Tetracycline hydrochloride

Empirical Formula (Hill Notation):	C22H24N2O8 · HCl
CAS Number:	64-75-5
Molecular Weight:	480.90
Beilstein/REAXYS Number:	3844873
EC Number:	200-593-8
MDL number:	MFCD00078142
PubChem Substance ID:	24900468

Кат. номер

T7660-5G-9

T7660-25G

T7660-5G

T7660-1G

Chemical structure: tetracycline
5, 25 g in poly bottle
Tetracycline is a broad spectrum polyketide antibiotic with clinical uses in treating bacterial infections such as Rocky Mountain spotted fever, typush fever, tick fevers, Q fever, and Brill-Zinsser disease and to treat upper respiratory infections and acne. It has been used in studies of multidrug resistance and potential side effects including acute pancreatitis. It is recommended for use in cell culture applications at 10 mg/L.
Mode of Action: Tetracycline passively diffuses through proin channels in the cell membrane, binding to 30S ribosomes and inhibits protein synthesis by preventing access of aminoacyl tRNA to the acceptor site on the mRNA-ribosome complex. It also binds to the bacterial 50S ribosomal subunit, altering the membrane and causing intracellular components to leak from bacterial cells. The inhibitory effects can be reversed by washing, suggesting that it is the reversibly bound antibiotic, and not the irreversibly bound drug, that is responsible for antibacterial action.
Mode of Resistance: The effects are inactivated via a loss of cell wall permeability.
Antimicrobial spectrum: Includes a wide range of antimicrobial activity against gram-positive and gram-negative bacteria.
This product should be frozen below 0°C and protected from light and moisture. In these conditions, the product has been shown to retain activity for 4 years. Stock solutions should be stored at -20°C and are stable at 37°C for 4 days.
The product is freely soluble in water, slightly soluble in 96% ethanol, and is practically insoluble in acetone. Tetracycline is rapidly destroyed by alkali hydroxide solutions and standing water solutions become turbid due to hydrolysis and precipitation. The potency of tetracycline is reduced in solutions with pH below 2.
Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place

Quality Level	200,
biological source	synthetic
product line	BioReagent
form	powder
storage condition	(Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)
application(s)	cell culture | mammalian: suitable
impurities	endotoxin, tested
color	yellow
mp	220-223 °C (lit.)
Mode of action	protein synthesis | interferes
antibiotic activity spectrum	Gram-negative bacteria, Gram-positive bacteria
storage temp.	−20°C
SMILES string	Cl.CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c4c(O)cccc4[C@@]3(C)O
InChI	1S/C22H24N2O8.ClH/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28;/h4-6,9-10,15,25,27-28,31-32H,7H2,1-3H3,(H2,23,30);1H/t9-,10-,15-,21+,22-;/m0./s1
InChI key	XMEVHPAGJVLHIG-FMZCEJRJSA-N

pictograms	GHS07,GHS08,GHS09
signalword	Warning
hcodes	H315 - H319 - H335 - H361fd - H410
pcodes	P202 - P261 - P273 - P302 + P352 - P305 + P351 + P338 - P308 + P313
Target Organs	Respiratory system
Personal Protective Equipment	dust mask type N95 (US),, Eyeshields,, Gloves,
RIDADR	UN 3077 9 / PGIII
WGK Germany	WGK 2
Flash Point F	Not applicable
Flash Point C	Not applicable