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Muscl Heart U. 21 one value. 75 Table 2. gut/ W. muscl/ P. V. THURSTON et al. body were very similar after 2 hours' exposure, but blood plasma concentration at 6 hours had not increased, whereas whole body concentration had more than doubled (Fig. 1). The obvious conclusion was that TCB equilibrium between exposure water and blood plasma was achieved within 2 hours or less, and after reaching saturation the blood was acting as a conduit to pass TCB from gills to body tissues. Thus, blood plasma could not be used to indicate either total body content or uptake rate of the toxicant.

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Consequently the bioavailability of oral doses of the metal is low in mammals (1-2% Kaehny et al, 1911 \ Recker et al, 1911 \ Yokel & McNamara, 1985) and rainbow trout (Handy, 1993). The excretion of Al is also controversial. Aluminium is excreted in the urine of mammals, but the renal mechanisms by which this is achieved are not understood (Kaehny et al, 1977; Recker et al, 1911 \ Stewart, 1989). Excretion in the bile might occur given the high Al content of mammalian livers compared to other organs (Fairweather-Tait et al, 1991).

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