Amphotericin B from Streptomyces sp.

Empirical Formula (Hill Notation):	C47H73NO17
CAS Number:	1397-89-3
Molecular Weight:	924.08
Beilstein/REAXYS Number:	78342
EC Number:	215-742-2
MDL number:	MFCD00877763
PubChem Substance ID:	57653841
NACRES:	NA.85

Кат. номер

A4888-500MG-PW

A4888-100G-PW

A4888-1G-PW

A4888-5G-PW

A4888-100MG-PW

A4888-250MG-PW

A4888-500MG

A4888-5G

A4888-1G

A4888-100G

A4888-100MG

A4888-250MG

A4888-25MG

Chemical structure: polyene
Amphotericin B is used to study the affects of the influx of calcium on antifungal activity, and to study the binding and kinetics of Amphotericin B to sterols in monolayers, aqueous solutions, and phospholipid bilayers . It is also commonly used in tissue culture as an antifungal supplement.
Amphotericin B from Streptomyces sp. has been used-

• for amphotericin perforated patch technique
• as a reference antifungal drug during MIC (minimum inhibitory concentration) agar dilution assay
• as a component of Arcobacter selective isolation broth

1, 5, 100 g in glass bottle
100, 250, 500 mg in glass bottle
Amphotericin B binds to sterols, forming pores in the membrane, and causing small molecules to leak out. The product is most effective against fungi and yeast.
Amphotericin B remains active for 3 days in culture at 37°C. At -20°C, and with protection from air and light, the product remains active for 5 years.
Amphotericin B is insoluble in water at pH 6 to 7, but soluble in water at pH 2 or 11. It is soluble in DMSO (30-40 mg/mL) and in dimethylformamide (2-4 mg/mL). Aqueous solutions cannot be sterile filtered due to poor solubility.
Keep container tightly closed in a dry and well-ventilated place. Product is sensitive to light and moisture. Keep in a dry place.

biological source	Streptomyces sp.
Quality Level	300,
assay	~80% (HPLC)
form	powder
color	yellow to orange
solubility	DMF: 2-4 mg/mL, DMSO: 30-40 mg/mL, H2O: insoluble
Mode of action	cell membrane | interferes
antibiotic activity spectrum	fungi, yeast
storage temp.	2-8°C
SMILES string	C[C@H]1O[C@@H](O[C@@H]2C[C@@H]3O[C@](O)(C[C@@H](O)C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)CC(=O)O[C@@H](C)[C@H](C)[C@H](O)[C@@H](C)\C=C\C=C\C=C\C=C\C=C\C=C\C=C\2)C[C@H](O)[C@H]3C(O)=O)[C@@H](O)[C@@H](N)[C@@H]1O
InChI	1S/C47H73NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-33(51)22-36(53)35(52)20-19-31(49)21-32(50)23-39(55)62-29(3)28(2)42(27)56/h5-18,27-38,40-44,46,49-54,56-58,61H,19-26,48H2,1-4H3,(H,59,60)/b6-5+,9-7+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31+,32+,33-,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1
InChI key	APKFDSVGJQXUKY-INPOYWNPSA-N

pictograms	GHS08
signalword	Danger
hcodes	H372
pcodes	P260 - P264 - P270 - P314 - P501
Personal Protective Equipment	dust mask type N95 (US),, Eyeshields,, Gloves,
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable