,24-33,36-37,39,42-43,45,48H,12,14-23H2,1-10H3,(H,46,47)/b13-11+,34-24-/t25-,26-,27+,28-,29-,30+,31+,32-,33+,36+,37-,39-,40+,41+/m1/s1
InChI key	PGHMRUGBZOYCAA-ADZNBVRBSA-N

Personal Protective Equipment	dust mask type N95 (US),, Eyeshields,, Gloves,
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Itraconazole I6657-100MG

Empirical Formula (Hill Notation):	C₃₅H₃₈Cl₂N₈O₄
CAS Number:	84625-61-6
Molecular Weight:	705.63
MDL number:	MFCD00870168
PubChem Substance ID:	329815394
NACRES:	NA.85

Itraconazole is a triazole antifungal agent. It is used to inhibit cytochrome P-450-dependent enzymes and ergosterol synthesis. It has been used against histoplasmosis, blastomycosis, cryptococcal meningitis, and aspergillosis. Its different formulations are used to study Candida strains in murine invasive infections. It has been used to study proliferative changes of the forestomach mucosa in alloxan-induced diabetic rats.

100 mg in poly bottle

Itraconazole inhibits cytochrome P-450-dependent enzymes which results in the inhibition of ergosterol synthesis. It does so by interacting with 14-α demethylase, which is a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. Ergosterol is a crucial compenent of fungal cell membranes. Therefore, it′s inhibition results in increased cellular permeability causing leakage of cellular contents. Itraconazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and phospholipid biosynthesis.

Quality Level	200,
assay	≥98% (TLC)
color	white
solubility	chloroform: 50 mg/mL, clear, colorless
Mode of action	enzyme \| inhibits
antibiotic activity spectrum	fungi
storage temp.	2-8°C
SMILES string	CCC(C)N1N=CN(C1=O)c2ccc(cc2)N3CCN(CC3)c4ccc(OCC5COC(Cn6cncn6)(O5)c7ccc(Cl)cc7Cl)cc4
InChI	1S/C35H38Cl2N8O4/c1-3-25(2)45-34(46)44(24-40-45)29-7-5-27(6-8-29)41-14-16-42(17-15-41)28-9-11-30(12-10-28)47-19-31-20-48-35(49-31,21-43-23-38-22-39-43)32-13-4-26(36)18-33(32)37/h4-13,18,22-25,31H,3,14-17,19-21H2,1-2H3
InChI key	VHVPQPYKVGDNFY-UHFFFAOYSA-N

pictograms	GHS07
signalword	Warning
hcodes	H302 - H315 - H319 - H335
pcodes	P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
Target Organs	Respiratory system
Personal Protective Equipment	dust mask type N95 (US),, Eyeshields,, Faceshields,, Gloves,
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Josamycin 59983-50MG

Empirical Formula (Hill Notation):	C₄₂H₆₉NO₁₅
CAS Number:	16846-24-5
Molecular Weight:	827.99
EC Number:	240-871-6
MDL number:	MFCD00211043
PubChem Substance ID:	57651709
NACRES:	NA.85

Chemical structure: macrolide

Josamycin is used to study the modification of phagocytosis and cytokine production by macrolide antibiotics, immunomodulatory effects, the suppression of matrix metalloproteinase production as well as study bacteria protein synthesis at the level of the the 23S rRNA, 50S ribosomal subunit.

50 mg in glass bottle
Bottomless glass bottle. Contents are inside inserted fused cone.

Josamycin inhibits bacterial protein biosynthesis by inhibiting peptidyltransferase and ribosomal translocation, and depleting the intracellular pools of aminoacyl-tRNAs available for protein synthesis by drop-off and incomplete peptidyl-tRNA hydrolase activity. It slows down formation of the first peptide bond of a nascent peptide in an amino acid-dependent way and inhibits formation of the second or third peptide bond.

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Quality Level	100,
assay	≥90% (HPLC)
form	powder
color	white to slightly yellow
Mode of action	protein synthesis \| interferes
antibiotic activity spectrum	Gram-positive bacteria
storage temp.	2-8°C
SMILES string	CO[C@H]1[C@@H](CC(=O)O[C@H](C)C\C=C\C=C\[C@H](O)[C@H](C)C[C@H](CC=O)[C@@H]1O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O3)[C@@H]([C@H]2O)N(C)C)OC(C)=O
InChI	1S/C42H69NO15/c1-23(2)19-32(47)56-40-27(6)53-34(22-42(40,8)50)57-37-26(5)54-41(36(49)35(37)43(9)10)58-38-29(17-18-44)20-24(3)30(46)16-14-12-13-15-25(4)52-33(48)21-31(39(38)51-11)55-28(7)45/h12-14,16,18,23-27,29-31,34-41,46,49-50H,15,17,19-22H2,1-11H3/b13-12+,16-14+/t24-,25-,26-,27+,29+,30+,31-,34+,35-,36-,37-,38+,39+,40+,41+,42-/m1/s1
InChI key	XJSFLOJWULLJQS-NGVXBBESSA-N

Personal Protective Equipment	Eyeshields,, Gloves,, type N95 (US),
RIDADR	NONH for all modes of transport
WGK Germany	WGK 2
Flash Point F	Not applicable
Flash Point C	Not applicable

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Kanamycin B sulfate salt

Empirical Formula (Hill Notation):	C₁₈H₃₇N₅O₁₀ · xH₂SO₄
Molecular Weight:	483.51 (free base basis)
Beilstein/REAXYS Number:	5235274
MDL number:	MFCD00078511
PubChem Substance ID:	24891829
NACRES:	NA.85

Used as a selection agent for cells transformed with kanamycin B (neoR, kanR) resistance gene.

Kanamycin B is an aminoglycoside antibiotic that is the 2-amino,2-deoxy-analog of kanamycin A. Mode of Action: Binds to 70S ribosomal subunit; inhibits translocation; elicits miscoding. Antimicrobial spectrum: Gram-negative and Gram-positive bacteria, and mycoplasm.
Mode of Action: The product acts by binding to the 70S ribosomal subunit, inhibiting translocation and eliciting miscoding.
Mode of Resistance: Aminoglycoside-modifying enzymes (including acetyltransferase, phosphotransferase, nucleotidyltransferase) can alter this antibiotic, preventing its interaction with ribosomes.
Antimicrobial Spectrum: Kanamycin sulfate is effective against gram-negative and gram-postiive bacteria, and mycoplasma.

Kanamycin sulfate is soluble in water at 50 mg/mL, yielding a clear solution. It is practically insoluble in alcohol, acetone, chloroform, ether and ethyl acetate. A 1% solution in water has a pH of 6.5 to 8.5. Sterile solutions can be prepared by a sterile filtration, through a .2μm filter.

Keep container tightly closed in a dry and well-ventilated place.

Quality Level	200,
form	powder or crystals
Mode of action	protein synthesis \| interferes
antibiotic activity spectrum	Gram-negative bacteria, Gram-positive bacteria, mycoplasma
storage temp.	−20°C
SMILES string	OS(O)(=O)=O.NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](N)[C@@H](O)[C@@H]1O
InChI	1S/C18H37N5O10.H2O4S/c19-2-6-11(26)12(27)9(23)17(30-6)32-15-4(20)1-5(21)16(14(15)29)33-18-13(28)8(22)10(25)7(3-24)31-18;1-5(2,3)4/h4-18,24-29H,1-3,19-23H2;(H2,1,2,3,4)/t4-,5+,6+,7+,8-,9+,10+,11+,12+,13+,14-,15+,16-,17+,18+;/m0./s1
InChI key	YGTPKDKJVZOVCO-KELBJJLKSA-N

Personal Protective Equipment	Eyeshields,, Gloves,, type N95 (US),
RIDADR	NONH for all modes of transport
WGK Germany	WGK 2
Flash Point F	Not applicable
Flash Point C	Not applicable

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Kanamycin disulfate salt from Streptomyces kanamyceticus

CAS Number:	64013-70-3
MDL number:	MFCD00143916
PubChem Substance ID:	329817127

Kanamycin sulfate is a broad spectrum minoglycoside-antibiotic It is used as an additive in culture media for the isolation of group D Streptococci on Kanamycin Esculin Azide Agar (Mossel et al.) or for selection of transformed plant cells containing the neomycin phosphotransferase (for kanamycin resistance); on a kanamycin-medium. Kanamycin has been used for electrophysiological recordings of outer hair cells and inner hair cells. It is used to inhibit shoot regeneration from Siberian Elmleaf explants. It is recommended for use in cell culture applications at 100 mg/mL.

Mode of Action: The product acts by binding to the 70S ribosomal subunit, inhibiting translocation and eliciting miscoding.
Mode of Resistance: Aminoglycoside-modifying enzymes (including acetyltransferase, phosphotransferase, nucleotidyltransferase) can alter this antibiotic, preventing its interaction with ribosomes.
Antimicrobial Spectrum: Kanamycin sulfate is effective against gram-negative and gram-postiive bacteria, and mycoplasma.

Solutions are stable at 37°C for approximately 5 days. Aqueous stock solutions can be stored at 2-8°C for long term storage.

Kanamycin sulfate is soluble in water at 10 mg/mL, yielding a clear solution. It is practically insoluble in alcohol, acetone, chloroform, ether and ethyl acetate. A 1% solution in water has a pH of 6.5 to 8.5. Sterile solutions can be prepared by a sterile filtration, through a .2μm filter.
Kanamycin acid sulfate is prepared by solubilizing kanamycin sulfate in dilute sulfuric acid and drying. The sulfate content is approximately 25%.

Quality Level	200,
biological source	Streptomyces kanamyceticus
potency	~650 µg per mg
impurities	4% Kanamycin B
color	white to off-white
solubility	H₂O: 10 mg/mL
Mode of action	protein synthesis \| interferes
antibiotic activity spectrum	Gram-negative bacteria, Gram-positive bacteria, mycobacteria, mycoplasma
SMILES string	OS(O)(=O)=O.OS(O)(=O)=O.NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O
InChI	1S/C18H36N4O11.2H2O4S/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17;21-5(2,3)4/h4-18,23-29H,1-3,19-22H2;2(H2,1,2,3,4)/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-;;/m1../s1
InChI key	OGTKIXVMLDAMNU-KNQICTBBSA-N

pictograms	GHS08
signalword	Danger
hcodes	H360
pcodes	P201 - P202 - P280 - P308 + P313 - P405 - P501
Personal Protective Equipment	Eyeshields,, Gloves,, type P1 (EN143) respirator filter,, type P3 (EN 143) respirator cartridges,
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Kanamycin sulfate

Linear Formula:	C₁₈H_36-37N_4-5O_10-11 · H₂SO₄
CAS Number:	70560-51-9
Beilstein/REAXYS Number:	3874279
MDL number:	MFCD00070253
PubChem Substance ID:	57651778
NACRES:	NA.85

Kanamycin sulfate is a broad spectrum aminoglycoside-antibiotic derived from Streptomyces kanamyceticus. It is used as an additive in culture media for the isolation of group D streptococci on Kanamycin Esculin Azide Agar and for selection of transformed plant cells containing the neomycin phosphotransferase on a kanamycin-medium.†† Kanamycin sulfate can also be used as a selection agent for cells transformed with kanamycin B resistance gene. It is recommended for use in cell culture applications at 100 µg/mL.

5g, 25 g

Solutions are stable at 37°C for approximately 5 days. Aqueous stock solutions can be stored at 2-8°C for long term storage.

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.Storage class (TRGS 510): Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

Quality Level	200,
form	powder or crystals
potency	750 units per mg (calculated with reference to dried substance)
ign. residue	0.5% (as SO₄)
loss	1.5% loss on drying
color	white to off-white
Mode of action	protein synthesis \| interferes
antibiotic activity spectrum	Gram-negative bacteria, Gram-positive bacteria, mycobacteria, mycoplasma
SMILES string	OS(O)(=O)=O.NC[C@H]1O[C@@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O
InChI	1S/C18H36N4O11.H2O4S/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17;1-5(2,3)4/h4-18,23-29H,1-3,19-22H2;(H2,1,2,3,4)/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-;/m1./s1
InChI key	OOYGSFOGFJDDHP-KMCOLRRFSA-N

pictograms	GHS08
signalword	Danger
hcodes	H360
pcodes	P201 - P202 - P280 - P308 + P313 - P405 - P501
Personal Protective Equipment	Eyeshields,, Gloves,, type N95 (US),
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Kanamycin sulfate from Streptomyces kanamyceticus

Empirical Formula (Hill Notation):	C₁₈H₃₆N₄O₁₁ · H₂O₄S
CAS Number:	25389-94-0
Molecular Weight:	582.58
EC Number:	246-933-9
MDL number:	MFCD00070253
PubChem Substance ID:	24896236
NACRES:	NA.76

1, 5, 25, 50 g in poly bottle

Kanamycin sulfate is a broad spectrum aminoglycoside-antibiotic derived from Streptomyces kanamyceticus. It is used as an additive in culture media for the isolation of group D streptococci on Kanamycin Esculin Azide Agar and for selection of transformed plant cells containing the neomycin phosphotransferase on a kanamycin-medium. Kanamycin sulfate can also be used as a selection agent for cells transformed with kanamycin B resistance gene. It is recommended for use in cell culture applications at 100 µg/mL.

Mode of Action: The product acts by binding to the 70S ribosomal subunit, inhibiting translocation and eliciting miscoding.
Mode of Resistance:Aminoglycoside-modifying enzymes (including acetyltransferase, phosphotransferase, nucleotidyltransferase) can alter this antibiotic, preventing its interaction with ribosomes.
Antimicrobial spectrum: Kanamycin sulfate is effective against gram-negative and gram-postiive bacteria, and mycoplasma.

Solutions are stable at 37°C for approximately 5 days. Aqueous stock solutions can be stored at 2-8°C for long term storage.

Quality Level	200,
biological source	Streptomyces kanamyceticus
potency	750 µg per mg (dry basis)
impurities	5% Kanamycin B
color	white to off-white
solubility	H₂O: 50 mg/mL, clear, colorless to faintly yellow
Mode of action	protein synthesis \| interferes
antibiotic activity spectrum	Gram-negative bacteria, Gram-positive bacteria, mycobacteria, mycoplasma
SMILES string	OS(O)(=O)=O.NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O
InChI	1S/C18H36N4O11.H2O4S/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17;1-5(2,3)4/h4-18,23-29H,1-3,19-22H2;(H2,1,2,3,4)/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-;/m1./s1
InChI key	OOYGSFOGFJDDHP-KMCOLRRFSA-N

pictograms	GHS08
signalword	Danger
hcodes	H360D
pcodes	P201 - P202 - P280 - P308 + P313 - P405 - P501
Personal Protective Equipment	Eyeshields,, Gloves,, type N95 (US),
RIDADR	NONH for all modes of transport
WGK Germany	WGK 2

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Kasugamycin hydrochloride from Streptomyces kasugaensis

Empirical Formula (Hill Notation):	C₁₄H₂₅N₃O₉ · HCl
CAS Number:	19408-46-9
Molecular Weight:	415.82
MDL number:	MFCD00058459
PubChem Substance ID:	24896238
NACRES:	NA.85

Kasugamycin (Ksg) is an aminoglycoside antibiotic isolated from Streptomyces kasugaensis. It is used to study ribosome structure and interactions near the m26A m26A sequence. It is used to study the mechanisms of kasugamycin resistance.

10 g in glass bottle

Kasugamycin binds within the mRNA channel of the 30S subunit between the universally conserved G926 and A794 nucleotides in 16S ribosomal RNA. It inhibits protein synthesis and binding of aminoacyl-sRNA to the ribosomes in fungi and induces f-met-tRNA dissociation from the P-site of the 30S subunit.

Quality Level	200,
biological source	Streptomyces kasugaensis
color	white to off-white
Mode of action	protein synthesis \| interferes
antibiotic activity spectrum	Gram-negative bacteria, Gram-positive bacteria
storage temp.	2-8°C
SMILES string	C[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)[C@@H]2O)[C@@H](N)C[C@@H]1NC(C(O)=O)=N.Cl
InChI	1S/C14H25N3O9.ClH/c1-3-5(17-12(16)13(23)24)2-4(15)14(25-3)26-11-9(21)7(19)6(18)8(20)10(11)22;/h3-11,14,18-22H,2,15H2,1H3,(H2,16,17)(H,23,24);1H/t3-,4+,5+,6-,7+,8+,9-,10+,11+,14-;/m1./s1
InChI key	ZDRBJJNXJOSCLR-NZXABURVSA-N

Chemical structure: peptide

Personal Protective Equipment	Eyeshields,, Gloves,, type N95 (US),
RIDADR	NONH for all modes of transport
WGK Germany	WGK 2
Flash Point F	Not applicable
Flash Point C	Not applicable

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Kendomycin from Streptomyces violaceoruber

Empirical Formula (Hill Notation):	C₂₉H₄₂O₆
CAS Number:	183202-73-5
Molecular Weight:	486.64
MDL number:	MFCD00076711
PubChem Substance ID:	24896208
NACRES:	NA.77

Potent endothelin receptor antagonist. Antiosteoporotic compound. Shows also remarkable antibacterial and cytotoxic activity. A putative cellular target for cytotoxicity has been identified: inhibition or altered regulation of the proteasome.

Quality Level	200,
form	solid
Mode of action	protein synthesis \| interferes
antibiotic activity spectrum	Gram-negative bacteria, Gram-positive bacteria, neoplastics
storage temp.	20°C
SMILES string	CC(C)CC(N)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCNC(N)=N)C(=O)NC(C)C(=O)NC(CO)C(=O)NC(C(C)C)C(=O)NC(C)C(O)=O
InChI	1S/C32H61N13O9/c1-15(2)13-19(33)25(48)42-21(10-8-12-39-32(36)37)27(50)43-20(9-7-11-38-31(34)35)26(49)40-17(5)24(47)44-22(14-46)28(51)45-23(16(3)4)29(52)41-18(6)30(53)54/h15-23,46H,7-14,33H2,1-6H3,(H,40,49)(H,41,52)(H,42,48)(H,43,50)(H,44,47)(H,45,51)(H,53,54)(H4,34,35,38)(H4,36,37,39)
InChI key	PPBZOEOSJVJLRX-UHFFFAOYSA-N

Chemical structure: imidazole

Personal Protective Equipment	Eyeshields,, Gloves,, type N95 (US),
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Ketoconazole

Empirical Formula (Hill Notation):	C₂₆H₂₈Cl₂N₄O₄
CAS Number:	65277-42-1
Molecular Weight:	531.43
EC Number:	265-667-4
MDL number:	MFCD00058579
PubChem Substance ID:	24278176
NACRES:	NA.85

Ketoconazole is a broad spectrum antifungal agent used to treat candidiasis, chronic mucocutaneous candidiasis, oral thrush, candiduria, blastomycosis, coccidioidomycosis, histoplasmosis, chromomycosis, and paracoccidioidomycosis. It is used to identify p-glycoprotein/CYP3A-limited bioavailability in the monkey model, to study interleukin 1 mediated antitumor effects, and drug interactions in vivo
CYP3A4 inhibitor

100 mg in glass bottle

Ketoconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme that is necessary for the conversion of lanosterol to ergosterol. This interaction inhibits ergosterol synthesis and results in increased fungal cellular permeability. Other possible mechanisms of action are the inhibition of endogenous respiration, interaction with membrane phospholipids, inhibition of yeast transformation to mycelial forms, inhibition of purine uptake, and impairment of triglyceride and/or phospholipid biosynthesis. Ketoconazole inhibits the synthesis of thromboxane and sterols such as aldosterone, cortisol, and testosterone .
Antifungal agent

description	Specific Optical Rotation (EP): (0.10) +0.10 °
Quality Level	300,
assay	99.0-101.0% (EP, titration)
color	white to off-white
Mode of action	enzyme \| inhibits
antibiotic activity spectrum	Gram-positive bacteria, fungi, yeast
storage temp.	2-8°C
SMILES string	CC(=O)N1CCN(CC1)c2ccc(OC[C@H]3CO[C@@](Cn4ccnc4)(O3)c5ccc(Cl)cc5Cl)cc2
InChI	1S/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23-,26-/m0/s1
InChI key	XMAYWYJOQHXEEK-OZXSUGGESA-N
Gene Information	human ... ABCB1(5243), CYP11B1(1584), CYP11B2(1585), CYP17A1(1586), CYP19A1(1588), CYP1A2(1544), CYP24A1(1591), CYP26A1(1592), CYP3A4(1576), CYP51A1(1595), KCNH1(3756) mouse ... Abcb1a(18671), Abcb1b(18669) rat ... Alox5(25290), Cyp17a1(25146), Cyp51(25427), Cyp7a1(25428)

Chemical structure: polyene

pictograms	GHS06,GHS08,GHS09
signalword	Danger
hcodes	H301 - H360F - H373 - H410
pcodes	P201 - P202 - P260 - P264 - P273 - P301 + P310
Personal Protective Equipment	Eyeshields,, Faceshields,, Gloves,, type P2 (EN 143) respirator cartridges,
RIDADR	UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., HI: all
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Kirromycin from Streptomyces collinus

Empirical Formula (Hill Notation):	C₄₃H₆₀N₂O₁₂
CAS Number:	50935-71-2
Molecular Weight:	796.94
EC Number:	256-859-9
MDL number:	MFCD00467139
PubChem Substance ID:	24896207
NACRES:	NA.85

Kirromycin is a polyketide antibiotic which is produced by the actinomycetes Streptomyces collinus. Kirromycin has been used to stimulate GTPase action of EF-Tu in the absence of programmed ribosomes in Thermus thermophilus. Kirromycin is used to study bacterial protein synthesis at the level of elongation factor EF-Tu-GDP release.

5 mg in glass bottle

Binding of kirromycin to EF-Tu prevents EF-TuGDP from being ejected from the ribosome, which immobilizes the ribsome, as well as all of the following ribosomes on the mRNA.

biological source	Streptomyces collinus
Quality Level	200,
color	yellow
solubility	methanol: 1.90-2.10 mg/mL, clear, yellow
Mode of action	protein synthesis \| interferes
antibiotic activity spectrum	Gram-negative bacteria, Gram-positive bacteria
storage temp.	20°C
SMILES string	CCC(C(=O)NC\C=C\C=C(/C)C(OC)C(C)C1OC(\C=C\C=C\C=C(/C)C(=O)C2=C(O)C=CNC2=O)C(O)C1O)C3(O)OC(\C=C\C=C\C)C(C)(C)C(O)C3O
InChI	1S/C43H60N2O12/c1-9-11-13-21-31-42(6,7)38(50)39(51)43(54,57-31)28(10-2)40(52)44-23-17-16-19-26(4)36(55-8)27(5)37-35(49)34(48)30(56-37)20-15-12-14-18-25(3)33(47)32-29(46)22-24-45-41(32)53/h9,11-22,24,27-28,30-31,34-39,48-51,54H,10,23H2,1-8H3,(H,44,52)(H2,45,46,53)/b11-9+,14-12+,17-16+,20-15+,21-13+,25-18+,26-19+
InChI key	HMSYAPGFKGSXAJ-DSMBXYKSSA-N

Chemical structure: amino acid derivatives

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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L-Alanyl-L-1-aminoethylphosphonic acid

Empirical Formula (Hill Notation):	C₅H₁₃N₂O₄P
CAS Number:	60668-24-8
Molecular Weight:	196.14
Beilstein/REAXYS Number:	4801790
EC Number:	262-362-8
MDL number:	MFCD01569244
PubChem Substance ID:	329747669
NACRES:	NA.85

Alaphosphin is used as a selection agent for isolation of Salmonella and as a dipeptide mimetic antibacterial agent.

Alaphosphin is an antibacterial phosphonopeptide which mimics the terminal dipeptide moiety (D-Ala-D-Ala) of bacterial cell wall peptidoglycan . It metabolizes aminophosphonic acid which inhibits alanine racemase and uridine 5-diphosphate-N-acetylmuramoylalanine synthetase.
Alaphosphin is used as a selection agent for isolation of Salmonella and as a dipeptide mimetic antibacterial agent. It metabolizes aminophosphonic acid which inhibits alanine racemase and uridine 5-diphosphate-N-acetylmuramoylalanine synthetase.

250MG

Keep container tightly closed in a dry and well-ventilated place. Store under inert gas. Moisture sensitive. Keep in a dry place.

Quality Level	200,
assay	95% (HPLC)
form	powder
optical activity	[]20/D 45±2°, c = 1% in H₂O
color	white
Mode of action	cell wall synthesis \| interferes, enzyme \| inhibits
antibiotic activity spectrum	Gram-negative bacteria, Gram-positive bacteria
storage temp.	2-8°C
SMILES string	C[C@H](N)C(=O)N[C@@H](C)P(O)(O)=O
InChI	1S/C5H13N2O4P/c1-3(6)5(8)7-4(2)12(9,10)11/h3-4H,6H2,1-2H3,(H,7,8)(H2,9,10,11)/t3-,4+/m0/s1
InChI key	BHAYDBSYOBONRV-IUYQGCFVSA-N

This antibiotic solution is used to reduce or eliminate bacterial contamination in primary cell cultures. It is recommended for us at 10 mL/L.

pictograms	GHS07
signalword	Warning
hcodes	H302
Personal Protective Equipment	dust mask type N95 (US),, Eyeshields,, Gloves,
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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L-Glutamine–Penicillin–Streptomycin solution

MDL number:	MFCD00283636
NACRES:	NA.76

Mode of Action: The product acts in three ways: Glutamine is an essential energy source for most mammalian cells in culture due to its amino acid carbon skeleton. Penicillin inhibits bacterial cell wall synthesis. Streptomycin inhibits prokaryote protein synthesis by preventing the transition from initiation complex to chain-elongating ribosome, causing miscoding.

Antimicrobial spectrum: This product acts against both gram-negative and gram-positive bacteria.

Components

This solution is formulated to contain 200 mM L-glutamine, 10,000 units of Penicillin and 10 mg/mL of streptomycin, solubilized in a proprietary buffer.

biological source	synthetic
Quality Level	300,
description	stabilized
sterility	0.1 µm filtered
product line	BioReagent
form	liquid
composition	L-glutamine, 200 mM , penicillin, 10,000 units , streptomycin, 10 mg/mL
application(s)	cell culture \| mammalian: suitable
impurities	endotoxin, tested
Mode of action	cell wall synthesis \| interferes, protein synthesis \| interferes
antibiotic activity spectrum	Gram-negative bacteria, Gram-positive bacteria
storage temp.	20°C

Leptomycin B is an anti-fungal antibiotic, anti-tumor cytotoxin that inhibits CRM1-dependent, NES-dependent nucleo-cytoplasmic translocation (nuclear export inhibitor). NES containing proteins include HIV-1 REV; actin, c-Abl, cyclin B1, MDM2/p53, I?B, MPF, PKA and MEK.

Personal Protective Equipment	Eyeshields,, Faceshields,, Gloves,, multi-purpose combination respirator cartridge (US),
RIDADR	NONH for all modes of transport
WGK Germany	WGK 2
Flash Point F	Not applicable
Flash Point C	Not applicable

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Leptomycin B solution from Streptomyces sp.

Empirical Formula (Hill Notation):	C₃₃H₄₈O₆
CAS Number:	87081-35-4
Molecular Weight:	540.73
MDL number:	MFCD06795848
PubChem Substance ID:	24896330
NACRES:	NA.77

Leptomycin B is an unsaturated, branched-chain fatty acid, and is an important tool in the study of nuclear export. Leptomycin B is a specific inhibitor of proteins containing nuclear export signal. Leptomycin B inhibits nucleo-cytoplasmic translocation of molecules such as the HIV-1 Rev protein and Rev-dependent export of mRNA. The addition of very small amounts to fibroblasts causes accumulation of MEK in the nucleus. Other proteins that are influenced by leptomycin B are actin, c-Abl, cyclin B1, MDM2/p53, IκB, MPF, and PKA. The suggested inhibition mechanism involves the direct binding of leptomycin B to CRM1, which blocks the binding of CRM1 to proteins containing the nuclear export signal, via the interaction with cysteine residue in CRM1 control conserved region.

Quality Level	300,
assay	95% (HPLC)
storage condition	protect from light
Mode of action	protein synthesis \| interferes
antibiotic activity spectrum	fungi
shipped in	dry ice
storage temp.	20°C
SMILES string	CCC(\C=C\[C@@H]1OC(=O)C=C[C@@H]1C)=C\[C@H](C)C\C=C\C(C)=C\[C@@H](C)C(=O)[C@@H](C)[C@H](O)[C@@H](C)C\C(C)=C\C(O)=O
InChI	1S/C33H48O6/c1-9-28(14-15-29-24(5)13-16-31(36)39-29)19-22(3)12-10-11-21(2)17-25(6)32(37)27(8)33(38)26(7)18-23(4)20-30(34)35/h10-11,13-17,19-20,22,24-27,29,33,38H,9,12,18H2,1-8H3,(H,34,35)/b11-10+,15-14+,21-17+,23-20+,28-19-/t22-,24+,25-,26+,27-,29+,33-/m1/s1
InChI key	YACHGFWEQXFSBS-XYERBDPFSA-N

Levofloxacin is a broad-spectrum antibiotic used in pharmacokinetic , antibiotic resistance , and resistance prevention studies. Antibiotic against bacterial respiratory tract infections.

pictograms	GHS02,GHS06,GHS08
signalword	Danger
hcodes	H225 - H301 + H311 + H331 - H370
pcodes	P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
Target Organs	Eyes
RIDADR	UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany	WGK 2
Flash Point F	64.4 °F - closed cup
Flash Point C	18 °C - closed cup

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Levofloxacin

Empirical Formula (Hill Notation):	C₁₈H₂₀FN₃O₄
CAS Number:	100986-85-4
Molecular Weight:	361.37
Beilstein/REAXYS Number:	7327015
MDL number:	MFCD00865049
PubChem Substance ID:	57648297
NACRES:	NA.85

Levofloxacin is active against Gram-positive and Gram-negative bacteria. It inhibits DNA gyrase (type II topoisomerase) and topoisomerase IV, thereby inhibiting cell division.

10mg, 1g, 10g

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. 28266.pdf , Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.,

Quality Level	200,
biological source	synthetic
assay	98.0-102.0% anhydrous basis (HPLC)
form	powder or crystals
color	light yellow-white to yellow-white
Mode of action	enzyme \| inhibits
antibiotic activity spectrum	Gram-negative bacteria, Gram-positive bacteria
SMILES string	OC(C(C1=O)=CN2C(C1=CC(F)=C3N4CCN(C)CC4)=C3OC[C@@H]2C)=O
InChI	1S/C18H20FN3O4/c1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21/h7-8,10H,3-6,9H2,1-2H3,(H,24,25)/t10-/m0/s1
InChI key	GSDSWSVVBLHKDQ-JTQLQIEISA-N
Gene Information	human ... KCNH1(3756)

Chemical structure: macrolide

pictograms	GHS07,GHS08
signalword	Danger
hcodes	H302 - H317 - H334
pcodes	P261 - P264 - P280 - P301 + P312 - P302 + P352 - P304 + P340 + P312
Personal Protective Equipment	dust mask type N95 (US),, Eyeshields,, Faceshields,, Gloves,
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Lincomycin hydrochloride

Empirical Formula (Hill Notation):	C₁₈H₃₄N₂O₆S · HCl
CAS Number:	859-18-7
Molecular Weight:	443.00
Beilstein/REAXYS Number:	4171650
EC Number:	212-726-7
MDL number:	MFCD00083647
PubChem Substance ID:	329759714
NACRES:	NA.85

1, 5 g in glass bottle

Mode of action: Lincomycin inhibits bacterial protein synthesis by forming cross-links within the peptidyl transferase loop region of the 23S rRNA.†

Antimicrobial spectrum: Lincomycin hydrochloride is effective against gram-positive bacteria.

This product is soluble in water at 50 mg/mL, yielding a clear, colorless solution.

Keep container tightly closed in a dry and well-ventilated place.

Quality Level	200,
assay	95.0% (TLC)
form	solid
impurities	5% water
color	white to off-white
solubility	H₂O: 50 mg/mL, clear, colorless
Mode of action	protein synthesis \| interferes
antibiotic activity spectrum	Gram-positive bacteria
storage temp.	2-8°C
SMILES string	Cl.CCC[C@@H]1C[C@H](N(C)C1)C(=O)N[C@H]([C@@H](C)O)[C@H]2O[C@H](SC)[C@H](O)[C@@H](O)[C@H]2O
InChI	1S/C18H34N2O6S.ClH/c1-5-6-10-7-11(20(3)8-10)17(25)19-12(9(2)21)16-14(23)13(22)15(24)18(26-16)27-4;/h9-16,18,21-24H,5-8H2,1-4H3,(H,19,25);1H/t9-,10-,11+,12-,13+,14-,15-,16-,18-;/m1./s1
InChI key	POUMFISTNHIPTI-BOMBIWCESA-N

Lithium mupirocin as been used to study mupirocin resistance in staphylococcus aureus and in mycoplasma susceptibility studies .

pictograms	GHS07
signalword	Warning
hcodes	H315 - H319 - H335
pcodes	P302 + P352 - P305 + P351 + P338
Target Organs	Respiratory system
Personal Protective Equipment	dust mask type N95 (US),, Eyeshields,, Gloves,
RIDADR	NONH for all modes of transport
WGK Germany	WGK 2
Flash Point F	Not applicable
Flash Point C	Not applicable

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Lithium mupirocin

Empirical Formula (Hill Notation):	C₂₆H₄₃LiO₉
CAS Number:	73346-79-9
Molecular Weight:	506.56
MDL number:	MFCD11977847
PubChem Substance ID:	329748364
NACRES:	NA.85

Bottomless glass bottle. Contents are inside inserted fused cone.

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place. Storage class (TRGS 510): Non Combustible Solids

Quality Level	200,
assay	≥95.0% (HPLC)
form	powder
color	white to off-white
Mode of action	protein synthesis \| interferes
antibiotic activity spectrum	Gram-positive bacteria
SMILES string	[Li+].C[C@H](O)[C@H](C)[C@@H]1O[C@H]1C[C@H]2CO[C@@H](C\C(C)=C\C(=O)OCCCCCCCCC([O-])=O)[C@H](O)[C@@H]2O
InChI	1S/C26H44O9.Li/c1-16(13-23(30)33-11-9-7-5-4-6-8-10-22(28)29)12-20-25(32)24(31)19(15-34-20)14-21-26(35-21)17(2)18(3)27;/h13,17-21,24-27,31-32H,4-12,14-15H2,1-3H3,(H,28,29);/q;+1/p-1/b16-13+;/t17-,18-,19-,20-,21-,24+,25-,26-;/m0./s1
InChI key	XFIKMPRBSORKQP-JATHGWPISA-M

Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser-NH2

Personal Protective Equipment	Eyeshields,, Gloves,, type N95 (US),
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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LL-37 (human) trifluoroacetate salt 94261-1MG

Empirical Formula (Hill Notation):	C₂₀₅H₃₄₁N₆₁O₅₂ · xC₂HF₃O₂
Molecular Weight:	4492.28 (free base basis)
NACRES:	NA.85

Amino Acid Sequence

Chemical structure: peptide

LL-37 is used to study host defense mechanisms.

LL-37 is a muntifunctional host defense peptide with antibacterial, antiviral, and immunomodulating activities. It is the only cathelicidin-type peptide found in human. In addition to its antimicrobial activities, LL-37 has been found to regulate inflammation and neutralize lipopolysaccharides from Gram-negative bacteria.

1mg

Keep container tightly closed in a dry and well-ventilated place. Store under inert gas. Keep in a dry place.

Quality Level	200,
assay	95% (HPLC)
form	powder (Lyophilisate)
color	colorless to white
solubility	H₂O: 1 mg/mL, clear, colorless
Mode of action	cell membrane \| interferes
antibiotic activity spectrum	Gram-negative bacteria, Gram-positive bacteria, viruses
storage temp.	20°C

Chemical structure: fluoroquinolone

Personal Protective Equipment	Eyeshields,, Gloves,, type N95 (US),
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Lomefloxacin hydrochloride

Empirical Formula (Hill Notation):	C₁₇H₁₉F₂N₃O₃ · HCl
CAS Number:	98079-52-8
Molecular Weight:	387.81
MDL number:	MFCD00214312
PubChem Substance ID:	24278514
NACRES:	NA.85

Lomefloxacin is a fluoroquinolone antibiotic that is commonly used to treat bacterial infections, including bronchitis and urinary tract infections. It is used as a pre-operative prophylactic to prevent urinary tract infection caused by S. pneumoniae, H. influenzae, S. aureus, P. aeruginosa, E. cloacae, P. mirabilis, C. civersus, S. asprphyticus, E. coli, and K. pneumoniae. It is used to induce genomic instability in mice and modification of the kinetics of growth of Gram-negative bacteria.

1, 10 g in poly bottle

Lomefloxacin is a bactericidal fluoroquinolone agent that is active against gram-negative and gram-positive organisms. Lomefloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase is thought to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV is thought to be the primary target in gram-positive organisms. The inhibition of the topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. Therefore, DNA replication and transcription is inhibited.

Quality Level	100,
biological source	synthetic
color	white to off-white
Mode of action	DNA synthesis \| interferes, enzyme \| inhibits
antibiotic activity spectrum	Gram-negative bacteria, Gram-positive bacteria
storage temp.	−20°C
SMILES string	Cl.CCN1C=C(C(O)=O)C(=O)c2cc(F)c(N3CCNC(C)C3)c(F)c12
InChI	1S/C17H19F2N3O3.ClH/c1-3-21-8-11(17(24)25)16(23)10-6-12(18)15(13(19)14(10)21)22-5-4-20-9(2)7-22;/h6,8-9,20H,3-5,7H2,1-2H3,(H,24,25);1H
InChI key	KXEBLAPZMOQCKO-UHFFFAOYSA-N

Chemical structure: tetracycline

pictograms	GHS07
signalword	Warning
hcodes	H302
Personal Protective Equipment	dust mask type N95 (US),, Eyeshields,, Gloves,
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3

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Meclocycline sulfosalicylate salt

Empirical Formula (Hill Notation):	C₂₂H₂₁ClN₂O₈ · C₇H₆O₆S
CAS Number:	73816-42-9
Molecular Weight:	695.05
EC Number:	277-614-2
MDL number:	MFCD00082372
PubChem Substance ID:	24896641
NACRES:	NA.85

Meclocycline is a tetracycline antibiotic. It is used topically for skin infections. It is used to study papulopustular acne and to study the effectiveness of oral versus topical administration.

500 mg in poly bottle

Meclocycline sulfosalicylate prevents bacterial protein synthesis through 30S ribosome-mediated chain elongation and blocks amino-acyl tRNA A-site binding.

Quality Level	200,
color	yellow-green powder
solubility	methanol: 10 mL, clear, very dark yellow (200 mg + 10 mL MeOH)
Mode of action	protein synthesis \| interferes
antibiotic activity spectrum	Gram-negative bacteria, Gram-positive bacteria
SMILES string	OC(=O)c1cc(ccc1O)S(O)(=O)=O.CN(C)[C@H]2[C@@H]3[C@@H](O)C4C(=C)c5c(Cl)ccc(O)c5C(=O)C4=C(O)[C@]3(O)C(=O)C(C(N)=O)=C2O
InChI	1S/C22H21ClN2O8.C7H6O6S/c1-6-9-7(23)4-5-8(26)11(9)16(27)12-10(6)17(28)14-15(25(2)3)18(29)13(21(24)32)20(31)22(14,33)19(12)30;8-6-2-1-4(14(11,12)13)3-5(6)7(9)10/h4-5,10,14-15,17,26,28-30,33H,1H2,2-3H3,(H2,24,32);1-3,8H,(H,9,10)(H,11,12,13)/t10?,14-,15+,17+,22+;/m1./s1
InChI key	FYSVKUUNXYGFLA-FRGFDCQGSA-N

Personal Protective Equipment	Eyeshields,, Gloves,, type N95 (US),
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Methicillin sodium salt 51454-50MG

Empirical Formula (Hill Notation):	C₁₇H₁₉N₂NaO₆S
CAS Number:	132-92-3
Molecular Weight:	402.40
EC Number:	205-083-9
MDL number:	MFCD07787409
PubChem Substance ID:	329757690
NACRES:	NA.85

Methicillin is used to study bacterium susceptibility , methicillin-resistance in Staphylococcus aureus , and to inhibit cell-wall synthesis .

Methicillin inhibits cell wall synthesis. In Legionella pneumophila, methicillin causes the formation of membranous lesions through which cytoplasmic contents are lost .

Bottomless glass bottle. Contents are inside inserted fused cone.

Keep container tightly closed in a dry and well-ventilated place.Light sensitive

Quality Level	200,
biological source	synthetic
assay	≥95% (HPLC)
form	powder
color	white to off-white
Mode of action	cell wall synthesis \| interferes
antibiotic activity spectrum	Gram-positive bacteria
storage temp.	2-8°C
SMILES string	[Na+].COc1cccc(OC)c1C(=O)N[C@H]2C3SC(C)(C)[C@@H](N3C2=O)C([O-])=O
InChI	1S/C17H20N2O6S.Na/c1-17(2)12(16(22)23)19-14(21)11(15(19)26-17)18-13(20)10-8(24-3)6-5-7-9(10)25-4;/h5-7,11-12,15H,1-4H3,(H,18,20)(H,22,23);/q;+1/p-1/t11-,12+,15-;/m1./s1
InChI key	MGFZNWDWOKASQZ-UMLIZJHQSA-M

Methotrexate hydrate has been used:

pictograms	GHS07,GHS08
signalword	Danger
hcodes	H315 - H317 - H319 - H334 - H335
pcodes	P280 - P302 + P352 - P305 + P351 + P338
Target Organs	Respiratory system
Personal Protective Equipment	dust mask type N95 (US),, Eyeshields,, Faceshields,, Gloves,
RIDADR	NONH for all modes of transport
WGK Germany	WGK 2
Flash Point F	Not applicable
Flash Point C	Not applicable

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Methotrexate hydrate

Empirical Formula (Hill Notation):	C₂₀H₂₂N₈O₅ · xH₂O
CAS Number:	133073-73-1
Molecular Weight:	454.44 (anhydrous basis)
MDL number:	MFCD00150847
PubChem Substance ID:	24897252
NACRES:	NA.75

as a dihydrofolate (DHFR) inhibitor in sphere forming assay culture
as a component of dulbecco modified Eagles medium (DMEM) for selection of transfected cells
in viability and co-culture assays

Potent inhibitor of dihydrofolate reductase and agent for antitumor studies. Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also shows immunosuppressive effects in, e.g., rheumatoid arthritis.
Potent inhibitor of dihydrofolate reductase and agent for antitumor studies. Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also effective in treatment of pyrimethamine-resistant Plasmodium vivax malaria parasites.

Methotrexate used to inhibit dihyrofolate reductase and select for DHFR overexpresssion.
Methotrexate is a folic acid antagonist.

Quality Level	200,
product line	BioReagent
assay	98% (HPLC)
form	powder
application(s)	cell culture \| mammalian: suitable
solubility	H₂O: insoluble
Mode of action	enzyme \| inhibits
antibiotic activity spectrum	neoplastics, parasites
storage temp.	20°C
SMILES string	[H]O[H].CN(Cc1cnc2nc(N)nc(N)c2n1)c3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O
InChI	1S/C20H22N8O5.H2O/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30;/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27);1H2/t13-;/m0./s1
InChI key	FPJYMUQSRFJSEW-ZOWNYOTGSA-N
Gene Information	human ... DHFR(1719)

Chemical structure: imidazole

pictograms	GHS06,GHS08
signalword	Danger
hcodes	H301 - H315 - H319 - H360FD
pcodes	P201 - P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338
Personal Protective Equipment	Eyeshields,, Faceshields,, Gloves,, type P1 (EN143) respirator filter,, type P3 (EN 143) respirator cartridges,
RIDADR	UN 1544PSN1 6.1 / PGIII
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Metronidazole

Empirical Formula (Hill Notation):	C₆H₉N₃O₃
CAS Number:	443-48-1
Molecular Weight:	171.15
Beilstein/REAXYS Number:	611683
EC Number:	207-136-1
MDL number:	MFCD00009750
PubChem Substance ID:	24896667

Metronidazole is a nitroimidazole used to treat amebiasis, vaginitis, Trichomonas infections, giardiasis, anaerobic bacteria and treponemal infections. Metronidazole is used to study DNA damage and repair and has been found to induce the gene transfer agent VSH-1 in Brachyspira hyodysenteriae. It is commonly used for treatment of periodontitis and is used in bioavailability studies.

5, 25 g in glass bottle

Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce metronidazole to its active form. Reduced metronidazole covalently binds to DNA which disrupts its helical structure, induces DNA strand breaks and inhibits bacterial nucleic acid synthesis. Bacterial cell death results.

product line	BioXtra
Quality Level	200,
impurities	0.0005% Phosphorus (P), 0.1% Insoluble matter
ign. residue	0.1%
color	white to light yellow
mp	159-161 °C (lit.)
solubility	acetic acid: 0.1 M, clear, colorless to yellow
anion traces	chloride (Cl^-): 0.05%, sulfate (SO₄^2-): 0.05%
cation traces	Al: 0.0005%, Ca: 0.005%, Cu: 0.0005%, Fe: 0.0005%, K: 0.005%, Mg: 0.0005%, Na: 0.01%, Pb: 0.001%, Zn: 0.0005%
Mode of action	DNA synthesis \| interferes
antibiotic activity spectrum	Gram-negative bacteria, parasites
storage temp.	2-8°C
SMILES string	CC1=NC=C([N+]([O-])=O)N1CCO
InChI	1S/C6H9N3O3/c1-5-7-4-6(9(11)12)8(5)2-3-10/h4,10H,2-3H2,1H3
InChI key	VAOCPAMSLUNLGC-UHFFFAOYSA-N

Chemical structure: tetracycline

pictograms	GHS08
signalword	Danger
hcodes	H340 - H350 - H373
pcodes	P202 - P260 - P280 - P308 + P313 - P405 - P501
Personal Protective Equipment	dust mask type N95 (US),, Eyeshields,, Gloves,
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3

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Minocycline hydrochloride

Empirical Formula (Hill Notation):	C₂₃H₂₇N₃O₇ · HCl
CAS Number:	13614-98-7
Molecular Weight:	493.94
EC Number:	237-099-7
MDL number:	MFCD00083669
PubChem Substance ID:	24278175
NACRES:	NA.77

Minocycline hydrochloride has been used:

to prepare nanoliposomes to check its effect on macrophages
for the inhibition of neuroinflammation and neuropathic pain
to treat glioma in murine GL261 glioma cells

25 mg in glass bottle
100, 250 mg in poly bottle
1 g in poly bottle
Bottomless glass bottle. Contents are inside inserted fused cone.

Minocycline is a broad spectrum antibiotic with bacteriostatic function. Minocycline has anti-inflammatory properties. Minocycline inhibits lipopolysaccharide mediated inflammatory cytokine tumour necrosis factor (TNF-α) secretion by macrophages. Minocycline inhibits macrophage proliferation in a dose dependent manner. Minocycline inhibits neuroinflammation in pre-plaque of Alzheimer′s disease-like amyloid pathology through inhibition of key inflammatory enzymes like inducible nitric oxide synthase (iNOS), matrix metalloproteinase 9 (MMP-9) and 5-lipoxygenase. Minocycline inhibits endothelial cell proliferation and angiogenesis. Minocycline exhibits anti-tumor activity in glioma by inhibiting membrane type 1 matrix metalloproteinase (MT1-MMP). Minocycline increases cognition and neuronal differentiation. zMinocycline effectively reduces neuropathic pain by increasing the functions of nociceptin/orphanin FQ.

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This compound was developed by Teva,. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here, to learn more.

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form	powder
Quality Level	200,
Mode of action	protein synthesis \| interferes
antibiotic activity spectrum	mycobacteria
originator	Teva
storage temp.	2-8°C
SMILES string	Cl.CN(C)[C@H]1[C@@H]2C[C@@H]3Cc4c(ccc(O)c4C(=O)C3=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)N(C)C
InChI	1S/C23H27N3O7.ClH/c1-25(2)12-5-6-13(27)15-10(12)7-9-8-11-17(26(3)4)19(29)16(22(24)32)21(31)23(11,33)20(30)14(9)18(15)28;/h5-6,9,11,17,27,29-30,33H,7-8H2,1-4H3,(H2,24,32);1H/t9-,11-,17-,23-;/m0./s1
InChI key	GLMUAFMGXXHGLU-VQAITOIOSA-N

Personal Protective Equipment	dust mask type N95 (US),, Eyeshields,, Gloves,
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Mitomycin C 10107409001

Empirical Formula (Hill Notation):	C₁₅H₁₈N₄O₅
CAS Number:	50-07-7
Molecular Weight:	334.33

Mitomycin C is an antitumor antibiotic.

Mitomycin C is used as an inhibitor for studies of cell-free protein biosynthesis. It also inhibits DNA synthesis. It has been used as a genotoxic agent for tumor cells.
Mitomycin C has been used:

to cease mitosis
in phosphate buffer saline (PBS) for inactivation and plating mouse embryonic fibroblasts (MEFs)
as mutagen in mutagenicity assay

Mitomycin C (MMC) acts as a prototype for drugs with bioreductive alkylation. It is mainly found to be active under anaerobic conditions. MMC exhibits a vast clinical antitumor spectrum effectively in gastric, pancreatic and breast cancer.

For life science research only. Not for use in diagnostic procedures.

assay	98%
Quality Level	100,
mol wt	334.3
packaging	pkg of 2 mg
Торговая марка	Roche
Mode of action	DNA synthesis \| interferes
antibiotic activity spectrum	Gram-negative bacteria, Gram-positive bacteria
shipped in	wet ice
storage temp.	2-8°C
InChI	1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7+,13+,15-/m1/s1
InChI key	NWIBSHFKIJFRCO-WUDYKRTCSA-N

Mitomycin C is a systemic chemotherapy compound and an antibiotic obtained from Streptomyces caespitosus. It is the first bioreductive alkylating agent to be identified and is a derivative of 3-amino-5-hydroxybenzoic acid (AHBA), D-glucosamine, L-methionine and carbamoyl phosphate.
Chemical structure: Aziridine

pictograms	GHS06,GHS08
signalword	Danger
hcodes	H300 - H351
pcodes	P201 - P264 - P280 - P301 + P310 + P330 - P308 + P313 - P501
RIDADR	UN 2811 6.1 / PGII
WGK Germany	WGK 3
Flash Point F	does not flash
Flash Point C	does not flash

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Mitomycin C from Streptomyces caespitosus

Empirical Formula (Hill Notation):	C₁₅H₁₈N₄O₅
CAS Number:	50-07-7
Molecular Weight:	334.33
Beilstein/REAXYS Number:	7231816
MDL number:	MFCD00078109
PubChem Substance ID:	24896917
NACRES:	NA.76

Mitomycin C from Streptomyces caespitosus has been used for the treatment of feeder layers such as, PMEF (primary mouse embryonic fibroblasts) and CD1 mouse embryonic fibroblasts (MEFs) for the culture of hESCs (human embryonic stem cells). It has also been used for the treatment of BLC (basal-like cancer) cell line.

Mitomycin C causes the cross-linking of double-stranded DNA, which results in mutagenesis, inhibition of DNA synthesis, initiation of DNA repair events, and activation of apoptosis. The capability to inhibit DNA synthesis is attributable to the aminoquinone group present in mitomcyin C. This compound does not affect the synthesis of RNA and protein. In tissue culture, this compound decreases cell viability and suppresses mitosis, and causes disorganization of nucleus and the production of giant cells. Mitomycin C has potent anti-Gram negative and anti-Gram positive activities. It contains three moieties, quinine, urethane, and aziridine groups. It is used to generate mitotically inactive feeder cells in cell culture systems, such as the mitotically inactive fibroblasts used in embryonic stem cell systems.
Mode of Action: This product is an alkylating agent that specifically targets the guanine nucleoside sequence 5-CpG-3. It inhibits DNA synthesis by covalently reacting with DNA, forming crosslinks between complementary strands of DNA. This interaction prevents separation of complementary DNA strands, inhibiting DNA replication.
Antimicrobial Spectrum: Mitomycin C has strong antitumor activity, especially against Ehrlich ascites tumor cells, and strong bactericidal action against gram-positive and gram-negative bacteria.

This vial contains 2 mg Mitomycin C and 48 mg NaCl. Stock solutions should be filter sterilized and stored at 2-8°C in the dark. Solutions at pH 6-9 can be stored at 0-5°C for up to a week, but if a precipitate forms, a fresh solution should be prepared - the precipitated solution has been proven toxic to cells.

Mitomycin C is soluble in water at .5 mg/mL, with a pH of 6.0-7.5. It undergoes rapid degradation in acidic solutions with pH<6, and is mostly likely to retain activity in solutions with a pH between 6-9.

