Fmoc-L-photo-leucine 907391-50MG

Empirical Formula (Hill Notation):	C20H19N3O4
CAS Number:	1360651-24-6
Molecular Weight:	365.38

Fmoc-L-Photo-Leucine is a diazirine-containing, Fmoc-protected leucine, amino acid and multifunctional photo-crosslinker. Its incorporation into peptides or small-molecule probes and tools allows for photoaffinity labeling of cellular targets and protein-protein interactions upon UV light (360 nm) irradiation to form a covalent bond. This and other multifunctional probe building blocks, will continue to accelerate drug discovery research for probing cellular mechanisms, target ID/validation, and understanding traditionally undruggable targets. An unprotected version is also available as 907278.
Synthesis of a polymyxin derivative for photolabeling studies in the gram-negative bacterium Escherichia coli,
Developing diazirine-based chemical probes to identify histone modification readers and erasers,
Protein-Polymer Conjugation via Ligand Affinity and Photoactivation of Glutathione S-Transferase,
Fishing for Drug Targets: A Focus on Diazirine Photoaffinity Probe Synthesis,
Photo-affinity labeling (PAL) in chemical proteomics: a handy tool to investigate protein-protein interactions (PPIs),

assay	98%
form	powder
reaction suitability	reaction type: Fmoc solid-phase peptide synthesis
application(s)	peptide synthesis: suitable
functional group	Fmoc
storage temp.	2-8°C

WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable