By Togas Tulandi, Morrie Gelfand
The topic of androgen remedy in reproductive elderly men and women is attracting expanding curiosity from experts in copy medication, endocrinology and first care prone, in addition to from sufferers and the media.
The first booklet to hide androgen substitute in males and girls, Androgens and Reproductive Aging addresses the emotive issues of reproductive getting older, the menopause and using androgen vitamins to mitigate their results.
Edited by way of major specialists in reproductive medication and infertility, and boasting an all-star forged of authors, this finished textual content covers:
* androgen creation within the fit female and male
* the decline of androgen creation in the course of getting older, with the linked results on physique composition and libido
* the advantages and power side-effects of androgen alternative therapy.
Ideal for quite a lot of clinicians and scientists attracted to reproductive getting older, the menopause, hormone substitute and androgen treatment, in addition to obstetricians, gynecologists and relatives practitioners, this special textual content is a hugely very important addition to literature within the area.
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Extra resources for Androgens and Reproductive Aging
The rise in FSH has been explained by falling levels of inhibin B from the ovary. Inhibin levels fall secondary to the declining number and quality of ovarian follicles and may be thought of as measures of ‘ovarian reserve’. Follicular atresia begins before birth and long before puberty. This early, accelerated loss translates into a reduction from a peak of 6–7 million follicles at around 20 weeks’ gestation to 1–2 million follicles at birth. This rate of follicular atresia is independent of gonadotropic stimulation.
J Clin Endocrinol Metab 2001; 86:5541–5546. 32. Illingworth PJ, Groome NP, Byrd W, et al. Inhibin B: a likely candidate for the physiologically important form of inhibin in men. J Clin Endocrinol Metab 1996; 81:11321–1325. 33. Handelsman DJ. Male reproductive ageing: Human fertility, androgens, and hormone dependent disease. Novartis Foundation Symposium 242 2002; 66–81. 34. Handelsman DJ, Staraj S, Testicular Size: the effects of aging, malnutrition, and Illness. J Androl 1985; 6:144–151. 35. Mulligan T, Iranmanesh A, Kerzner R, et al.
Compared the expression of androgen receptors in human cardinal ligaments of prolapsed uteri with nonprolapsed controls59 and demonstrated that the cardinal ligaments of women with uterine prolapse expressed three to four times more androgen receptors than women without prolapse, implying that androgens may play a role in pelvic organ prolapse. Androgens may also play a role in stress urinary incontinence as urinary levels of androgens have been demonstrated to be significantly higher in postmenopausal patients with stress urinary incontinence compared to postmenopausal women without incontinence.
Androgens and Reproductive Aging by Togas Tulandi, Morrie Gelfand