Quality Level	200
biological source	Streptomyces caespitosus
product line	BioReagent
form	powder
application(s)	cell culture \| mammalian: suitable
color	gray, purple/blue
A	(1) 3.2, (2) 6.5
solubility	H₂O: 4 mL/vial, clear to slightly hazy, blue to purple (Stock solutions should be filter sterilized and stored at 2-8 °C in the dark.)
Mode of action	DNA synthesis \| interferes
antibiotic activity spectrum	Gram-negative bacteria, Gram-positive bacteria
storage temp.	2-8°C
SMILES string	[H][C@]12CN3C4=C([C@@H](COC(N)=O)[C@@]3(OC)[C@@]1([H])N2)C(=O)C(N)=C(C)C4=O
InChI	1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7+,13+,15-/m1/s1
InChI key	NWIBSHFKIJFRCO-WUDYKRTCSA-N

50, 250 mg in serum bottle

Pictograms	GHS07,GHS08
Signal Word	Warning
Hazard Statements	H302 - H351
Precautionary Statements	P201 - P301 + P312 + P330 - P308 + P313
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

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Mycophenolic acid

Empirical Formula (Hill Notation):	C₁₇H₂₀O₆
CAS Number:	24280-93-1
Molecular Weight:	320.34
Beilstein/REAXYS Number:	1295848
EC Number:	246-119-3
MDL number:	MFCD00036814
PubChem Substance ID:	24896854
NACRES:	NA.76

Mycophenolic acid (MPA), produced by Penicillum brevi-compactum, is a selective inhibitor of inosine monphosphate dehydrogenase, thus inhibiting DNA synthesis in T and B lymphocytes. It has also been shown to act as an immunosuppressive agent, and as an inducer of monocyte differentiation and apoptosis in human lymphoid and monocytic cell lines. As a selection agent, MPA is used for transfected animal cells expressing the E. Coli gene for xanthine-guanine phosphoribosyl transferase, and is recommended for use at 25µg/mL.

Mode of Action: This product acts by suppressing the cytokine-induced nitric oxide production, inhibiting early stage biosynthesis of purine nucleotides and as a specific inhibitor of IMP dehydrogenase.

As supplied, this product should be stored desiccated at 2-8°C, and is stable for 5 years when stored properly.

Mycophenolic acid is soluble in methanol at 50 mg/mL, yielding a colorless to faint yellow solution, as well as chloroform, dichloromethane, ethanol and .1 N NaOH. After reconstitution, the recommendation is to sterilize via filtration thorugh a 0.22 μm pore-size filter, aliquot, and freeze at -20°C.

biological source	Penicillium brevicompactum
Quality Level	300,
product line	BioReagent
form	powder
application(s)	cell culture \| mammalian: suitable
color	white to yellow-white
mp	<143.0 °C
solubility	methanol: 50 mg/mL
Mode of action	enzyme \| inhibits
storage temp.	2-8°C
SMILES string	COc1c(C)c2COC(=O)c2c(O)c1C\C=C(/C)CCC(O)=O
InChI	1S/C17H20O6/c1-9(5-7-13(18)19)4-6-11-15(20)14-12(8-23-17(14)21)10(2)16(11)22-3/h4,20H,5-8H2,1-3H3,(H,18,19)/b9-4+
InChI key	HPNSFSBZBAHARI-RUDMXATFSA-N
Gene Information	human ... IMPDH1(3614), IMPDH2(3615)

Chemical structure: glucosamine

pictograms	GHS07,GHS08,GHS09
signalword	Danger
hcodes	H302 - H341 - H360D - H372 - H410
pcodes	P201 - P273 - P301 + P312 + P330 - P308 + P313
Target Organs	Immune system
Personal Protective Equipment	Eyeshields,, Faceshields,, Gloves,, type P1 (EN143) respirator filter,, type P3 (EN 143) respirator cartridges,
RIDADR	UN 3077 9 / PGIII
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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N-Methyl-1-deoxynojirimycin

Empirical Formula (Hill Notation):	C₇H₁₅NO₄
CAS Number:	69567-10-8
Molecular Weight:	177.20
Beilstein/REAXYS Number:	1524564
MDL number:	MFCD00133609
PubChem Substance ID:	24896690
NACRES:	NA.32

5 mg in glass bottle

Interferes with metabolism of N-linked glycoproteins by inhibition of glucosidase.

Features and Benefits

This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here, to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

biological source	synthetic (organic)
Quality Level	200,
assay	98%
form	powder
solubility	methanol: 10 mg/mL, clear, colorless
Mode of action	enzyme \| inhibits
antibiotic activity spectrum	viruses
storage temp.	20°C
SMILES string	CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
InChI	1S/C7H15NO4/c1-8-2-5(10)7(12)6(11)4(8)3-9/h4-7,9-12H,2-3H2,1H3/t4-,5+,6-,7-/m1/s1
InChI key	AAKDPDFZMNYDLR-XZBKPIIZSA-N
Gene Information	mouse ... Gaa(14387), Glb1(12091), Treh(58866) rat ... Man2a1(25478), Si(497756)

Chemical structure: fluoroquinolone
Nadifloxacin is antimicrobial in nature, and is a fluorinated quinolone. It is highly potent against Gram-negative and Gram-positive bacteria, especially Propionibacteruim acnes.

Personal Protective Equipment	Eyeshields,, Gloves,, type N95 (US),
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Nadifloxacin

Empirical Formula (Hill Notation):	C₁₉H₂₁FN₂O₄
CAS Number:	124858-35-1
Molecular Weight:	360.38
NACRES:	NA.85

100 mg in poly bottle
1 g in poly bottle

Nadifloxacin is used as a topical antibacterial, which is bactericidal due to its capability of preventing the negative supercoiling of bacterial DNA. DNA supercoiling, replication, transcription are catalyzed by DNA gyrase. In Japan, it is used to treat skin infection and acne. Studies show, that nadifloxacin is capable of successfully treating green nail syndrome (GNS) caused by Pseudomonas aeruginosa.

Keep container tightly closed in a dry and well-ventilated place. Heat sensitive. Storage class (TRGS 510): Non Combustible Solids

biological source	synthetic (Organic)
Quality Level	200,
assay	≥98% (HPLC)
form	powder
storage condition	(Keep container tightly closed in a dry and well-ventilated place. Heat sensitive. Storage class (TRGS 510) Non Combustible liquids.)
color	white to yellow
Mode of action	DNA synthesis \| interferes, enzyme \| interferes
antibiotic activity spectrum	Gram-negative bacteria, Gram-positive bacteria
storage temp.	−20°C
InChI	1S/C19H21FN2O4/c1-10-2-3-12-16-13(18(24)14(19(25)26)9-22(10)16)8-15(20)17(12)21-6-4-11(23)5-7-21/h8-11,23H,2-7H2,1H3,(H,25,26)
InChI key	JYJTVFIEFKZWCJ-UHFFFAOYSA-N

Chemical structure: -lactam

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Nafcillin sodium salt monohydrate

Empirical Formula (Hill Notation):	C₂₁H₂₁N₂NaO₅S · H₂O
Linear Formula:	C₂₁H₂₁N₂O₅SNa · H₂O
CAS Number:	7177-50-6
Molecular Weight:	454.47
MDL number:	MFCD01941128
PubChem Substance ID:	24897636
NACRES:	NA.85

Nafcillin sodium is a narrow-spectrum -lactam antibiotic. It is used to treat infections caused by Gram-positive bacteria, in particular, species of Staphylococci that are resistant to other penicillins. It has been used to study penicillin-binding proteins (PBPs), such as 2a, and heterogeneous expression of methicillin resistance in Staphylococcus aureus. It is a potential therapy of meningitis due to Staphylococcus aureus.

Nafcillin inhibits bacterial cell wall formation by inhibiting PBPs. The irreversible inhibition of the PBPs prevents the final crosslinking (transpeptidation) of the nascent peptidoglycan layer, which disrupts cell wall synthesis.

5g
Keep container tightly closed in a dry and well-ventilated place.

Quality Level	200,
Mode of action	cell wall synthesis \| interferes
antibiotic activity spectrum	Gram-positive bacteria
storage temp.	2-8°C
SMILES string	O.[Na+].CCOc1ccc2ccccc2c1C(=O)N[C@H]3C4SC(C)(C)[C@@H](N4C3=O)C([O-])=O
InChI	1S/C21H22N2O5S.Na.H2O/c1-4-28-13-10-9-11-7-5-6-8-12(11)14(13)17(24)22-15-18(25)23-16(20(26)27)21(2,3)29-19(15)23;;/h5-10,15-16,19H,4H2,1-3H3,(H,22,24)(H,26,27);;1H2/q;+1;/p-1/t15-,16+,19-;;/m1../s1
InChI key	OCXSDHJRMYFTMA-KMFBOIRUSA-M