Erythromycin

Empirical Formula (Hill Notation):	C37H67NO13
CAS Number:	114-07-8
Molecular Weight:	733.93
Beilstein/REAXYS Number:	75279
EC Number:	204-040-1
MDL number:	MFCD00084654
PubChem Substance ID:	24894612
NACRES:	NA.76

Кат. номер

E5389-5G

E5389-1G

Chemical structure: macrolide
Erythromycin is an antibiotic produced by growth of certain strains of Streptomyces erythreus. This product is composed largely of erythromycin A with small amounts of erythromycins B and C and is recommended for concentration at 100 mg/L. Concentrations between 50 and 200 mg/L have also proven effective in controlling bacterial growth. Erythromycin has been used as a motilin receptor agonist, to block respiratory glycoconjugate secretion in human airways in vitro, and for selecting plasmid-cured and recombinant lactococcus lactis MG1363 strains.
Erythromycin has been used:

• as a supplement for nutrient broth medium for culturing green fluorescent protein (GFP)- expressing E. coli
• as a model drug to determine small intestinal (SMI) microtissue viability using the MTT assay{254
• as an antibiotic to study the treatment strategies of chronic infections

1, 5 g in poly bottle
Mode of Action: Erythromycin acts by inhibiting elongation at the transpeptidation step, specifically aminoacyl translocation from the A-site to P-site by binding to the 50s subunit of the bacterial 70s rRNA complex.
Antimicrobial Spectrum: This product acts against both gram-negative and gram-positive bacteria.
This product is stable in solution at 37°C for 3 days. Stock solutions should be stored at 2-8°C.
This product is soluble in water at 2 mg/mL, with a 0.067% solution in water yielding a pH of 8.0-10.5. It is also soluble in ethanol at 50 mg/mL, yielding a clear, colorless to faint yellow solution. It is freely soluble in alcohol, acetone, chloroform, acetonitrile and ethyl acetate but forms salts with acids. All solutions should be protected from light.

Quality Level	200,
product line	BioReagent
form	powder
potency	850 µg per mg
application(s)	cell culture | mammalian: suitable
impurities	0.1 EU/mg endotoxin
color	white
mp	133 °C
solubility	2 M HCl: 50 mg/mL (Stock solutions should be stored at 2-8 °C. Stable at 37 °C for 3 days.), ethanol: soluble (Stock solutions should be stored at 2-8 °C. Stable at 37 °C for 3 days.)
Mode of action	protein synthesis | interferes
antibiotic activity spectrum	Gram-negative bacteria, Gram-positive bacteria
SMILES string	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O
InChI	1S/C37H67NO13/c1-14-25-37(10,45)30(41)20(4)27(39)18(2)16-35(8,44)32(51-34-28(40)24(38(11)12)15-19(3)47-34)21(5)29(22(6)33(43)49-25)50-26-17-36(9,46-13)31(42)23(7)48-26/h18-26,28-32,34,40-42,44-45H,14-17H2,1-13H3/t18-,19-,20+,21+,22-,23+,24+,25-,26+,28-,29+,30-,31+,32-,34+,35-,36-,37-/m1/s1
InChI key	ULGZDMOVFRHVEP-RWJQBGPGSA-N
Gene Information	human ... ABCB1(5243), CYP3A4(1576), MLNR(2862) mouse ... Abcb1a(18671), Abcb1b(18669)

Personal Protective Equipment	Eyeshields,, Gloves,, type N95 (US),
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable