By Anish Bhardwaj, Nabil J. Alkayed, Jeffrey R. Kirsch, Richard J. Traystman
Because the 3rd best reason behind dying within the usa, stroke bills for one in each fifteen deaths and is the key reason behind incapacity within the kingdom. Compiled through a popular editorial staff, this reference bridges the distance among easy technology and sufferer care protocols, and collects forty three expertly written chapters that diversity from laboratory-based study on animal versions to the development, mechanisms, remedy, and analysis of illnesses corresponding to subarachnoid hemorrhage (SAH), intracerebral hemorrhage (ICH), focal ischemic stroke, and worldwide cerebral ischemia.
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Extra resources for Acute Stroke: Bench to Bedside (Neurological Disease and Therapy)
J Neurosurg 1981; 55:869–876. 17. Hughes JT, Schianchi PM. Cerebral artery spasm. A histological study at necropsy of the blood vessels in cases of subarachnoid hemorrhage. J Neurosurg 1978; 48:515–525. 18. Smith RR, Clower BR, Grotendorst GM, Yabuno N, Cruse JM. Arterial wall changes in early human vasospasm. Neurosurgery 1985; 16:171–176. 19. Wilkins RH, Wilkins GK, Gunnells JC, Odom GL. Experimental studies of intracranial arterial spasm using aortic strip assays. J Neurosurg 1967; 27:490–500.
77. Pickard JD, Walker V, Vile J, Perry S, Smythe PJ, Hunt R. Oral nimodipine reduces prostaglandin and thromboxane production by arteries chronically exposed to a periarterial haematoma and the antifibrinolytic agent tranexamic acid. J Neurol Neurosurg Psychiatr 1987; 50:727–731. 78. Lougheed WM, Tom M. A method of introducing blood into the subarachnoid space in the region of the circle of Willis in dogs. Can J Surg 1961; 4:329–337. 79. Brawley BW, Strandness DE Jr. Continuous recording of the intracranial internal carotid artery size in the dog.
Therapeutic approaches tested in this model include prophylactic laser treatment and transluminal angioplasty. DOG MODELS The first dog model described for the study of vasospasm used a transoral/transclival approach to the chiasmatic cistern (78). In this study, only 42% of the animals experienced SAH after injection of 5 ml of arterial blood. Complications, such as intraventricular hemorrhages, meningitis, and subdural hematomas, developed, and the study showed that some of the animals developed symptomatic vasospasm.
Acute Stroke: Bench to Bedside (Neurological Disease and Therapy) by Anish Bhardwaj, Nabil J. Alkayed, Jeffrey R. Kirsch, Richard J. Traystman