Fmoc-L-Photo-Phe-OH 907294-50MG

Empirical Formula (Hill Notation):	C26H20F3N3O4
CAS Number:	133342-64-0
Molecular Weight:	495.45
MDL number:	MFCD30187628

Fmoc-L-Photo-Phe-OH is a diazirine-containing, Fmoc-protected phenylalanine, amino acid and multifunctional photo-crosslinker. Its incorporation into peptides or small-molecule probes and tools allows for photoaffinity labeling of cellular targets and protein-protein interactions upon UV light (360 nm) irradiation to form a covalent bond. This and other multifunctional probe building blocks, will continue to accelerate drug discovery research for probing cellular mechanisms, target ID/validation, and understanding traditionally undruggable targets. An unprotected version is also available as 907340.
Covalent modifier-type aggregation inhibitor of amyloid- based on a cyclo-KLVFF motif,
Mode of Action of cGMP-dependent Protein Kinase-specific Inhibitors Probed by Photoaffinity Cross-linking Mass Spectrometry,
Trifluoromethyldiazirine: an effective photo-induced cross-linking probe for exploring amyloid formation,
Simple and Versatile Method for Tagging Phenyldiazirine Photophores,
Fishing for Drug Targets: A Focus on Diazirine Photoaffinity Probe Synthesis,
Photo-affinity labeling (PAL) in chemical proteomics: a handy tool to investigate protein-protein interactions (PPIs),

assay	95%
form	powder
reaction suitability	reaction type: Fmoc solid-phase peptide synthesis
application(s)	peptide synthesis: suitable
functional group	Fmoc
storage temp.	20°C

WGK Germany

WGK 3